HUP0203734A2 - Eljárás lizofoszfatidil-etanol-amin előállítására - Google Patents
Eljárás lizofoszfatidil-etanol-amin előállításáraInfo
- Publication number
- HUP0203734A2 HUP0203734A2 HU0203734A HUP0203734A HUP0203734A2 HU P0203734 A2 HUP0203734 A2 HU P0203734A2 HU 0203734 A HU0203734 A HU 0203734A HU P0203734 A HUP0203734 A HU P0203734A HU P0203734 A2 HUP0203734 A2 HU P0203734A2
- Authority
- HU
- Hungary
- Prior art keywords
- order
- mixture containing
- lysophosphatidylethanolamine
- phospholipid mixture
- solvent
- Prior art date
Links
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 title abstract 4
- CWRILEGKIAOYKP-SSDOTTSWSA-M [(2r)-3-acetyloxy-2-hydroxypropyl] 2-aminoethyl phosphate Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCCN CWRILEGKIAOYKP-SSDOTTSWSA-M 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003904 phospholipids Chemical class 0.000 abstract 2
- 102100037611 Lysophospholipase Human genes 0.000 abstract 1
- 108010058864 Phospholipases A2 Proteins 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
Abstract
Az ismertetés tárgya eljárás nagy tisztaságú lizofoszfatidil-etanol-amin tisztítására, foszfolipid keverék enzimes kezelésével, melyetoldószeres frakcionálás követ, az oszlop tisztítása nélkül. A jelentalálmány szerinti eljárás tartalmazza a 10-99 tömegszázalékfoszfatidil-etanol-amin-tartalmú foszfolipid-keverék hidrolízisétfoszfolipáz A2-vel, lizofoszfolipid képződése érdekében; és alizofoszfolipid kezelését oldószerkeverékkel, mely tartalmaz vizet ésegy vagy több szerves oldószert, melyet kiválasztanak a kisszénatomszámú alkohol, szénhidrogén és alkil-észter csoportból, aszennyezések, kivéve a lizofoszfatidil-etanol-amin eltávolításaérdekében. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019990053780A KR100331932B1 (ko) | 1999-11-30 | 1999-11-30 | 리소포스파티딜에탄올아민의 제조방법 |
PCT/KR2000/001369 WO2001040496A1 (en) | 1999-11-30 | 2000-11-28 | A method for preparing lysophosphatidylethanolamine |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203734A2 true HUP0203734A2 (hu) | 2003-03-28 |
HUP0203734A3 HUP0203734A3 (en) | 2004-03-01 |
Family
ID=36314055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203734A HUP0203734A3 (en) | 1999-11-30 | 2000-11-28 | A method for preparing lysophosphatidylethanolamine |
Country Status (21)
Country | Link |
---|---|
US (1) | US6773902B1 (hu) |
EP (1) | EP1238093B1 (hu) |
JP (1) | JP4045100B2 (hu) |
KR (1) | KR100331932B1 (hu) |
CN (1) | CN1253578C (hu) |
AT (1) | ATE323777T1 (hu) |
AU (1) | AU779636B2 (hu) |
BR (1) | BR0016179A (hu) |
CA (1) | CA2392998A1 (hu) |
CR (1) | CR6646A (hu) |
CZ (1) | CZ20021652A3 (hu) |
DE (1) | DE60027462D1 (hu) |
HU (1) | HUP0203734A3 (hu) |
IL (1) | IL149680A0 (hu) |
MX (1) | MXPA02005383A (hu) |
NO (1) | NO20022343L (hu) |
NZ (1) | NZ519060A (hu) |
PL (1) | PL355480A1 (hu) |
RU (1) | RU2002117277A (hu) |
WO (1) | WO2001040496A1 (hu) |
ZA (1) | ZA200204281B (hu) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100472297B1 (ko) * | 2001-09-27 | 2005-03-07 | 주식회사 두산 | 리소인지질의 수용성 조성물 |
KR20030084200A (ko) * | 2002-04-25 | 2003-11-01 | 주식회사 두산 | 비 유기용매시스템에서의 포스파티딜에탄올아민 및리소포스파티딜에탄올아민의 제조방법 및 그 방법으로제조된 리소포스파티딜에탄올아민을 포함하는 수용성 조성물 |
KR100454086B1 (ko) * | 2002-09-14 | 2004-10-26 | 학교법인 한양학원 | 회수율과 감도를 높인 인지질분해효소 d의 활성확인을위한 지질 추출방법 |
JP4650746B2 (ja) * | 2004-03-18 | 2011-03-16 | ナガセケムテックス株式会社 | 酵素の除去方法および該方法を用いるリン脂質の塩基転移または加水分解方法 |
US7189544B2 (en) * | 2004-04-09 | 2007-03-13 | Cargill, Incorporated | Enzymatic modification of lecithin |
US20080207503A1 (en) * | 2005-06-22 | 2008-08-28 | Chung Byung-Hong | Composition and Treatment Methods for Coronary Artery Disease |
KR101028489B1 (ko) * | 2005-06-30 | 2011-04-14 | 주식회사 두산 | 리소포스파티딜에탄올아민 또는 레시틴을 함유한 안정한수용성 조성물 |
JP2009148244A (ja) * | 2007-11-29 | 2009-07-09 | Gunma Prefecture | リゾホスファチジルエタノールアミンの製造法 |
CN101302547B (zh) * | 2008-06-10 | 2010-06-02 | 江南大学 | 一种磷脂酰月桂醇的酶法制备方法 |
CN102286559A (zh) * | 2011-09-06 | 2011-12-21 | 三河汇福粮油集团有限公司 | 一种制备溶血磷脂的方法及所制备的溶血磷脂 |
CN103073571A (zh) * | 2011-11-29 | 2013-05-01 | 江南大学 | 一种磷脂酰乙醇胺的制备方法 |
KR101661706B1 (ko) * | 2014-06-24 | 2016-10-04 | 한국생명공학연구원 | 미생물로부터 리소포스파티딜에탄올아민 18:1의 생산 방법 |
CN104262387B (zh) * | 2014-09-19 | 2016-06-29 | 河南省农科院农副产品加工研究所 | 一种硅胶柱色谱分离纯化溶血磷脂酰乙醇胺的方法 |
CN104931618B (zh) * | 2015-06-26 | 2016-10-26 | 卢航 | 复杂样品中6种磷脂的多重检测方法 |
CN106479993A (zh) * | 2016-09-26 | 2017-03-08 | 南京工业大学 | 一种磷脂酶d催化磷脂酰胆碱合成磷脂酰乙醇胺的方法 |
CN109851630B (zh) * | 2017-11-30 | 2021-11-30 | 江苏曼氏生物科技股份有限公司 | 一种高含量磷脂酰乙醇胺的制备方法 |
CN110144369A (zh) * | 2019-05-22 | 2019-08-20 | 杨利平 | 一种制备高纯度溶血磷脂酰胆碱的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2731852B2 (ja) * | 1988-10-22 | 1998-03-25 | 富山化学工業株式会社 | リゾホスファチジルコリンの新規な製造法 |
JPH03123493A (ja) * | 1989-10-05 | 1991-05-27 | Nippon Oil & Fats Co Ltd | ジアシルグリセロリン脂質の加水分解法 |
JPH053791A (ja) | 1991-06-25 | 1993-01-14 | Mercian Corp | リノール酸を唯一の構成脂肪酸とするリゾホスフアチジルコリン及びリゾホスフアチジルエタノールアミンの製造方法 |
TW362115B (en) * | 1992-06-16 | 1999-06-21 | Sankyo Lifetech Co Ltd | Novel phospholipase A1, process for its preparation and the use thereof |
JP3650168B2 (ja) * | 1995-06-20 | 2005-05-18 | 株式会社ヤクルト本社 | リゾ化リン脂質組成物及びその製造法 |
US5716814A (en) * | 1996-02-02 | 1998-02-10 | Biomolecular Products, Inc. | Methods for making lysophosphatidylcholine |
JP3853464B2 (ja) * | 1997-04-08 | 2006-12-06 | 辻製油株式会社 | 植物性リゾレシチンの製造法 |
US6268187B1 (en) * | 1997-07-24 | 2001-07-31 | Doosan Corporation | Process for preparing lysophospholipid using enzyme |
-
1999
- 1999-11-30 KR KR1019990053780A patent/KR100331932B1/ko active IP Right Grant
-
2000
- 2000-11-28 WO PCT/KR2000/001369 patent/WO2001040496A1/en active IP Right Grant
- 2000-11-28 AU AU20244/01A patent/AU779636B2/en not_active Ceased
- 2000-11-28 NZ NZ519060A patent/NZ519060A/en unknown
- 2000-11-28 IL IL14968000A patent/IL149680A0/xx unknown
- 2000-11-28 BR BR0016179-9A patent/BR0016179A/pt not_active IP Right Cessation
- 2000-11-28 EP EP00983493A patent/EP1238093B1/en not_active Expired - Lifetime
- 2000-11-28 DE DE60027462T patent/DE60027462D1/de not_active Expired - Lifetime
- 2000-11-28 HU HU0203734A patent/HUP0203734A3/hu unknown
- 2000-11-28 CA CA002392998A patent/CA2392998A1/en not_active Abandoned
- 2000-11-28 US US10/031,809 patent/US6773902B1/en not_active Expired - Lifetime
- 2000-11-28 MX MXPA02005383A patent/MXPA02005383A/es unknown
- 2000-11-28 AT AT00983493T patent/ATE323777T1/de not_active IP Right Cessation
- 2000-11-28 JP JP2001542560A patent/JP4045100B2/ja not_active Expired - Fee Related
- 2000-11-28 RU RU2002117277/13A patent/RU2002117277A/ru not_active Application Discontinuation
- 2000-11-28 CN CNB008164452A patent/CN1253578C/zh not_active Expired - Lifetime
- 2000-11-28 PL PL00355480A patent/PL355480A1/xx not_active Application Discontinuation
- 2000-11-28 CZ CZ20021652A patent/CZ20021652A3/cs unknown
-
2002
- 2002-05-16 NO NO20022343A patent/NO20022343L/no not_active Application Discontinuation
- 2002-05-20 CR CR6646A patent/CR6646A/es not_active Application Discontinuation
- 2002-05-29 ZA ZA200204281A patent/ZA200204281B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR0016179A (pt) | 2002-08-27 |
KR20010048900A (ko) | 2001-06-15 |
EP1238093A1 (en) | 2002-09-11 |
NZ519060A (en) | 2003-11-28 |
EP1238093B1 (en) | 2006-04-19 |
CZ20021652A3 (cs) | 2002-11-13 |
IL149680A0 (en) | 2002-11-10 |
MXPA02005383A (es) | 2004-06-21 |
HUP0203734A3 (en) | 2004-03-01 |
ATE323777T1 (de) | 2006-05-15 |
AU779636B2 (en) | 2005-02-03 |
DE60027462D1 (de) | 2006-05-24 |
US6773902B1 (en) | 2004-08-10 |
NO20022343L (no) | 2002-07-04 |
JP2003515346A (ja) | 2003-05-07 |
AU2024401A (en) | 2001-06-12 |
JP4045100B2 (ja) | 2008-02-13 |
CN1402794A (zh) | 2003-03-12 |
CR6646A (es) | 2004-08-16 |
PL355480A1 (en) | 2004-05-04 |
CN1253578C (zh) | 2006-04-26 |
RU2002117277A (ru) | 2004-02-10 |
NO20022343D0 (no) | 2002-05-16 |
KR100331932B1 (ko) | 2002-04-09 |
WO2001040496A1 (en) | 2001-06-07 |
ZA200204281B (en) | 2003-04-30 |
CA2392998A1 (en) | 2001-06-07 |
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