HU224212B1 - 5-[4-[2-(N-metil-N-(2-piridil)amino)etoxi]benzil]tiazolidin-2,4-dion-maleát és ezt tartalmazó gyógyszerkészítmények - Google Patents
5-[4-[2-(N-metil-N-(2-piridil)amino)etoxi]benzil]tiazolidin-2,4-dion-maleát és ezt tartalmazó gyógyszerkészítmények Download PDFInfo
- Publication number
- HU224212B1 HU224212B1 HU9500659A HU9500659A HU224212B1 HU 224212 B1 HU224212 B1 HU 224212B1 HU 9500659 A HU9500659 A HU 9500659A HU 9500659 A HU9500659 A HU 9500659A HU 224212 B1 HU224212 B1 HU 224212B1
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- Prior art keywords
- thiazolidine
- pyridyl
- amino
- methyl
- dione
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
A vizsgált minta | %-os tömegnövekedés | A higroszkópos tulajdonság értékelése |
Nátriumsó | 15,2% | mérsékelten higroszkópos |
Maleátsó | 0,9% | nem higroszkópos |
%-os tömegnövekedés | Osztályozás |
<2% | nem higroszkópos |
2-10% | kissé higroszkópos |
10-20% | mérsékelten higroszkópos |
>20% | nagyon higroszkópos |
A vizsgált minta | Oldhatóság (mg/ml) | A kapott csapadék tömege (mg) | A kivált oldhatatlan anyag olvadáspontja (°C) |
Nátriumsó | 42 | 9,5(θ) | 154 |
Maleátsó | 2 | - | - |
Claims (6)
- SZABADALMI IGÉNYPONTOK1. 5-[4-[2-(N-Metil-N-(2-piridil)-amino)-etoxi]-benzil]-tiazolidin-2,4-dion-maleát, tautomer formái és/vagy gyógyászatilag elfogadható szolvátjai.
- 2. Eljárás 5-[4-[2-(N-metil-N-(2-piridil)-amino)etoxi]-benzil]-tiazolidin-2,4-dion-maleát, tautomer formái és/vagy gyógyászatilag elfogadható szolvátjai előállítására, azzal jellemezve, hogy az 5-[4-[2-(N-metil-N-(2-piridil)-amino)-etoxi]-benzil]-tiazolidin-2,4-diont a HOOC-CH=CH-COOH~ képletű maleátion forrásával reagáltatjuk.
- 3. 5-[4-[2-(N-Metil-N-(2-piridil)-amino)-etoxi]benzil]-tiazolidin-2,4-dion-maleátot, tautomer formáit és/vagy gyógyászatilag elfogadható szolvátjait, valamint gyógyászatilag elfogadható hordozót tartalmazó gyógyászati készítmény.
- 4. A 3. igénypont szerinti 5-[4-[2-(N-metil-N-(2-piridil)-amino)-etoxi]-benzil]-tiazolidin-2,4-dion-maleátot, tautomer formáit és/vagy gyógyászatilag elfogadható szolvátjait, valamint gyógyászatilag elfogadható hordozót tartalmazó gyógyászati készítmény hiperglikémia, hiperlipidémia, magas vérnyomás, kardiovaszkuláris megbetegedések és bizonyos étkezési rendellenességek kezelésében és/vagy megelőzésében való alkalmazásra.
- 5. Az 1. igénypont szerinti 5-[4-[2-(N-metil-N-(2-pirídil)-amino)-etoxi]-benzil]-tiazolidin-2,4-dion-maleát, tautomer formái és/vagy gyógyászatilag elfogadható szolvátjai gyógyászatilag hatásos anyagként történő alkalmazásra.
- 6. Az 5. igénypont szerinti 5-[4-[2-(N-metil-N-(2-piridil)-amino)-etoxi]-benzil]-tiazolidin-2,4-dion-maleát, tautomer formái és/vagy gyógyászatilag elfogadható szolvátjai hiperglikémia, hiperlipidémia, magas vérnyomás, kardiovaszkuláris megbetegedések és bizonyos étkezési rendellenességek kezelésében és/vagy megelőzésében való alkalmazásra.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929218830A GB9218830D0 (en) | 1992-09-05 | 1992-09-05 | Novel compounds |
PCT/GB1993/001853 WO1994005659A1 (en) | 1992-09-05 | 1993-09-01 | Substituted thiazolidinedione derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9500659D0 HU9500659D0 (en) | 1995-04-28 |
HUT72639A HUT72639A (en) | 1996-05-28 |
HU224212B1 true HU224212B1 (hu) | 2005-06-28 |
Family
ID=10721461
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0500355A HU0500355D0 (en) | 1992-09-05 | 1993-09-01 | Substituted thiazolidinedione derivatives |
HU9500659A HU224212B1 (hu) | 1992-09-05 | 1993-09-01 | 5-[4-[2-(N-metil-N-(2-piridil)amino)etoxi]benzil]tiazolidin-2,4-dion-maleát és ezt tartalmazó gyógyszerkészítmények |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0500355A HU0500355D0 (en) | 1992-09-05 | 1993-09-01 | Substituted thiazolidinedione derivatives |
Country Status (38)
Country | Link |
---|---|
US (1) | US5910592A (hu) |
EP (2) | EP0658161B1 (hu) |
JP (5) | JP2828777B2 (hu) |
KR (3) | KR20080081099A (hu) |
CN (4) | CN1040323C (hu) |
AP (1) | AP513A (hu) |
AT (1) | ATE182147T1 (hu) |
AU (1) | AU674880B2 (hu) |
BR (1) | BR1100916A (hu) |
CA (2) | CA2273147A1 (hu) |
CY (1) | CY2138B1 (hu) |
CZ (2) | CZ287473B6 (hu) |
DE (2) | DE69325658T2 (hu) |
DK (1) | DK0658161T3 (hu) |
ES (1) | ES2133410T3 (hu) |
FI (2) | FI106263B (hu) |
GB (1) | GB9218830D0 (hu) |
GR (1) | GR3030794T3 (hu) |
HK (1) | HK1012363A1 (hu) |
HU (2) | HU0500355D0 (hu) |
IL (1) | IL106904A (hu) |
LU (1) | LU90712I2 (hu) |
MA (1) | MA22970A1 (hu) |
MX (1) | MX9305397A (hu) |
MY (1) | MY111190A (hu) |
NL (1) | NL300035I2 (hu) |
NO (4) | NO303016B1 (hu) |
NZ (1) | NZ255505A (hu) |
PL (1) | PL173725B1 (hu) |
RU (3) | RU2128179C1 (hu) |
SA (1) | SA93140245B1 (hu) |
SG (2) | SG83747A1 (hu) |
SI (1) | SI9300452B (hu) |
SK (1) | SK280777B6 (hu) |
TW (1) | TW385309B (hu) |
UA (1) | UA41901C2 (hu) |
WO (1) | WO1994005659A1 (hu) |
ZA (1) | ZA936509B (hu) |
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US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
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Free format text: PRODUCT NAME: ROSIGLITAZONE MALEATE TAUTOMERIC FORM THEREOF AND/OR PHARMACEUTICALLY ACCEPTABLE SOLVATE THEREOF ; REG. NO/DATE: EU/1/00/137/001-0012 20000711; FIRST REG.: CH 55176 02,55176 03, 55176 04 19990929 Spc suppl protection certif: S0500018 Filing date: 20050824 Expiry date: 20130901 Extension date: 20140929 Free format text: PRODUCT NAME: ROSIGLITAZONE MALEATE TAUTOMERIC FORM THEREOF AND/OR PHARMACEUTICALLY ACCEPTABLE SOLVATE THEREOF (AVANDIA); REGISTRATION NO/DATE: EU/1/00/137/001-0012 20000711; FIRST REGISTRATION: CH 55176 02-04 19990929 Spc suppl protection certif: S0500018 Filing date: 20050824 Expiry date: 20130901 Extension date: 20140929 |