JP2017529340A5 - - Google Patents
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- Publication number
- JP2017529340A5 JP2017529340A5 JP2017511926A JP2017511926A JP2017529340A5 JP 2017529340 A5 JP2017529340 A5 JP 2017529340A5 JP 2017511926 A JP2017511926 A JP 2017511926A JP 2017511926 A JP2017511926 A JP 2017511926A JP 2017529340 A5 JP2017529340 A5 JP 2017529340A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazo
- pyridine
- carbonitrile
- methoxy
- methylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043590P | 2014-08-29 | 2014-08-29 | |
| US62/043,590 | 2014-08-29 | ||
| PCT/US2015/047401 WO2016033440A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529340A JP2017529340A (ja) | 2017-10-05 |
| JP2017529340A5 true JP2017529340A5 (enExample) | 2018-10-11 |
| JP6754353B2 JP6754353B2 (ja) | 2020-09-09 |
Family
ID=55400645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511926A Active JP6754353B2 (ja) | 2014-08-29 | 2015-08-28 | ハンチントンタンパク質のイメージング用プローブ |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11104691B2 (enExample) |
| EP (1) | EP3197277B1 (enExample) |
| JP (1) | JP6754353B2 (enExample) |
| KR (1) | KR102410733B1 (enExample) |
| CN (1) | CN107105667B (enExample) |
| AU (2) | AU2015308769A1 (enExample) |
| BR (1) | BR112017004140B1 (enExample) |
| CA (1) | CA2959533C (enExample) |
| DK (1) | DK3197277T3 (enExample) |
| EA (1) | EA039923B1 (enExample) |
| ES (1) | ES2905095T3 (enExample) |
| HR (1) | HRP20220001T1 (enExample) |
| HU (1) | HUE057702T2 (enExample) |
| IL (1) | IL250802B (enExample) |
| MX (1) | MX386798B (enExample) |
| PL (1) | PL3197277T3 (enExample) |
| PT (1) | PT3197277T (enExample) |
| SG (1) | SG11201701592SA (enExample) |
| SI (1) | SI3197277T1 (enExample) |
| WO (1) | WO2016033440A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2818107T3 (es) | 2014-08-29 | 2021-04-09 | Chdi Foundation Inc | Sondas para obtener imágenes de la proteína huntingtina |
| DK3186241T3 (da) | 2014-08-29 | 2021-01-11 | Chdi Foundation Inc | Prober til billeddannelse af huntington-protein |
| MX386798B (es) | 2014-08-29 | 2025-03-19 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| US10479802B2 (en) | 2014-08-29 | 2019-11-19 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| PT3340796T (pt) | 2015-08-28 | 2021-07-28 | Chdi Foundation Inc | Sondas para imagens da proteína huntingtina |
| US20190381030A1 (en) * | 2017-10-12 | 2019-12-19 | University Of Kansas | Methods of treating radiation induced gastrointestinal syndrome (rigs) and related disease states using yel002/bcn057 |
| EP3931186A1 (en) | 2019-02-25 | 2022-01-05 | CHDI Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| TWI751548B (zh) | 2019-05-09 | 2022-01-01 | 瑞士商赫孚孟拉羅股份公司 | 經標記之咪唑并[1,2-a]嘧啶之合成 |
| CN114773312B (zh) * | 2021-10-29 | 2024-03-26 | 北京鑫诺康桥药物研究有限公司 | 一种盐酸阿罗洛尔中间体的制备工艺 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10050663A1 (de) | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
| WO2005016888A1 (ja) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤 |
| WO2007148755A1 (ja) * | 2006-06-21 | 2007-12-27 | Nihon Medi-Physics Co., Ltd. | 新規アミロイド親和性化合物 |
| US20100173930A1 (en) * | 2006-08-01 | 2010-07-08 | Alex Muci | Certain Chemical Entities, Compositions and Methods |
| NZ577318A (en) * | 2006-11-17 | 2012-04-27 | Nihon Mediphysics Co Ltd | Novel compounds with affinity for amyloid |
| NZ577511A (en) * | 2006-11-30 | 2012-04-27 | Nihon Mediphysics Co Ltd | 2-Phenyl-imidazo[1,2-a]pyridine derivatives substituted with a radioactive halogen substituent |
| US20100092385A1 (en) * | 2007-01-22 | 2010-04-15 | Astrazeneca Ab | Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives |
| KR20100101576A (ko) * | 2007-10-30 | 2010-09-17 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법 |
| FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| US8420052B2 (en) * | 2008-07-24 | 2013-04-16 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying AD pathology |
| MX2011002647A (es) | 2008-09-23 | 2011-04-07 | Wista Lab Ltd | Ligandos para moleculas tau agregadas. |
| US8614201B2 (en) * | 2009-06-05 | 2013-12-24 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of TRPA1 |
| AU2012259929B2 (en) * | 2011-05-20 | 2016-08-04 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| JP5167436B2 (ja) * | 2011-06-24 | 2013-03-21 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物 |
| JP2013237655A (ja) | 2012-05-17 | 2013-11-28 | Kyoto Univ | コンフォメーション病診断用分子プローブ |
| RU2015118985A (ru) * | 2012-11-14 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Производные имидазопиридина |
| PL3269716T3 (pl) | 2013-03-14 | 2021-02-08 | Galapagos N.V. | Nowe związki i ich kompozycje farmaceutyczne do leczenia zaburzeń zapalnych |
| CA2920068A1 (en) | 2013-09-26 | 2015-04-02 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]pyridin-7-amines as imaging tools |
| MX386798B (es) | 2014-08-29 | 2025-03-19 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| ES2818107T3 (es) | 2014-08-29 | 2021-04-09 | Chdi Foundation Inc | Sondas para obtener imágenes de la proteína huntingtina |
| US10479802B2 (en) | 2014-08-29 | 2019-11-19 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| DK3186241T3 (da) | 2014-08-29 | 2021-01-11 | Chdi Foundation Inc | Prober til billeddannelse af huntington-protein |
| PT3340796T (pt) | 2015-08-28 | 2021-07-28 | Chdi Foundation Inc | Sondas para imagens da proteína huntingtina |
-
2015
- 2015-08-28 MX MX2017002702A patent/MX386798B/es unknown
- 2015-08-28 CN CN201580058314.XA patent/CN107105667B/zh active Active
- 2015-08-28 PL PL15836261T patent/PL3197277T3/pl unknown
- 2015-08-28 DK DK15836261.6T patent/DK3197277T3/da active
- 2015-08-28 HR HRP20220001TT patent/HRP20220001T1/hr unknown
- 2015-08-28 PT PT158362616T patent/PT3197277T/pt unknown
- 2015-08-28 AU AU2015308769A patent/AU2015308769A1/en not_active Abandoned
- 2015-08-28 CA CA2959533A patent/CA2959533C/en active Active
- 2015-08-28 SI SI201531778T patent/SI3197277T1/sl unknown
- 2015-08-28 EA EA201790400A patent/EA039923B1/ru unknown
- 2015-08-28 JP JP2017511926A patent/JP6754353B2/ja active Active
- 2015-08-28 WO PCT/US2015/047401 patent/WO2016033440A1/en not_active Ceased
- 2015-08-28 US US15/507,203 patent/US11104691B2/en active Active
- 2015-08-28 BR BR112017004140-5A patent/BR112017004140B1/pt active IP Right Grant
- 2015-08-28 HU HUE15836261A patent/HUE057702T2/hu unknown
- 2015-08-28 ES ES15836261T patent/ES2905095T3/es active Active
- 2015-08-28 SG SG11201701592SA patent/SG11201701592SA/en unknown
- 2015-08-28 KR KR1020177007881A patent/KR102410733B1/ko active Active
- 2015-08-28 EP EP15836261.6A patent/EP3197277B1/en active Active
-
2017
- 2017-02-26 IL IL250802A patent/IL250802B/en active IP Right Grant
-
2019
- 2019-12-20 AU AU2019283999A patent/AU2019283999B2/en active Active
-
2021
- 2021-06-21 US US17/353,627 patent/US11851446B2/en active Active
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