HU203238B - Process for producing antiinflammatory tricyclic oxindole derivatives - Google Patents

Process for producing antiinflammatory tricyclic oxindole derivatives Download PDF

Info

Publication number
HU203238B
HU203238B HU844219A HU421984A HU203238B HU 203238 B HU203238 B HU 203238B HU 844219 A HU844219 A HU 844219A HU 421984 A HU421984 A HU 421984A HU 203238 B HU203238 B HU 203238B
Authority
HU
Hungary
Prior art keywords
arh
ethyl
mmol
methyl
indole
Prior art date
Application number
HU844219A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT47580A (en
Inventor
Lawrence Sherman Melvin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HUT47580A publication Critical patent/HUT47580A/hu
Publication of HU203238B publication Critical patent/HU203238B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HU844219A 1984-08-24 1984-08-24 Process for producing antiinflammatory tricyclic oxindole derivatives HU203238B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1984/001371 WO1986001510A1 (en) 1984-08-24 1984-08-24 Tricyclic oxindole antiinflammatory agents

Publications (2)

Publication Number Publication Date
HUT47580A HUT47580A (en) 1989-03-28
HU203238B true HU203238B (en) 1991-06-28

Family

ID=22182243

Family Applications (2)

Application Number Title Priority Date Filing Date
HU844219A HU203238B (en) 1984-08-24 1984-08-24 Process for producing antiinflammatory tricyclic oxindole derivatives
HU902020A HU203350B (en) 1984-08-24 1984-08-24 Process for producing antiinflammatory tricyclic oxindole derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU902020A HU203350B (en) 1984-08-24 1984-08-24 Process for producing antiinflammatory tricyclic oxindole derivatives

Country Status (21)

Country Link
US (1) US4695571A (enExample)
EP (1) EP0173520B1 (enExample)
JP (1) JPS6157554A (enExample)
KR (1) KR870001144B1 (enExample)
AT (1) ATE49211T1 (enExample)
AU (1) AU553859B2 (enExample)
CA (1) CA1244427A (enExample)
DE (1) DE3575140D1 (enExample)
DK (1) DK160098C (enExample)
EG (1) EG17287A (enExample)
ES (2) ES8704497A1 (enExample)
FI (1) FI79319C (enExample)
GR (1) GR852026B (enExample)
HU (2) HU203238B (enExample)
IE (1) IE58739B1 (enExample)
IL (1) IL76175A (enExample)
PH (1) PH23065A (enExample)
PL (2) PL147395B1 (enExample)
PT (1) PT81004B (enExample)
WO (1) WO1986001510A1 (enExample)
ZA (1) ZA856403B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS63223492A (ja) * 1987-03-11 1988-09-16 Okawara Mfg Co Ltd 熱交換器
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
WO1990008146A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
JPH04217684A (ja) * 1990-05-30 1992-08-07 Shionogi & Co Ltd アルド−ス還元酵素阻害物質
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US4644005A (en) * 1984-10-31 1987-02-17 Pfizer Inc. Oxindole antiinflammatory agents

Also Published As

Publication number Publication date
PL255089A1 (en) 1986-12-30
AU553859B2 (en) 1986-07-31
EG17287A (en) 1993-02-28
JPH0450316B2 (enExample) 1992-08-13
US4695571A (en) 1987-09-22
IL76175A (en) 1989-08-15
ATE49211T1 (de) 1990-01-15
ES8706116A1 (es) 1987-06-01
PL147395B1 (en) 1989-05-31
GR852026B (enExample) 1985-12-19
CA1244427A (en) 1988-11-08
ES552044A0 (es) 1987-06-01
DE3575140D1 (de) 1990-02-08
HU203350B (en) 1991-07-29
ES8704497A1 (es) 1987-04-01
EP0173520A3 (en) 1986-05-14
FI79319C (fi) 1989-12-11
AU4663785A (en) 1986-02-27
EP0173520B1 (en) 1990-01-03
DK382685A (da) 1986-02-25
WO1986001510A1 (en) 1986-03-13
IE58739B1 (en) 1993-11-03
IE852081L (en) 1986-02-24
PT81004B (pt) 1987-12-30
DK160098C (da) 1991-06-24
FI79319B (fi) 1989-08-31
DK382685D0 (da) 1985-08-23
ES546377A0 (es) 1987-04-01
IL76175A0 (en) 1985-12-31
PH23065A (en) 1989-03-27
FI861704A0 (fi) 1986-04-23
ZA856403B (en) 1987-04-29
PT81004A (en) 1985-09-01
DK160098B (da) 1991-01-28
PL147393B1 (en) 1989-05-31
FI861704A7 (fi) 1986-04-23
JPS6157554A (ja) 1986-03-24
HU902020D0 (en) 1990-07-28
HUT47580A (en) 1989-03-28
KR870001144B1 (ko) 1987-06-11
EP0173520A2 (en) 1986-03-05
KR870002143A (ko) 1987-03-30

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee