BR112014028904A2 - 6-sulfato de condroitina biotecnológico de baixo peso molecular para prevenção de osteoartrite - Google Patents

6-sulfato de condroitina biotecnológico de baixo peso molecular para prevenção de osteoartrite

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Publication number
BR112014028904A2
BR112014028904A2 BR112014028904A BR112014028904A BR112014028904A2 BR 112014028904 A2 BR112014028904 A2 BR 112014028904A2 BR 112014028904 A BR112014028904 A BR 112014028904A BR 112014028904 A BR112014028904 A BR 112014028904A BR 112014028904 A2 BR112014028904 A2 BR 112014028904A2
Authority
BR
Brazil
Prior art keywords
sulfate
chondroitin
molecular weight
low molecular
osteoarthritis
Prior art date
Application number
BR112014028904A
Other languages
English (en)
Other versions
BR112014028904B1 (pt
Inventor
Trentin Antonella
Trilli Antonio
Bianchi Davide
Valoti Ermanno
Busiello Immacolata
Agostinetto Marco
Valetti Marco
Miraglia Niccolò
Bazza Paola
Original Assignee
Gnosis Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gnosis Spa filed Critical Gnosis Spa
Publication of BR112014028904A2 publication Critical patent/BR112014028904A2/pt
Publication of BR112014028904B1 publication Critical patent/BR112014028904B1/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

resumo patente de invenção: "6-sulfato de condroitina biotecnológico de baixo peso molecular para prevenção de osteoartrite". a presente invenção refere-se a um sulfato de condroitina (cs) de baixo peso molecular (1000 a 5000 daltons) produzido pela sulfatação química e subsequente despolimerização de um arcabouço de condroitina não sulfatado obtido por técnicas de biotecnologia. o cs descrito é substancialmente monosulfatado, principalmente na posição 6, com muito pouca sulfatação na posição 4 e com uma proporção de mono/dissacarídeo e densidade de carga similares aquelas de cs natural. o dito 6-sulfato de condroitina biotecnológico (c6s) é útil no tratamento e prevenção da osteoartrite e em processos inflamatórios agudos e crônicos.
BR112014028904-2A 2012-05-22 2013-05-22 6-sulfato de condroitina biotecnológico e composição que compreende o mesmo BR112014028904B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000880A ITMI20120880A1 (it) 2012-05-22 2012-05-22 Condroitin 6-solfato biotecnologico a basso peso molecolare dotato di attivita' antiinfiammatoria e antiartritica e suo uso nel trattamento e nella prevenzione dell'osteoartrite
ITMI2012A000880 2012-05-22
PCT/EP2013/060471 WO2013174847A1 (en) 2012-05-22 2013-05-22 Low -molecular -weight biotechnological chondroitin 6 - sulphate for prevention of osteoarthritis

Publications (2)

Publication Number Publication Date
BR112014028904A2 true BR112014028904A2 (pt) 2017-06-27
BR112014028904B1 BR112014028904B1 (pt) 2022-09-20

Family

ID=46582917

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014028904-2A BR112014028904B1 (pt) 2012-05-22 2013-05-22 6-sulfato de condroitina biotecnológico e composição que compreende o mesmo

Country Status (25)

Country Link
US (2) US20150152198A1 (pt)
EP (1) EP2852437B1 (pt)
JP (1) JP6273264B2 (pt)
KR (2) KR20200006625A (pt)
CN (1) CN104411363B (pt)
AU (1) AU2013265350B2 (pt)
BR (1) BR112014028904B1 (pt)
CA (1) CA2874216C (pt)
CY (1) CY1117636T1 (pt)
DK (1) DK2852437T3 (pt)
EA (1) EA032748B8 (pt)
ES (1) ES2571583T3 (pt)
GE (1) GEP201606585B (pt)
HR (1) HRP20160773T1 (pt)
HU (1) HUE030224T2 (pt)
IL (1) IL235803B (pt)
IN (1) IN2014DN09832A (pt)
IT (1) ITMI20120880A1 (pt)
MX (1) MX368965B (pt)
PH (1) PH12014502444B1 (pt)
PL (1) PL2852437T3 (pt)
SI (1) SI2852437T1 (pt)
UA (1) UA113005C2 (pt)
WO (1) WO2013174847A1 (pt)
ZA (1) ZA201408536B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20130117A1 (it) 2013-01-25 2014-07-26 Gnosis Spa Composizioni comprendenti condroitin solfato, enzimi proteolitici e composti sulfidrilati capaci di migliorare la biodisponibilita' del condroitin solfato
JP2016138062A (ja) * 2015-01-28 2016-08-04 一丸ファルコス株式会社 特定分子結合単位が分子内の末端部位に存在する高分子糖鎖化合物とその利用
JP2016138061A (ja) * 2015-01-28 2016-08-04 一丸ファルコス株式会社 特定分子結合単位が分子内の末端部位に存在する高分子糖鎖化合物とその利用
KR102231289B1 (ko) 2018-12-26 2021-03-23 (주)휴온스 고함량 콘드로이틴설페이트 약학 제제 및 이의 제조방법
WO2020219497A1 (en) * 2019-04-25 2020-10-29 The University Of Massachusetts Compositions and methods for treatment of angiogenesis related diseases
WO2021179319A1 (zh) * 2020-03-13 2021-09-16 南京汉欣医药科技有限公司 一种含水解硫酸软骨素的用于防治骨关节病的组合物
KR20220091552A (ko) * 2019-11-01 2022-06-30 난징 레탑 바이오테크놀로지 컴퍼니, 리미티드 저분자량 콘드로이틴 술페이트, 이를 함유하는 조성물, 및 이의 제조 방법 및 이의 용도
CN111234048A (zh) * 2020-03-09 2020-06-05 河北农业大学 鳐鱼硫酸软骨素的降解产物及其降解方法
IT202000013633A1 (it) 2020-06-08 2021-12-08 Vivatis Pharma Gmbh Processo di estrazione di una condroitina solfato da un fungo, una condroitina solfato di origine vegetale e suo uso
IT202000013618A1 (it) 2020-06-08 2021-12-08 Vivatis Pharma Gmbh Processo di estrazione di un acido ialuronico da un fungo, un acido ialuronico di origine vegetale e suo uso
IT202100030935A1 (it) 2021-12-09 2023-06-09 Fidia Farm Spa Compresse comprendenti condroitin solfato, glucosamina cloridrato e vitamina c per il trattamento di danni cartilaginei, tendinei, ossei
CN115895987B (zh) * 2022-08-02 2024-02-13 衢州益康园生物科技有限公司 一种提高果糖软骨素产量的重组菌株及其构建方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI991465A1 (it) 1999-07-02 2001-01-02 Inalco Spa Processo per la preparazione dei polisaccaridi k4 e k5 da escherichiacoli
ITMI20012200A1 (it) * 2001-10-22 2003-04-22 Ibsa Inst Biochimique Sa Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti
WO2005110438A2 (en) * 2004-04-15 2005-11-24 Massachusetts Institute Of Technology Methods and products related to the intracellular delivery of polysaccharides
KR100706294B1 (ko) * 2005-03-18 2007-04-11 한국식품연구원 연골어류의 연골로부터 얻은 저분자 콘드로이틴 황산 및 이의 제조방법
WO2009044765A1 (ja) * 2007-10-01 2009-04-09 Seikagaku Corporation 新規な低分子化コンドロイチン硫酸およびその用途
US9109243B2 (en) * 2008-06-04 2015-08-18 Amano Enzyme Usa, Ltd. Microbial-derived chondroitin sulfate
AU2011275996B2 (en) * 2010-07-09 2015-03-26 Gnosis S.P.A. Biotechnological production of chondroitin
US8664196B2 (en) * 2011-05-20 2014-03-04 Gnosis S.P.A. Shark-like chondroitin sulphate and process for the preparation thereof

Also Published As

Publication number Publication date
CY1117636T1 (el) 2017-04-26
CN104411363B (zh) 2017-09-08
ES2571583T3 (es) 2016-05-26
MX2014014115A (es) 2015-02-24
HUE030224T2 (en) 2017-04-28
IL235803B (en) 2019-11-28
HRP20160773T1 (hr) 2016-09-23
BR112014028904B1 (pt) 2022-09-20
WO2013174847A1 (en) 2013-11-28
EA032748B1 (ru) 2019-07-31
ITMI20120880A1 (it) 2013-11-23
PH12014502444A1 (en) 2015-01-12
AU2013265350A1 (en) 2014-12-11
KR20150013565A (ko) 2015-02-05
EA201491919A1 (ru) 2015-05-29
GEP201606585B (en) 2016-12-12
IN2014DN09832A (pt) 2015-08-07
SI2852437T1 (sl) 2016-06-30
CA2874216C (en) 2020-09-01
PL2852437T3 (pl) 2016-10-31
EA032748B8 (ru) 2019-09-30
JP2015517602A (ja) 2015-06-22
US20160074429A1 (en) 2016-03-17
ZA201408536B (en) 2016-08-31
CA2874216A1 (en) 2013-11-28
CN104411363A (zh) 2015-03-11
MX368965B (es) 2019-10-23
JP6273264B2 (ja) 2018-01-31
DK2852437T3 (en) 2016-06-06
EP2852437B1 (en) 2016-04-06
KR20200006625A (ko) 2020-01-20
IL235803A0 (en) 2015-01-29
EP2852437A1 (en) 2015-04-01
PH12014502444B1 (en) 2015-01-12
AU2013265350B2 (en) 2017-05-04
UA113005C2 (uk) 2016-11-25
US20150152198A1 (en) 2015-06-04

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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