ES8706116A1 - Un procedimiento para la preparacion de oxindol-carboxamidas triciclicas - Google Patents
Un procedimiento para la preparacion de oxindol-carboxamidas triciclicasInfo
- Publication number
- ES8706116A1 ES8706116A1 ES552044A ES552044A ES8706116A1 ES 8706116 A1 ES8706116 A1 ES 8706116A1 ES 552044 A ES552044 A ES 552044A ES 552044 A ES552044 A ES 552044A ES 8706116 A1 ES8706116 A1 ES 8706116A1
- Authority
- ES
- Spain
- Prior art keywords
- pct
- antiinflammatory agents
- sec
- tricyclic
- tricyclic oxindole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Photoreceptors In Electrophotography (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE OXINDOLCARBOXAMIDAS TRICICLICAS, DE FORMULA HET-CONH-AR.COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA HET0H, CON UN ISOCIANATO DE FORMULA AR-NCOOO, EN LAS QUE HET REPRESENTA UNO DE VARIOS TIPOS DE RADICALES HETEROPOLICICLICOS Y AR ES FENILO O FENILO SUSTITUIDO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, TAL COMO DIMETILFORMAMIDA, EN PRESENCIA DE UNA BASE, TAL COMO HIDRURO SODICO, POR MEZCLA DE LOS REACTIVOS A UNA TEMPERATURA COMPRENDIDA ENTRE C10JC Y 0JC Y POSTERIOR CALENTAMIENTO A TEMPERATURA ENTRE LA AMBIENTE Y 45JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ARTRITIS REUMATOIDE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1984/001371 WO1986001510A1 (en) | 1984-08-24 | 1984-08-24 | Tricyclic oxindole antiinflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES552044A0 ES552044A0 (es) | 1987-06-01 |
| ES8706116A1 true ES8706116A1 (es) | 1987-06-01 |
Family
ID=22182243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546377A Expired ES8704497A1 (es) | 1984-08-24 | 1985-08-23 | Un procedimiento para la preparacion de oxindal-carboxamidas triciclicas. |
| ES552044A Expired ES8706116A1 (es) | 1984-08-24 | 1986-02-14 | Un procedimiento para la preparacion de oxindol-carboxamidas triciclicas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES546377A Expired ES8704497A1 (es) | 1984-08-24 | 1985-08-23 | Un procedimiento para la preparacion de oxindal-carboxamidas triciclicas. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4695571A (es) |
| EP (1) | EP0173520B1 (es) |
| JP (1) | JPS6157554A (es) |
| KR (1) | KR870001144B1 (es) |
| AT (1) | ATE49211T1 (es) |
| AU (1) | AU553859B2 (es) |
| CA (1) | CA1244427A (es) |
| DE (1) | DE3575140D1 (es) |
| DK (1) | DK160098C (es) |
| EG (1) | EG17287A (es) |
| ES (2) | ES8704497A1 (es) |
| FI (1) | FI79319C (es) |
| GR (1) | GR852026B (es) |
| HU (2) | HU203238B (es) |
| IE (1) | IE58739B1 (es) |
| IL (1) | IL76175A (es) |
| PH (1) | PH23065A (es) |
| PL (2) | PL147393B1 (es) |
| PT (1) | PT81004B (es) |
| WO (1) | WO1986001510A1 (es) |
| ZA (1) | ZA856403B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3531678A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JPS63223492A (ja) * | 1987-03-11 | 1988-09-16 | Okawara Mfg Co Ltd | 熱交換器 |
| WO1990008145A1 (en) * | 1989-01-10 | 1990-07-26 | Pfizer Inc. | Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles |
| US5128352A (en) * | 1989-01-10 | 1992-07-07 | Pfizer Inc. | Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides |
| US5300655A (en) * | 1989-04-18 | 1994-04-05 | Pfizer Inc. | 2-carboxy-thiophene derivatives |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| JPH04217684A (ja) * | 1990-05-30 | 1992-08-07 | Shionogi & Co Ltd | アルド−ス還元酵素阻害物質 |
| DE4027592A1 (de) * | 1990-08-31 | 1992-03-05 | Beiersdorf Ag | Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| WO2005041957A1 (en) * | 2003-10-29 | 2005-05-12 | Pfizer Products Inc. | Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors |
| DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
| US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
| ES2728225T3 (es) | 2009-02-20 | 2019-10-23 | 2 Bbb Medicines B V | Sistema de administración de fármacos a base de glutatión |
| EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3749731A (en) * | 1971-07-08 | 1973-07-31 | Warner Lambert Co | 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide |
| US4644005A (en) * | 1984-10-31 | 1987-02-17 | Pfizer Inc. | Oxindole antiinflammatory agents |
-
1984
- 1984-08-24 WO PCT/US1984/001371 patent/WO1986001510A1/en active IP Right Grant
- 1984-08-24 HU HU844219A patent/HU203238B/hu not_active IP Right Cessation
- 1984-08-24 HU HU902020A patent/HU203350B/hu not_active IP Right Cessation
- 1984-08-24 US US06/867,185 patent/US4695571A/en not_active Expired - Lifetime
-
1985
- 1985-08-16 AT AT85305830T patent/ATE49211T1/de not_active IP Right Cessation
- 1985-08-16 DE DE8585305830T patent/DE3575140D1/de not_active Expired - Fee Related
- 1985-08-16 EP EP85305830A patent/EP0173520B1/en not_active Expired - Lifetime
- 1985-08-21 GR GR852026A patent/GR852026B/el unknown
- 1985-08-22 PT PT81004A patent/PT81004B/pt not_active IP Right Cessation
- 1985-08-22 CA CA000489226A patent/CA1244427A/en not_active Expired
- 1985-08-22 PL PL1985255089A patent/PL147393B1/pl unknown
- 1985-08-22 PL PL1985260270A patent/PL147395B1/pl unknown
- 1985-08-23 IE IE208185A patent/IE58739B1/en not_active IP Right Cessation
- 1985-08-23 DK DK382685A patent/DK160098C/da not_active IP Right Cessation
- 1985-08-23 IL IL76175A patent/IL76175A/xx not_active IP Right Cessation
- 1985-08-23 PH PH32688A patent/PH23065A/en unknown
- 1985-08-23 KR KR1019850006095A patent/KR870001144B1/ko not_active IP Right Cessation
- 1985-08-23 JP JP60185619A patent/JPS6157554A/ja active Granted
- 1985-08-23 ES ES546377A patent/ES8704497A1/es not_active Expired
- 1985-08-23 ZA ZA856403A patent/ZA856403B/xx unknown
- 1985-08-26 AU AU46637/85A patent/AU553859B2/en not_active Ceased
- 1985-09-01 EG EG538/85A patent/EG17287A/xx active
-
1986
- 1986-02-14 ES ES552044A patent/ES8706116A1/es not_active Expired
- 1986-04-23 FI FI861704A patent/FI79319C/fi not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20020401 |