MX2021005891A - Sondas para la proyeccion de imagen de la proteina huntingtina. - Google Patents

Sondas para la proyeccion de imagen de la proteina huntingtina.

Info

Publication number
MX2021005891A
MX2021005891A MX2021005891A MX2021005891A MX2021005891A MX 2021005891 A MX2021005891 A MX 2021005891A MX 2021005891 A MX2021005891 A MX 2021005891A MX 2021005891 A MX2021005891 A MX 2021005891A MX 2021005891 A MX2021005891 A MX 2021005891A
Authority
MX
Mexico
Prior art keywords
probes
huntingtin protein
imaging
imaging huntingtin
protein
Prior art date
Application number
MX2021005891A
Other languages
English (en)
Inventor
Celia Dominguez
Christopher John Brown
John Wityak
Jonathan Bard
Daniel Clark-Frew
Thomas Martin Krülle
Sarah Hayes
Original Assignee
Chdi Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation Inc filed Critical Chdi Foundation Inc
Publication of MX2021005891A publication Critical patent/MX2021005891A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

Se proporcionan agentes de formación de imágenes que comprenden un compuesto de la Fórmula I, o su sal farmacéuticamente aceptable, y métodos de su uso.
MX2021005891A 2014-08-29 2017-02-28 Sondas para la proyeccion de imagen de la proteina huntingtina. MX2021005891A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462043644P 2014-08-29 2014-08-29

Publications (1)

Publication Number Publication Date
MX2021005891A true MX2021005891A (es) 2021-06-23

Family

ID=55400644

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017002704A MX2017002704A (es) 2014-08-29 2015-08-28 Sondas para la proyección de imagen de la proteína huntingtina.
MX2021005891A MX2021005891A (es) 2014-08-29 2017-02-28 Sondas para la proyeccion de imagen de la proteina huntingtina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017002704A MX2017002704A (es) 2014-08-29 2015-08-28 Sondas para la proyección de imagen de la proteína huntingtina.

Country Status (20)

Country Link
US (2) US11071793B2 (es)
EP (1) EP3186241B1 (es)
JP (3) JP2017527559A (es)
KR (1) KR102410760B1 (es)
CN (1) CN107074817B (es)
AU (1) AU2015308765B2 (es)
BR (1) BR112017004136B1 (es)
CA (1) CA2959531C (es)
DK (1) DK3186241T3 (es)
EA (1) EA037275B1 (es)
ES (1) ES2841746T3 (es)
HR (1) HRP20202032T1 (es)
HU (1) HUE052892T2 (es)
IL (1) IL250805B (es)
MX (2) MX2017002704A (es)
PL (1) PL3186241T3 (es)
PT (1) PT3186241T (es)
SG (1) SG11201701578YA (es)
SI (1) SI3186241T1 (es)
WO (1) WO2016033436A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20211778T1 (hr) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
ES2818107T3 (es) 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina
SG11201701592SA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
JP6944929B2 (ja) 2015-08-28 2021-10-06 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ
CA3041033A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Monocyclic compounds useful as gpr120 modulators
CA3041038A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Bicyclic compounds useful as gpr120 modulators
WO2020176424A1 (en) 2019-02-25 2020-09-03 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
JP2023507185A (ja) * 2019-12-18 2023-02-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチンチンタンパク質をイメージングするための化合物及びプローブ
BR112023020857A2 (pt) * 2021-04-08 2023-12-12 Chdi Foundation Inc Compostos de isoindolinona e agentes de imaginologia para imaginologia da proteína huntingtina

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
DZ3262A1 (fr) * 1999-06-10 2000-12-12 Warner Lambert Co Procede d'inhibition d'agregation de proteines amyloides et d'imagerie de depots amyloides au moyen de derives d'isoindoline
WO2003074046A1 (fr) 2002-03-01 2003-09-12 Takeda Chemical Industries, Ltd. Antidepresseur
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
CA2700841A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
WO2009072581A1 (ja) * 2007-12-05 2009-06-11 Aska Pharmaceutical Co., Ltd. ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
RU2646754C2 (ru) 2012-04-25 2018-03-07 Раквалиа Фарма Инк. Производные пирролопиридинона в качестве ttx-s блокаторов
CN104903312B (zh) * 2013-10-07 2019-01-29 卡德门企业有限公司 Rho激酶抑制剂
ES2818107T3 (es) 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina
HRP20211778T1 (hr) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
SG11201701592SA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
JP6944929B2 (ja) 2015-08-28 2021-10-06 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ

Also Published As

Publication number Publication date
EP3186241A4 (en) 2018-04-18
JP2020079272A (ja) 2020-05-28
KR102410760B1 (ko) 2022-06-20
US20210379211A1 (en) 2021-12-09
HRP20202032T1 (hr) 2021-02-19
DK3186241T3 (da) 2021-01-11
PT3186241T (pt) 2021-01-08
EP3186241A1 (en) 2017-07-05
EP3186241B1 (en) 2020-10-07
CA2959531C (en) 2023-01-10
EA201790432A1 (ru) 2017-09-29
JP6843282B2 (ja) 2021-03-17
BR112017004136A2 (pt) 2017-12-12
ES2841746T3 (es) 2021-07-09
WO2016033436A1 (en) 2016-03-03
US20170281804A1 (en) 2017-10-05
JP7042940B2 (ja) 2022-03-28
IL250805B (en) 2020-08-31
HUE052892T2 (hu) 2021-05-28
AU2015308765A1 (en) 2017-03-23
PL3186241T3 (pl) 2021-05-17
SG11201701578YA (en) 2017-03-30
CN107074817B (zh) 2023-12-15
SI3186241T1 (sl) 2021-03-31
JP2017527559A (ja) 2017-09-21
MX2017002704A (es) 2017-10-23
KR20170047348A (ko) 2017-05-04
CA2959531A1 (en) 2016-03-03
JP2021088584A (ja) 2021-06-10
IL250805A0 (en) 2017-04-30
US11071793B2 (en) 2021-07-27
CN107074817A (zh) 2017-08-18
BR112017004136B1 (pt) 2022-05-03
AU2015308765B2 (en) 2020-06-04
EA037275B1 (ru) 2021-03-03

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