MX383202B - Sondas para la proyección de imagen de la proteína huntingtina. - Google Patents

Sondas para la proyección de imagen de la proteína huntingtina.

Info

Publication number
MX383202B
MX383202B MX2017002704A MX2017002704A MX383202B MX 383202 B MX383202 B MX 383202B MX 2017002704 A MX2017002704 A MX 2017002704A MX 2017002704 A MX2017002704 A MX 2017002704A MX 383202 B MX383202 B MX 383202B
Authority
MX
Mexico
Prior art keywords
imaging
probes
huntingtin protein
huntingtin
protein
Prior art date
Application number
MX2017002704A
Other languages
English (en)
Other versions
MX2017002704A (es
Inventor
Celia Dominguez
Christopher John Brown
Daniel Clark-Frew
John Wityak
Jonathan Bard
Sarah Hayes
Thomas Martin Krülle
Original Assignee
Chdi Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation Inc filed Critical Chdi Foundation Inc
Publication of MX2017002704A publication Critical patent/MX2017002704A/es
Publication of MX383202B publication Critical patent/MX383202B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Se proporcionan agentes de formación de imágenes que comprenden un compuesto de la Formula I, o su sal farmacéuticamente aceptable, y métodos de su uso.
MX2017002704A 2014-08-29 2015-08-28 Sondas para la proyección de imagen de la proteína huntingtina. MX383202B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462043644P 2014-08-29 2014-08-29
PCT/US2015/047396 WO2016033436A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
MX2017002704A MX2017002704A (es) 2017-10-23
MX383202B true MX383202B (es) 2025-03-13

Family

ID=55400644

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017002704A MX383202B (es) 2014-08-29 2015-08-28 Sondas para la proyección de imagen de la proteína huntingtina.
MX2021005891A MX2021005891A (es) 2014-08-29 2017-02-28 Sondas para la proyeccion de imagen de la proteina huntingtina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021005891A MX2021005891A (es) 2014-08-29 2017-02-28 Sondas para la proyeccion de imagen de la proteina huntingtina.

Country Status (20)

Country Link
US (2) US11071793B2 (es)
EP (1) EP3186241B1 (es)
JP (3) JP2017527559A (es)
KR (1) KR102410760B1 (es)
CN (2) CN118005611A (es)
AU (1) AU2015308765B2 (es)
BR (1) BR112017004136B1 (es)
CA (1) CA2959531C (es)
DK (1) DK3186241T3 (es)
EA (1) EA037275B1 (es)
ES (1) ES2841746T3 (es)
HR (1) HRP20202032T1 (es)
HU (1) HUE052892T2 (es)
IL (1) IL250805B (es)
MX (2) MX383202B (es)
PL (1) PL3186241T3 (es)
PT (1) PT3186241T (es)
SG (1) SG11201701578YA (es)
SI (1) SI3186241T1 (es)
WO (1) WO2016033436A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102410733B1 (ko) 2014-08-29 2022-06-20 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질을 영상화하기 위한 프로브
US10907197B2 (en) 2014-08-29 2021-02-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
CA2959501C (en) 2014-08-29 2023-10-10 Chdi Foundation, Inc. Probes for imaging huntingtin protein
PT3186241T (pt) 2014-08-29 2021-01-08 Chdi Foundation Inc Sondas para imagística de proteína de huntington
RU2721419C2 (ru) 2015-08-28 2020-05-19 СиЭйчДиАй ФАУНДЕЙШН, ИНК. Зонды визуализации белка гентингтина
EP3509588B1 (en) 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
WO2018049324A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Monocyclic compounds useful as gpr120 modulators
US11389438B2 (en) 2019-02-25 2022-07-19 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
US11992535B2 (en) * 2019-12-18 2024-05-28 Chdi Foundation, Inc. Compounds and probes for imaging huntingtin protein
CA3186583A1 (en) * 2020-06-11 2021-12-16 Chdi Foundation, Inc. Heterocyclic compounds and imaging agents for imaging huntingtin protein
CN117412960A (zh) * 2021-04-08 2024-01-16 Chdi基金会股份有限公司 用于对亨廷顿蛋白成像的异吲哚啉酮化合物和显像剂

Family Cites Families (16)

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US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
YU86801A (sh) * 1999-06-10 2004-07-15 Warner-Lambert Company Izoindol derivati korisni u inhibiciji agregacije amiloidnih proteina i snimanju amiloidnih naslaga
US20050148650A1 (en) 2002-03-01 2005-07-07 Shigenori Ohkawa Antidepressant
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US8110681B2 (en) * 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
WO2009042907A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
JP5632612B2 (ja) * 2007-12-05 2014-11-26 あすか製薬株式会社 ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
BR112014026283B1 (pt) 2012-04-25 2022-08-02 Raqualia Pharma Inc Compostos da fórmula (i), (ii), (iii), uso dos mesmos, composição farmacêutica, e processo para a preparação de uma composição farmacêutica
US10125144B2 (en) * 2013-10-07 2018-11-13 Kadmon Corporation, Llc Rho kinase inhibitors
CA2959501C (en) 2014-08-29 2023-10-10 Chdi Foundation, Inc. Probes for imaging huntingtin protein
PT3186241T (pt) 2014-08-29 2021-01-08 Chdi Foundation Inc Sondas para imagística de proteína de huntington
US10907197B2 (en) 2014-08-29 2021-02-02 Chdi Foundation, Inc. Probes for imaging huntingtin protein
KR102410733B1 (ko) 2014-08-29 2022-06-20 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질을 영상화하기 위한 프로브
RU2721419C2 (ru) 2015-08-28 2020-05-19 СиЭйчДиАй ФАУНДЕЙШН, ИНК. Зонды визуализации белка гентингтина

Also Published As

Publication number Publication date
HUE052892T2 (hu) 2021-05-28
CA2959531A1 (en) 2016-03-03
SI3186241T1 (sl) 2021-03-31
MX2017002704A (es) 2017-10-23
US11071793B2 (en) 2021-07-27
US20170281804A1 (en) 2017-10-05
CN118005611A (zh) 2024-05-10
BR112017004136A2 (pt) 2017-12-12
ES2841746T3 (es) 2021-07-09
BR112017004136B1 (pt) 2022-05-03
IL250805B (en) 2020-08-31
JP2021088584A (ja) 2021-06-10
DK3186241T3 (da) 2021-01-11
CN107074817B (zh) 2023-12-15
AU2015308765B2 (en) 2020-06-04
EP3186241A1 (en) 2017-07-05
EP3186241B1 (en) 2020-10-07
PL3186241T3 (pl) 2021-05-17
CN107074817A (zh) 2017-08-18
EA201790432A1 (ru) 2017-09-29
US20210379211A1 (en) 2021-12-09
CA2959531C (en) 2023-01-10
JP7042940B2 (ja) 2022-03-28
WO2016033436A1 (en) 2016-03-03
US12036291B2 (en) 2024-07-16
KR20170047348A (ko) 2017-05-04
EA037275B1 (ru) 2021-03-03
JP2020079272A (ja) 2020-05-28
IL250805A0 (en) 2017-04-30
EP3186241A4 (en) 2018-04-18
PT3186241T (pt) 2021-01-08
KR102410760B1 (ko) 2022-06-20
MX2021005891A (es) 2021-06-23
JP6843282B2 (ja) 2021-03-17
JP2017527559A (ja) 2017-09-21
AU2015308765A1 (en) 2017-03-23
SG11201701578YA (en) 2017-03-30
HRP20202032T1 (hr) 2021-02-19

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