HRP980434A2 - 4-AMINOPYRROLE (3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS - Google Patents
4-AMINOPYRROLE (3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTSInfo
- Publication number
- HRP980434A2 HRP980434A2 HR60/054,734A HRP980434A HRP980434A2 HR P980434 A2 HRP980434 A2 HR P980434A2 HR P980434 A HRP980434 A HR P980434A HR P980434 A2 HRP980434 A2 HR P980434A2
- Authority
- HR
- Croatia
- Prior art keywords
- image
- methyl
- alkyl
- phenyl
- pyrrolidin
- Prior art date
Links
- WAUGGYPDCQZJKK-UHFFFAOYSA-N 1h-pyrrol-3-amine Chemical compound NC=1C=CNC=1 WAUGGYPDCQZJKK-UHFFFAOYSA-N 0.000 title description 2
- 150000003230 pyrimidines Chemical class 0.000 title description 2
- 239000002660 neuropeptide Y receptor antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 96
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
- 201000010099 disease Diseases 0.000 claims description 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 239000001257 hydrogen Substances 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
- 101710151321 Melanostatin Proteins 0.000 claims description 18
- 102400000064 Neuropeptide Y Human genes 0.000 claims description 18
- 230000002159 abnormal effect Effects 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 13
- URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 claims description 13
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- HZUBQZOSSIBAFP-OAHLLOKOSA-N (3r)-n,n-dimethyl-1-(2-methyl-6-phenyl-5h-pyrrolo[3,2-d]pyrimidin-4-yl)pyrrolidin-3-amine Chemical compound C1[C@H](N(C)C)CCN1C1=NC(C)=NC2=C1NC(C=1C=CC=CC=1)=C2 HZUBQZOSSIBAFP-OAHLLOKOSA-N 0.000 claims description 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 3
- SJOOTYROPWOHLH-UHFFFAOYSA-N 2-(1H-imidazol-2-yl)-5-methyl-7-pyrrolidin-1-yl-1H-imidazo[4,5-b]pyridine Chemical compound C=12N=C(C=3NC=CN=3)NC2=NC(C)=CC=1N1CCCC1 SJOOTYROPWOHLH-UHFFFAOYSA-N 0.000 claims description 3
- ZKPWMKDTOFLIIW-UHFFFAOYSA-N 2-(2,4-dimethoxyphenyl)-7-methoxy-5-methyl-1h-imidazo[4,5-b]pyridine Chemical compound COC1=CC(OC)=CC=C1C1=NC2=C(OC)C=C(C)N=C2N1 ZKPWMKDTOFLIIW-UHFFFAOYSA-N 0.000 claims description 3
- KAARVEBGIBILBH-UHFFFAOYSA-N 2-(4-fluorophenyl)-5-methyl-7-piperidin-1-yl-1h-imidazo[4,5-b]pyridine Chemical compound C=12N=C(C=3C=CC(F)=CC=3)NC2=NC(C)=CC=1N1CCCCC1 KAARVEBGIBILBH-UHFFFAOYSA-N 0.000 claims description 3
- KUWPETDUKCRCHF-UHFFFAOYSA-N 2-(5-methyl-7-pyrrolidin-1-yl-1h-imidazo[4,5-b]pyridin-2-yl)-1,3-thiazole Chemical compound C=12N=C(C=3SC=CN=3)NC2=NC(C)=CC=1N1CCCC1 KUWPETDUKCRCHF-UHFFFAOYSA-N 0.000 claims description 3
- HQPKSLLHTRGJRK-SFHVURJKSA-N 2-methyl-6-phenyl-4-[(2s)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]-5h-pyrrolo[3,2-d]pyrimidine Chemical compound C([C@@H]1CCCN1C=1N=C(N=C2C=C(NC2=1)C=1C=CC=CC=1)C)N1CCCC1 HQPKSLLHTRGJRK-SFHVURJKSA-N 0.000 claims description 3
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5473497P | 1997-08-05 | 1997-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP980434A2 true HRP980434A2 (en) | 1999-04-30 |
Family
ID=21993163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR60/054,734A HRP980434A2 (en) | 1997-08-05 | 1998-08-04 | 4-AMINOPYRROLE (3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS |
Country Status (32)
Country | Link |
---|---|
US (1) | US6187778B1 (fr) |
EP (1) | EP1003744B1 (fr) |
JP (1) | JP3711238B2 (fr) |
KR (1) | KR20010022583A (fr) |
CN (1) | CN1264381A (fr) |
AP (1) | AP9801312A0 (fr) |
AT (1) | ATE296825T1 (fr) |
AU (1) | AU7927498A (fr) |
BG (1) | BG104107A (fr) |
BR (1) | BR9811844A (fr) |
CA (1) | CA2293621C (fr) |
CO (1) | CO4960634A1 (fr) |
DE (1) | DE69830409T2 (fr) |
EA (1) | EA200000098A1 (fr) |
ES (1) | ES2241146T3 (fr) |
GT (1) | GT199800114A (fr) |
HR (1) | HRP980434A2 (fr) |
HU (1) | HUP0002956A3 (fr) |
ID (1) | ID24300A (fr) |
IL (1) | IL133430A0 (fr) |
IS (1) | IS5294A (fr) |
MA (1) | MA24629A1 (fr) |
NO (1) | NO996178L (fr) |
OA (1) | OA11277A (fr) |
PA (1) | PA8456601A1 (fr) |
PE (1) | PE106199A1 (fr) |
PL (1) | PL338575A1 (fr) |
SA (1) | SA98190435A (fr) |
TN (1) | TNSN98148A1 (fr) |
TR (1) | TR200000333T2 (fr) |
WO (1) | WO1999007703A1 (fr) |
ZA (1) | ZA986968B (fr) |
Families Citing this family (35)
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US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
IL148904A0 (en) * | 1999-09-30 | 2002-09-12 | Neurogen Corp | Amino substituted pyrazolo {1,5,-a}-1,5- pyrimidines and pyrazolo{1,5,-a}-1,3,5-triazines |
MXPA02006338A (es) * | 1999-12-24 | 2002-12-13 | Aventis Pharma Ltd | Azaindoles. |
GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
MEP8409A (en) | 2004-06-02 | 2011-12-20 | Fused heterocyclic compound | |
EP1756093A1 (fr) | 2004-06-17 | 2007-02-28 | Wyeth | Procedes pour la preparation d'antagonistes du recepteur de la gonadoliberine |
AU2005264996A1 (en) | 2004-06-17 | 2006-01-26 | Wyeth | Gonadotropin releasing hormone receptor antagonists |
CA2575808A1 (fr) * | 2004-08-02 | 2006-02-16 | Osi Pharmaceuticals, Inc. | Composes a base de pyrrolopyrimidine a substitution arylamine inhibiteurs de kinases multiples |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
AU2006209117B2 (en) * | 2005-01-28 | 2009-12-10 | Daewoong Pharmaceutical Co., Ltd. | Novel benzoimidazole derivatives and pharmaceutical composition comprising the same |
KR20060087386A (ko) * | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
US20090213731A1 (en) * | 2005-04-15 | 2009-08-27 | Regenertech Pty Limited | Use of neuropeptide y (npy) and agonists and antagonists thereof for tissue regeneration |
US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
CA2614544C (fr) * | 2005-07-13 | 2013-09-10 | Banyu Pharmaceutical Co., Ltd. | Derive du benzimidazole a substitution par un heterocycle |
AR057525A1 (es) * | 2005-10-03 | 2007-12-05 | Astrazeneca Ab | Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion |
AR055669A1 (es) * | 2005-10-03 | 2007-08-29 | Astrazeneca Ab | Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales. |
US20070129364A1 (en) * | 2005-12-07 | 2007-06-07 | Han-Qing Dong | Pyrrolopyridine kinase inhibiting compounds |
WO2007072017A2 (fr) * | 2005-12-22 | 2007-06-28 | The Institute Of Cancer Research | Inhibiteurs d'enzymes |
ES2374455T3 (es) | 2006-02-17 | 2012-02-16 | Pfizer Limited | Derivados de 3-deazapurinza como moduladores de tlr7. |
JP5606734B2 (ja) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
KR101134239B1 (ko) | 2006-07-11 | 2012-04-10 | 주식회사 대웅제약 | 신규한 바이아릴 벤조이미다졸 유도체 및 이를 함유하는 약학 조성물 |
PL2054405T3 (pl) * | 2006-07-11 | 2014-03-31 | Dae Woong Pharma | Nowe pochodne biarylobenzimidazolu i zawierająca je kompozycja farmaceutyczna |
CL2007002617A1 (es) | 2006-09-11 | 2008-05-16 | Sanofi Aventis | Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto. |
WO2008121064A1 (fr) * | 2007-03-30 | 2008-10-09 | Astrazeneca Ab | Nouveaux composés d'imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryle 705 |
DE102007027800A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
ES2522365T3 (es) | 2007-10-11 | 2014-11-14 | Astrazeneca Ab | Derivados de pirrolo [2,3-D] pirimidina como inhibidores de proteína quinasas B |
CN101965350A (zh) | 2008-01-11 | 2011-02-02 | 纳科法尔马有限公司 | 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物 |
PL2694056T3 (pl) | 2011-04-01 | 2020-03-31 | Astrazeneca Ab | Leczenie terapeutyczne |
PL2785349T5 (pl) | 2011-11-30 | 2023-01-30 | Astrazeneca Ab | Kombinacja do leczenia nowotworu |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
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US3274213A (en) | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
DE2818676A1 (de) * | 1978-04-27 | 1979-11-08 | Troponwerke Gmbh & Co Kg | Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
GB9022644D0 (en) * | 1990-10-18 | 1990-11-28 | Ici Plc | Heterocyclic compounds |
US5877178A (en) * | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
US5235053A (en) * | 1992-06-22 | 1993-08-10 | Eli Lilly And Company | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates |
US5284971A (en) | 1992-07-16 | 1994-02-08 | Syntex (U.S.A.) Inc. | 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents |
ES2108855T3 (es) | 1992-07-21 | 1998-01-01 | Ciba Geigy Ag | Derivados de acido oxamico como agentes hipocolesteremicos. |
EP0682027B1 (fr) * | 1994-05-03 | 1997-10-15 | Novartis AG | Dérivés de la pyrrolopyrimidine avec une activité anti-proliférative |
MX9702307A (es) * | 1994-09-29 | 1998-04-30 | Novartis Ag | Pirrolo (2,3-d)pirimidinas y su uso. |
US6562862B1 (en) | 1994-10-20 | 2003-05-13 | Eli Lilly And Company | Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y |
CA2203878C (fr) | 1994-11-07 | 2002-06-25 | John M. Peterson | Certains derives de benzylamine a substitutions; une nouvelle classe de ligands specifiques du neuropeptide y1 |
US5644057A (en) * | 1995-05-12 | 1997-07-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
EP0759441A3 (fr) | 1995-06-30 | 1999-06-30 | Eli Lilly And Company | Procédés de traitement des pathologies associées aux peptides neuropeptide Y |
WO1997025041A1 (fr) * | 1996-01-09 | 1997-07-17 | Eli Lilly And Company | Antagonistes benzimidazolyles du recepteur du neuropeptide y |
-
1998
- 1998-07-10 IL IL13343098A patent/IL133430A0/xx unknown
- 1998-07-10 TR TR2000/00333T patent/TR200000333T2/xx unknown
- 1998-07-10 BR BR9811844-7A patent/BR9811844A/pt not_active Application Discontinuation
- 1998-07-10 KR KR1020007001174A patent/KR20010022583A/ko not_active Application Discontinuation
- 1998-07-10 ID IDW20000021A patent/ID24300A/id unknown
- 1998-07-10 AU AU79274/98A patent/AU7927498A/en not_active Abandoned
- 1998-07-10 CN CN98807398A patent/CN1264381A/zh active Pending
- 1998-07-10 PL PL98338575A patent/PL338575A1/xx unknown
- 1998-07-10 US US09/380,901 patent/US6187778B1/en not_active Expired - Fee Related
- 1998-07-10 CA CA002293621A patent/CA2293621C/fr not_active Expired - Fee Related
- 1998-07-10 WO PCT/IB1998/001053 patent/WO1999007703A1/fr not_active Application Discontinuation
- 1998-07-10 HU HU0002956A patent/HUP0002956A3/hu unknown
- 1998-07-10 EA EA200000098A patent/EA200000098A1/ru unknown
- 1998-07-10 AT AT98929573T patent/ATE296825T1/de not_active IP Right Cessation
- 1998-07-10 DE DE69830409T patent/DE69830409T2/de not_active Expired - Fee Related
- 1998-07-10 ES ES98929573T patent/ES2241146T3/es not_active Expired - Lifetime
- 1998-07-10 JP JP2000506207A patent/JP3711238B2/ja not_active Expired - Fee Related
- 1998-07-10 EP EP98929573A patent/EP1003744B1/fr not_active Expired - Lifetime
- 1998-07-27 GT GT199800114A patent/GT199800114A/es unknown
- 1998-07-30 AP APAP/P/1998/001312A patent/AP9801312A0/en unknown
- 1998-07-30 PE PE1998000678A patent/PE106199A1/es not_active Application Discontinuation
- 1998-08-03 PA PA19988456601A patent/PA8456601A1/es unknown
- 1998-08-04 MA MA25203A patent/MA24629A1/fr unknown
- 1998-08-04 ZA ZA9806968A patent/ZA986968B/xx unknown
- 1998-08-04 TN TNTNSN98148A patent/TNSN98148A1/fr unknown
- 1998-08-04 HR HR60/054,734A patent/HRP980434A2/hr not_active Application Discontinuation
- 1998-08-05 CO CO98044925A patent/CO4960634A1/es unknown
- 1998-08-19 SA SA98190435A patent/SA98190435A/ar unknown
-
1999
- 1999-12-10 IS IS5294A patent/IS5294A/is unknown
- 1999-12-14 NO NO996178A patent/NO996178L/no not_active Application Discontinuation
-
2000
- 2000-01-14 OA OA1200000007A patent/OA11277A/en unknown
- 2000-01-26 BG BG104107A patent/BG104107A/bg unknown
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