AT376674B - Verfahren zur herstellung von trans-8-fluor-5- - Google Patents
Verfahren zur herstellung von trans-8-fluor-5-Info
- Publication number
- AT376674B AT376674B AT0033380A AT33380A AT376674B AT 376674 B AT376674 B AT 376674B AT 0033380 A AT0033380 A AT 0033380A AT 33380 A AT33380 A AT 33380A AT 376674 B AT376674 B AT 376674B
- Authority
- AT
- Austria
- Prior art keywords
- fluor
- producing trans
- trans
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/005,698 US4224329A (en) | 1979-01-23 | 1979-01-23 | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA33380A ATA33380A (de) | 1984-05-15 |
| AT376674B true AT376674B (de) | 1984-12-27 |
Family
ID=21717248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0033380A AT376674B (de) | 1979-01-23 | 1980-01-22 | Verfahren zur herstellung von trans-8-fluor-5- |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US4224329A (de) |
| JP (4) | JPS55100386A (de) |
| KR (1) | KR830001932A (de) |
| AR (1) | AR231291A1 (de) |
| AT (1) | AT376674B (de) |
| AU (1) | AU521986B2 (de) |
| BE (1) | BE881283A (de) |
| CA (1) | CA1144168A (de) |
| CH (2) | CH651040A5 (de) |
| CS (4) | CS221807B2 (de) |
| DD (2) | DD149071A5 (de) |
| DE (1) | DE3002367A1 (de) |
| DK (1) | DK25580A (de) |
| EG (1) | EG14767A (de) |
| FI (1) | FI800179A (de) |
| FR (3) | FR2447379A1 (de) |
| GB (1) | GB2041925B (de) |
| GR (1) | GR73567B (de) |
| HU (3) | HU189174B (de) |
| IE (1) | IE49500B1 (de) |
| IL (1) | IL59189A (de) |
| IN (1) | IN153300B (de) |
| IT (1) | IT1149927B (de) |
| LU (1) | LU82105A1 (de) |
| NL (1) | NL8000385A (de) |
| NO (2) | NO151895C (de) |
| NZ (3) | NZ197581A (de) |
| PH (4) | PH15736A (de) |
| PL (4) | PL126032B1 (de) |
| PT (1) | PT70724A (de) |
| SE (3) | SE441358B (de) |
| SU (3) | SU1168094A3 (de) |
| YU (2) | YU269379A (de) |
| ZA (1) | ZA796374B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4432978A (en) * | 1979-07-30 | 1984-02-21 | Pfizer Inc. | Hexahydro-trans-pyridoindole |
| US4337250A (en) * | 1979-07-30 | 1982-06-29 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
| US4431649A (en) * | 1979-07-30 | 1984-02-14 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
| US4431646A (en) * | 1979-07-30 | 1984-02-14 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
| US4427679A (en) | 1981-01-16 | 1984-01-24 | Pfizer Inc. | Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents |
| US4477669A (en) * | 1982-09-30 | 1984-10-16 | Pfizer Inc. | Processes and intermediates useful in the preparation of flutroline |
| US4467090A (en) * | 1982-09-30 | 1984-08-21 | Pfizer Inc. | Compound, 8-fluoro-5-(p-fluorophenyl)-2-[4-(p-fluorophenyl)-4-hydroxybutyryl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole |
| US4451655A (en) * | 1982-05-17 | 1984-05-29 | Pfizer Inc. | Process for preparing carboline derivatives and compounds used in their preparation |
| US4698444A (en) * | 1982-09-30 | 1987-10-06 | Pfizer Inc. | 1,1-bis(p-fluorophenyl)urea |
| US4568748A (en) * | 1982-09-30 | 1986-02-04 | Pfizer Inc. | 2-Carbobenzoxy-8-fluoro-5-(p-fluorophenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole |
| JPS61248502A (ja) * | 1985-04-26 | 1986-11-05 | Pioneer Electronic Corp | 磁性材料の接合方法 |
| US4636563A (en) * | 1985-09-16 | 1987-01-13 | American Home Products Corporation | Antipsychotic γ-carbolines |
| US4672117A (en) * | 1985-09-16 | 1987-06-09 | American Home Products Corporation | Antipsychotic gamma-carbolines |
| US4798896A (en) * | 1988-01-19 | 1989-01-17 | American Home Products Corporation | Antipsychotic gamma-carboline N-oxides |
| US5075315A (en) * | 1990-05-17 | 1991-12-24 | Mcneilab, Inc. | Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives |
| EA003606B1 (ru) * | 1998-12-21 | 2003-06-26 | Янссен Фармацевтика Н.В. | 1,5-ПЕНТАНДИИЛЗАМЕЩЕННЫЕ 1,2,3,4-ТЕТРАГИДРОБЕНЗО (ФУРО, АЗО И ТИО) [3,2-c] ПИРИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ α-АНТАГОНИСТОВ |
| RU2329044C1 (ru) * | 2006-11-16 | 2008-07-20 | Андрей Александрович Иващенко | Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA551241A (en) * | 1958-01-07 | S. Abbott Leslie | Production of substituted piperidines | |
| US3382250A (en) * | 1966-12-07 | 1968-05-07 | Abbott Lab | Aroylalkyl derivatives of 1, 2, 3, 4-tetrahydro-5h-pyrido[4, 3b]indoles |
| US3687961A (en) * | 1971-05-03 | 1972-08-29 | Abbott Lab | 8-fluoro-2-{8 3-(4-fluorophenylanilinopropyl{9 -gamma-carboline |
| AR205452A1 (es) * | 1973-12-06 | 1976-05-07 | Endo Lab | Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles |
| JPS50126699A (de) * | 1974-03-20 | 1975-10-04 | ||
| US4001263A (en) * | 1974-04-01 | 1977-01-04 | Pfizer Inc. | 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines |
| AR206812A1 (es) * | 1974-04-01 | 1976-08-23 | Pfizer | Compuestos intermediarios de azaciclo(3,4-a)indoles 4- y 5-fenil substituidos desprovistos de actividad terapeutica |
| SE7702301L (sv) * | 1976-04-08 | 1977-10-09 | Endo Lab | Trans-hexahydro-pyrido-indoler |
| SE441448B (sv) * | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
-
1979
- 1979-01-23 US US06/005,698 patent/US4224329A/en not_active Expired - Lifetime
- 1979-10-17 IN IN726/DEL/79A patent/IN153300B/en unknown
- 1979-10-22 PH PH23203A patent/PH15736A/en unknown
- 1979-11-05 YU YU02693/79A patent/YU269379A/xx unknown
- 1979-11-19 EG EG668/79D patent/EG14767A/xx active
- 1979-11-20 AR AR278965A patent/AR231291A1/es active
- 1979-11-20 NZ NZ197581A patent/NZ197581A/en unknown
- 1979-11-20 NZ NZ197582A patent/NZ197582A/en unknown
- 1979-11-20 NZ NZ192175A patent/NZ192175A/en unknown
- 1979-11-23 ZA ZA00796374A patent/ZA796374B/xx unknown
- 1979-12-28 NO NO794317A patent/NO151895C/no unknown
-
1980
- 1980-01-03 CS CS815710A patent/CS221807B2/cs unknown
- 1980-01-03 CS CS815712A patent/CS221809B2/cs unknown
- 1980-01-03 CS CS8098A patent/CS221806B2/cs unknown
- 1980-01-03 CS CS815711A patent/CS221808B2/cs unknown
- 1980-01-04 HU HU822858A patent/HU189174B/hu unknown
- 1980-01-04 SU SU802865803A patent/SU1168094A3/ru active
- 1980-01-04 HU HU822859A patent/HU188201B/hu unknown
- 1980-01-04 HU HU8023A patent/HU184712B/hu unknown
- 1980-01-07 PL PL1980231005A patent/PL126032B1/pl unknown
- 1980-01-07 PL PL1980221248A patent/PL120774B1/pl unknown
- 1980-01-07 PL PL1980231006A patent/PL126532B1/pl unknown
- 1980-01-07 PL PL1980231004A patent/PL126867B1/pl unknown
- 1980-01-15 SE SE8000329A patent/SE441358B/sv unknown
- 1980-01-15 GB GB8001232A patent/GB2041925B/en not_active Expired
- 1980-01-18 CA CA000343988A patent/CA1144168A/en not_active Expired
- 1980-01-21 GR GR60998A patent/GR73567B/el unknown
- 1980-01-21 AU AU54765/80A patent/AU521986B2/en not_active Ceased
- 1980-01-21 JP JP561180A patent/JPS55100386A/ja active Granted
- 1980-01-21 CH CH456/80A patent/CH651040A5/fr not_active IP Right Cessation
- 1980-01-21 CH CH5785/83A patent/CH648314A5/fr not_active IP Right Cessation
- 1980-01-22 IE IE121/80A patent/IE49500B1/en unknown
- 1980-01-22 LU LU82105A patent/LU82105A1/fr unknown
- 1980-01-22 BE BE0/199065A patent/BE881283A/fr not_active IP Right Cessation
- 1980-01-22 KR KR1019800000225A patent/KR830001932A/ko unknown
- 1980-01-22 IL IL59189A patent/IL59189A/xx unknown
- 1980-01-22 DD DD80218578A patent/DD149071A5/de unknown
- 1980-01-22 FR FR8001301A patent/FR2447379A1/fr active Granted
- 1980-01-22 NL NL8000385A patent/NL8000385A/nl not_active Application Discontinuation
- 1980-01-22 AT AT0033380A patent/AT376674B/de not_active IP Right Cessation
- 1980-01-22 FI FI800179A patent/FI800179A/fi not_active Application Discontinuation
- 1980-01-22 IT IT19373/80A patent/IT1149927B/it active
- 1980-01-22 DK DK25580A patent/DK25580A/da not_active Application Discontinuation
- 1980-01-23 DE DE19803002367 patent/DE3002367A1/de not_active Ceased
- 1980-01-23 PT PT70724A patent/PT70724A/pt unknown
- 1980-05-16 JP JP6515480A patent/JPS5636475A/ja active Pending
- 1980-05-16 JP JP55065153A patent/JPS5855151B2/ja not_active Expired
- 1980-05-16 JP JP6515580A patent/JPS5636487A/ja active Pending
- 1980-05-28 FR FR8011815A patent/FR2453174A1/fr active Granted
- 1980-05-28 FR FR8011816A patent/FR2453175A1/fr active Granted
- 1980-06-17 PH PH24153A patent/PH15072A/en unknown
- 1980-06-17 PH PH24155A patent/PH15086A/en unknown
- 1980-06-17 PH PH24154A patent/PH17773A/en unknown
-
1981
- 1981-01-22 DD DD22761181A patent/DD156369A5/de unknown
- 1981-01-26 SU SU813233005A patent/SU1080746A3/ru active
- 1981-01-26 SU SU813233012A patent/SU1333239A3/ru active
-
1983
- 1983-12-13 YU YU02421/83A patent/YU242183A/xx unknown
-
1984
- 1984-07-27 NO NO843041A patent/NO843041L/no unknown
- 1984-09-11 SE SE8404555A patent/SE8404555L/xx not_active Application Discontinuation
- 1984-09-11 SE SE8404554A patent/SE8404554L/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |