PT3197277T - Sondas para imagens da proteína huntingtina - Google Patents
Sondas para imagens da proteína huntingtinaInfo
- Publication number
- PT3197277T PT3197277T PT158362616T PT15836261T PT3197277T PT 3197277 T PT3197277 T PT 3197277T PT 158362616 T PT158362616 T PT 158362616T PT 15836261 T PT15836261 T PT 15836261T PT 3197277 T PT3197277 T PT 3197277T
- Authority
- PT
- Portugal
- Prior art keywords
- probes
- huntingtin protein
- imaging
- imaging huntingtin
- protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043590P | 2014-08-29 | 2014-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3197277T true PT3197277T (pt) | 2022-02-01 |
Family
ID=55400645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT158362616T PT3197277T (pt) | 2014-08-29 | 2015-08-28 | Sondas para imagens da proteína huntingtina |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11104691B2 (pt) |
| EP (1) | EP3197277B1 (pt) |
| JP (1) | JP6754353B2 (pt) |
| KR (1) | KR102410733B1 (pt) |
| CN (1) | CN107105667B (pt) |
| AU (2) | AU2015308769A1 (pt) |
| BR (1) | BR112017004140B1 (pt) |
| CA (1) | CA2959533C (pt) |
| DK (1) | DK3197277T3 (pt) |
| EA (1) | EA039923B1 (pt) |
| ES (1) | ES2905095T3 (pt) |
| HR (1) | HRP20220001T1 (pt) |
| HU (1) | HUE057702T2 (pt) |
| IL (1) | IL250802B (pt) |
| MX (1) | MX2017002702A (pt) |
| PL (1) | PL3197277T3 (pt) |
| PT (1) | PT3197277T (pt) |
| SG (1) | SG11201701592SA (pt) |
| SI (1) | SI3197277T1 (pt) |
| WO (1) | WO2016033440A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201701578YA (en) | 2014-08-29 | 2017-03-30 | Chdi Foundation Inc | Probes for imaging huntingtin protein |
| EA039923B1 (ru) | 2014-08-29 | 2022-03-28 | Сиэйчдиай Фаундэйшн, Инк. | Зонды для визуализации белка хантингтина |
| CN107105655A (zh) | 2014-08-29 | 2017-08-29 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| MX2017002703A (es) | 2014-08-29 | 2018-01-16 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| EP3340796B1 (en) | 2015-08-28 | 2021-04-21 | CHDI Foundation, Inc. | Probes for imaging huntingtin protein |
| AU2018346962A1 (en) * | 2017-10-12 | 2020-05-28 | BCN Biosciences L.L.C. | Methods of treating radiation induced gastrointestinal syndrome |
| WO2020176424A1 (en) | 2019-02-25 | 2020-09-03 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| JP7369208B2 (ja) | 2019-05-09 | 2023-10-25 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 標識されたイミダゾ［１，２－ａ］ピリミジンの合成 |
| CN114773312B (zh) * | 2021-10-29 | 2024-03-26 | 北京鑫诺康桥药物研究有限公司 | 一种盐酸阿罗洛尔中间体的制备工艺 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10050663A1 (de) * | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
| EP1655287A1 (en) * | 2003-08-13 | 2006-05-10 | BF Research Institute, Inc. | Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change |
| AU2007261985B2 (en) * | 2006-06-21 | 2012-04-19 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| US20100173930A1 (en) * | 2006-08-01 | 2010-07-08 | Alex Muci | Certain Chemical Entities, Compositions and Methods |
| EP2098523A4 (en) * | 2006-11-17 | 2011-09-21 | Nihon Mediphysics Co Ltd | NEW, AMYLOID-AFFINE COMPOUNDS |
| TW200823211A (en) * | 2006-11-30 | 2008-06-01 | Nihon Mediphysics Co Ltd | Novel compound having affinity for amyloid |
| JP2010516672A (ja) * | 2007-01-22 | 2010-05-20 | アストラゼネカ・アクチエボラーグ | 新規なヘテロアリール置換されたイミダゾ［１，２−ａ］ピリジン誘導体 |
| CN102702195A (zh) * | 2007-10-30 | 2012-10-03 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法 |
| FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| WO2010011964A2 (en) * | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
| SI2338059T1 (sl) * | 2008-09-23 | 2015-08-31 | Wista Laboratories Ltd. | Ligandi za agregirane molekule tau |
| US8614201B2 (en) * | 2009-06-05 | 2013-12-24 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of TRPA1 |
| ES2628221T3 (es) * | 2011-05-20 | 2017-08-02 | Nihon Medi-Physics Co., Ltd. | Compuesto marcado con yodo radioactivo con afinidad por amiloide |
| IN2014DN00185A (pt) * | 2011-06-24 | 2015-07-10 | Nihon Mediphysics Co Ltd | |
| JP2013237655A (ja) | 2012-05-17 | 2013-11-28 | Kyoto Univ | コンフォメーション病診断用分子プローブ |
| MX2015005560A (es) * | 2012-11-14 | 2015-07-23 | Hoffmann La Roche | Derivados de imidazopiridina. |
| EP3760630A1 (en) | 2013-03-14 | 2021-01-06 | Galapagos N.V. | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| WO2015044095A1 (en) * | 2013-09-26 | 2015-04-02 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]pyridin-7-amines as imaging tools |
| MX2017002703A (es) | 2014-08-29 | 2018-01-16 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| CN107105655A (zh) | 2014-08-29 | 2017-08-29 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| EA039923B1 (ru) | 2014-08-29 | 2022-03-28 | Сиэйчдиай Фаундэйшн, Инк. | Зонды для визуализации белка хантингтина |
| SG11201701578YA (en) | 2014-08-29 | 2017-03-30 | Chdi Foundation Inc | Probes for imaging huntingtin protein |
| EP3340796B1 (en) | 2015-08-28 | 2021-04-21 | CHDI Foundation, Inc. | Probes for imaging huntingtin protein |
-
2015
- 2015-08-28 EA EA201790400A patent/EA039923B1/ru unknown
- 2015-08-28 PT PT158362616T patent/PT3197277T/pt unknown
- 2015-08-28 PL PL15836261T patent/PL3197277T3/pl unknown
- 2015-08-28 KR KR1020177007881A patent/KR102410733B1/ko active IP Right Grant
- 2015-08-28 HR HRP20220001TT patent/HRP20220001T1/hr unknown
- 2015-08-28 SG SG11201701592SA patent/SG11201701592SA/en unknown
- 2015-08-28 HU HUE15836261A patent/HUE057702T2/hu unknown
- 2015-08-28 JP JP2017511926A patent/JP6754353B2/ja active Active
- 2015-08-28 ES ES15836261T patent/ES2905095T3/es active Active
- 2015-08-28 AU AU2015308769A patent/AU2015308769A1/en not_active Abandoned
- 2015-08-28 US US15/507,203 patent/US11104691B2/en active Active
- 2015-08-28 EP EP15836261.6A patent/EP3197277B1/en active Active
- 2015-08-28 CA CA2959533A patent/CA2959533C/en active Active
- 2015-08-28 DK DK15836261.6T patent/DK3197277T3/da active
- 2015-08-28 SI SI201531778T patent/SI3197277T1/sl unknown
- 2015-08-28 CN CN201580058314.XA patent/CN107105667B/zh active Active
- 2015-08-28 BR BR112017004140-5A patent/BR112017004140B1/pt active IP Right Grant
- 2015-08-28 MX MX2017002702A patent/MX2017002702A/es unknown
- 2015-08-28 WO PCT/US2015/047401 patent/WO2016033440A1/en active Application Filing
-
2017
- 2017-02-26 IL IL250802A patent/IL250802B/en active IP Right Grant
-
2019
- 2019-12-20 AU AU2019283999A patent/AU2019283999B2/en active Active
-
2021
- 2021-06-21 US US17/353,627 patent/US11851446B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL250803A0 (en) | Imaging means for the huntingtin protein | |
| GB201417164D0 (en) | Measurement Probe | |
| IL250805B (en) | Imaging means for the huntingtin protein | |
| GB201413245D0 (en) | ImAGE Analysis | |
| IL250802A0 (en) | Imaging means for the huntingtin protein | |
| IL257537B (en) | Antigen protein imaging markers | |
| IL250804A0 (en) | Imaging means for the huntingtin protein | |
| GB201500641D0 (en) | Ultrasound probe | |
| EP3197341A4 (en) | Probe for iridocorneal angle imaging | |
| SG11201606516RA (en) | Probe unit | |
| IL259034B (en) | Test device cover | |
| SG11201702178TA (en) | Probe unit | |
| TWI561825B (en) | Probe device | |
| GB2533151B (en) | Improved probe | |
| GB201406616D0 (en) | Imaging | |
| GB2550120B (en) | Probe | |
| GB201517390D0 (en) | Protein variant analysis | |
| GB201407787D0 (en) | Imaging techniques |