HRP960386B1 - Substituted benzylaminopiperidine compounds - Google Patents

Substituted benzylaminopiperidine compounds

Info

Publication number
HRP960386B1
HRP960386B1 HR960386A HRP960386A HRP960386B1 HR P960386 B1 HRP960386 B1 HR P960386B1 HR 960386 A HR960386 A HR 960386A HR P960386 A HRP960386 A HR P960386A HR P960386 B1 HRP960386 B1 HR P960386B1
Authority
HR
Croatia
Prior art keywords
compounds
substituted
substituted benzylaminopiperidine
benzylaminopiperidine compounds
benzylaminopiperidine
Prior art date
Application number
HR960386A
Other languages
English (en)
Inventor
Satake Kunio
Yuji Shishido
Hiroaki Wakabayashi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HRP960386A2 publication Critical patent/HRP960386A2/hr
Publication of HRP960386B1 publication Critical patent/HRP960386B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HR960386A 1995-08-24 1996-08-22 Substituted benzylaminopiperidine compounds HRP960386B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24

Publications (2)

Publication Number Publication Date
HRP960386A2 HRP960386A2 (en) 1998-04-30
HRP960386B1 true HRP960386B1 (en) 2002-04-30

Family

ID=11004362

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960386A HRP960386B1 (en) 1995-08-24 1996-08-22 Substituted benzylaminopiperidine compounds

Country Status (42)

Country Link
US (1) US6506775B1 (es)
EP (2) EP1114817B1 (es)
JP (1) JP3084069B2 (es)
KR (1) KR100288673B1 (es)
CN (1) CN1153764C (es)
AP (1) AP643A (es)
AR (1) AR006305A1 (es)
AT (2) ATE258166T1 (es)
AU (1) AU702698B2 (es)
BG (1) BG64126B1 (es)
BR (1) BR9609989A (es)
CA (1) CA2227814C (es)
CO (1) CO4480738A1 (es)
CZ (1) CZ297543B6 (es)
DE (2) DE69616817T2 (es)
DK (2) DK1114817T3 (es)
DZ (1) DZ2086A1 (es)
ES (2) ES2163017T3 (es)
HK (1) HK1014935A1 (es)
HR (1) HRP960386B1 (es)
HU (1) HU225480B1 (es)
IL (1) IL119078A (es)
IS (1) IS1947B (es)
MA (1) MA23961A1 (es)
MX (1) MX9801467A (es)
MY (1) MY114800A (es)
NO (1) NO310720B1 (es)
NZ (1) NZ308207A (es)
OA (1) OA10666A (es)
PE (2) PE20010700A1 (es)
PL (1) PL186773B1 (es)
PT (2) PT1114817E (es)
RO (1) RO119299B1 (es)
RU (1) RU2152930C2 (es)
SI (2) SI1114817T1 (es)
SK (1) SK282925B6 (es)
TN (1) TNSN96107A1 (es)
TR (1) TR199800300T1 (es)
TW (1) TW340842B (es)
UA (1) UA48981C2 (es)
WO (1) WO1997008144A1 (es)
YU (1) YU49122B (es)

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WO2000071538A2 (en) 1999-05-21 2000-11-30 Pfizer Products Inc. 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のｎｋ−１レセプターアンタゴニスト及びエレトリプタン
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (en) * 2000-09-28 2003-03-26 Pfizer Products Inc. Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
EP1626958B1 (en) 2003-04-18 2012-06-27 Eli Lilly And Company (piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht 1f agonists
MXPA06013484A (es) * 2004-05-21 2007-01-23 Pfizer Prod Inc Metabolitos de (+)-(2s, 3s)-3-(2- metoxi-5- trifluorometoxibencilamino) -2-fenil- piperidina.
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CA2615403C (en) 2005-07-15 2015-06-16 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
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CA2664113C (en) 2006-09-22 2013-05-28 Merck & Co., Inc. Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2109608B1 (en) 2007-01-10 2011-03-23 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
US8106086B2 (en) 2007-04-02 2012-01-31 Msd K.K. Indoledione derivative
JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
AU2009222122A1 (en) 2008-03-03 2009-09-11 Tiger Pharmatech Tyrosine kinase inhibitors
EP2264029A4 (en) 2008-03-31 2011-08-24 Kowa Co 1,3-dihydroisobenzofuran DERIVATIVE
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
KR20120034644A (ko) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
EP2429293B1 (en) 2009-05-12 2014-10-29 Bristol-Myers Squibb Company CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
ES2662072T3 (es) 2009-05-12 2018-04-05 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma
KR101485645B1 (ko) 2009-10-14 2015-01-22 머크 샤프 앤드 돔 코포레이션 ｐ53 활성을 증가시키는 치환된 피페리딘 및 그의 용도
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
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HUE044815T2 (hu) 2010-08-17 2019-11-28 Sirna Therapeutics Inc Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
US9351965B2 (en) 2010-12-21 2016-05-31 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
CN103732592A (zh) 2011-04-21 2014-04-16 默沙东公司 胰岛素样生长因子-1受体抑制剂
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
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EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA
LT2925888T (lt) 2012-11-28 2018-01-10 Merck Sharp & Dohme Corp. Vėžio gydymo kompozicijos ir būdai
BR112015013611A2 (pt) 2012-12-20 2017-11-14 Merck Sharp & Dohme composto, e, composição farmacêutica
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
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Also Published As

Publication number Publication date
IL119078A (en) 2003-11-23
DE69631390T2 (de) 2004-11-25
HUP9901159A3 (en) 2000-05-29
US6506775B1 (en) 2003-01-14
CZ297543B6 (cs) 2007-02-07
EP0861235A1 (en) 1998-09-02
WO1997008144A1 (en) 1997-03-06
CN1193961A (zh) 1998-09-23
CA2227814A1 (en) 1997-03-06
BG64126B1 (bg) 2004-01-30
AU5776996A (en) 1997-03-19
NZ308207A (en) 1998-07-28
AP9600850A0 (en) 1996-10-31
DZ2086A1 (fr) 2002-07-22
HUP9901159A2 (hu) 1999-07-28
SI1114817T1 (en) 2004-06-30
PL186773B1 (pl) 2004-02-27
PE1398A1 (es) 1998-02-27
EP1114817A1 (en) 2001-07-11
ATE208377T1 (de) 2001-11-15
DK1114817T3 (da) 2004-04-26
MY114800A (en) 2003-01-31
SK20798A3 (en) 1999-03-12
MA23961A1 (fr) 1997-04-01
EP1114817B1 (en) 2004-01-21
AR006305A1 (es) 1999-08-25
YU49122B (sh) 2004-03-12
NO310720B1 (no) 2001-08-20
NO980751D0 (no) 1998-02-23
SI0861235T1 (en) 2002-04-30
SK282925B6 (sk) 2003-01-09
AU702698B2 (en) 1999-03-04
JPH10510554A (ja) 1998-10-13
UA48981C2 (uk) 2002-09-16
TNSN96107A1 (fr) 2005-03-15
ES2163017T3 (es) 2002-01-16
DE69616817T2 (de) 2002-04-04
HRP960386A2 (en) 1998-04-30
DE69616817D1 (de) 2001-12-13
NO980751L (no) 1998-02-23
ATE258166T1 (de) 2004-02-15
PL325332A1 (en) 1998-07-20
PT861235E (pt) 2002-03-28
PE20010700A1 (es) 2001-07-09
YU47896A (sh) 1998-12-23
CA2227814C (en) 2002-12-31
AP643A (en) 1998-04-24
MX9801467A (es) 1998-05-31
RU2152930C2 (ru) 2000-07-20
EP0861235B1 (en) 2001-11-07
ES2211684T3 (es) 2004-07-16
IS4644A (is) 1997-12-30
IS1947B (is) 2004-10-13
KR19990044077A (ko) 1999-06-25
TR199800300T1 (xx) 1998-06-22
CO4480738A1 (es) 1997-07-09
DE69631390D1 (de) 2004-02-26
HU225480B1 (en) 2006-12-28
TW340842B (en) 1998-09-21
OA10666A (en) 2002-11-25
CZ52198A3 (cs) 1999-01-13
DK0861235T3 (da) 2001-12-27
BR9609989A (pt) 1999-07-06
BG102288A (en) 1998-09-30
CN1153764C (zh) 2004-06-16
PT1114817E (pt) 2004-05-31
JP3084069B2 (ja) 2000-09-04
KR100288673B1 (ko) 2001-05-02
RO119299B1 (ro) 2004-07-30
IL119078A0 (en) 1996-11-14
HK1014935A1 (en) 1999-10-08

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