BR112023020857A2 - Compostos de isoindolinona e agentes de imaginologia para imaginologia da proteína huntingtina - Google Patents
Compostos de isoindolinona e agentes de imaginologia para imaginologia da proteína huntingtinaInfo
- Publication number
- BR112023020857A2 BR112023020857A2 BR112023020857A BR112023020857A BR112023020857A2 BR 112023020857 A2 BR112023020857 A2 BR 112023020857A2 BR 112023020857 A BR112023020857 A BR 112023020857A BR 112023020857 A BR112023020857 A BR 112023020857A BR 112023020857 A2 BR112023020857 A2 BR 112023020857A2
- Authority
- BR
- Brazil
- Prior art keywords
- imaging
- isoindolinone compounds
- huntingtin protein
- imaging agents
- agents
- Prior art date
Links
- 239000012216 imaging agent Substances 0.000 title abstract 3
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title abstract 3
- 102000016252 Huntingtin Human genes 0.000 title abstract 2
- 108050004784 Huntingtin Proteins 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004845 protein aggregation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
compostos de isoindolinona e agentes de imaginologia para imaginologia da proteína huntingtina. são fornecidos no presente documento certos compostos de isoindolinona e agentes de imaginologia úteis para detectar uma doença ou condição associada à agregação de proteínas, composições dos mesmos e métodos de seu uso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163172617P | 2021-04-08 | 2021-04-08 | |
| PCT/US2022/023861 WO2022216947A1 (en) | 2021-04-08 | 2022-04-07 | Isoindolinone compounds and imaging agents for imaging huntingtin protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023020857A2 true BR112023020857A2 (pt) | 2023-12-12 |
Family
ID=81448483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023020857A BR112023020857A2 (pt) | 2021-04-08 | 2022-04-07 | Compostos de isoindolinona e agentes de imaginologia para imaginologia da proteína huntingtina |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220339302A1 (pt) |
| EP (1) | EP4320114A1 (pt) |
| JP (1) | JP2024513913A (pt) |
| KR (1) | KR20240024045A (pt) |
| CN (1) | CN117412960A (pt) |
| AU (1) | AU2022253897A1 (pt) |
| BR (1) | BR112023020857A2 (pt) |
| CA (1) | CA3214756A1 (pt) |
| IL (1) | IL307507A (pt) |
| WO (1) | WO2022216947A1 (pt) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2017002703A (es) * | 2014-08-29 | 2018-01-16 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| JP2017527559A (ja) * | 2014-08-29 | 2017-09-21 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | ハンチントンタンパク質のイメージング用プローブ |
-
2022
- 2022-04-07 CN CN202280038903.1A patent/CN117412960A/zh active Pending
- 2022-04-07 AU AU2022253897A patent/AU2022253897A1/en active Pending
- 2022-04-07 BR BR112023020857A patent/BR112023020857A2/pt unknown
- 2022-04-07 CA CA3214756A patent/CA3214756A1/en active Pending
- 2022-04-07 KR KR1020237038197A patent/KR20240024045A/ko unknown
- 2022-04-07 IL IL307507A patent/IL307507A/en unknown
- 2022-04-07 WO PCT/US2022/023861 patent/WO2022216947A1/en active Application Filing
- 2022-04-07 US US17/715,661 patent/US20220339302A1/en active Pending
- 2022-04-07 EP EP22720147.2A patent/EP4320114A1/en active Pending
- 2022-04-07 JP JP2023561668A patent/JP2024513913A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL307507A (en) | 2023-12-01 |
| US20220339302A1 (en) | 2022-10-27 |
| EP4320114A1 (en) | 2024-02-14 |
| AU2022253897A1 (en) | 2023-10-19 |
| CN117412960A (zh) | 2024-01-16 |
| WO2022216947A1 (en) | 2022-10-13 |
| CA3214756A1 (en) | 2022-10-13 |
| KR20240024045A (ko) | 2024-02-23 |
| JP2024513913A (ja) | 2024-03-27 |
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