KR870001144B1 - 삼환 옥스인돌 카복스아미드 유도체의 제조방법 - Google Patents

삼환 옥스인돌 카복스아미드 유도체의 제조방법 Download PDF

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Publication number
KR870001144B1
KR870001144B1 KR1019850006095A KR850006095A KR870001144B1 KR 870001144 B1 KR870001144 B1 KR 870001144B1 KR 1019850006095 A KR1019850006095 A KR 1019850006095A KR 850006095 A KR850006095 A KR 850006095A KR 870001144 B1 KR870001144 B1 KR 870001144B1
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KR
South Korea
Prior art keywords
phenyl
formula
ethyl
fluoro
compound
Prior art date
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Expired
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KR1019850006095A
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English (en)
Korean (ko)
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KR870002143A (ko
Inventor
쉐르만 멜빈 2세 로렌스
Original Assignee
화이자 인코포레이티드
윌리암 데이비스 훈
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Publication of KR870002143A publication Critical patent/KR870002143A/ko
Application granted granted Critical
Publication of KR870001144B1 publication Critical patent/KR870001144B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
KR1019850006095A 1984-08-24 1985-08-23 삼환 옥스인돌 카복스아미드 유도체의 제조방법 Expired KR870001144B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
USPCT84-01371 1984-08-24
PCT/US1984/001371 WO1986001510A1 (en) 1984-08-24 1984-08-24 Tricyclic oxindole antiinflammatory agents
USPCT84/01371 1984-08-24

Publications (2)

Publication Number Publication Date
KR870002143A KR870002143A (ko) 1987-03-30
KR870001144B1 true KR870001144B1 (ko) 1987-06-11

Family

ID=22182243

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850006095A Expired KR870001144B1 (ko) 1984-08-24 1985-08-23 삼환 옥스인돌 카복스아미드 유도체의 제조방법

Country Status (21)

Country Link
US (1) US4695571A (enExample)
EP (1) EP0173520B1 (enExample)
JP (1) JPS6157554A (enExample)
KR (1) KR870001144B1 (enExample)
AT (1) ATE49211T1 (enExample)
AU (1) AU553859B2 (enExample)
CA (1) CA1244427A (enExample)
DE (1) DE3575140D1 (enExample)
DK (1) DK160098C (enExample)
EG (1) EG17287A (enExample)
ES (2) ES8704497A1 (enExample)
FI (1) FI79319C (enExample)
GR (1) GR852026B (enExample)
HU (2) HU203238B (enExample)
IE (1) IE58739B1 (enExample)
IL (1) IL76175A (enExample)
PH (1) PH23065A (enExample)
PL (2) PL147393B1 (enExample)
PT (1) PT81004B (enExample)
WO (1) WO1986001510A1 (enExample)
ZA (1) ZA856403B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS63223492A (ja) * 1987-03-11 1988-09-16 Okawara Mfg Co Ltd 熱交換器
US5128352A (en) * 1989-01-10 1992-07-07 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
JPH04217684A (ja) * 1990-05-30 1992-08-07 Shionogi & Co Ltd アルド−ス還元酵素阻害物質
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US4644005A (en) * 1984-10-31 1987-02-17 Pfizer Inc. Oxindole antiinflammatory agents

Also Published As

Publication number Publication date
ZA856403B (en) 1987-04-29
IL76175A (en) 1989-08-15
AU4663785A (en) 1986-02-27
FI861704A0 (fi) 1986-04-23
PT81004B (pt) 1987-12-30
IL76175A0 (en) 1985-12-31
WO1986001510A1 (en) 1986-03-13
ES8706116A1 (es) 1987-06-01
IE58739B1 (en) 1993-11-03
PL147395B1 (en) 1989-05-31
HU203238B (en) 1991-06-28
EP0173520B1 (en) 1990-01-03
DK160098C (da) 1991-06-24
ES8704497A1 (es) 1987-04-01
DK382685D0 (da) 1985-08-23
ES552044A0 (es) 1987-06-01
HU902020D0 (en) 1990-07-28
PL147393B1 (en) 1989-05-31
US4695571A (en) 1987-09-22
ES546377A0 (es) 1987-04-01
EP0173520A2 (en) 1986-03-05
DE3575140D1 (de) 1990-02-08
AU553859B2 (en) 1986-07-31
HUT47580A (en) 1989-03-28
FI79319C (fi) 1989-12-11
FI861704A7 (fi) 1986-04-23
PH23065A (en) 1989-03-27
CA1244427A (en) 1988-11-08
PT81004A (en) 1985-09-01
EP0173520A3 (en) 1986-05-14
GR852026B (enExample) 1985-12-19
DK160098B (da) 1991-01-28
EG17287A (en) 1993-02-28
JPH0450316B2 (enExample) 1992-08-13
KR870002143A (ko) 1987-03-30
ATE49211T1 (de) 1990-01-15
DK382685A (da) 1986-02-25
FI79319B (fi) 1989-08-31
JPS6157554A (ja) 1986-03-24
IE852081L (en) 1986-02-24
PL255089A1 (en) 1986-12-30
HU203350B (en) 1991-07-29

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