CZ121199A3 - Farmaceuticky účinné mikrokuličky kyseliny valprové k peronálnímu podávání - Google Patents

Farmaceuticky účinné mikrokuličky kyseliny valprové k peronálnímu podávání

Info

Publication number
CZ121199A3
CZ121199A3 CZ991211A CZ121199A CZ121199A3 CZ 121199 A3 CZ121199 A3 CZ 121199A3 CZ 991211 A CZ991211 A CZ 991211A CZ 121199 A CZ121199 A CZ 121199A CZ 121199 A3 CZ121199 A3 CZ 121199A3
Authority
CZ
Czechia
Prior art keywords
spheres
pharmaceutically active
valproic acid
peroral administration
active micro
Prior art date
Application number
CZ991211A
Other languages
English (en)
Other versions
CZ288876B6 (cs
Inventor
Christian Langlois
Jean-Yves Lanne
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of CZ121199A3 publication Critical patent/CZ121199A3/cs
Publication of CZ288876B6 publication Critical patent/CZ288876B6/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
CZ19991211A 1996-10-07 1997-10-03 Farmaceutické mikrokuličky valprové kyseliny k orálnímu podávání, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje CZ288876B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9612201A FR2754177B1 (fr) 1996-10-07 1996-10-07 Microspheres pharmaceutiques d'acide valproique pour administration orale
PCT/FR1997/001762 WO1998015268A1 (fr) 1996-10-07 1997-10-03 Microspheres pharmaceutiques d'acide valproique pour administration orale

Publications (2)

Publication Number Publication Date
CZ121199A3 true CZ121199A3 (cs) 1999-08-11
CZ288876B6 CZ288876B6 (cs) 2001-09-12

Family

ID=9496427

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ19991211A CZ288876B6 (cs) 1996-10-07 1997-10-03 Farmaceutické mikrokuličky valprové kyseliny k orálnímu podávání, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje

Country Status (40)

Country Link
US (3) US20020001598A1 (cs)
EP (1) EP0956010B1 (cs)
JP (1) JP3523270B2 (cs)
KR (1) KR100334687B1 (cs)
CN (1) CN100367945C (cs)
AR (1) AR013613A1 (cs)
AT (1) ATE216228T1 (cs)
AU (1) AU731235B2 (cs)
BR (1) BR9712268A (cs)
CA (1) CA2267096C (cs)
CO (1) CO4900080A1 (cs)
CZ (1) CZ288876B6 (cs)
DE (1) DE69712100T2 (cs)
DK (1) DK0956010T3 (cs)
DZ (1) DZ2316A1 (cs)
EE (1) EE03744B1 (cs)
EG (1) EG24070A (cs)
ES (1) ES2174293T3 (cs)
FR (1) FR2754177B1 (cs)
HK (1) HK1021939A1 (cs)
HR (1) HRP970537B1 (cs)
HU (1) HU225103B1 (cs)
ID (1) ID24596A (cs)
IL (1) IL128745A (cs)
IS (1) IS1985B (cs)
ME (1) ME00664B (cs)
MY (1) MY120521A (cs)
NO (1) NO325723B1 (cs)
NZ (1) NZ334399A (cs)
PL (1) PL190105B1 (cs)
PT (1) PT956010E (cs)
RS (1) RS49602B (cs)
RU (1) RU2177315C2 (cs)
SI (1) SI0956010T1 (cs)
SK (1) SK282113B6 (cs)
TR (1) TR199900789T2 (cs)
TW (1) TW508251B (cs)
UY (1) UY24738A1 (cs)
WO (1) WO1998015268A1 (cs)
ZA (1) ZA978954B (cs)

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MXPA01012659A (es) 1999-06-07 2003-09-04 Altana Pharma Ag Nueva forma de administracion y preparacion que comprende un compuesto activo labil acido.
US20060223888A1 (en) * 2002-12-16 2006-10-05 Abbott Frank S Valproic acid analogues and pharmaceutical composition thereof
TWI356036B (en) * 2004-06-09 2012-01-11 Smithkline Beecham Corp Apparatus and method for pharmaceutical production
CA2579576A1 (en) * 2004-09-07 2006-03-16 Orphan Medical, Inc. Improved ghb compositions
US9149433B2 (en) * 2004-11-30 2015-10-06 Basf Corporation Method for formation of micro-prilled polymers
US20060252831A1 (en) * 2005-05-06 2006-11-09 Christopher Offen Method for the treatment of magnesium and potassium deficiencies
US20060252830A1 (en) * 2005-05-06 2006-11-09 Brandon Stephen F Method for the treatment of magnesium and potassium deficiencies
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
CN101543631B (zh) * 2008-03-28 2012-01-11 沈阳兴齐制药有限公司 含蜂蜡的微球基质、含有它的药物组合物及其用途
WO2010131887A2 (ko) * 2009-05-12 2010-11-18 (주)아모레퍼시픽 탈모 방지 또는 육모 촉진을 위한 조성물
AU2014350208B2 (en) * 2013-11-13 2017-09-07 Tillotts Pharma Ag Multi-particulate drug delivery system
CN104013596A (zh) * 2014-05-16 2014-09-03 安士制药（中山）有限公司 一种丙戊酸软胶囊及其制备方法
CN105456217A (zh) * 2014-08-27 2016-04-06 捷思英达医药技术（上海）有限公司 一种双丙戊酸钠缓释剂组合物及其制备方法
KR20200035095A (ko) 2017-08-24 2020-04-01 미쓰이 가가쿠 가부시키가이샤 리튬 이차 전지 및 비수 전해액
WO2019039346A1 (ja) 2017-08-24 2019-02-28 三井化学株式会社 電池用非水電解液及びリチウム二次電池
CN111012753A (zh) * 2020-01-07 2020-04-17 仁和堂药业有限公司 一种提高丙戊酸钠片剂稳定性的方法
CN112274499A (zh) * 2020-11-16 2021-01-29 仁和堂药业有限公司 一种提高丙戊酸钠片剂稳定性的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2293974A1 (fr) * 1973-03-02 1976-07-09 Kaltenbach Roger Procede et dispositif pour la granulation reguliere de divers produits
US5212326A (en) * 1979-08-20 1993-05-18 Abbott Laboratories Sodium hydrogen divalproate oligomer
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
IL72381A (en) * 1983-07-20 1988-03-31 Sanofi Sa Pharmaceutical composition based on valproic acid
US5185159A (en) * 1983-07-20 1993-02-09 Sanofi Pharmaceutical composition based on valproic acid and a process for preparing it
US4913906B1 (en) * 1985-02-28 2000-06-06 Yissum Res Dev Co Controlled release dosage form of valproic acid
JP2893191B2 (ja) * 1988-11-08 1999-05-17 武田薬品工業株式会社 放出制御性マトリックス剤
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
TW209174B (cs) * 1991-04-19 1993-07-11 Takeda Pharm Industry Co Ltd
NZ242806A (en) * 1991-05-20 1994-01-26 Marion Laboratories Inc Multi-layered acid-containing coated drug beads.
FR2682677A1 (fr) * 1991-10-17 1993-04-23 Sanofi Elf Complexe forme de l'acide propyl-2 pentene-2 ouique (e) et de son sel de sodium, sa preparation et compositions pharmaceutiques le contenant.
US6287598B1 (en) * 1993-05-28 2001-09-11 Alza Corporation Method for providing sustained antiepileptic therapy
US5690959A (en) * 1993-05-29 1997-11-25 Smithkline Beecham Corporation Pharmaceutical thermal infusion process
AUPN969796A0 (en) * 1996-05-07 1996-05-30 F.H. Faulding & Co. Limited Taste masked liquid suspensions
US5916910A (en) * 1997-06-04 1999-06-29 Medinox, Inc. Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці

Also Published As

Publication number Publication date
DZ2316A1 (fr) 2002-12-28
MY120521A (en) 2005-11-30
PL332249A1 (en) 1999-08-30
EP0956010B1 (fr) 2002-04-17
IS4996A (is) 1999-03-11
PL190105B1 (pl) 2005-10-31
KR100334687B1 (ko) 2002-04-27
HK1021939A1 (en) 2000-07-21
EE03744B1 (et) 2002-06-17
DE69712100T2 (de) 2002-11-28
HUP9903855A2 (hu) 2000-05-28
EP0956010A1 (fr) 1999-11-17
CZ288876B6 (cs) 2001-09-12
IS1985B (is) 2005-02-15
CA2267096C (fr) 2003-09-16
HRP970537B1 (en) 2002-08-31
NO991613D0 (no) 1999-04-06
US8535721B2 (en) 2013-09-17
NZ334399A (en) 2000-05-26
PT956010E (pt) 2002-08-30
ID24596A (id) 2000-07-27
AU731235B2 (en) 2001-03-29
CA2267096A1 (fr) 1998-04-16
EG24070A (en) 2008-05-11
ATE216228T1 (de) 2002-05-15
SK36499A3 (en) 2000-12-11
AU4560297A (en) 1998-05-05
DK0956010T3 (da) 2002-08-12
US20060263437A1 (en) 2006-11-23
US20030157177A1 (en) 2003-08-21
JP2000504038A (ja) 2000-04-04
WO1998015268A1 (fr) 1998-04-16
ES2174293T3 (es) 2002-11-01
NO991613L (no) 1999-04-06
SI0956010T1 (en) 2002-10-31
IL128745A (en) 2004-05-12
CO4900080A1 (es) 2000-03-27
US20020001598A1 (en) 2002-01-03
EE9900140A (et) 1999-12-15
FR2754177B1 (fr) 1999-08-06
CN100367945C (zh) 2008-02-13
UY24738A1 (es) 2001-05-31
NO325723B1 (no) 2008-07-07
YU17899A (sh) 2000-03-21
CN1232391A (zh) 1999-10-20
AR013613A1 (es) 2001-01-10
HRP970537A2 (en) 1998-08-31
JP3523270B2 (ja) 2004-04-26
TW508251B (en) 2002-11-01
BR9712268A (pt) 1999-08-31
RU2177315C2 (ru) 2001-12-27
ME00664B (me) 2007-06-04
DE69712100D1 (de) 2002-05-23
ZA978954B (en) 1999-04-07
HUP9903855A3 (en) 2000-06-28
KR20000048828A (ko) 2000-07-25
IL128745A0 (en) 2000-01-31
FR2754177A1 (fr) 1998-04-10
TR199900789T2 (xx) 1999-07-21
RS49602B (sr) 2007-06-04
HU225103B1 (en) 2006-06-28
SK282113B6 (sk) 2001-11-06

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20171003