MX386798B - Sondas para la proyección de imagen de la proteína huntingtina. - Google Patents

Sondas para la proyección de imagen de la proteína huntingtina.

Info

Publication number
MX386798B
MX386798B MX2017002702A MX2017002702A MX386798B MX 386798 B MX386798 B MX 386798B MX 2017002702 A MX2017002702 A MX 2017002702A MX 2017002702 A MX2017002702 A MX 2017002702A MX 386798 B MX386798 B MX 386798B
Authority
MX
Mexico
Prior art keywords
imaging
probes
huntingtin protein
formula
huntingtin
Prior art date
Application number
MX2017002702A
Other languages
English (en)
Other versions
MX2017002702A (es
Inventor
Alex Kiselyov
Celia Dominguez
Christopher John Brown
Daniel Clark-Frew
John Wityak
Jonathan Bard
Michael Edward Prime
Peter David Johnson
Original Assignee
Chdi Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation Inc filed Critical Chdi Foundation Inc
Publication of MX2017002702A publication Critical patent/MX2017002702A/es
Publication of MX386798B publication Critical patent/MX386798B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporcionan agentes de formación de imágenes que comprenden un compuesto de la Formula I, o su sal farmacéuticamente aceptable, y métodos de su uso.
MX2017002702A 2014-08-29 2015-08-28 Sondas para la proyección de imagen de la proteína huntingtina. MX386798B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462043590P 2014-08-29 2014-08-29
PCT/US2015/047401 WO2016033440A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
MX2017002702A MX2017002702A (es) 2017-10-23
MX386798B true MX386798B (es) 2025-03-19

Family

ID=55400645

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017002702A MX386798B (es) 2014-08-29 2015-08-28 Sondas para la proyección de imagen de la proteína huntingtina.

Country Status (20)

Country Link
US (2) US11104691B2 (es)
EP (1) EP3197277B1 (es)
JP (1) JP6754353B2 (es)
KR (1) KR102410733B1 (es)
CN (1) CN107105667B (es)
AU (2) AU2015308769A1 (es)
BR (1) BR112017004140B1 (es)
CA (1) CA2959533C (es)
DK (1) DK3197277T3 (es)
EA (1) EA039923B1 (es)
ES (1) ES2905095T3 (es)
HR (1) HRP20220001T1 (es)
HU (1) HUE057702T2 (es)
IL (1) IL250802B (es)
MX (1) MX386798B (es)
PL (1) PL3197277T3 (es)
PT (1) PT3197277T (es)
SG (1) SG11201701592SA (es)
SI (1) SI3197277T1 (es)
WO (1) WO2016033440A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3186233T3 (da) 2014-08-29 2021-11-22 Chdi Foundation Inc Prober til billeddannelse af huntingtin-protein
JP2017527559A (ja) 2014-08-29 2017-09-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ
HRP20220001T1 (hr) 2014-08-29 2022-04-01 Chdi Foundation, Inc. Sonde za snimanje huntingtin proteina
US10907197B2 (en) 2014-08-29 2021-02-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
WO2019075402A1 (en) * 2017-10-12 2019-04-18 University Of Kansas METHODS FOR TREATING GASTROINTESTINAL SYNDROME INDUCED BY RADIATION
EP3931186A1 (en) 2019-02-25 2022-01-05 CHDI Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
WO2020227575A1 (en) 2019-05-09 2020-11-12 Genentech, Inc. Synthesis of labeled imidazo[1,2-a]pyrimidines
CN114773312B (zh) * 2021-10-29 2024-03-26 北京鑫诺康桥药物研究有限公司 一种盐酸阿罗洛尔中间体的制备工艺

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DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
WO2005016888A1 (ja) * 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
US8277777B2 (en) * 2006-06-21 2012-10-02 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
US20100173930A1 (en) * 2006-08-01 2010-07-08 Alex Muci Certain Chemical Entities, Compositions and Methods
AU2007320581A1 (en) * 2006-11-17 2008-05-22 Nihon Medi-Physics Co., Ltd. Novel compounds with affinity for amyloid
CN101595108A (zh) * 2006-11-30 2009-12-02 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的新化合物
EP2125800A1 (en) 2007-01-22 2009-12-02 AstraZeneca AB Novel heteroaryl substituted imidazo ý1,2 -a¨pyridine derivatives
CN102702195A (zh) * 2007-10-30 2012-10-03 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
JP2011529086A (ja) * 2008-07-24 2011-12-01 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド Ａｄ病変を同定するために有用な造影剤
BRPI0919079B1 (pt) * 2008-09-23 2022-02-15 Wista Laboratories Ltd Métodos para marcar filamentos helicoidais pareados (phfs), e para marcar tau agregado, bem como compostos ligantes para moléculas tau agregadas
US8614201B2 (en) * 2009-06-05 2013-12-24 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of TRPA1
TWI528977B (zh) * 2011-05-20 2016-04-11 Nihon Mediphysics Co Ltd New amyloid affinity products
EP2725027B1 (en) * 2011-06-24 2017-03-01 Nihon Medi-Physics Co., Ltd. Novel compound with amyloid affinity
JP2013237655A (ja) 2012-05-17 2013-11-28 Kyoto Univ コンフォメーション病診断用分子プローブ
HK1214244A1 (zh) * 2012-11-14 2016-07-22 霍夫曼-拉罗奇有限公司 咪唑并吡啶衍生物
DK3269716T3 (da) 2013-03-14 2020-10-19 Galapagos Nv Hidtil ukendte forbindelser og farmaceutiske sammensætninger deraf til behandling af inflammatoriske lidelser
JP6182668B2 (ja) * 2013-09-26 2017-08-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン
HRP20220001T1 (hr) 2014-08-29 2022-04-01 Chdi Foundation, Inc. Sonde za snimanje huntingtin proteina
JP2017527559A (ja) 2014-08-29 2017-09-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ
DK3186233T3 (da) 2014-08-29 2021-11-22 Chdi Foundation Inc Prober til billeddannelse af huntingtin-protein
US10907197B2 (en) 2014-08-29 2021-02-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina

Also Published As

Publication number Publication date
ES2905095T3 (es) 2022-04-07
AU2015308769A1 (en) 2017-03-23
PL3197277T3 (pl) 2022-04-04
EA039923B1 (ru) 2022-03-28
KR20170047303A (ko) 2017-05-04
CA2959533C (en) 2023-03-07
BR112017004140A2 (pt) 2017-12-12
US11851446B2 (en) 2023-12-26
AU2019283999A1 (en) 2020-01-23
WO2016033440A1 (en) 2016-03-03
CA2959533A1 (en) 2016-03-03
MX2017002702A (es) 2017-10-23
EP3197277A1 (en) 2017-08-02
HRP20220001T1 (hr) 2022-04-01
JP6754353B2 (ja) 2020-09-09
BR112017004140B1 (pt) 2023-01-10
KR102410733B1 (ko) 2022-06-20
HUE057702T2 (hu) 2022-05-28
US11104691B2 (en) 2021-08-31
CN107105667A (zh) 2017-08-29
DK3197277T3 (da) 2022-01-31
IL250802B (en) 2020-08-31
CN107105667B (zh) 2021-08-17
EP3197277B1 (en) 2021-12-22
SI3197277T1 (sl) 2022-04-29
JP2017529340A (ja) 2017-10-05
EP3197277A4 (en) 2018-04-18
EA201790400A1 (ru) 2017-09-29
IL250802A0 (en) 2017-04-30
SG11201701592SA (en) 2017-03-30
US20210380608A1 (en) 2021-12-09
US20170283439A1 (en) 2017-10-05
PT3197277T (pt) 2022-02-01
AU2019283999B2 (en) 2021-07-22

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