HUE030224T2 - Alacsony molekulasúlyú, biotechnológiai kondroitin-6-szulfát oszteoartritisz megelõzésére - Google Patents
Alacsony molekulasúlyú, biotechnológiai kondroitin-6-szulfát oszteoartritisz megelõzésére Download PDFInfo
- Publication number
- HUE030224T2 HUE030224T2 HUE13728982A HUE13728982A HUE030224T2 HU E030224 T2 HUE030224 T2 HU E030224T2 HU E13728982 A HUE13728982 A HU E13728982A HU E13728982 A HUE13728982 A HU E13728982A HU E030224 T2 HUE030224 T2 HU E030224T2
- Authority
- HU
- Hungary
- Prior art keywords
- molecular
- ékok
- sulphate
- glucose
- biotechnological
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Claims (5)
- Szabadalmi igénypontok j. IÖÖ0-5ÖÖÖ dalion molefculatömegii, gyoíiadáscsökkeutő és gpritíszeMkfeéoí# biológiai tótrvMssaí rendelkező köftdföíÖs^szsIfakjéSfe vagy anaál több dls^ch8né-6^monö^ü!ÍK)k kevesebb mint 1% d3$zacharid-4-sHo«öSz«ffiÍalj 20¾¾ vagy annál kevesebb dísxaébarid^^^teüiföttal, kevesebb í»ibi '$% diszaeharíd^d^rdís^lfélÉÉk kévesabb mint í% diszachafkl~1.4*disxí}Í®tal, kevesebb mint ÍS% nem szuííat&lt díszaehmáddai, és l~ls25 ^lté§$ürőaé^e^llémezv«. 2i Egy 1, igényjpiit ;3fepád*oit|i&>^í:aIf^,. amelyet E oe£ K.4 tokos |x>is2psbáríd kémiai ^Í^Íát4^::IP04:^:'kSMb savas vagy gyöküs depöllmerizáoiőjával kapunk, a#ufctós3namiékok ítldtolízlsseí válé oltáv^íMsa litáö, J, Egy 1. íff$e$$em. szermii kondmitimSZalfát. amelyet £. eöfö M4 tokos pobs^haríd alacsony molefcuíasúlyű természetes Eakeiójmtak kÉniat szulfátáiásávaí maid ezt kővel® savas vagy gyökös depolimerizáeipjlva! kapóik, mélyeket a inktózmaradekok hidrolizisseí való eltávolítása után hajtunk végre.
- 4. Egy i. Igénypont széőnii kmtdföitiíKszulílt, amelyet DSM33B44 E mii törzs által termelt, eredetileg tmktózmaradékíoí mentes tokos pidiszaeharid (:K4->á> kémiai szaífáiáíásávai majd ezt követő savas vagy gypMs déplte kapunk.
- 5. Egy L igénypont szerinti kondroittn-szul^.. amelyet J3>SM2fŐ44 & mit törzs által termelt, eredetileg ityktöZínaradéktöl mentes (K4«d) ftakeiöjának kémsal szuHatálásáyal majd ezt követő sa^a:y^r'|p3k^'élf^Umer^^:í^tel''l^pÍnnk
- 6. Az :í-5, igénypontok szerinti kondröttin-szoífái, akut vagy krónikus gyulladásos állapotok megelőzésében vagy kezelésében való alkalmazásra és/v&gy a vázizomzat! egészség megőrzésére emberekben és ál 1 átokban, 7. Á 6. igénypont szerinti alkalmazásra szolgáló kondroiió^sEZulfáí, ahol a gyulladásos állapot oszteoartriüsz.
- 8. Készítmények, amelyek aktív hatóanyagként 1-5. igénypontok szerinti kondroitin-szuliatot tartalmaznak gyógyászatiagi és gyógyhatású élelmiszerként elfogadható segédanyagokkal és adott esetben egyéb aktív Összetevőkkel való kombinációban, %,Á 8. igénypont szerinti készítmények, ahol az egyéb aktfv Összemvők glnkózantm-Mdroktorid, glökózamm-sznlfat, 14-aeetil-glnkózamm, hiáíuroosav, aminosavak, kollagén, bidrolizált kollagén, többszörösen telítetlen zsírsavak, keratin, dermatin, metiíszaifbmlmetán kbíSM), felélők, redukált foiátok, vitaminok, B vitaminok, S-adenozií-rneiionin (SőMej, aszkörfainsav vagy maugán-aszkorhát köréből választottak, íih Á 8, vagy f, igénypont s^rinti készitmények kapszula, puha gélkapszula, tabletta, folyékony kiszerelésben lévő balok Vagy feloldható por kíszerelésben lévő italok formájában.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000880A ITMI20120880A1 (it) | 2012-05-22 | 2012-05-22 | Condroitin 6-solfato biotecnologico a basso peso molecolare dotato di attivita' antiinfiammatoria e antiartritica e suo uso nel trattamento e nella prevenzione dell'osteoartrite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE030224T2 true HUE030224T2 (hu) | 2017-04-28 |
Family
ID=46582917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE13728982A HUE030224T2 (hu) | 2012-05-22 | 2013-05-22 | Alacsony molekulasúlyú, biotechnológiai kondroitin-6-szulfát oszteoartritisz megelõzésére |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20150152198A1 (hu) |
| EP (1) | EP2852437B1 (hu) |
| JP (1) | JP6273264B2 (hu) |
| KR (2) | KR20150013565A (hu) |
| CN (1) | CN104411363B (hu) |
| AU (1) | AU2013265350B2 (hu) |
| BR (1) | BR112014028904B1 (hu) |
| CA (1) | CA2874216C (hu) |
| CY (1) | CY1117636T1 (hu) |
| DK (1) | DK2852437T3 (hu) |
| EA (1) | EA032748B8 (hu) |
| ES (1) | ES2571583T3 (hu) |
| GE (1) | GEP201606585B (hu) |
| HR (1) | HRP20160773T1 (hu) |
| HU (1) | HUE030224T2 (hu) |
| IL (1) | IL235803B (hu) |
| IN (1) | IN2014DN09832A (hu) |
| IT (1) | ITMI20120880A1 (hu) |
| MX (1) | MX368965B (hu) |
| PH (1) | PH12014502444A1 (hu) |
| PL (1) | PL2852437T3 (hu) |
| SI (1) | SI2852437T1 (hu) |
| UA (1) | UA113005C2 (hu) |
| WO (1) | WO2013174847A1 (hu) |
| ZA (1) | ZA201408536B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20130117A1 (it) | 2013-01-25 | 2014-07-26 | Gnosis Spa | Composizioni comprendenti condroitin solfato, enzimi proteolitici e composti sulfidrilati capaci di migliorare la biodisponibilita' del condroitin solfato |
| JP2016138062A (ja) * | 2015-01-28 | 2016-08-04 | 一丸ファルコス株式会社 | 特定分子結合単位が分子内の末端部位に存在する高分子糖鎖化合物とその利用 |
| JP2016138061A (ja) * | 2015-01-28 | 2016-08-04 | 一丸ファルコス株式会社 | 特定分子結合単位が分子内の末端部位に存在する高分子糖鎖化合物とその利用 |
| KR102231289B1 (ko) | 2018-12-26 | 2021-03-23 | (주)휴온스 | 고함량 콘드로이틴설페이트 약학 제제 및 이의 제조방법 |
| WO2020219497A1 (en) * | 2019-04-25 | 2020-10-29 | The University Of Massachusetts | Compositions and methods for treatment of angiogenesis related diseases |
| WO2021179319A1 (zh) * | 2020-03-13 | 2021-09-16 | 南京汉欣医药科技有限公司 | 一种含水解硫酸软骨素的用于防治骨关节病的组合物 |
| JP2023500294A (ja) * | 2019-11-01 | 2023-01-05 | ナンチン ハンシン ファーマシューティカル テクノロジー カンパニー，リミティド | 低分子量コンドロイチン硫酸、組成物、製造方法及びそれらの使用 |
| CN111234048A (zh) * | 2020-03-09 | 2020-06-05 | 河北农业大学 | 鳐鱼硫酸软骨素的降解产物及其降解方法 |
| IT202000013618A1 (it) | 2020-06-08 | 2021-12-08 | Vivatis Pharma Gmbh | Processo di estrazione di un acido ialuronico da un fungo, un acido ialuronico di origine vegetale e suo uso |
| IT202000013633A1 (it) | 2020-06-08 | 2021-12-08 | Vivatis Pharma Gmbh | Processo di estrazione di una condroitina solfato da un fungo, una condroitina solfato di origine vegetale e suo uso |
| IT202100030935A1 (it) | 2021-12-09 | 2023-06-09 | Fidia Farm Spa | Compresse comprendenti condroitin solfato, glucosamina cloridrato e vitamina c per il trattamento di danni cartilaginei, tendinei, ossei |
| CN115895987B (zh) * | 2022-08-02 | 2024-02-13 | 衢州益康园生物科技有限公司 | 一种提高果糖软骨素产量的重组菌株及其构建方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI991465A1 (it) | 1999-07-02 | 2001-01-02 | Inalco Spa | Processo per la preparazione dei polisaccaridi k4 e k5 da escherichiacoli |
| ITMI20012200A1 (it) * | 2001-10-22 | 2003-04-22 | Ibsa Inst Biochimique Sa | Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti |
| WO2005110438A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| KR100706294B1 (ko) * | 2005-03-18 | 2007-04-11 | 한국식품연구원 | 연골어류의 연골로부터 얻은 저분자 콘드로이틴 황산 및 이의 제조방법 |
| US20100286085A1 (en) * | 2007-10-01 | 2010-11-11 | Seikagaku Corporation | Novel chondroitin sulfate having decreased molecular weight and use thereof |
| US9109243B2 (en) * | 2008-06-04 | 2015-08-18 | Amano Enzyme Usa, Ltd. | Microbial-derived chondroitin sulfate |
| SI2591127T1 (sl) | 2010-07-09 | 2017-12-29 | Gnosis S.P.A. | Biotehnološka proizvodnja hondroitina |
| US8664196B2 (en) * | 2011-05-20 | 2014-03-04 | Gnosis S.P.A. | Shark-like chondroitin sulphate and process for the preparation thereof |
-
2012
- 2012-05-22 IT IT000880A patent/ITMI20120880A1/it unknown
-
2013
- 2013-05-22 BR BR112014028904-2A patent/BR112014028904B1/pt active IP Right Grant
- 2013-05-22 EA EA201491919A patent/EA032748B8/ru not_active IP Right Cessation
- 2013-05-22 KR KR1020147032617A patent/KR20150013565A/ko not_active Application Discontinuation
- 2013-05-22 WO PCT/EP2013/060471 patent/WO2013174847A1/en active Application Filing
- 2013-05-22 HU HUE13728982A patent/HUE030224T2/hu unknown
- 2013-05-22 JP JP2015513151A patent/JP6273264B2/ja active Active
- 2013-05-22 EP EP13728982.3A patent/EP2852437B1/en active Active
- 2013-05-22 US US14/402,646 patent/US20150152198A1/en not_active Abandoned
- 2013-05-22 ES ES13728982T patent/ES2571583T3/es active Active
- 2013-05-22 MX MX2014014115A patent/MX368965B/es active IP Right Grant
- 2013-05-22 GE GEAP201313640A patent/GEP201606585B/en unknown
- 2013-05-22 AU AU2013265350A patent/AU2013265350B2/en active Active
- 2013-05-22 SI SI201330182A patent/SI2852437T1/sl unknown
- 2013-05-22 CN CN201380026473.2A patent/CN104411363B/zh active Active
- 2013-05-22 UA UAA201412484A patent/UA113005C2/uk unknown
- 2013-05-22 PL PL13728982.3T patent/PL2852437T3/pl unknown
- 2013-05-22 DK DK13728982.3T patent/DK2852437T3/en active
- 2013-05-22 IN IN9832DEN2014 patent/IN2014DN09832A/en unknown
- 2013-05-22 CA CA2874216A patent/CA2874216C/en active Active
- 2013-05-22 KR KR1020207000570A patent/KR20200006625A/ko not_active Application Discontinuation
-
2014
- 2014-10-31 PH PH12014502444A patent/PH12014502444A1/en unknown
- 2014-11-20 ZA ZA2014/08536A patent/ZA201408536B/en unknown
- 2014-11-20 IL IL23580314A patent/IL235803B/en active IP Right Grant
-
2015
- 2015-11-20 US US14/947,634 patent/US20160074429A1/en not_active Abandoned
-
2016
- 2016-05-09 CY CY20161100385T patent/CY1117636T1/el unknown
- 2016-07-01 HR HRP20160773TT patent/HRP20160773T1/hr unknown
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