HU229450B1 - Új citokróm P450 monoxigenázok és alkalmazásuk szerves vegyületek oxidálására - Google Patents
Új citokróm P450 monoxigenázok és alkalmazásuk szerves vegyületek oxidálásáraInfo
- Publication number
- HU229450B1 HU229450B1 HU0202074A HUP0202074A HU229450B1 HU 229450 B1 HU229450 B1 HU 229450B1 HU 0202074 A HU0202074 A HU 0202074A HU P0202074 A HUP0202074 A HU P0202074A HU 229450 B1 HU229450 B1 HU 229450B1
- Authority
- HU
- Hungary
- Prior art keywords
- monooxygenases
- organic compounds
- novel cytochrome
- oxidizing organic
- methods
- Prior art date
Links
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 title abstract 2
- 101710198130 NADPH-cytochrome P450 reductase Proteins 0.000 title abstract 2
- 230000001590 oxidative effect Effects 0.000 title abstract 2
- 150000002894 organic compounds Chemical class 0.000 title 1
- CRDNMYFJWFXOCH-YPKPFQOOSA-N (3z)-3-(3-oxo-1h-indol-2-ylidene)-1h-indol-2-one Chemical compound N/1C2=CC=CC=C2C(=O)C\1=C1/C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-YPKPFQOOSA-N 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- CRDNMYFJWFXOCH-BUHFOSPRSA-N Couroupitine B Natural products N\1C2=CC=CC=C2C(=O)C/1=C1/C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-BUHFOSPRSA-N 0.000 abstract 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 229940097275 indigo Drugs 0.000 abstract 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 abstract 1
- CRDNMYFJWFXOCH-UHFFFAOYSA-N isoindigotin Natural products N1C2=CC=CC=C2C(=O)C1=C1C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-UHFFFAOYSA-N 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19935115A DE19935115A1 (de) | 1999-07-27 | 1999-07-27 | Elektronendonorsystem für Enzyme |
| DE19955605A DE19955605A1 (de) | 1999-11-18 | 1999-11-18 | Neue Cytochrom P450-Monoxygenasen und deren Verwendung zur Oxidation N-heterocyclischer Aromaten |
| DE10014085A DE10014085A1 (de) | 2000-03-22 | 2000-03-22 | Neue Cytochrom P450-Monooxygenasen und deren Verwendung zur Oxidation von organischen Verbindungen |
| PCT/EP2000/007253 WO2001007630A1 (de) | 1999-07-27 | 2000-07-27 | Neue cytochrom p450-monooxygenasen und deren verwendung zur oxidation von organischen verbindungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0202074A2 HUP0202074A2 (en) | 2002-09-28 |
| HUP0202074A3 HUP0202074A3 (en) | 2010-01-28 |
| HU229450B1 true HU229450B1 (hu) | 2013-12-30 |
Family
ID=27213745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202074A HU229450B1 (hu) | 1999-07-27 | 2000-07-27 | Új citokróm P450 monoxigenázok és alkalmazásuk szerves vegyületek oxidálására |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7960155B1 (hu) |
| EP (1) | EP1196605B1 (hu) |
| JP (1) | JP4791664B2 (hu) |
| KR (2) | KR100740368B1 (hu) |
| CN (1) | CN1183252C (hu) |
| AT (1) | ATE409232T1 (hu) |
| AU (1) | AU780694B2 (hu) |
| BR (1) | BR0012772B1 (hu) |
| CA (1) | CA2380186C (hu) |
| DE (1) | DE50015373D1 (hu) |
| EE (1) | EE200200048A (hu) |
| ES (1) | ES2311470T3 (hu) |
| HU (1) | HU229450B1 (hu) |
| IL (2) | IL147580A0 (hu) |
| MY (1) | MY126592A (hu) |
| NO (1) | NO20020380L (hu) |
| UA (1) | UA76701C2 (hu) |
| WO (1) | WO2001007630A1 (hu) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001007573A1 (de) * | 1999-07-27 | 2001-02-01 | Basf Aktiengesellschaft | Elektronendonorsystem für enzyme und dessen anwendung bei der biochemischen umsetzung von substraten |
| JP2004504025A (ja) | 2000-07-18 | 2004-02-12 | ナショナル・リサーチ・カウンシル・オブ・カナダ | 大腸菌における、コマモナスのシクロペンタノン１，２−モノオキシゲナーゼをコードする遺伝子 |
| DE10051175A1 (de) | 2000-10-16 | 2002-05-02 | Basf Ag | Cytochrom P450 Monoxygenasen aus thermophilen Bakterien |
| DE10321082A1 (de) * | 2003-05-09 | 2004-11-25 | Basf Ag | Verfahren zur Herstellung eines Hydroxylierungskatalysators und seine Verwendung |
| WO2006009334A1 (en) * | 2004-07-23 | 2006-01-26 | Genechem Inc. | Cytochrome p450 enzyme and the gene encoding the same |
| DE102004042102A1 (de) * | 2004-08-30 | 2006-03-09 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Verfahren zur regio-selektiven Oxidation |
| US8715988B2 (en) * | 2005-03-28 | 2014-05-06 | California Institute Of Technology | Alkane oxidation by modified hydroxylases |
| CN100400652C (zh) * | 2005-07-21 | 2008-07-09 | 南开大学 | 高效降解芘基因工程菌及其构建 |
| CN100429314C (zh) * | 2006-04-18 | 2008-10-29 | 浙江大学 | 能催化吲哚生成靛蓝的质粒pET28a(+)－P450 BM3－gdh0310、制备方法及其用途 |
| JP5186497B2 (ja) * | 2006-07-27 | 2013-04-17 | チバ ホールディング インコーポレーテッド | ポリオレフィンの生体触媒的な親水化 |
| GB0719620D0 (en) | 2007-10-08 | 2007-11-14 | Isis Innovation | Mutant Enzymes |
| KR100975404B1 (ko) * | 2008-02-28 | 2010-08-11 | 주식회사 종합건축사사무소근정 | 블록담장용 지주 및 이의 시공방법 |
| CN101333521B (zh) * | 2008-04-25 | 2010-12-15 | 浙江大学 | 细胞色素p450bm-3d168w变体酶以及应用其制备靛玉红的方法 |
| DE102008054918A1 (de) * | 2008-12-18 | 2010-07-01 | Evonik Degussa Gmbh | Verfahren zur enzymatischen Umsetzung von Alkanen |
| CN101580821B (zh) * | 2009-01-19 | 2011-04-27 | 广东省微生物研究所 | 用于制备抗癌药物靛玉红的2-萘酸单加氧酶 |
| EP2426198A1 (en) | 2010-09-03 | 2012-03-07 | B.R.A.I.N. Biotechnology Research And Information Network AG | Cytochrome P450 monooxygenase variants |
| CN102154234A (zh) * | 2011-01-18 | 2011-08-17 | 浙江大学 | 具有多环芳烃羟化酶活性的细胞色素p450单加氧酶 |
| CN103146596A (zh) * | 2012-12-14 | 2013-06-12 | 徐州工程学院 | 一种生产靛蓝色素的专用菌株 |
| WO2014100251A1 (en) * | 2012-12-18 | 2014-06-26 | California Institute Of Technology | A cytochrome p450-based biodesulfurization pathway |
| US10975243B2 (en) | 2018-12-28 | 2021-04-13 | Industrial Technology Research Institute | Genetically modified microorganism and method for producing indigo dye |
| EP3858986A1 (en) | 2020-02-03 | 2021-08-04 | Bayer Aktiengesellschaft | P450 bm3 monooxygenase variants for c19-hydroxylation of steroids |
| US11345818B1 (en) | 2020-12-29 | 2022-05-31 | Industrial Technology Research Institute | Dye for fiber and dyeing method |
| WO2024004921A1 (ja) * | 2022-06-27 | 2024-01-04 | 天野エンザイム株式会社 | ポリペプチド、オキシゲナーゼ及びこれらの応用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9422205D0 (en) | 1994-11-03 | 1994-12-21 | British Gas Plc | Enzyme mutant and method |
| DE19507546C2 (de) | 1995-03-03 | 2001-05-03 | Max Delbrueck Centrum | Verfahren zur regioselektiven Hydroxylierung von langkettigen Alkanen, Fettsäuren und anderen Alkylverbindungen |
| US5691171A (en) | 1995-10-23 | 1997-11-25 | Board Of Trustees Operating Michigan State University | Method for production of indigo and indirubin dyes |
| CA2236381A1 (en) | 1995-11-01 | 1997-05-09 | Bg Plc | Mutant mono-oxygenase cytochrome p450cam |
| EP1104459A1 (en) | 1998-08-12 | 2001-06-06 | Maxygen, Inc. | Dna shuffling of monooxygenase genes for production of industrial chemicals |
| GB9825421D0 (en) * | 1998-11-19 | 1999-01-13 | Isis Innovation | Process for oxidising terpenes |
| WO2001007573A1 (de) * | 1999-07-27 | 2001-02-01 | Basf Aktiengesellschaft | Elektronendonorsystem für enzyme und dessen anwendung bei der biochemischen umsetzung von substraten |
-
2000
- 2000-07-26 MY MYPI20003409 patent/MY126592A/en unknown
- 2000-07-27 WO PCT/EP2000/007253 patent/WO2001007630A1/de active IP Right Grant
- 2000-07-27 KR KR1020027001132A patent/KR100740368B1/ko active IP Right Grant
- 2000-07-27 AT AT00956319T patent/ATE409232T1/de active
- 2000-07-27 ES ES00956319T patent/ES2311470T3/es not_active Expired - Lifetime
- 2000-07-27 JP JP2001512896A patent/JP4791664B2/ja not_active Expired - Fee Related
- 2000-07-27 HU HU0202074A patent/HU229450B1/hu not_active IP Right Cessation
- 2000-07-27 CA CA2380186A patent/CA2380186C/en not_active Expired - Lifetime
- 2000-07-27 UA UA2002021606A patent/UA76701C2/uk unknown
- 2000-07-27 EP EP00956319A patent/EP1196605B1/de not_active Expired - Lifetime
- 2000-07-27 CN CNB008109184A patent/CN1183252C/zh not_active Expired - Fee Related
- 2000-07-27 US US10/031,146 patent/US7960155B1/en not_active Expired - Fee Related
- 2000-07-27 EE EEP200200048A patent/EE200200048A/xx unknown
- 2000-07-27 DE DE50015373T patent/DE50015373D1/de not_active Expired - Lifetime
- 2000-07-27 KR KR1020077007332A patent/KR20070041792A/ko not_active Application Discontinuation
- 2000-07-27 AU AU68307/00A patent/AU780694B2/en not_active Ceased
- 2000-07-27 BR BRPI0012772-8A patent/BR0012772B1/pt not_active IP Right Cessation
- 2000-07-27 IL IL14758000A patent/IL147580A0/xx unknown
-
2002
- 2002-01-10 IL IL147580A patent/IL147580A/en active IP Right Grant
- 2002-01-24 NO NO20020380A patent/NO20020380L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1196605A1 (de) | 2002-04-17 |
| ES2311470T3 (es) | 2009-02-16 |
| JP4791664B2 (ja) | 2011-10-12 |
| ATE409232T1 (de) | 2008-10-15 |
| IL147580A (en) | 2013-12-31 |
| KR20020016924A (ko) | 2002-03-06 |
| WO2001007630A1 (de) | 2001-02-01 |
| EE200200048A (et) | 2003-04-15 |
| BR0012772B1 (pt) | 2013-05-28 |
| NO20020380L (no) | 2002-03-22 |
| HUP0202074A2 (en) | 2002-09-28 |
| AU780694B2 (en) | 2005-04-14 |
| KR20070041792A (ko) | 2007-04-19 |
| CN1183252C (zh) | 2005-01-05 |
| IL147580A0 (en) | 2002-08-14 |
| US7960155B1 (en) | 2011-06-14 |
| BR0012772A (pt) | 2002-04-02 |
| CN1365393A (zh) | 2002-08-21 |
| DE50015373D1 (de) | 2008-11-06 |
| JP2003521889A (ja) | 2003-07-22 |
| CA2380186C (en) | 2012-03-13 |
| UA76701C2 (uk) | 2006-09-15 |
| AU6830700A (en) | 2001-02-13 |
| HUP0202074A3 (en) | 2010-01-28 |
| EP1196605B1 (de) | 2008-09-24 |
| MY126592A (en) | 2006-10-31 |
| NO20020380D0 (no) | 2002-01-24 |
| CA2380186A1 (en) | 2001-02-01 |
| KR100740368B1 (ko) | 2007-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FH91 | Appointment of a representative |
Free format text: FORMER REPRESENTATIVE(S): BELICZAY LASZLO, S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU Representative=s name: RATHONYI ZOLTAN, S.B.G. & K. SZABADALMI UEGYVI, HU |
|
| FH92 | Termination of representative |
Representative=s name: BELICZAY LASZLO, S.B.G. & K. SZABADALMI UEGYVI, HU |
|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |