KR870002143A - 삼환 옥스인돌 카복스아미드 유도체의 제조방법 - Google Patents

삼환 옥스인돌 카복스아미드 유도체의 제조방법 Download PDF

Info

Publication number
KR870002143A
KR870002143A KR1019850006095A KR850006095A KR870002143A KR 870002143 A KR870002143 A KR 870002143A KR 1019850006095 A KR1019850006095 A KR 1019850006095A KR 850006095 A KR850006095 A KR 850006095A KR 870002143 A KR870002143 A KR 870002143A
Authority
KR
South Korea
Prior art keywords
sub
formula
phenyl
compound
solvent
Prior art date
Application number
KR1019850006095A
Other languages
English (en)
Other versions
KR870001144B1 (ko
Inventor
쉐르만 멜빈 2세 로렌스
Original Assignee
윌리암 데이비스 훈
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 윌리암 데이비스 훈, 화이자 인코포레이티드 filed Critical 윌리암 데이비스 훈
Publication of KR870002143A publication Critical patent/KR870002143A/ko
Application granted granted Critical
Publication of KR870001144B1 publication Critical patent/KR870001144B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

삼환 옥스인돌 카복스아미드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. (a)일반식(Ⅱ)의 화합물을 방향족 용매 중에서 일반식(Ⅲ)의 화합물과 상기 용매의 환류온도에서반응시키거나, (b) 일반식(Ⅳ)의 화합물을 염기 존재하의 반응-불활성 용매중에서 일반식(Ⅴ)의 이소시아네이트와 반응시킴을 특징으로 하는, 일반식(Ⅰ)화합물의 제조방법.
    [여기서, R1은 탄소수 1내지 3의 알킬 또는 페닐이며; R3및 R4는 각각 수소 또는 메틸이고;X는 N,CH 또는 C(CH3)이며;Y는 산소 또는 황이고; Z는 산소 또는 메틸렌이며;n은 1 또는 2의 정수이다.]이며; Ar은 페닐 또는 플루오로, 클로로, 트리플루오로메틸, 메틸티오, 메톡시, 아세틸, 에톡시보닐 또는 메틸술피닐로 일치환된 페닐;플루오로 또는 메톡시로 이치환된 페닐;또는 2-티아졸일, 2-옥사졸일, 5-이소티아졸일, 3-이속사졸일, 벤조티아졸일, 2-티아졸리닐, 2-티아디아졸릴, 2-피리미딜 또는 피리딜의 헤테로시클릭 또는 모노-또는 디메틸 치환된 헤테로시클릭이고;R은 탄소수 1 내지 3의 알킬이다.
  2. 제1항에 있어서, 방법(a)의 용매가 벤젠, 톨루엔 또는 크실렌인 방법.
  3. 제1항에 있어서, 방법(b)의 용매가 디메틸포름아미드이며, 염기가 수소화나트륨인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850006095A 1984-08-24 1985-08-23 삼환 옥스인돌 카복스아미드 유도체의 제조방법 KR870001144B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1984/001371 WO1986001510A1 (en) 1984-08-24 1984-08-24 Tricyclic oxindole antiinflammatory agents
USPCT84/01371 1984-08-24
USPCT84-01371 1984-08-24

Publications (2)

Publication Number Publication Date
KR870002143A true KR870002143A (ko) 1987-03-30
KR870001144B1 KR870001144B1 (ko) 1987-06-11

Family

ID=22182243

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850006095A KR870001144B1 (ko) 1984-08-24 1985-08-23 삼환 옥스인돌 카복스아미드 유도체의 제조방법

Country Status (21)

Country Link
US (1) US4695571A (ko)
EP (1) EP0173520B1 (ko)
JP (1) JPS6157554A (ko)
KR (1) KR870001144B1 (ko)
AT (1) ATE49211T1 (ko)
AU (1) AU553859B2 (ko)
CA (1) CA1244427A (ko)
DE (1) DE3575140D1 (ko)
DK (1) DK160098C (ko)
EG (1) EG17287A (ko)
ES (2) ES8704497A1 (ko)
FI (1) FI79319C (ko)
GR (1) GR852026B (ko)
HU (2) HU203238B (ko)
IE (1) IE58739B1 (ko)
IL (1) IL76175A (ko)
PH (1) PH23065A (ko)
PL (2) PL147393B1 (ko)
PT (1) PT81004B (ko)
WO (1) WO1986001510A1 (ko)
ZA (1) ZA856403B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS63223492A (ja) * 1987-03-11 1988-09-16 Okawara Mfg Co Ltd 熱交換器
HU217072B (hu) * 1989-01-10 1999-11-29 Pfizer Inc. 1-Heteroaril-oxindol-3-karboxamid-származékok, azok előállítása, és az azokat tartalmazó gyógyszerkészítmények
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
JPH04217684A (ja) * 1990-05-30 1992-08-07 Shionogi & Co Ltd アルド−ス還元酵素阻害物質
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
WO2003009815A2 (en) 2001-07-25 2003-02-06 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US4644005A (en) * 1984-10-31 1987-02-17 Pfizer Inc. Oxindole antiinflammatory agents

Also Published As

Publication number Publication date
ZA856403B (en) 1987-04-29
PL147395B1 (en) 1989-05-31
HU203350B (en) 1991-07-29
IE852081L (en) 1986-02-24
PT81004A (en) 1985-09-01
US4695571A (en) 1987-09-22
DK160098C (da) 1991-06-24
ES546377A0 (es) 1987-04-01
GR852026B (ko) 1985-12-19
DK160098B (da) 1991-01-28
EP0173520B1 (en) 1990-01-03
ES552044A0 (es) 1987-06-01
PH23065A (en) 1989-03-27
ES8706116A1 (es) 1987-06-01
AU4663785A (en) 1986-02-27
DK382685D0 (da) 1985-08-23
PT81004B (pt) 1987-12-30
AU553859B2 (en) 1986-07-31
FI861704A (fi) 1986-04-23
FI861704A0 (fi) 1986-04-23
JPS6157554A (ja) 1986-03-24
EP0173520A3 (en) 1986-05-14
EP0173520A2 (en) 1986-03-05
HUT47580A (en) 1989-03-28
DE3575140D1 (de) 1990-02-08
IE58739B1 (en) 1993-11-03
PL147393B1 (en) 1989-05-31
WO1986001510A1 (en) 1986-03-13
HU203238B (en) 1991-06-28
EG17287A (en) 1993-02-28
CA1244427A (en) 1988-11-08
IL76175A (en) 1989-08-15
JPH0450316B2 (ko) 1992-08-13
DK382685A (da) 1986-02-25
ATE49211T1 (de) 1990-01-15
PL255089A1 (en) 1986-12-30
FI79319B (fi) 1989-08-31
KR870001144B1 (ko) 1987-06-11
ES8704497A1 (es) 1987-04-01
HU902020D0 (en) 1990-07-28
FI79319C (fi) 1989-12-11
IL76175A0 (en) 1985-12-31

Similar Documents

Publication Publication Date Title
KR870002143A (ko) 삼환 옥스인돌 카복스아미드 유도체의 제조방법
KR870007180A (ko) 티에노-1,4-디아제핀의 제조방법
HUT44044A (en) Process for preparing place-specific alkylating agents
KR870004981A (ko) 헤테로시클릭 옥소프탈라지닐 아세트산의 제조방법
KR860001793A (ko) 벤즈 이미다졸 유도체의 제조방법
ATE103592T1 (de) Carbamoylpyrrolidonderivate, ihre verwendung und herstellung.
KR830005162A (ko) 색소형성 퀴나졸린
ES2005186A6 (es) Procedimiento para preparar nuevos derivados de pirazol y metodo paraobtener composiciones fungicidas que los contienen.
KR840006475A (ko) 나프탈렌 유도체의 제조방법
EA200000484A1 (ru) Способ получения производных тиазолидиндиона
KR920012023A (ko) 아릴피롤 화합물의 제조방법
IE780705L (en) Benzimidazole-2-thiones.
SE7601206L (sv) Acetylenderivat
ES455909A1 (es) Procedimiento para preparar derivados de piperacina.
SE8302379D0 (sv) Ergolinderivat
KR960017790A (ko) 열전사 기록용 피리돈계 옐로우 모노아조 염료
DK316589A (da) Substituerede azacyclohexylderivater af rifamyciner
ES456400A1 (es) Un procedimiento para la preparacion de derivados de tieno- tiacina.
KR890016006A (ko) 피롤 유도체
KR830005225A (ko) 데오필린의 피페라진 유도체의 제조방법
SE8800863D0 (sv) 3-(2-haloethyl)-1,4-oxathiins and 2-(2-haloethyl)-1,4-dithiins and treatment of leukemia and tumors therewith
KR840007420A (ko) 치환된 카복시-티아졸로[3,2-α] 피리미딘 유도체의 제조방법
KR920012026A (ko) 2-아릴-2-치환-5-(트리플루오로메틸)피롤 화합물의 제조방법
KR860000296A (ko) 이소옥사졸로퀴롤리논 유도체의 제조방법
NO920619L (no) Oxazinobenzazolforbindelser

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
E902 Notification of reason for refusal
FPAY Annual fee payment

Payment date: 19990402

Year of fee payment: 13

LAPS Lapse due to unpaid annual fee