HU189174B - Process for the production of trans-2-substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido/4,3-b/ indol derivatives - Google Patents

Process for the production of trans-2-substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido/4,3-b/ indol derivatives Download PDF

Info

Publication number
HU189174B
HU189174B HU822858A HU285882A HU189174B HU 189174 B HU189174 B HU 189174B HU 822858 A HU822858 A HU 822858A HU 285882 A HU285882 A HU 285882A HU 189174 B HU189174 B HU 189174B
Authority
HU
Hungary
Prior art keywords
formula
compounds
fluorophenyl
acid
pyrido
Prior art date
Application number
HU822858A
Other languages
German (de)
English (en)
Hungarian (hu)
Inventor
Willard M Welch
Original Assignee
Pfizer Inc,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc,Us filed Critical Pfizer Inc,Us
Publication of HU189174B publication Critical patent/HU189174B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
HU822858A 1979-01-23 1980-01-04 Process for the production of trans-2-substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido/4,3-b/ indol derivatives HU189174B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/005,698 US4224329A (en) 1979-01-23 1979-01-23 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles

Publications (1)

Publication Number Publication Date
HU189174B true HU189174B (en) 1986-06-30

Family

ID=21717248

Family Applications (3)

Application Number Title Priority Date Filing Date
HU822858A HU189174B (en) 1979-01-23 1980-01-04 Process for the production of trans-2-substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido/4,3-b/ indol derivatives
HU8023A HU184712B (en) 1979-01-23 1980-01-04 Process for producing dextrorotating trans-2-substituted-5-phenyl-2,3,4,4a,5,9b,hexahydro-h-pyrido-bracket-4,3,b-bracket closedindol derivatives
HU822859A HU188201B (en) 1979-01-23 1980-01-04 Process for the resulation of trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido/4,3-b/-indol derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
HU8023A HU184712B (en) 1979-01-23 1980-01-04 Process for producing dextrorotating trans-2-substituted-5-phenyl-2,3,4,4a,5,9b,hexahydro-h-pyrido-bracket-4,3,b-bracket closedindol derivatives
HU822859A HU188201B (en) 1979-01-23 1980-01-04 Process for the resulation of trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido/4,3-b/-indol derivatives

Country Status (34)

Country Link
US (1) US4224329A (enExample)
JP (4) JPS55100386A (enExample)
KR (1) KR830001932A (enExample)
AR (1) AR231291A1 (enExample)
AT (1) AT376674B (enExample)
AU (1) AU521986B2 (enExample)
BE (1) BE881283A (enExample)
CA (1) CA1144168A (enExample)
CH (2) CH651040A5 (enExample)
CS (4) CS221806B2 (enExample)
DD (2) DD149071A5 (enExample)
DE (1) DE3002367A1 (enExample)
DK (1) DK25580A (enExample)
EG (1) EG14767A (enExample)
FI (1) FI800179A7 (enExample)
FR (3) FR2447379A1 (enExample)
GB (1) GB2041925B (enExample)
GR (1) GR73567B (enExample)
HU (3) HU189174B (enExample)
IE (1) IE49500B1 (enExample)
IL (1) IL59189A (enExample)
IN (1) IN153300B (enExample)
IT (1) IT1149927B (enExample)
LU (1) LU82105A1 (enExample)
NL (1) NL8000385A (enExample)
NO (2) NO151895C (enExample)
NZ (3) NZ197582A (enExample)
PH (4) PH15736A (enExample)
PL (4) PL120774B1 (enExample)
PT (1) PT70724A (enExample)
SE (3) SE441358B (enExample)
SU (3) SU1168094A3 (enExample)
YU (2) YU269379A (enExample)
ZA (1) ZA796374B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337250A (en) * 1979-07-30 1982-06-29 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
US4432978A (en) * 1979-07-30 1984-02-21 Pfizer Inc. Hexahydro-trans-pyridoindole
US4431649A (en) * 1979-07-30 1984-02-14 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
US4431646A (en) * 1979-07-30 1984-02-14 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
US4427679A (en) 1981-01-16 1984-01-24 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents
US4467090A (en) * 1982-09-30 1984-08-21 Pfizer Inc. Compound, 8-fluoro-5-(p-fluorophenyl)-2-[4-(p-fluorophenyl)-4-hydroxybutyryl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
US4477669A (en) * 1982-09-30 1984-10-16 Pfizer Inc. Processes and intermediates useful in the preparation of flutroline
US4451655A (en) * 1982-05-17 1984-05-29 Pfizer Inc. Process for preparing carboline derivatives and compounds used in their preparation
US4698444A (en) * 1982-09-30 1987-10-06 Pfizer Inc. 1,1-bis(p-fluorophenyl)urea
US4568748A (en) * 1982-09-30 1986-02-04 Pfizer Inc. 2-Carbobenzoxy-8-fluoro-5-(p-fluorophenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
JPS61248502A (ja) * 1985-04-26 1986-11-05 Pioneer Electronic Corp 磁性材料の接合方法
US4636563A (en) * 1985-09-16 1987-01-13 American Home Products Corporation Antipsychotic γ-carbolines
US4672117A (en) * 1985-09-16 1987-06-09 American Home Products Corporation Antipsychotic gamma-carbolines
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
US5075315A (en) * 1990-05-17 1991-12-24 Mcneilab, Inc. Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives
JP4717216B2 (ja) * 1998-12-21 2011-07-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ α２−アンタゴニストとしてのベンズイソキサゾールおよびフェノン類
RU2329044C1 (ru) * 2006-11-16 2008-07-20 Андрей Александрович Иващенко Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA551241A (en) * 1958-01-07 S. Abbott Leslie Production of substituted piperidines
US3382250A (en) * 1966-12-07 1968-05-07 Abbott Lab Aroylalkyl derivatives of 1, 2, 3, 4-tetrahydro-5h-pyrido[4, 3b]indoles
US3687961A (en) * 1971-05-03 1972-08-29 Abbott Lab 8-fluoro-2-{8 3-(4-fluorophenylanilinopropyl{9 -gamma-carboline
AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
JPS50126699A (enExample) * 1974-03-20 1975-10-04
US4001263A (en) * 1974-04-01 1977-01-04 Pfizer Inc. 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines
AR206812A1 (es) * 1974-04-01 1976-08-23 Pfizer Compuestos intermediarios de azaciclo(3,4-a)indoles 4- y 5-fenil substituidos desprovistos de actividad terapeutica
SE7702301L (sv) * 1976-04-08 1977-10-09 Endo Lab Trans-hexahydro-pyrido-indoler
SE441448B (sv) * 1977-05-23 1985-10-07 Pfizer Sett att framstella hexahydro-gamma-karbolinforeningar

Also Published As

Publication number Publication date
PH15736A (en) 1983-03-18
FR2453175A1 (fr) 1980-10-31
AR231291A1 (es) 1984-10-31
JPS5855151B2 (ja) 1983-12-08
PL126532B1 (en) 1983-08-31
AU5476580A (en) 1980-07-31
KR830001932A (ko) 1983-05-19
SE8404555D0 (sv) 1984-09-11
SU1333239A3 (ru) 1987-08-23
ZA796374B (en) 1980-11-26
NZ197581A (en) 1984-05-31
JPS5636486A (en) 1981-04-09
JPS5636475A (en) 1981-04-09
SE8404554L (sv) 1984-09-11
JPS5636487A (en) 1981-04-09
IE800121L (en) 1980-07-23
IL59189A (en) 1984-01-31
DD156369A5 (de) 1982-08-18
CS221807B2 (en) 1983-04-29
YU242183A (en) 1984-06-30
NO151895B (no) 1985-03-18
PH15086A (en) 1982-07-02
CH651040A5 (fr) 1985-08-30
SE8404555L (sv) 1984-09-11
CS221808B2 (en) 1983-04-29
IE49500B1 (en) 1985-10-16
ATA33380A (de) 1984-05-15
DD149071A5 (de) 1981-06-24
GB2041925B (en) 1982-10-20
FR2447379A1 (fr) 1980-08-22
IN153300B (enExample) 1984-06-30
AU521986B2 (en) 1982-05-13
JPS5740151B2 (enExample) 1982-08-25
FR2447379B1 (enExample) 1983-08-19
EG14767A (en) 1985-12-31
DE3002367A1 (de) 1980-07-24
SE441358B (sv) 1985-09-30
NZ197582A (en) 1984-05-31
SU1080746A3 (ru) 1984-03-15
FR2453175B1 (enExample) 1983-07-29
PT70724A (en) 1980-02-01
FI800179A7 (fi) 1981-01-01
SU1168094A3 (ru) 1985-07-15
NO794317L (no) 1980-07-24
PL120774B1 (en) 1982-03-31
PL126867B1 (en) 1983-09-30
PL126032B1 (en) 1983-07-30
FR2453174A1 (fr) 1980-10-31
NZ192175A (en) 1984-05-31
SE8404554D0 (sv) 1984-09-11
CA1144168A (en) 1983-04-05
GB2041925A (en) 1980-09-17
PL221248A1 (enExample) 1980-12-01
NO843041L (no) 1980-07-24
FR2453174B1 (enExample) 1983-07-29
PH17773A (en) 1984-12-11
LU82105A1 (fr) 1980-08-08
IT8019373A0 (it) 1980-01-22
DK25580A (da) 1980-07-24
YU269379A (en) 1984-04-30
HU184712B (en) 1984-10-29
GR73567B (enExample) 1984-03-16
CS221809B2 (en) 1983-04-29
NL8000385A (nl) 1980-07-25
JPS55100386A (en) 1980-07-31
PH15072A (en) 1982-06-03
IT1149927B (it) 1986-12-10
NO151895C (no) 1985-06-26
CH648314A5 (fr) 1985-03-15
CS221806B2 (en) 1983-04-29
SE8000329L (sv) 1980-07-24
IL59189A0 (en) 1980-05-30
BE881283A (fr) 1980-07-22
AT376674B (de) 1984-12-27
US4224329A (en) 1980-09-23
HU188201B (en) 1986-03-28

Similar Documents

Publication Publication Date Title
TWI424846B (zh) 可作為ｄ3／ｄ2拮抗劑之新穎哌嗪鹽類
IL36237A (en) Substituted benzylimidazolidinones,their preparation and pharmaceutical compositions containing them
NZ200526A (en) 1,2,3,4-tetrahydro-2-naphthylamine derivatives
HU186760B (en) Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
WO1997042183A1 (en) Benzofuryl derivatives and their use
HU184712B (en) Process for producing dextrorotating trans-2-substituted-5-phenyl-2,3,4,4a,5,9b,hexahydro-h-pyrido-bracket-4,3,b-bracket closedindol derivatives
US4029731A (en) Aminophenyltetralin compounds
US4314943A (en) Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
US4045488A (en) Aminophenyltetralin compounds
EP0104632A2 (en) 1'-(3-(1,2-Benzisoxazol-3-yl)propyl)spiro-(benzofuran-2-(3H),3' or 4'-piperidine or 3'-pyrrolidines), a process for their preparation and their use as medicaments
GB2120662A (en) New azepinoindoles, their production and pharmaceutical compositions containing them
GB2297749A (en) 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives
US3459767A (en) Aminomethylindoles
NZ187333A (en) 2-substituted-trans-2,3,4,4a,5,9b-hexahydro-1h-pyrido-(4,3-b)indoles
JPS6130674B2 (enExample)
EP0233413A2 (en) 3-(2-Aminoethyl)indole and -indoline derivatives, processes for their preparation and pharmaceutical compositions containing them
JP2012505166A (ja) １‐ブチル‐２‐ヒドロキシアラルキルピペラジン誘導体およびその抗鬱剤としての使用
BRPI0607436A2 (pt) base cristalina, composição farmacêutica, uso da base cristalina, métodos para o tratamento de uma doença, para a preparação de base cristalina, e para a fabricação de composto e, base livre
JP4171413B2 (ja) フェニルエタノールアミンの結晶形およびそれを含む医薬組成物
EP1988086B2 (en) Process for resolving citalopram via its (S)-enriched citalopram tartrate compound.
JP2002517392A (ja) ５ｈｔレセプターに対して親和性を有するｎ−ベンゾジオキサニルメチル−１−ピペリジル−メチルアミン化合物
KR830001838B1 (ko) 페닐-퀴놀리지딘의 제조방법
CA2346506C (fr) Derives d'aryl-{4-fluoro-4-[(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl}-methanone comme agonistes du recepteur 5-ht1
US4495352A (en) Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
US3564012A (en) 5,7-dimethoxy-tryptamines