HRP970537B1 - Pharmaceutical microspheres containing valproic acid for oral administration - Google Patents

Pharmaceutical microspheres containing valproic acid for oral administration

Info

Publication number
HRP970537B1
HRP970537B1 HR970537A HRP970537A HRP970537B1 HR P970537 B1 HRP970537 B1 HR P970537B1 HR 970537 A HR970537 A HR 970537A HR P970537 A HRP970537 A HR P970537A HR P970537 B1 HRP970537 B1 HR P970537B1
Authority
HR
Croatia
Prior art keywords
oral administration
valproic acid
microspheres containing
containing valproic
pharmaceutical microspheres
Prior art date
Application number
HR970537A
Other languages
English (en)
Inventor
Christian Langlois
Jean-Yves Lanne
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of HRP970537A2 publication Critical patent/HRP970537A2/hr
Publication of HRP970537B1 publication Critical patent/HRP970537B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR970537A 1996-10-07 1997-10-07 Pharmaceutical microspheres containing valproic acid for oral administration HRP970537B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9612201A FR2754177B1 (fr) 1996-10-07 1996-10-07 Microspheres pharmaceutiques d'acide valproique pour administration orale

Publications (2)

Publication Number Publication Date
HRP970537A2 HRP970537A2 (en) 1998-08-31
HRP970537B1 true HRP970537B1 (en) 2002-08-31

Family

ID=9496427

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970537A HRP970537B1 (en) 1996-10-07 1997-10-07 Pharmaceutical microspheres containing valproic acid for oral administration

Country Status (40)

Country Link
US (3) US20020001598A1 (no)
EP (1) EP0956010B1 (no)
JP (1) JP3523270B2 (no)
KR (1) KR100334687B1 (no)
CN (1) CN100367945C (no)
AR (1) AR013613A1 (no)
AT (1) ATE216228T1 (no)
AU (1) AU731235B2 (no)
BR (1) BR9712268A (no)
CA (1) CA2267096C (no)
CO (1) CO4900080A1 (no)
CZ (1) CZ288876B6 (no)
DE (1) DE69712100T2 (no)
DK (1) DK0956010T3 (no)
DZ (1) DZ2316A1 (no)
EE (1) EE03744B1 (no)
EG (1) EG24070A (no)
ES (1) ES2174293T3 (no)
FR (1) FR2754177B1 (no)
HK (1) HK1021939A1 (no)
HR (1) HRP970537B1 (no)
HU (1) HU225103B1 (no)
ID (1) ID24596A (no)
IL (1) IL128745A (no)
IS (1) IS1985B (no)
ME (1) ME00664B (no)
MY (1) MY120521A (no)
NO (1) NO325723B1 (no)
NZ (1) NZ334399A (no)
PL (1) PL190105B1 (no)
PT (1) PT956010E (no)
RS (1) RS49602B (no)
RU (1) RU2177315C2 (no)
SI (1) SI0956010T1 (no)
SK (1) SK282113B6 (no)
TR (1) TR199900789T2 (no)
TW (1) TW508251B (no)
UY (1) UY24738A1 (no)
WO (1) WO1998015268A1 (no)
ZA (1) ZA978954B (no)

Families Citing this family (18)

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CN1361683A (zh) 1999-06-07 2002-07-31 比克·古尔顿·劳姆贝尔格化学公司 含有一种对酸不稳定的活性化合物的新型制剂和药物剂型
AU2003289782A1 (en) * 2002-12-16 2004-07-09 The University Of British Columbia Valproic acid analogues and pharmaceutical compositions thereof
TWI547431B (zh) * 2004-06-09 2016-09-01 史密斯克萊美占公司 生產藥物之裝置及方法
JP2008512386A (ja) * 2004-09-07 2008-04-24 オーファン メディカル，インコーポレイティド 改良型ｇｈｂ組成物
US9149433B2 (en) * 2004-11-30 2015-10-06 Basf Corporation Method for formation of micro-prilled polymers
US20060252830A1 (en) * 2005-05-06 2006-11-09 Brandon Stephen F Method for the treatment of magnesium and potassium deficiencies
US20060252831A1 (en) * 2005-05-06 2006-11-09 Christopher Offen Method for the treatment of magnesium and potassium deficiencies
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
CN101543631B (zh) * 2008-03-28 2012-01-11 沈阳兴齐制药有限公司 含蜂蜡的微球基质、含有它的药物组合物及其用途
JP5866279B2 (ja) * 2009-05-12 2016-02-17 株式会社アモーレパシフィックＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ 脱毛防止又は育毛促進のための組成物
AU2014350208B2 (en) * 2013-11-13 2017-09-07 Tillotts Pharma Ag Multi-particulate drug delivery system
CN104013596A (zh) * 2014-05-16 2014-09-03 安士制药（中山）有限公司 一种丙戊酸软胶囊及其制备方法
CN105456217A (zh) * 2014-08-27 2016-04-06 捷思英达医药技术（上海）有限公司 一种双丙戊酸钠缓释剂组合物及其制备方法
US11652237B2 (en) 2017-08-24 2023-05-16 Mitsui Chemicals, Inc. Nonaqueous electrolyte solution including boron compound additive having higher reductive decomposition potential than additional additive and lithium secondary battery including the same
CN111033865A (zh) 2017-08-24 2020-04-17 三井化学株式会社 锂二次电池及非水电解液
FR3087445B1 (fr) * 2018-10-19 2021-12-17 Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic Composition lipidique pour l'encapsulation d'une substance active et permettant le controle de la vitesse de liberation de ladite substance active
CN111012753A (zh) * 2020-01-07 2020-04-17 仁和堂药业有限公司 一种提高丙戊酸钠片剂稳定性的方法
CN112274499A (zh) * 2020-11-16 2021-01-29 仁和堂药业有限公司 一种提高丙戊酸钠片剂稳定性的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2293974A1 (fr) * 1973-03-02 1976-07-09 Kaltenbach Roger Procede et dispositif pour la granulation reguliere de divers produits
US5212326A (en) * 1979-08-20 1993-05-18 Abbott Laboratories Sodium hydrogen divalproate oligomer
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
IL72381A (en) * 1983-07-20 1988-03-31 Sanofi Sa Pharmaceutical composition based on valproic acid
US5185159A (en) * 1983-07-20 1993-02-09 Sanofi Pharmaceutical composition based on valproic acid and a process for preparing it
US4913906B1 (en) * 1985-02-28 2000-06-06 Yissum Res Dev Co Controlled release dosage form of valproic acid
JP2893191B2 (ja) * 1988-11-08 1999-05-17 武田薬品工業株式会社 放出制御性マトリックス剤
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
TW209174B (no) * 1991-04-19 1993-07-11 Takeda Pharm Industry Co Ltd
ES2073301T3 (es) * 1991-05-20 1995-08-01 Marion Laboratories Inc Composicion multi-capa de liberacion controlada.
FR2682677A1 (fr) * 1991-10-17 1993-04-23 Sanofi Elf Complexe forme de l'acide propyl-2 pentene-2 ouique (e) et de son sel de sodium, sa preparation et compositions pharmaceutiques le contenant.
US6287598B1 (en) * 1993-05-28 2001-09-11 Alza Corporation Method for providing sustained antiepileptic therapy
US5690959A (en) * 1993-05-29 1997-11-25 Smithkline Beecham Corporation Pharmaceutical thermal infusion process
AUPN969796A0 (en) * 1996-05-07 1996-05-30 F.H. Faulding & Co. Limited Taste masked liquid suspensions
US5916910A (en) * 1997-06-04 1999-06-29 Medinox, Inc. Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці

Also Published As

Publication number Publication date
RU2177315C2 (ru) 2001-12-27
CA2267096A1 (fr) 1998-04-16
UY24738A1 (es) 2001-05-31
DK0956010T3 (da) 2002-08-12
CO4900080A1 (es) 2000-03-27
KR100334687B1 (ko) 2002-04-27
FR2754177B1 (fr) 1999-08-06
ES2174293T3 (es) 2002-11-01
US8535721B2 (en) 2013-09-17
NO325723B1 (no) 2008-07-07
YU17899A (sh) 2000-03-21
TW508251B (en) 2002-11-01
PL190105B1 (pl) 2005-10-31
SI0956010T1 (en) 2002-10-31
ID24596A (id) 2000-07-27
ZA978954B (en) 1999-04-07
US20020001598A1 (en) 2002-01-03
CN1232391A (zh) 1999-10-20
IS4996A (is) 1999-03-11
HRP970537A2 (en) 1998-08-31
EP0956010A1 (fr) 1999-11-17
DE69712100T2 (de) 2002-11-28
US20060263437A1 (en) 2006-11-23
HU225103B1 (en) 2006-06-28
JP2000504038A (ja) 2000-04-04
CA2267096C (fr) 2003-09-16
AR013613A1 (es) 2001-01-10
EE03744B1 (et) 2002-06-17
ME00664B (me) 2007-06-04
PT956010E (pt) 2002-08-30
NO991613L (no) 1999-04-06
DE69712100D1 (de) 2002-05-23
IS1985B (is) 2005-02-15
AU4560297A (en) 1998-05-05
HUP9903855A3 (en) 2000-06-28
IL128745A (en) 2004-05-12
CN100367945C (zh) 2008-02-13
NO991613D0 (no) 1999-04-06
BR9712268A (pt) 1999-08-31
SK282113B6 (sk) 2001-11-06
SK36499A3 (en) 2000-12-11
CZ121199A3 (cs) 1999-08-11
RS49602B (sr) 2007-06-04
DZ2316A1 (fr) 2002-12-28
AU731235B2 (en) 2001-03-29
CZ288876B6 (cs) 2001-09-12
MY120521A (en) 2005-11-30
FR2754177A1 (fr) 1998-04-10
IL128745A0 (en) 2000-01-31
KR20000048828A (ko) 2000-07-25
PL332249A1 (en) 1999-08-30
EP0956010B1 (fr) 2002-04-17
JP3523270B2 (ja) 2004-04-26
US20030157177A1 (en) 2003-08-21
HK1021939A1 (en) 2000-07-21
ATE216228T1 (de) 2002-05-15
TR199900789T2 (xx) 1999-07-21
EG24070A (en) 2008-05-11
EE9900140A (et) 1999-12-15
HUP9903855A2 (hu) 2000-05-28
WO1998015268A1 (fr) 1998-04-16
NZ334399A (en) 2000-05-26

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-SYNTHELABO, FR

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS, FR

ODRP Renewal fee for the maintenance of a patent

Payment date: 20160914

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20171007