MX2018002338A - Sondas para formar imagenes de proteina de huntingtina. - Google Patents

Sondas para formar imagenes de proteina de huntingtina.

Info

Publication number
MX2018002338A
MX2018002338A MX2018002338A MX2018002338A MX2018002338A MX 2018002338 A MX2018002338 A MX 2018002338A MX 2018002338 A MX2018002338 A MX 2018002338A MX 2018002338 A MX2018002338 A MX 2018002338A MX 2018002338 A MX2018002338 A MX 2018002338A
Authority
MX
Mexico
Prior art keywords
probes
huntingtin protein
imaging
imaging huntingtin
protein
Prior art date
Application number
MX2018002338A
Other languages
English (en)
Inventor
Dominguez Celia
Wityak John
Bard Jonathan
Edward Prime Michael
John Brown Christopher
Martin Krulle Thomas
CLARK-FREW Daniel
Higgins Duane
Robert MILLS Matthew
Waldron Marston Richard
HAYES Sarah
Coe Samuel
David Johnson Peter
Louise Jones GREEN Samantha
Original Assignee
Chdi Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation Inc filed Critical Chdi Foundation Inc
Publication of MX2018002338A publication Critical patent/MX2018002338A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nuclear Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan agentes para formar en imagen que comprende un compuesto de la Fórmula I, o una sal farmacéuticamente aceptable del mismo, y métodos para su uso. (ver Fórmula).
MX2018002338A 2015-08-28 2016-08-26 Sondas para formar imagenes de proteina de huntingtina. MX2018002338A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562211118P 2015-08-28 2015-08-28
PCT/US2016/049112 WO2017040336A1 (en) 2015-08-28 2016-08-26 Probes for imaging huntingtin protein

Publications (1)

Publication Number Publication Date
MX2018002338A true MX2018002338A (es) 2018-07-06

Family

ID=58103449

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018002338A MX2018002338A (es) 2015-08-28 2016-08-26 Sondas para formar imagenes de proteina de huntingtina.

Country Status (18)

Country Link
US (3) US10137211B2 (es)
EP (1) EP3340796B1 (es)
JP (1) JP6944929B2 (es)
CN (1) CN108135172B (es)
AU (1) AU2016315648B2 (es)
BR (1) BR112018003331B1 (es)
CA (1) CA2995847A1 (es)
DK (1) DK3340796T3 (es)
ES (1) ES2885053T3 (es)
HR (1) HRP20211156T1 (es)
HU (1) HUE056509T2 (es)
IL (1) IL257537B (es)
MX (1) MX2018002338A (es)
PL (1) PL3340796T4 (es)
PT (1) PT3340796T (es)
RU (1) RU2721419C2 (es)
SI (1) SI3340796T1 (es)
WO (1) WO2017040336A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170047341A (ko) 2014-08-29 2017-05-04 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질을 영상화하기 위한 프로브
MX2017002703A (es) 2014-08-29 2018-01-16 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
JP2017527559A (ja) 2014-08-29 2017-09-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ
WO2016033440A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
EP3340796B1 (en) 2015-08-28 2021-04-21 CHDI Foundation, Inc. Probes for imaging huntingtin protein
WO2019157272A1 (en) * 2018-02-08 2019-08-15 Phraxis Inc. One piece anastomotic connector
US11389438B2 (en) 2019-02-25 2022-07-19 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
US11918662B2 (en) 2020-06-11 2024-03-05 Chdi Foundation, Inc. Heterocyclic compounds and imaging agents for imaging huntingtin protein

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2126636T3 (es) 1992-05-19 1999-04-01 Adir Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria.
AU2241400A (en) * 1999-04-06 2000-10-12 Yamanouchi Pharmaceutical Co., Ltd. Novel thiazolobenzoimidazole derivative
JP2000351782A (ja) * 1999-04-06 2000-12-19 Yamanouchi Pharmaceut Co Ltd メタボトロピックグルタメート受容体作用薬及び新規チアゾロベンゾイミダゾール誘導体
UY27003A1 (es) * 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer
EP1684762A4 (en) * 2003-11-13 2009-06-17 Ambit Biosciences Corp UREA DERIVATIVES AS MODULATORS OF KINASE
TW200736252A (en) * 2006-01-27 2007-10-01 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
FR2919610B1 (fr) * 2007-08-02 2009-10-16 Sanofi Aventis Sa Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique
EP2323697A2 (en) * 2008-07-24 2011-05-25 Siemens Medical Solutions USA, Inc. Imaging agents useful for identifying ad pathology
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
CN103739605B (zh) * 2009-03-23 2016-08-17 伊莱利利公司 用于检测神经障碍的显像剂
EP2872518A4 (en) 2012-07-11 2016-05-18 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
US9902702B2 (en) * 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
KR20170047341A (ko) 2014-08-29 2017-05-04 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴 단백질을 영상화하기 위한 프로브
MX2017002703A (es) 2014-08-29 2018-01-16 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
JP2017527559A (ja) 2014-08-29 2017-09-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ
WO2016033440A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
EP3340796B1 (en) 2015-08-28 2021-04-21 CHDI Foundation, Inc. Probes for imaging huntingtin protein

Also Published As

Publication number Publication date
BR112018003331B1 (pt) 2022-05-10
JP2018531897A (ja) 2018-11-01
CN108135172A (zh) 2018-06-08
ES2885053T3 (es) 2021-12-13
IL257537B (en) 2020-08-31
PT3340796T (pt) 2021-07-28
SI3340796T1 (sl) 2022-02-28
US10765764B2 (en) 2020-09-08
US20210060187A1 (en) 2021-03-04
RU2018110055A3 (es) 2019-10-28
EP3340796A4 (en) 2019-05-15
HRP20211156T1 (hr) 2021-12-24
BR112018003331A2 (pt) 2018-11-06
RU2721419C2 (ru) 2020-05-19
JP6944929B2 (ja) 2021-10-06
AU2016315648A1 (en) 2018-03-29
AU2016315648B2 (en) 2021-04-01
US20170056535A1 (en) 2017-03-02
US11344637B2 (en) 2022-05-31
CN108135172B (zh) 2021-03-30
WO2017040336A1 (en) 2017-03-09
IL257537A (en) 2018-04-30
RU2018110055A (ru) 2019-09-30
PL3340796T3 (pl) 2022-02-21
DK3340796T3 (da) 2021-07-26
US10137211B2 (en) 2018-11-27
EP3340796A1 (en) 2018-07-04
CA2995847A1 (en) 2017-03-09
EP3340796B1 (en) 2021-04-21
US20190167821A1 (en) 2019-06-06
HUE056509T2 (hu) 2022-02-28
PL3340796T4 (pl) 2022-02-21

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