HUE045797T2 - Hexahidropirrolo[3,4-c]pirrol-származékok és rokonvegyületek mint autotaxin (ATX) inhibitorok, valamint a lizofoszfatidsav (LPA) termelés inhibitorai, például vesebetegségek kezelésére - Google Patents
Hexahidropirrolo[3,4-c]pirrol-származékok és rokonvegyületek mint autotaxin (ATX) inhibitorok, valamint a lizofoszfatidsav (LPA) termelés inhibitorai, például vesebetegségek kezeléséreInfo
- Publication number
- HUE045797T2 HUE045797T2 HUE13766056A HUE13766056A HUE045797T2 HU E045797 T2 HUE045797 T2 HU E045797T2 HU E13766056 A HUE13766056 A HU E13766056A HU E13766056 A HUE13766056 A HU E13766056A HU E045797 T2 HUE045797 T2 HU E045797T2
- Authority
- HU
- Hungary
- Prior art keywords
- inhibitors
- autotaxin
- hexahydropyrrolo
- atx
- lpa
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12185941 | 2012-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE045797T2 true HUE045797T2 (hu) | 2020-01-28 |
Family
ID=47073290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE13766056A HUE045797T2 (hu) | 2012-09-25 | 2013-09-23 | Hexahidropirrolo[3,4-c]pirrol-származékok és rokonvegyületek mint autotaxin (ATX) inhibitorok, valamint a lizofoszfatidsav (LPA) termelés inhibitorai, például vesebetegségek kezelésére |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US20150353559A1 (hu) |
| EP (2) | EP2900669B1 (hu) |
| JP (1) | JP6285444B2 (hu) |
| KR (1) | KR102179599B1 (hu) |
| CN (1) | CN104684915B (hu) |
| AR (1) | AR092645A1 (hu) |
| AU (1) | AU2013322838B2 (hu) |
| BR (1) | BR112015004111A2 (hu) |
| CA (1) | CA2878442A1 (hu) |
| CL (1) | CL2015000706A1 (hu) |
| CR (1) | CR20150120A (hu) |
| DK (1) | DK2900669T3 (hu) |
| EA (1) | EA036630B1 (hu) |
| ES (1) | ES2753163T3 (hu) |
| HK (1) | HK1206722A1 (hu) |
| HR (1) | HRP20191937T1 (hu) |
| HU (1) | HUE045797T2 (hu) |
| IL (1) | IL237126A (hu) |
| IN (1) | IN2015DN00960A (hu) |
| LT (1) | LT2900669T (hu) |
| MA (1) | MA37940B1 (hu) |
| MX (1) | MX368615B (hu) |
| PE (1) | PE20150758A1 (hu) |
| PH (1) | PH12015500263A1 (hu) |
| PL (1) | PL2900669T3 (hu) |
| PT (1) | PT2900669T (hu) |
| RS (1) | RS59512B1 (hu) |
| SG (1) | SG11201500572YA (hu) |
| SI (1) | SI2900669T1 (hu) |
| TW (1) | TWI609018B (hu) |
| UA (1) | UA116547C2 (hu) |
| WO (1) | WO2014048865A1 (hu) |
| ZA (1) | ZA201500345B (hu) |
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| JP6258928B2 (ja) | 2012-06-13 | 2018-01-10 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規ジアザスピロシクロアルカンおよびアザスピロシクロアルカン |
| AU2013322838B2 (en) | 2012-09-25 | 2018-02-01 | F. Hoffmann-La Roche Ag | New bicyclic derivatives |
| CA2895448A1 (en) | 2012-12-19 | 2014-06-26 | Novartis Ag | Autotaxin inhibitors |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) * | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| MX2015017961A (es) * | 2013-07-03 | 2016-10-14 | Abide Therapeutics Inc | Compuestos orgánicos pirrolo-pirrol carbamato y relacionados, composiciones farmacéuticas y usos médicos de los mismos. |
| WO2015048507A1 (en) * | 2013-09-26 | 2015-04-02 | Mnemosyne Pharmaceuticals, Inc. | Selective octahydro-cyclopenta[c] pyrrole negative modulators of nr2b |
| MX2016006623A (es) | 2013-11-22 | 2017-03-10 | Pharmakea Inc | Compuestos de inhibidor de autotaxina. |
| UA118201C2 (uk) * | 2013-11-26 | 2018-12-10 | Ф. Хоффманн-Ля Рош Аг | НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ |
| EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| EA037928B1 (ru) * | 2014-03-26 | 2021-06-08 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
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