BR112017004136B1 - Agente de imagemamento, seu uso e compostos - Google Patents

Agente de imagemamento, seu uso e compostos Download PDF

Info

Publication number
BR112017004136B1
BR112017004136B1 BR112017004136-7A BR112017004136A BR112017004136B1 BR 112017004136 B1 BR112017004136 B1 BR 112017004136B1 BR 112017004136 A BR112017004136 A BR 112017004136A BR 112017004136 B1 BR112017004136 B1 BR 112017004136B1
Authority
BR
Brazil
Prior art keywords
imaging agent
imaging
alkyl
pet
pyridin
Prior art date
Application number
BR112017004136-7A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112017004136A2 (pt
Inventor
Celia Dominguez
John Wityak
Jonathan Bard
Christopher John Brown
Thomas Martin Krülle
Daniel Clark-Frew
Sarah Hayes
Original Assignee
Chdi Foundation, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation, Inc filed Critical Chdi Foundation, Inc
Publication of BR112017004136A2 publication Critical patent/BR112017004136A2/pt
Publication of BR112017004136B1 publication Critical patent/BR112017004136B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
BR112017004136-7A 2014-08-29 2015-08-28 Agente de imagemamento, seu uso e compostos BR112017004136B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462043644P 2014-08-29 2014-08-29
US62/043,644 2014-08-29
PCT/US2015/047396 WO2016033436A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
BR112017004136A2 BR112017004136A2 (pt) 2017-12-12
BR112017004136B1 true BR112017004136B1 (pt) 2022-05-03

Family

ID=55400644

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017004136-7A BR112017004136B1 (pt) 2014-08-29 2015-08-28 Agente de imagemamento, seu uso e compostos

Country Status (20)

Country Link
US (2) US11071793B2 (es)
EP (1) EP3186241B1 (es)
JP (3) JP2017527559A (es)
KR (1) KR102410760B1 (es)
CN (2) CN107074817B (es)
AU (1) AU2015308765B2 (es)
BR (1) BR112017004136B1 (es)
CA (1) CA2959531C (es)
DK (1) DK3186241T3 (es)
EA (1) EA037275B1 (es)
ES (1) ES2841746T3 (es)
HR (1) HRP20202032T1 (es)
HU (1) HUE052892T2 (es)
IL (1) IL250805B (es)
MX (2) MX2017002704A (es)
PL (1) PL3186241T3 (es)
PT (1) PT3186241T (es)
SG (1) SG11201701578YA (es)
SI (1) SI3186241T1 (es)
WO (1) WO2016033436A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170047341A (ko) 2014-08-29 2017-05-04 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질을 영상화하기 위한 프로브
MX2017002703A (es) 2014-08-29 2018-01-16 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
WO2016033440A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
EP3340796B1 (en) 2015-08-28 2021-04-21 CHDI Foundation, Inc. Probes for imaging huntingtin protein
EP3509588B1 (en) * 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
US10800773B2 (en) 2016-09-12 2020-10-13 Integral Health, Inc. Monocyclic compounds useful as GPR120 modulators
US11389438B2 (en) 2019-02-25 2022-07-19 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
AU2020407600A1 (en) * 2019-12-18 2022-06-30 Chdi Foundation, Inc. Compounds and probes for imaging huntingtin protein
CN117412960A (zh) * 2021-04-08 2024-01-16 Chdi基金会股份有限公司 用于对亨廷顿蛋白成像的异吲哚啉酮化合物和显像剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
HUP0201586A2 (en) 1999-06-10 2002-08-28 Warner Lambert Co Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives
CA2477903C (en) 2002-03-01 2010-10-12 Takeda Chemical Industries, Ltd. Substituted benzofurans useful as protein kinase b activators
US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
EP2573080A1 (en) * 2007-09-27 2013-03-27 The United States of America, as Represented by the Secretary, Department of Health and Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
WO2009072581A1 (ja) * 2007-12-05 2009-06-11 Aska Pharmaceutical Co., Ltd. ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CA2871229C (en) 2012-04-25 2020-10-27 Raqualia Pharma Inc. Pyrrolopyridinone derivatives as ttx-s blockers
EP3055301B1 (en) * 2013-10-07 2019-11-20 Kadmon Corporation, LLC (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases
MX2017002703A (es) 2014-08-29 2018-01-16 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
WO2016033440A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
KR20170047341A (ko) 2014-08-29 2017-05-04 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질을 영상화하기 위한 프로브
EP3340796B1 (en) 2015-08-28 2021-04-21 CHDI Foundation, Inc. Probes for imaging huntingtin protein

Also Published As

Publication number Publication date
DK3186241T3 (da) 2021-01-11
EA201790432A1 (ru) 2017-09-29
BR112017004136A2 (pt) 2017-12-12
AU2015308765A1 (en) 2017-03-23
KR102410760B1 (ko) 2022-06-20
JP2021088584A (ja) 2021-06-10
JP2020079272A (ja) 2020-05-28
PT3186241T (pt) 2021-01-08
ES2841746T3 (es) 2021-07-09
KR20170047348A (ko) 2017-05-04
CN107074817A (zh) 2017-08-18
SI3186241T1 (sl) 2021-03-31
JP2017527559A (ja) 2017-09-21
EP3186241A1 (en) 2017-07-05
CA2959531C (en) 2023-01-10
AU2015308765B2 (en) 2020-06-04
JP7042940B2 (ja) 2022-03-28
PL3186241T3 (pl) 2021-05-17
HRP20202032T1 (hr) 2021-02-19
CA2959531A1 (en) 2016-03-03
EP3186241B1 (en) 2020-10-07
EA037275B1 (ru) 2021-03-03
CN107074817B (zh) 2023-12-15
SG11201701578YA (en) 2017-03-30
CN118005611A (zh) 2024-05-10
JP6843282B2 (ja) 2021-03-17
MX2021005891A (es) 2021-06-23
US20210379211A1 (en) 2021-12-09
IL250805B (en) 2020-08-31
MX2017002704A (es) 2017-10-23
WO2016033436A1 (en) 2016-03-03
HUE052892T2 (hu) 2021-05-28
US11071793B2 (en) 2021-07-27
EP3186241A4 (en) 2018-04-18
IL250805A0 (en) 2017-04-30
US20170281804A1 (en) 2017-10-05

Similar Documents

Publication Publication Date Title
JP7042940B2 (ja) ハンチントンタンパク質のイメージング用プローブ
US11851446B2 (en) Probes for imaging Huntingtin protein
BR112017004141B1 (pt) Agente de imagemamento e seu uso
ES2885053T3 (es) Sondas para la obtención de imágenes de la proteína huntingtina
ES2818107T3 (es) Sondas para obtener imágenes de la proteína huntingtina

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11N Dismissal: publication cancelled [chapter 11.14 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 11.1 NA RPI NO 2493 DE 16/10/2018 POR TER SIDO INDEVIDA.

B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B15V Prolongation of time limit allowed

Free format text: DE ACORDO COM COMUNICADO PUBLICADO NA RPI 2487 DE 04/09/2018, COMUNICADO PUBLICADO NA RPI 2488 DE 11/09/2018 E RESOLUCAO INPI/PR NO 225/2018 FICAM DEVOLVIDOS ATE 14/09/2019 OS PRAZOS VENCIDOS NAS DATAS DIVULGADOS DENTRO DOS COMUNICADOS.

B11N Dismissal: publication cancelled [chapter 11.14 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 11.1 NA RPI NO 2495 DE 30/10/2018 POR TER SIDO INDEVIDA.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/08/2015, OBSERVADAS AS CONDICOES LEGAIS.