OA11277A - 4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists. - Google Patents

4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists. Download PDF

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Publication number
OA11277A
OA11277A OA1200000007A OA1200000007A OA11277A OA 11277 A OA11277 A OA 11277A OA 1200000007 A OA1200000007 A OA 1200000007A OA 1200000007 A OA1200000007 A OA 1200000007A OA 11277 A OA11277 A OA 11277A
Authority
OA
OAPI
Prior art keywords
alkyl
methyl
phenyl
imidazo
pyridine
Prior art date
Application number
OA1200000007A
Other languages
English (en)
Inventor
Robert Lee Dow
Marlys Hammond
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA11277A publication Critical patent/OA11277A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
OA1200000007A 1997-08-05 2000-01-14 4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists. OA11277A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5473497P 1997-08-05 1997-08-05

Publications (1)

Publication Number Publication Date
OA11277A true OA11277A (en) 2003-07-29

Family

ID=21993163

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000007A OA11277A (en) 1997-08-05 2000-01-14 4-Aminopyrrole (3,2-d)pyrimidines as Neuropeptide Y receptor antagonists.

Country Status (32)

Country Link
US (1) US6187778B1 (fr)
EP (1) EP1003744B1 (fr)
JP (1) JP3711238B2 (fr)
KR (1) KR20010022583A (fr)
CN (1) CN1264381A (fr)
AP (1) AP9801312A0 (fr)
AT (1) ATE296825T1 (fr)
AU (1) AU7927498A (fr)
BG (1) BG104107A (fr)
BR (1) BR9811844A (fr)
CA (1) CA2293621C (fr)
CO (1) CO4960634A1 (fr)
DE (1) DE69830409T2 (fr)
EA (1) EA200000098A1 (fr)
ES (1) ES2241146T3 (fr)
GT (1) GT199800114A (fr)
HR (1) HRP980434A2 (fr)
HU (1) HUP0002956A3 (fr)
ID (1) ID24300A (fr)
IL (1) IL133430A0 (fr)
IS (1) IS5294A (fr)
MA (1) MA24629A1 (fr)
NO (1) NO996178L (fr)
OA (1) OA11277A (fr)
PA (1) PA8456601A1 (fr)
PE (1) PE106199A1 (fr)
PL (1) PL338575A1 (fr)
SA (1) SA98190435A (fr)
TN (1) TNSN98148A1 (fr)
TR (1) TR200000333T2 (fr)
WO (1) WO1999007703A1 (fr)
ZA (1) ZA986968B (fr)

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CA2379633C (fr) * 1999-09-30 2006-06-20 Neurogen Corporation Pyrazolo[1,5,-a]-1,5-pyrimidines et pyrazolo[1,5-a]-1,3,5-triazines amino substituees
CZ301750B6 (cs) * 1999-12-24 2010-06-09 Aventis Pharma Limited Bicyklický pyrrolový derivát, jeho použití pri výrobe léciva, farmaceutická kompozice tento derivát obsahující a pro použití pri lécení
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
EP1752457B1 (fr) 2004-06-02 2014-03-19 Takeda Pharmaceutical Company Limited Composé heterocyclique fusionné
BRPI0512261A (pt) 2004-06-17 2008-02-26 Wyeth Corp antagonistas de receptor de hormÈnio liberador de gonadotropina
RU2007101509A (ru) 2004-06-17 2008-07-27 Уайт (Us) Способ получения антагонистов рецепторов гормона, высвобождающего гонадотропин
JP2008508358A (ja) * 2004-08-02 2008-03-21 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド アリール−アミノ置換ピロロピリミジンマルチキナーゼ阻害化合物
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
CA2596013C (fr) * 2005-01-28 2012-06-05 Daewoong Pharmaceutical Co., Ltd. Derives de benzoimidazole et composition pharmaceutique contenant ceux-ci
KR20060087386A (ko) 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
WO2006108218A1 (fr) * 2005-04-15 2006-10-19 Regenertech Pty Limited Utilisation de neuropeptides y (npy) et d'agoniste d'antagonistes de ceux-ci pour regenerer des tissus
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
CA2614544C (fr) * 2005-07-13 2013-09-10 Banyu Pharmaceutical Co., Ltd. Derive du benzimidazole a substitution par un heterocycle
UY29825A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones
UY29823A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones
JP2009531274A (ja) * 2005-12-07 2009-09-03 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド キナーゼ阻害性ピロロピリジン化合物
WO2007072017A2 (fr) * 2005-12-22 2007-06-28 The Institute Of Cancer Research Inhibiteurs d'enzymes
WO2007093901A1 (fr) 2006-02-17 2007-08-23 Pfizer Limited Dérivés de 3-déazapurine en tant que modulateurs de tlr7
EP3421471B1 (fr) 2006-04-25 2021-05-26 Astex Therapeutics Limited Dérivés de purine et de déazapurine comme composés pharmaceutiques
PL2054405T3 (pl) 2006-07-11 2014-03-31 Dae Woong Pharma Nowe pochodne biarylobenzimidazolu i zawierająca je kompozycja farmaceutyczna
KR101134239B1 (ko) 2006-07-11 2012-04-10 주식회사 대웅제약 신규한 바이아릴 벤조이미다졸 유도체 및 이를 함유하는 약학 조성물
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
WO2008121064A1 (fr) * 2007-03-30 2008-10-09 Astrazeneca Ab Nouveaux composés d'imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryle 705
DE102007027800A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
CN101861321B (zh) 2007-10-11 2013-02-06 阿斯利康(瑞典)有限公司 作为蛋白激酶b抑制剂的吡咯并[2,3-d]嘧啶衍生物
NZ586642A (en) 2008-01-11 2012-04-27 Natco Pharma Ltd Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents
BR112013025410A2 (pt) 2011-04-01 2016-12-20 Astrazeneca Ab tratamento terapêutico
MX367640B (es) 2011-11-30 2019-08-29 Astrazeneca Ab Tratamiento combinado del cáncer.
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms

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US3274213A (en) 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
DE2818676A1 (de) * 1978-04-27 1979-11-08 Troponwerke Gmbh & Co Kg Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9022644D0 (en) * 1990-10-18 1990-11-28 Ici Plc Heterocyclic compounds
US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5235053A (en) * 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
US5284971A (en) 1992-07-16 1994-02-08 Syntex (U.S.A.) Inc. 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
DK0580550T3 (da) 1992-07-21 1998-02-02 Ciba Geigy Ag Oxamidsyrederivater som hypercholesterolæmiske midler
EP0682027B1 (fr) * 1994-05-03 1997-10-15 Novartis AG Dérivés de la pyrrolopyrimidine avec une activité anti-proliférative
PT783505E (pt) * 1994-09-29 2001-08-30 Novartis Ag Pirrolo¬2,3-d|pirimidinas e sua utilizacao
US6562862B1 (en) 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
AU692977B2 (en) 1994-11-07 1998-06-18 Pfizer Inc. Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
US5644057A (en) * 1995-05-12 1997-07-01 Neurogen Corporation Deazapurine derivatives; a new class of CRF1 specific ligands
EP0759441A3 (fr) 1995-06-30 1999-06-30 Eli Lilly And Company Procédés de traitement des pathologies associées aux peptides neuropeptide Y
CA2242579A1 (fr) 1996-01-09 1997-07-17 Eli Lilly And Company Antagonistes benzimidazolyles du recepteur du neuropeptide y

Also Published As

Publication number Publication date
AU7927498A (en) 1999-03-01
DE69830409D1 (de) 2005-07-07
EA200000098A1 (ru) 2000-08-28
BG104107A (bg) 2000-08-31
WO1999007703A1 (fr) 1999-02-18
HRP980434A2 (en) 1999-04-30
HUP0002956A2 (hu) 2001-08-28
ZA986968B (en) 2000-02-04
ATE296825T1 (de) 2005-06-15
JP2001512729A (ja) 2001-08-28
GT199800114A (es) 2000-01-18
PL338575A1 (en) 2000-11-06
HUP0002956A3 (en) 2002-01-28
NO996178L (no) 2000-02-14
IS5294A (is) 1999-12-10
CA2293621A1 (fr) 1999-02-18
US6187778B1 (en) 2001-02-13
CN1264381A (zh) 2000-08-23
CA2293621C (fr) 2003-12-30
JP3711238B2 (ja) 2005-11-02
KR20010022583A (ko) 2001-03-26
ID24300A (id) 2000-07-13
NO996178D0 (no) 1999-12-14
BR9811844A (pt) 2000-08-08
CO4960634A1 (es) 2000-09-25
MA24629A1 (fr) 1999-04-01
DE69830409T2 (de) 2006-01-26
TR200000333T2 (tr) 2000-05-22
AP9801312A0 (en) 2000-01-30
IL133430A0 (en) 2001-04-30
ES2241146T3 (es) 2005-10-16
SA98190435A (ar) 2005-12-03
PA8456601A1 (es) 2000-05-24
PE106199A1 (es) 1999-11-02
EP1003744B1 (fr) 2005-06-01
EP1003744A1 (fr) 2000-05-31
TNSN98148A1 (fr) 2005-03-15

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