CL2015000114A1 - Anticuerpo anti-fractalkina (anti-fkn): composición farmacéutica que comprende dicho anticuerpo anti-fkn; ácido nucleico; vector; célula huésped; uso del anticuerpo anti-fkn para tratar colitis ulcerosa, enfermedad de crohn, o artritis reumática - Google Patents
Anticuerpo anti-fractalkina (anti-fkn): composición farmacéutica que comprende dicho anticuerpo anti-fkn; ácido nucleico; vector; célula huésped; uso del anticuerpo anti-fkn para tratar colitis ulcerosa, enfermedad de crohn, o artritis reumáticaInfo
- Publication number
- CL2015000114A1 CL2015000114A1 CL2015000114A CL2015000114A CL2015000114A1 CL 2015000114 A1 CL2015000114 A1 CL 2015000114A1 CL 2015000114 A CL2015000114 A CL 2015000114A CL 2015000114 A CL2015000114 A CL 2015000114A CL 2015000114 A1 CL2015000114 A1 CL 2015000114A1
- Authority
- CL
- Chile
- Prior art keywords
- fkn
- antibody
- fractalkine
- crohn
- vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25652109P | 2009-10-30 | 2009-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015000114A1 true CL2015000114A1 (es) | 2015-04-10 |
Family
ID=43922220
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012001143A CL2012001143A1 (es) | 2009-10-30 | 2012-04-30 | Anticuerpo anti-fractalkina (anti-fkn); composicion farmaceutica que comprende dicho anticuerpo anti-fkn; acido nucleico; vector; celula huesped; uso del anticuerpo anti-fkn para tratar trastornos inflamatorios. |
CL2015000114A CL2015000114A1 (es) | 2009-10-30 | 2015-01-15 | Anticuerpo anti-fractalkina (anti-fkn): composición farmacéutica que comprende dicho anticuerpo anti-fkn; ácido nucleico; vector; célula huésped; uso del anticuerpo anti-fkn para tratar colitis ulcerosa, enfermedad de crohn, o artritis reumática |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012001143A CL2012001143A1 (es) | 2009-10-30 | 2012-04-30 | Anticuerpo anti-fractalkina (anti-fkn); composicion farmaceutica que comprende dicho anticuerpo anti-fkn; acido nucleico; vector; celula huesped; uso del anticuerpo anti-fkn para tratar trastornos inflamatorios. |
Country Status (31)
Country | Link |
---|---|
US (1) | US8932592B2 (es) |
EP (1) | EP2493930B1 (es) |
JP (2) | JP5631991B2 (es) |
KR (2) | KR102099596B1 (es) |
CN (1) | CN102597003B (es) |
AR (2) | AR078796A1 (es) |
AU (1) | AU2010312408B2 (es) |
BR (1) | BR112012010266A2 (es) |
CA (1) | CA2778895C (es) |
CL (2) | CL2012001143A1 (es) |
CY (1) | CY1121167T1 (es) |
DK (1) | DK2493930T3 (es) |
ES (1) | ES2698389T3 (es) |
HR (1) | HRP20181973T1 (es) |
HU (1) | HUE041952T2 (es) |
IL (1) | IL219470A (es) |
JO (1) | JO3437B1 (es) |
LT (1) | LT2493930T (es) |
MX (1) | MX2012005052A (es) |
MY (1) | MY158481A (es) |
NZ (1) | NZ599779A (es) |
PE (1) | PE20121645A1 (es) |
PL (1) | PL2493930T3 (es) |
PT (1) | PT2493930T (es) |
RS (1) | RS58142B1 (es) |
RU (1) | RU2569109C2 (es) |
SI (1) | SI2493930T1 (es) |
TW (1) | TWI414308B (es) |
UA (1) | UA105073C2 (es) |
WO (1) | WO2011052799A1 (es) |
ZA (1) | ZA201203002B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9415118B2 (en) * | 2013-03-13 | 2016-08-16 | Novartis Ag | Antibody drug conjugates |
ES2807182T3 (es) | 2014-11-21 | 2021-02-22 | Bristol Myers Squibb Co | Anticuerpos frente a CD73 y sus usos |
HUE052526T2 (hu) | 2014-11-21 | 2021-05-28 | Bristol Myers Squibb Co | Antitestek, amelyek tartalmaznak módosított nehéz konstans régiókat |
EP3159007A1 (en) | 2015-10-19 | 2017-04-26 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating rheumatoid arthritis |
JP2017154975A (ja) * | 2016-02-29 | 2017-09-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | クローン病を治療するための医薬組成物 |
JP2018070473A (ja) * | 2016-10-26 | 2018-05-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 関節リウマチを治療するための医薬組成物 |
JP2018177701A (ja) * | 2017-04-14 | 2018-11-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | クローン病を治療するための医薬組成物 |
US20220196674A1 (en) * | 2019-04-17 | 2022-06-23 | Abdolamir Landi | Treatment of autoimmune liver disease |
WO2020218232A1 (ja) | 2019-04-23 | 2020-10-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 関節リウマチ治療のためのバイオマーカー |
KR20220110827A (ko) * | 2019-12-09 | 2022-08-09 | 알렉시온 파마슈티칼스, 인코포레이티드 | 시신경척수염 스펙트럼 장애의 치료를 위한 항-c5 항체 |
CN113087795A (zh) * | 2019-12-23 | 2021-07-09 | 上海普铭生物科技有限公司 | 针对趋化因子cx3cl1的抗体及其应用 |
TW202227483A (zh) | 2020-10-30 | 2022-07-16 | 日商衛材R&D企管股份有限公司 | 醫藥組合物 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2052027T5 (es) | 1988-11-11 | 2005-04-16 | Medical Research Council | Clonacion de secuencias de dominio variable de inmunoglobulina. |
US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
US6114507A (en) | 1995-06-30 | 2000-09-05 | Mochida Pharmaceutical Co., Ltd. | Anti-Fas ligand antibody and assay method using the anti-Fas ligand antibody |
CA2225852C (en) | 1995-06-30 | 2009-04-14 | Mochida Pharmaceutical Co., Ltd. | Anti-fas ligand antibody and assay method using the anti-fas ligand antibody |
US6096312A (en) | 1995-06-30 | 2000-08-01 | Mochida Pharmaceutical Co., Ltd. | Agent for suppressing a reduction of CD4+ lymphocytes |
US6548654B1 (en) | 1996-01-24 | 2003-04-15 | Schering Corporation | DNA encoding mammalian CX3C chemokine genes |
US6566503B2 (en) | 1996-01-24 | 2003-05-20 | Schering Corporation | Mammalian CX3C chemokine |
CA2240409C (en) | 1996-01-24 | 2011-03-22 | Schering Corporation | Mammalian cx3c chemokine genes |
US7115379B1 (en) | 1996-01-24 | 2006-10-03 | Schering Corporation | Anti-mammalian CX3C cytokine antibodies |
US6043086A (en) * | 1996-05-07 | 2000-03-28 | Millenium Biotherapeutics, Inc. | Neurotactin and uses therefor |
AU730989B2 (en) | 1996-05-07 | 2001-03-22 | Millennium Pharmaceuticals, Inc. | Neurotactin and uses therefor |
SE9802729D0 (sv) | 1998-08-13 | 1998-08-13 | Astra Pharma Prod | Novel Compounds |
US6420121B1 (en) | 1998-08-31 | 2002-07-16 | Oregon Health Sciences University | Prevention of cell migration initiation with CMV US28 receptor antagonists |
JP2001218581A (ja) | 1999-11-30 | 2001-08-14 | Eisai Co Ltd | モノクローナル抗体の作製法 |
US6677321B1 (en) | 1999-12-09 | 2004-01-13 | Bruce Levin | Methods and compositions for treatment of inflammatory disease |
WO2001060406A1 (en) | 2000-02-18 | 2001-08-23 | Millennium Pharmaceuticals, Inc. | Therapeutic methods that target fractalkine or cx3cr1 |
US8647612B2 (en) | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
JP4263391B2 (ja) * | 2001-03-19 | 2009-05-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗cx3cr1抗体、抗フラクタルカイン抗体及びフラクタルカインの利用 |
US20020192212A1 (en) | 2001-03-19 | 2002-12-19 | Toshio Imai | Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine |
SE0101082D0 (sv) | 2001-03-27 | 2001-03-27 | Astrazeneca Ab | Novel use |
WO2003018549A2 (en) | 2001-08-30 | 2003-03-06 | Chemocentryx, Inc. | Bicyclic compounds as inhibitors of chemokine binding to us28 |
CA2502429A1 (en) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
EP1520586A1 (en) | 2003-09-30 | 2005-04-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibition of fractalkine or of its receptor for the treatment of atopic allergic diseases |
JPWO2005032589A1 (ja) | 2003-10-02 | 2007-11-15 | 独立行政法人科学技術振興機構 | Gvhdの予防及び治療 |
KR20060120014A (ko) | 2003-10-07 | 2006-11-24 | 아스트라제네카 아베 | 케모킨, 특히 cx3cr1 수용체 길항제로서 유용한 신규한2-치환된 4-아미노-티아졸로[4,5-d]피리미딘 |
ES2387312T3 (es) | 2004-09-22 | 2012-09-20 | Kyowa Hakko Kirin Co., Ltd. | Anticuerpos IgG4 humanos estabilizados |
WO2006046739A1 (ja) | 2004-10-29 | 2006-05-04 | Eisai R & D Management Co., Ltd. | 炎症性疾患治療剤 |
AR053347A1 (es) | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
UA90707C2 (en) | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
DK2094728T3 (da) | 2006-10-26 | 2013-07-01 | Janssen Biotech Inc | Fremgangsmåder til anvendelse for human-adapterende monoklonale antistoffer |
JP5963341B2 (ja) * | 2007-09-14 | 2016-08-10 | アムジエン・インコーポレーテツド | 均質な抗体集団 |
-
2010
- 2010-10-27 JO JOP/2010/0374A patent/JO3437B1/ar active
- 2010-10-28 ES ES10826929T patent/ES2698389T3/es active Active
- 2010-10-28 RU RU2012122203/10A patent/RU2569109C2/ru active
- 2010-10-28 KR KR1020167014386A patent/KR102099596B1/ko active IP Right Grant
- 2010-10-28 MY MYPI2012001924A patent/MY158481A/en unknown
- 2010-10-28 JP JP2012520621A patent/JP5631991B2/ja active Active
- 2010-10-28 AU AU2010312408A patent/AU2010312408B2/en active Active
- 2010-10-28 EP EP10826929.1A patent/EP2493930B1/en active Active
- 2010-10-28 MX MX2012005052A patent/MX2012005052A/es active IP Right Grant
- 2010-10-28 PE PE2012000580A patent/PE20121645A1/es active IP Right Grant
- 2010-10-28 HU HUE10826929A patent/HUE041952T2/hu unknown
- 2010-10-28 PL PL10826929T patent/PL2493930T3/pl unknown
- 2010-10-28 BR BR112012010266A patent/BR112012010266A2/pt not_active Application Discontinuation
- 2010-10-28 US US13/504,742 patent/US8932592B2/en active Active
- 2010-10-28 AR ARP100103947A patent/AR078796A1/es active IP Right Grant
- 2010-10-28 NZ NZ599779A patent/NZ599779A/en not_active IP Right Cessation
- 2010-10-28 RS RS20181424A patent/RS58142B1/sr unknown
- 2010-10-28 LT LTEP10826929.1T patent/LT2493930T/lt unknown
- 2010-10-28 WO PCT/JP2010/069653 patent/WO2011052799A1/en active Application Filing
- 2010-10-28 KR KR1020127014048A patent/KR101627605B1/ko active IP Right Grant
- 2010-10-28 UA UAA201206559A patent/UA105073C2/uk unknown
- 2010-10-28 PT PT10826929T patent/PT2493930T/pt unknown
- 2010-10-28 CN CN201080049138.0A patent/CN102597003B/zh active Active
- 2010-10-28 TW TW099137131A patent/TWI414308B/zh active
- 2010-10-28 DK DK10826929.1T patent/DK2493930T3/en active
- 2010-10-28 SI SI201031803T patent/SI2493930T1/sl unknown
- 2010-10-28 CA CA2778895A patent/CA2778895C/en active Active
-
2012
- 2012-04-24 ZA ZA2012/03002A patent/ZA201203002B/en unknown
- 2012-04-29 IL IL219470A patent/IL219470A/en active IP Right Grant
- 2012-04-30 CL CL2012001143A patent/CL2012001143A1/es unknown
-
2014
- 2014-09-18 JP JP2014189668A patent/JP2015027304A/ja not_active Abandoned
-
2015
- 2015-01-15 CL CL2015000114A patent/CL2015000114A1/es unknown
-
2017
- 2017-09-15 AR ARP170102555A patent/AR109533A2/es unknown
-
2018
- 2018-11-23 HR HRP20181973TT patent/HRP20181973T1/hr unknown
- 2018-11-29 CY CY20181101274T patent/CY1121167T1/el unknown
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BR112012012912A2 (pt) | anticorpo ou fragmento do mesmo, ácido nucleico, vetor, célula hospedeira, método para a produção de um anticorpo ou um fragmento do mesmo, composição farmacêutica, método para tratar ou prevenir uma condição médica em um indivíduo, uso de um anticorpo ou fragmento do mesmo e métodos in vitro para neutralizar il-10 em uma amostra e para detectar a presença de il-10 em uma amostra. | |
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CL2013003336A1 (es) | Anticuerpo anti-cgrp humano; acido nucleico que lo codifica; vector; celula huesped; metodo de produccion; composicion farmaceutica y diagnostica que lo comprende; y su uso terapéutico | |
BR112016030424A2 (pt) | construções de anticorpo multiespecíficas | |
CL2007001488A1 (es) | Anticuerpo humano o humanizado anti-integrina alfa5beta1; acido nucleico que lo codifica; vector y celula huesped que lo comprenden; procedimiento de produccion; composicion farmaceutica que lo comprende; y su uso para prevenir o tratar trastornos asociados con la integrina. | |
CL2013000074A1 (es) | Proteina de union con capacidad de unir un par de antigenos; acido nucleico que la codifica; vector; celula huesped; metodo de produccion; composicion farmaceutica que la comprende; conjugado que comprende dicha proteina de union; y sus usos. | |
BRPI1006215A2 (pt) | " anticorpos multiespecíficos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, método de tratamento, método de inibição de uma atividade bíologica e uso do anticorpo " | |
CL2014000183A1 (es) | Formulación farmacéutica que contienen anticuerpos anti-pcsk9; metodo para preparar dicha formulación. | |
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CL2014002348A1 (es) | Compuestos derivados de fenicol; composicion farmaceutica que los comprende; y su uso para controlar o tratar infecciones bacterianas en ganado. | |
CL2009001277A1 (es) | Anticuerpo que enlaza especificamente el flt3 humano; fragmento de cualquiera de los anticuerpos antes dichos; acido polinucleico aislado; vector de expresion; celula recombinante; composicion farmaceutica y sus usos; producto que contiene el anticuerpo para tratar cancer | |
CL2012003054A1 (es) | Anticuerpos contra la angiopoyetina 2 humana (ang-2); composicion farmaceutica que contiene dicho anticuerpo; uso del anticuerpo para preparar medicamento destinado a la prevencion de metastasis; acido nucleico que codifica dicho anticuerpo; vector de expresión. |