JP2017529340A5 - - Google Patents
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- Publication number
- JP2017529340A5 JP2017529340A5 JP2017511926A JP2017511926A JP2017529340A5 JP 2017529340 A5 JP2017529340 A5 JP 2017529340A5 JP 2017511926 A JP2017511926 A JP 2017511926A JP 2017511926 A JP2017511926 A JP 2017511926A JP 2017529340 A5 JP2017529340 A5 JP 2017529340A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazo
- pyridine
- carbonitrile
- methoxy
- methylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043590P | 2014-08-29 | 2014-08-29 | |
| US62/043,590 | 2014-08-29 | ||
| PCT/US2015/047401 WO2016033440A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529340A JP2017529340A (ja) | 2017-10-05 |
| JP2017529340A5 true JP2017529340A5 (enExample) | 2018-10-11 |
| JP6754353B2 JP6754353B2 (ja) | 2020-09-09 |
Family
ID=55400645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511926A Active JP6754353B2 (ja) | 2014-08-29 | 2015-08-28 | ハンチントンタンパク質のイメージング用プローブ |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11104691B2 (enExample) |
| EP (1) | EP3197277B1 (enExample) |
| JP (1) | JP6754353B2 (enExample) |
| KR (1) | KR102410733B1 (enExample) |
| CN (1) | CN107105667B (enExample) |
| AU (2) | AU2015308769A1 (enExample) |
| BR (1) | BR112017004140B1 (enExample) |
| CA (1) | CA2959533C (enExample) |
| DK (1) | DK3197277T3 (enExample) |
| EA (1) | EA039923B1 (enExample) |
| ES (1) | ES2905095T3 (enExample) |
| HR (1) | HRP20220001T1 (enExample) |
| HU (1) | HUE057702T2 (enExample) |
| IL (1) | IL250802B (enExample) |
| MX (1) | MX386798B (enExample) |
| PL (1) | PL3197277T3 (enExample) |
| PT (1) | PT3197277T (enExample) |
| SG (1) | SG11201701592SA (enExample) |
| SI (1) | SI3197277T1 (enExample) |
| WO (1) | WO2016033440A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20211778T1 (hr) | 2014-08-29 | 2022-03-18 | Chdi Foundation, Inc. | Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina |
| SG11201701578YA (en) | 2014-08-29 | 2017-03-30 | Chdi Foundation Inc | Probes for imaging huntingtin protein |
| SG11201701580XA (en) | 2014-08-29 | 2017-03-30 | Chdi Foundation Inc | Probes for imaging huntingtin protein |
| PL3197277T3 (pl) | 2014-08-29 | 2022-04-04 | Chdi Foundation, Inc. | Sondy do obrazowania molekularnego białka huntingtyny |
| CA2995847C (en) | 2015-08-28 | 2024-05-28 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| AU2018346962A1 (en) * | 2017-10-12 | 2020-05-28 | BCN Biosciences L.L.C. | Methods of treating radiation induced gastrointestinal syndrome |
| WO2020176424A1 (en) | 2019-02-25 | 2020-09-03 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| CA3138873C (en) | 2019-05-09 | 2024-01-09 | Kyle Bradley Pascual CLAGG | Synthesis of labeled imidazo[1,2-a]pyrimidines |
| CN114773312B (zh) * | 2021-10-29 | 2024-03-26 | 北京鑫诺康桥药物研究有限公司 | 一种盐酸阿罗洛尔中间体的制备工艺 |
| WO2026064501A1 (en) * | 2024-09-18 | 2026-03-26 | The University Of Chicago | Reversible and irreversible kinome probes and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10050663A1 (de) * | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
| EP1655287A1 (en) * | 2003-08-13 | 2006-05-10 | BF Research Institute, Inc. | Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change |
| CN101501033B (zh) * | 2006-06-21 | 2012-08-01 | 通用电气医疗有限公司 | 对淀粉状蛋白具有亲和性的化合物 |
| WO2008016648A2 (en) * | 2006-08-01 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions and methods |
| WO2008059714A1 (en) * | 2006-11-17 | 2008-05-22 | Nihon Medi-Physics Co., Ltd. | Novel compounds with affinity for amyloid |
| CN101595108A (zh) * | 2006-11-30 | 2009-12-02 | 日本医事物理股份有限公司 | 对淀粉状蛋白具有亲和性的新化合物 |
| AU2008208091A1 (en) * | 2007-01-22 | 2008-07-31 | Astrazeneca Ab | Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives |
| JPWO2009057577A1 (ja) * | 2007-10-30 | 2011-03-10 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物の使用及び製造方法 |
| FR2928923B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| WO2010011964A2 (en) * | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
| MX2011002647A (es) * | 2008-09-23 | 2011-04-07 | Wista Lab Ltd | Ligandos para moleculas tau agregadas. |
| WO2010141805A1 (en) * | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
| KR20140040722A (ko) * | 2011-05-20 | 2014-04-03 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물 |
| IN2014DN00185A (enExample) * | 2011-06-24 | 2015-07-10 | Nihon Mediphysics Co Ltd | |
| JP2013237655A (ja) * | 2012-05-17 | 2013-11-28 | Kyoto Univ | コンフォメーション病診断用分子プローブ |
| CN105209461A (zh) * | 2012-11-14 | 2015-12-30 | 霍夫曼-拉罗奇有限公司 | 咪唑并吡啶衍生物 |
| WO2014139882A1 (en) | 2013-03-14 | 2014-09-18 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| KR101770532B1 (ko) * | 2013-09-26 | 2017-08-22 | 에프. 호프만-라 로슈 아게 | 이미징 수단으로서의 이미다조[1,2-a]피리딘-7-아민 |
| SG11201701580XA (en) | 2014-08-29 | 2017-03-30 | Chdi Foundation Inc | Probes for imaging huntingtin protein |
| PL3197277T3 (pl) | 2014-08-29 | 2022-04-04 | Chdi Foundation, Inc. | Sondy do obrazowania molekularnego białka huntingtyny |
| HRP20211778T1 (hr) | 2014-08-29 | 2022-03-18 | Chdi Foundation, Inc. | Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina |
| SG11201701578YA (en) | 2014-08-29 | 2017-03-30 | Chdi Foundation Inc | Probes for imaging huntingtin protein |
| CA2995847C (en) | 2015-08-28 | 2024-05-28 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
-
2015
- 2015-08-28 PL PL15836261T patent/PL3197277T3/pl unknown
- 2015-08-28 AU AU2015308769A patent/AU2015308769A1/en not_active Abandoned
- 2015-08-28 KR KR1020177007881A patent/KR102410733B1/ko active Active
- 2015-08-28 EA EA201790400A patent/EA039923B1/ru unknown
- 2015-08-28 DK DK15836261.6T patent/DK3197277T3/da active
- 2015-08-28 SI SI201531778T patent/SI3197277T1/sl unknown
- 2015-08-28 HU HUE15836261A patent/HUE057702T2/hu unknown
- 2015-08-28 BR BR112017004140-5A patent/BR112017004140B1/pt active IP Right Grant
- 2015-08-28 PT PT158362616T patent/PT3197277T/pt unknown
- 2015-08-28 EP EP15836261.6A patent/EP3197277B1/en active Active
- 2015-08-28 SG SG11201701592SA patent/SG11201701592SA/en unknown
- 2015-08-28 MX MX2017002702A patent/MX386798B/es unknown
- 2015-08-28 CA CA2959533A patent/CA2959533C/en active Active
- 2015-08-28 US US15/507,203 patent/US11104691B2/en active Active
- 2015-08-28 ES ES15836261T patent/ES2905095T3/es active Active
- 2015-08-28 HR HRP20220001TT patent/HRP20220001T1/hr unknown
- 2015-08-28 WO PCT/US2015/047401 patent/WO2016033440A1/en not_active Ceased
- 2015-08-28 JP JP2017511926A patent/JP6754353B2/ja active Active
- 2015-08-28 CN CN201580058314.XA patent/CN107105667B/zh active Active
-
2017
- 2017-02-26 IL IL250802A patent/IL250802B/en active IP Right Grant
-
2019
- 2019-12-20 AU AU2019283999A patent/AU2019283999B2/en active Active
-
2021
- 2021-06-21 US US17/353,627 patent/US11851446B2/en active Active
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