SG11201701592SA - Probes for imaging huntingtin protein - Google Patents
Probes for imaging huntingtin proteinInfo
- Publication number
- SG11201701592SA SG11201701592SA SG11201701592SA SG11201701592SA SG11201701592SA SG 11201701592S A SG11201701592S A SG 11201701592SA SG 11201701592S A SG11201701592S A SG 11201701592SA SG 11201701592S A SG11201701592S A SG 11201701592SA SG 11201701592S A SG11201701592S A SG 11201701592SA
- Authority
- SG
- Singapore
- Prior art keywords
- probes
- huntingtin protein
- imaging
- imaging huntingtin
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043590P | 2014-08-29 | 2014-08-29 | |
| PCT/US2015/047401 WO2016033440A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201701592SA true SG11201701592SA (en) | 2017-03-30 |
Family
ID=55400645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201701592SA SG11201701592SA (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11104691B2 (en) |
| EP (1) | EP3197277B1 (en) |
| JP (1) | JP6754353B2 (en) |
| KR (1) | KR102410733B1 (en) |
| CN (1) | CN107105667B (en) |
| AU (2) | AU2015308769A1 (en) |
| BR (1) | BR112017004140B1 (en) |
| CA (1) | CA2959533C (en) |
| DK (1) | DK3197277T3 (en) |
| EA (1) | EA039923B1 (en) |
| ES (1) | ES2905095T3 (en) |
| HR (1) | HRP20220001T1 (en) |
| HU (1) | HUE057702T2 (en) |
| IL (1) | IL250802B (en) |
| MX (1) | MX2017002702A (en) |
| PL (1) | PL3197277T3 (en) |
| PT (1) | PT3197277T (en) |
| SG (1) | SG11201701592SA (en) |
| SI (1) | SI3197277T1 (en) |
| WO (1) | WO2016033440A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016033460A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN118005611A (en) | 2014-08-29 | 2024-05-10 | Chdi基金会股份有限公司 | Probes for imaging huntingtin |
| CA2959533C (en) | 2014-08-29 | 2023-03-07 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| SI3186233T1 (en) | 2014-08-29 | 2022-04-29 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN108135172B (en) | 2015-08-28 | 2021-03-30 | Chdi基金会股份有限公司 | Probes for imaging huntingtin |
| US20190381030A1 (en) * | 2017-10-12 | 2019-12-19 | University Of Kansas | Methods of treating radiation induced gastrointestinal syndrome (rigs) and related disease states using yel002/bcn057 |
| WO2020176424A1 (en) | 2019-02-25 | 2020-09-03 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| AU2020267664B2 (en) | 2019-05-09 | 2023-04-27 | F. Hoffmann-La Roche Ag | Synthesis of labeled imidazo[1,2-A]pyrimidines |
| CN114773312B (en) * | 2021-10-29 | 2024-03-26 | 北京鑫诺康桥药物研究有限公司 | Preparation process of alolol hydrochloride intermediate |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10050663A1 (en) * | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Use of amino-substituted imidazo(1,2-a)pyridine, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine derivatives as NO synthase inhibitors, e.g. in treatment of migraine and neurodegenerative diseases |
| MXPA06001742A (en) * | 2003-08-13 | 2006-08-11 | Bf Res Inst Inc | Probe for diseases wth amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change. |
| EP2042501B1 (en) * | 2006-06-21 | 2017-04-12 | Nihon Medi-Physics Co., Ltd. | Compound having affinity for amyloid |
| WO2008016648A2 (en) * | 2006-08-01 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions and methods |
| CN101535309A (en) * | 2006-11-17 | 2009-09-16 | 日本医事物理股份有限公司 | Novel compounds with affinity for amyloid |
| NZ577511A (en) * | 2006-11-30 | 2012-04-27 | Nihon Mediphysics Co Ltd | 2-Phenyl-imidazo[1,2-a]pyridine derivatives substituted with a radioactive halogen substituent |
| EP2125800A1 (en) | 2007-01-22 | 2009-12-02 | AstraZeneca AB | Novel heteroaryl substituted imidazo ý1,2 -a¨pyridine derivatives |
| EP2216052A4 (en) * | 2007-10-30 | 2012-11-21 | Nihon Mediphysics Co Ltd | Use of novel compound having affinity for amyloid, and process for production of the same |
| FR2928923B1 (en) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYL-IMIDAZO-1,2-A! PYRIDINES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS |
| KR20110046503A (en) * | 2008-07-24 | 2011-05-04 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | Useful imaging agents to identify AD etiology |
| EP2338059B1 (en) * | 2008-09-23 | 2015-04-08 | WisTa Laboratories Ltd. | Ligands for aggregated tau molecules |
| WO2010141805A1 (en) * | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
| TWI528977B (en) * | 2011-05-20 | 2016-04-11 | Nihon Mediphysics Co Ltd | New amyloid affinity products |
| EP2725027B1 (en) * | 2011-06-24 | 2017-03-01 | Nihon Medi-Physics Co., Ltd. | Novel compound with amyloid affinity |
| JP2013237655A (en) | 2012-05-17 | 2013-11-28 | Kyoto Univ | Molecular probe for conformational disease diagnosis |
| MX2015005560A (en) * | 2012-11-14 | 2015-07-23 | Hoffmann La Roche | Imidazopyridine derivatives. |
| PT2970255T (en) | 2013-03-14 | 2017-09-05 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| CN105579453B (en) * | 2013-09-26 | 2017-12-22 | 豪夫迈·罗氏有限公司 | The amine of imidazo [1,2 a] pyridine 7 as imaging tool |
| SI3186233T1 (en) | 2014-08-29 | 2022-04-29 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| WO2016033460A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CA2959533C (en) | 2014-08-29 | 2023-03-07 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN118005611A (en) | 2014-08-29 | 2024-05-10 | Chdi基金会股份有限公司 | Probes for imaging huntingtin |
| CN108135172B (en) | 2015-08-28 | 2021-03-30 | Chdi基金会股份有限公司 | Probes for imaging huntingtin |
-
2015
- 2015-08-28 CA CA2959533A patent/CA2959533C/en active Active
- 2015-08-28 KR KR1020177007881A patent/KR102410733B1/en active IP Right Grant
- 2015-08-28 EA EA201790400A patent/EA039923B1/en unknown
- 2015-08-28 HU HUE15836261A patent/HUE057702T2/en unknown
- 2015-08-28 MX MX2017002702A patent/MX2017002702A/en unknown
- 2015-08-28 AU AU2015308769A patent/AU2015308769A1/en not_active Abandoned
- 2015-08-28 ES ES15836261T patent/ES2905095T3/en active Active
- 2015-08-28 PL PL15836261T patent/PL3197277T3/en unknown
- 2015-08-28 SI SI201531778T patent/SI3197277T1/en unknown
- 2015-08-28 HR HRP20220001TT patent/HRP20220001T1/en unknown
- 2015-08-28 BR BR112017004140-5A patent/BR112017004140B1/en active IP Right Grant
- 2015-08-28 EP EP15836261.6A patent/EP3197277B1/en active Active
- 2015-08-28 US US15/507,203 patent/US11104691B2/en active Active
- 2015-08-28 PT PT158362616T patent/PT3197277T/en unknown
- 2015-08-28 JP JP2017511926A patent/JP6754353B2/en active Active
- 2015-08-28 SG SG11201701592SA patent/SG11201701592SA/en unknown
- 2015-08-28 WO PCT/US2015/047401 patent/WO2016033440A1/en active Application Filing
- 2015-08-28 DK DK15836261.6T patent/DK3197277T3/en active
- 2015-08-28 CN CN201580058314.XA patent/CN107105667B/en active Active
-
2017
- 2017-02-26 IL IL250802A patent/IL250802B/en active IP Right Grant
-
2019
- 2019-12-20 AU AU2019283999A patent/AU2019283999B2/en active Active
-
2021
- 2021-06-21 US US17/353,627 patent/US11851446B2/en active Active
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