EA201790432A1 - Зонды для визуализации белка хантингтина - Google Patents

Зонды для визуализации белка хантингтина

Info

Publication number
EA201790432A1
EA201790432A1 EA201790432A EA201790432A EA201790432A1 EA 201790432 A1 EA201790432 A1 EA 201790432A1 EA 201790432 A EA201790432 A EA 201790432A EA 201790432 A EA201790432 A EA 201790432A EA 201790432 A1 EA201790432 A1 EA 201790432A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hantingtin
visualization
probes
protein
compound
Prior art date
Application number
EA201790432A
Other languages
English (en)
Other versions
EA037275B1 (ru
Inventor
Селиа Домингез
Джон Витяк
Джонатан Бард
Кристофер Джон Браун
Томас Мартин Крюлле
Дэниел Кларк-Фрю
Сара Хейз
Original Assignee
Сиэйчдиай Фаундэйшн, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сиэйчдиай Фаундэйшн, Инк. filed Critical Сиэйчдиай Фаундэйшн, Инк.
Publication of EA201790432A1 publication Critical patent/EA201790432A1/ru
Publication of EA037275B1 publication Critical patent/EA037275B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Предложены визуализирующие агенты, содержащие соединение формулы I или его фармацевтически приемлемую соль, и способы их применения.
EA201790432A 2014-08-29 2015-08-28 Зонды для визуализации белка хантингтина EA037275B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462043644P 2014-08-29 2014-08-29
PCT/US2015/047396 WO2016033436A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
EA201790432A1 true EA201790432A1 (ru) 2017-09-29
EA037275B1 EA037275B1 (ru) 2021-03-03

Family

ID=55400644

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790432A EA037275B1 (ru) 2014-08-29 2015-08-28 Зонды для визуализации белка хантингтина

Country Status (20)

Country Link
US (2) US11071793B2 (ru)
EP (1) EP3186241B1 (ru)
JP (3) JP2017527559A (ru)
KR (1) KR102410760B1 (ru)
CN (2) CN107074817B (ru)
AU (1) AU2015308765B2 (ru)
BR (1) BR112017004136B1 (ru)
CA (1) CA2959531C (ru)
DK (1) DK3186241T3 (ru)
EA (1) EA037275B1 (ru)
ES (1) ES2841746T3 (ru)
HR (1) HRP20202032T1 (ru)
HU (1) HUE052892T2 (ru)
IL (1) IL250805B (ru)
MX (2) MX2017002704A (ru)
PL (1) PL3186241T3 (ru)
PT (1) PT3186241T (ru)
SG (1) SG11201701578YA (ru)
SI (1) SI3186241T1 (ru)
WO (1) WO2016033436A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3190888B1 (en) 2014-08-29 2020-06-10 CHDI Foundation, Inc. Probes for imaging huntingtin protein
JP6754353B2 (ja) 2014-08-29 2020-09-09 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ
BR112017004136B1 (pt) 2014-08-29 2022-05-03 Chdi Foundation, Inc Agente de imagemamento, seu uso e compostos
SI3186233T1 (sl) 2014-08-29 2022-04-29 Chdi Foundation, Inc. Sonde za slikanje proteina huntingtina
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
EP3509588B1 (en) * 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
EP3509587B1 (en) 2016-09-12 2023-12-06 Valo Health, Inc. Monocyclic compounds useful as gpr120 modulators
JP2022521431A (ja) 2019-02-25 2022-04-07 シーエイチディーアイ ファウンデーション，インコーポレーテッド 変異型ハンチンチンタンパク質を標的とするための化合物及びその使用
WO2021127265A1 (en) * 2019-12-18 2021-06-24 Chdi Foundation, Inc. Compounds and probes for imaging huntingtin protein
WO2022216947A1 (en) * 2021-04-08 2022-10-13 Chdi Foundation, Inc. Isoindolinone compounds and imaging agents for imaging huntingtin protein

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726197A (en) * 1992-11-02 1998-03-10 Syntex (U.S.A.) Inc. Isoindolinyl derivatives
SK17622001A3 (sk) * 1999-06-10 2003-06-03 Warner-Lambert Company Izoindolínové deriváty, ich použitie a farmaceutické kompozície na ich báze
KR101011657B1 (ko) * 2002-03-01 2011-01-28 다케다 야쿠힌 고교 가부시키가이샤 항우울제
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
CA2700841A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
JP5632612B2 (ja) * 2007-12-05 2014-11-26 あすか製薬株式会社 ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
JP6175672B2 (ja) * 2012-04-25 2017-08-09 ラクオリア創薬株式会社 Ｔｔｘ−ｓ遮断薬としてのピロロピリジノン誘導体
EP3055301B1 (en) * 2013-10-07 2019-11-20 Kadmon Corporation, LLC (2-(5-isoindolin-2-yl)pyrimidin-4-yl)-amine derivatives as rho kinase inhibitors for treating autoimmune diseases
JP6754353B2 (ja) 2014-08-29 2020-09-09 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ
BR112017004136B1 (pt) 2014-08-29 2022-05-03 Chdi Foundation, Inc Agente de imagemamento, seu uso e compostos
SI3186233T1 (sl) 2014-08-29 2022-04-29 Chdi Foundation, Inc. Sonde za slikanje proteina huntingtina
EP3190888B1 (en) 2014-08-29 2020-06-10 CHDI Foundation, Inc. Probes for imaging huntingtin protein
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina

Also Published As

Publication number Publication date
WO2016033436A1 (en) 2016-03-03
KR20170047348A (ko) 2017-05-04
AU2015308765B2 (en) 2020-06-04
BR112017004136B1 (pt) 2022-05-03
CN118005611A (zh) 2024-05-10
CN107074817B (zh) 2023-12-15
PT3186241T (pt) 2021-01-08
IL250805A0 (en) 2017-04-30
EP3186241A4 (en) 2018-04-18
US20170281804A1 (en) 2017-10-05
HRP20202032T1 (hr) 2021-02-19
US20210379211A1 (en) 2021-12-09
DK3186241T3 (da) 2021-01-11
HUE052892T2 (hu) 2021-05-28
JP7042940B2 (ja) 2022-03-28
IL250805B (en) 2020-08-31
PL3186241T3 (pl) 2021-05-17
EP3186241B1 (en) 2020-10-07
SI3186241T1 (sl) 2021-03-31
CA2959531A1 (en) 2016-03-03
SG11201701578YA (en) 2017-03-30
JP2017527559A (ja) 2017-09-21
MX2021005891A (es) 2021-06-23
KR102410760B1 (ko) 2022-06-20
JP2021088584A (ja) 2021-06-10
US11071793B2 (en) 2021-07-27
BR112017004136A2 (pt) 2017-12-12
US12036291B2 (en) 2024-07-16
MX2017002704A (es) 2017-10-23
EA037275B1 (ru) 2021-03-03
JP6843282B2 (ja) 2021-03-17
CA2959531C (en) 2023-01-10
ES2841746T3 (es) 2021-07-09
EP3186241A1 (en) 2017-07-05
AU2015308765A1 (en) 2017-03-23
CN107074817A (zh) 2017-08-18
JP2020079272A (ja) 2020-05-28

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