HRP20220001T1 - Sonde za snimanje huntingtin proteina - Google Patents
Sonde za snimanje huntingtin proteina Download PDFInfo
- Publication number
- HRP20220001T1 HRP20220001T1 HRP20220001TT HRP20220001T HRP20220001T1 HR P20220001 T1 HRP20220001 T1 HR P20220001T1 HR P20220001T T HRP20220001T T HR P20220001TT HR P20220001 T HRP20220001 T HR P20220001T HR P20220001 T1 HRP20220001 T1 HR P20220001T1
- Authority
- HR
- Croatia
- Prior art keywords
- imidazo
- pyridine
- carbonitrile
- methoxy
- methylamino
- Prior art date
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- 238000003384 imaging method Methods 0.000 title claims 4
- 102000016252 Huntingtin Human genes 0.000 title claims 2
- 108050004784 Huntingtin Proteins 0.000 title claims 2
- 239000000523 sample Substances 0.000 title 1
- -1 -C(O)O- C1-6 alkyl Chemical group 0.000 claims 44
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 239000012216 imaging agent Substances 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 238000002600 positron emission tomography Methods 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- KIYOXVPZRXLLDR-UHFFFAOYSA-N imidazo[1,2-a]pyridine-7-carbonitrile Chemical compound C1=C(C#N)C=CN2C=CN=C21 KIYOXVPZRXLLDR-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000023105 Huntington disease Diseases 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- ZPMWXDOTBGBOJU-UHFFFAOYSA-N 2-(5-bromo-1-benzofuran-2-yl)-3-(methylamino)imidazo[1,2-a]pyridine-7-carbonitrile Chemical compound BrC=1C=CC2=C(C=C(O2)C=2N=C3N(C=CC(=C3)C#N)C=2NC)C=1 ZPMWXDOTBGBOJU-UHFFFAOYSA-N 0.000 claims 2
- MPRMRYWPRROMHA-UHFFFAOYSA-N 2-(5-methoxy-1-methylbenzimidazol-2-yl)-3-(methylamino)imidazo[1,2-a]pyridine-7-carbonitrile Chemical compound COC1=CC2=C(N(C(=N2)C=2N=C3N(C=CC(=C3)C#N)C=2NC)C)C=C1 MPRMRYWPRROMHA-UHFFFAOYSA-N 0.000 claims 2
- VJFJMCSJLDRDRR-UHFFFAOYSA-N 2-[5-[(5-methoxypyrazin-2-yl)methoxy]pyridin-2-yl]-3-(methylamino)imidazo[1,2-a]pyridine-7-carbonitrile Chemical compound COC=1N=CC(=NC=1)COC=1C=CC(=NC=1)C=1N=C2N(C=CC(=C2)C#N)C=1NC VJFJMCSJLDRDRR-UHFFFAOYSA-N 0.000 claims 2
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- 238000002591 computed tomography Methods 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043590P | 2014-08-29 | 2014-08-29 | |
| EP15836261.6A EP3197277B1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
| PCT/US2015/047401 WO2016033440A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220001T1 true HRP20220001T1 (hr) | 2022-04-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220001TT HRP20220001T1 (hr) | 2014-08-29 | 2015-08-28 | Sonde za snimanje huntingtin proteina |
Country Status (20)
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|---|---|
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| EP (1) | EP3197277B1 (enExample) |
| JP (1) | JP6754353B2 (enExample) |
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| CN (1) | CN107105667B (enExample) |
| AU (2) | AU2015308769A1 (enExample) |
| BR (1) | BR112017004140B1 (enExample) |
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| ES (1) | ES2905095T3 (enExample) |
| HR (1) | HRP20220001T1 (enExample) |
| HU (1) | HUE057702T2 (enExample) |
| IL (1) | IL250802B (enExample) |
| MX (1) | MX386798B (enExample) |
| PL (1) | PL3197277T3 (enExample) |
| PT (1) | PT3197277T (enExample) |
| SG (1) | SG11201701592SA (enExample) |
| SI (1) | SI3197277T1 (enExample) |
| WO (1) | WO2016033440A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2818107T3 (es) | 2014-08-29 | 2021-04-09 | Chdi Foundation Inc | Sondas para obtener imágenes de la proteína huntingtina |
| DK3186241T3 (da) | 2014-08-29 | 2021-01-11 | Chdi Foundation Inc | Prober til billeddannelse af huntington-protein |
| MX386798B (es) | 2014-08-29 | 2025-03-19 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| US10479802B2 (en) | 2014-08-29 | 2019-11-19 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| PT3340796T (pt) | 2015-08-28 | 2021-07-28 | Chdi Foundation Inc | Sondas para imagens da proteína huntingtina |
| US20190381030A1 (en) * | 2017-10-12 | 2019-12-19 | University Of Kansas | Methods of treating radiation induced gastrointestinal syndrome (rigs) and related disease states using yel002/bcn057 |
| EP3931186A1 (en) | 2019-02-25 | 2022-01-05 | CHDI Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| TWI751548B (zh) | 2019-05-09 | 2022-01-01 | 瑞士商赫孚孟拉羅股份公司 | 經標記之咪唑并[1,2-a]嘧啶之合成 |
| CN114773312B (zh) * | 2021-10-29 | 2024-03-26 | 北京鑫诺康桥药物研究有限公司 | 一种盐酸阿罗洛尔中间体的制备工艺 |
Family Cites Families (23)
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| DE10050663A1 (de) | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
| WO2005016888A1 (ja) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤 |
| WO2007148755A1 (ja) * | 2006-06-21 | 2007-12-27 | Nihon Medi-Physics Co., Ltd. | 新規アミロイド親和性化合物 |
| US20100173930A1 (en) * | 2006-08-01 | 2010-07-08 | Alex Muci | Certain Chemical Entities, Compositions and Methods |
| NZ577318A (en) * | 2006-11-17 | 2012-04-27 | Nihon Mediphysics Co Ltd | Novel compounds with affinity for amyloid |
| NZ577511A (en) * | 2006-11-30 | 2012-04-27 | Nihon Mediphysics Co Ltd | 2-Phenyl-imidazo[1,2-a]pyridine derivatives substituted with a radioactive halogen substituent |
| US20100092385A1 (en) * | 2007-01-22 | 2010-04-15 | Astrazeneca Ab | Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives |
| KR20100101576A (ko) * | 2007-10-30 | 2010-09-17 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법 |
| FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| US8420052B2 (en) * | 2008-07-24 | 2013-04-16 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying AD pathology |
| MX2011002647A (es) | 2008-09-23 | 2011-04-07 | Wista Lab Ltd | Ligandos para moleculas tau agregadas. |
| US8614201B2 (en) * | 2009-06-05 | 2013-12-24 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of TRPA1 |
| AU2012259929B2 (en) * | 2011-05-20 | 2016-08-04 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| JP5167436B2 (ja) * | 2011-06-24 | 2013-03-21 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物 |
| JP2013237655A (ja) | 2012-05-17 | 2013-11-28 | Kyoto Univ | コンフォメーション病診断用分子プローブ |
| RU2015118985A (ru) * | 2012-11-14 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Производные имидазопиридина |
| PL3269716T3 (pl) | 2013-03-14 | 2021-02-08 | Galapagos N.V. | Nowe związki i ich kompozycje farmaceutyczne do leczenia zaburzeń zapalnych |
| CA2920068A1 (en) | 2013-09-26 | 2015-04-02 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]pyridin-7-amines as imaging tools |
| MX386798B (es) | 2014-08-29 | 2025-03-19 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| ES2818107T3 (es) | 2014-08-29 | 2021-04-09 | Chdi Foundation Inc | Sondas para obtener imágenes de la proteína huntingtina |
| US10479802B2 (en) | 2014-08-29 | 2019-11-19 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| DK3186241T3 (da) | 2014-08-29 | 2021-01-11 | Chdi Foundation Inc | Prober til billeddannelse af huntington-protein |
| PT3340796T (pt) | 2015-08-28 | 2021-07-28 | Chdi Foundation Inc | Sondas para imagens da proteína huntingtina |
-
2015
- 2015-08-28 MX MX2017002702A patent/MX386798B/es unknown
- 2015-08-28 CN CN201580058314.XA patent/CN107105667B/zh active Active
- 2015-08-28 PL PL15836261T patent/PL3197277T3/pl unknown
- 2015-08-28 DK DK15836261.6T patent/DK3197277T3/da active
- 2015-08-28 HR HRP20220001TT patent/HRP20220001T1/hr unknown
- 2015-08-28 PT PT158362616T patent/PT3197277T/pt unknown
- 2015-08-28 AU AU2015308769A patent/AU2015308769A1/en not_active Abandoned
- 2015-08-28 CA CA2959533A patent/CA2959533C/en active Active
- 2015-08-28 SI SI201531778T patent/SI3197277T1/sl unknown
- 2015-08-28 EA EA201790400A patent/EA039923B1/ru unknown
- 2015-08-28 JP JP2017511926A patent/JP6754353B2/ja active Active
- 2015-08-28 WO PCT/US2015/047401 patent/WO2016033440A1/en not_active Ceased
- 2015-08-28 US US15/507,203 patent/US11104691B2/en active Active
- 2015-08-28 BR BR112017004140-5A patent/BR112017004140B1/pt active IP Right Grant
- 2015-08-28 HU HUE15836261A patent/HUE057702T2/hu unknown
- 2015-08-28 ES ES15836261T patent/ES2905095T3/es active Active
- 2015-08-28 SG SG11201701592SA patent/SG11201701592SA/en unknown
- 2015-08-28 KR KR1020177007881A patent/KR102410733B1/ko active Active
- 2015-08-28 EP EP15836261.6A patent/EP3197277B1/en active Active
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2017
- 2017-02-26 IL IL250802A patent/IL250802B/en active IP Right Grant
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2019
- 2019-12-20 AU AU2019283999A patent/AU2019283999B2/en active Active
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2021
- 2021-06-21 US US17/353,627 patent/US11851446B2/en active Active
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