KR102410733B1 - 헌팅틴 단백질을 영상화하기 위한 프로브 - Google Patents

헌팅틴 단백질을 영상화하기 위한 프로브 Download PDF

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Publication number
KR102410733B1
KR102410733B1 KR1020177007881A KR20177007881A KR102410733B1 KR 102410733 B1 KR102410733 B1 KR 102410733B1 KR 1020177007881 A KR1020177007881 A KR 1020177007881A KR 20177007881 A KR20177007881 A KR 20177007881A KR 102410733 B1 KR102410733 B1 KR 102410733B1
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South Korea
Prior art keywords
imidazo
pyridine
carbonitrile
methoxy
methylamino
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KR20170047303A (ko
Inventor
셀리아 도밍게즈
존 휘트약
조나단 바드
알렉스 키셀료프
크리스토퍼 존 브라운
마이클 에드워드 프라임
피터 데이비드 존슨
다니엘 클락-프류
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씨에이치디아이 파운데이션, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020177007881A 2014-08-29 2015-08-28 헌팅틴 단백질을 영상화하기 위한 프로브 Active KR102410733B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462043590P 2014-08-29 2014-08-29
US62/043,590 2014-08-29
PCT/US2015/047401 WO2016033440A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
KR20170047303A KR20170047303A (ko) 2017-05-04
KR102410733B1 true KR102410733B1 (ko) 2022-06-20

Family

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KR1020177007881A Active KR102410733B1 (ko) 2014-08-29 2015-08-28 헌팅틴 단백질을 영상화하기 위한 프로브

Country Status (20)

Country Link
US (2) US11104691B2 (enExample)
EP (1) EP3197277B1 (enExample)
JP (1) JP6754353B2 (enExample)
KR (1) KR102410733B1 (enExample)
CN (1) CN107105667B (enExample)
AU (2) AU2015308769A1 (enExample)
BR (1) BR112017004140B1 (enExample)
CA (1) CA2959533C (enExample)
DK (1) DK3197277T3 (enExample)
EA (1) EA039923B1 (enExample)
ES (1) ES2905095T3 (enExample)
HR (1) HRP20220001T1 (enExample)
HU (1) HUE057702T2 (enExample)
IL (1) IL250802B (enExample)
MX (1) MX386798B (enExample)
PL (1) PL3197277T3 (enExample)
PT (1) PT3197277T (enExample)
SG (1) SG11201701592SA (enExample)
SI (1) SI3197277T1 (enExample)
WO (1) WO2016033440A1 (enExample)

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ES2818107T3 (es) 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina
DK3186241T3 (da) 2014-08-29 2021-01-11 Chdi Foundation Inc Prober til billeddannelse af huntington-protein
MX386798B (es) 2014-08-29 2025-03-19 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
US10479802B2 (en) 2014-08-29 2019-11-19 Chdi Foundation, Inc. Probes for imaging huntingtin protein
PT3340796T (pt) 2015-08-28 2021-07-28 Chdi Foundation Inc Sondas para imagens da proteína huntingtina
US20190381030A1 (en) * 2017-10-12 2019-12-19 University Of Kansas Methods of treating radiation induced gastrointestinal syndrome (rigs) and related disease states using yel002/bcn057
EP3931186A1 (en) 2019-02-25 2022-01-05 CHDI Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
TWI751548B (zh) 2019-05-09 2022-01-01 瑞士商赫孚孟拉羅股份公司 經標記之咪唑并[1,2-a]嘧啶之合成
CN114773312B (zh) * 2021-10-29 2024-03-26 北京鑫诺康桥药物研究有限公司 一种盐酸阿罗洛尔中间体的制备工艺

Citations (3)

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US20110171739A1 (en) 2008-09-23 2011-07-14 Wista Laboratories Ltd. Ligands for aggregated tau molecules
WO2015044095A1 (en) 2013-09-26 2015-04-02 F. Hoffmann-La Roche Ag Imidazo[1,2-a]pyridin-7-amines as imaging tools

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DE10050663A1 (de) 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
WO2005016888A1 (ja) * 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
WO2007148755A1 (ja) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
US20100173930A1 (en) * 2006-08-01 2010-07-08 Alex Muci Certain Chemical Entities, Compositions and Methods
NZ577318A (en) * 2006-11-17 2012-04-27 Nihon Mediphysics Co Ltd Novel compounds with affinity for amyloid
NZ577511A (en) * 2006-11-30 2012-04-27 Nihon Mediphysics Co Ltd 2-Phenyl-imidazo[1,2-a]pyridine derivatives substituted with a radioactive halogen substituent
US20100092385A1 (en) * 2007-01-22 2010-04-15 Astrazeneca Ab Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives
KR20100101576A (ko) * 2007-10-30 2010-09-17 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
US8420052B2 (en) * 2008-07-24 2013-04-16 Siemens Medical Solutions Usa, Inc. Imaging agents useful for identifying AD pathology
US8614201B2 (en) * 2009-06-05 2013-12-24 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of TRPA1
AU2012259929B2 (en) * 2011-05-20 2016-08-04 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
JP5167436B2 (ja) * 2011-06-24 2013-03-21 日本メジフィジックス株式会社 新規アミロイド親和性化合物
JP2013237655A (ja) 2012-05-17 2013-11-28 Kyoto Univ コンフォメーション病診断用分子プローブ
RU2015118985A (ru) * 2012-11-14 2017-01-10 Ф. Хоффманн-Ля Рош Аг Производные имидазопиридина
PL3269716T3 (pl) 2013-03-14 2021-02-08 Galapagos N.V. Nowe związki i ich kompozycje farmaceutyczne do leczenia zaburzeń zapalnych
MX386798B (es) 2014-08-29 2025-03-19 Chdi Foundation Inc Sondas para la proyección de imagen de la proteína huntingtina.
ES2818107T3 (es) 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina
US10479802B2 (en) 2014-08-29 2019-11-19 Chdi Foundation, Inc. Probes for imaging huntingtin protein
DK3186241T3 (da) 2014-08-29 2021-01-11 Chdi Foundation Inc Prober til billeddannelse af huntington-protein
PT3340796T (pt) 2015-08-28 2021-07-28 Chdi Foundation Inc Sondas para imagens da proteína huntingtina

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110065727A1 (en) 2008-03-21 2011-03-17 Sanofi-Aventis POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF
US20110171739A1 (en) 2008-09-23 2011-07-14 Wista Laboratories Ltd. Ligands for aggregated tau molecules
WO2015044095A1 (en) 2013-09-26 2015-04-02 F. Hoffmann-La Roche Ag Imidazo[1,2-a]pyridin-7-amines as imaging tools

Also Published As

Publication number Publication date
WO2016033440A1 (en) 2016-03-03
BR112017004140A2 (pt) 2017-12-12
EA039923B1 (ru) 2022-03-28
ES2905095T3 (es) 2022-04-07
SG11201701592SA (en) 2017-03-30
IL250802B (en) 2020-08-31
AU2019283999A1 (en) 2020-01-23
PL3197277T3 (pl) 2022-04-04
SI3197277T1 (sl) 2022-04-29
MX2017002702A (es) 2017-10-23
BR112017004140B1 (pt) 2023-01-10
CA2959533A1 (en) 2016-03-03
US20170283439A1 (en) 2017-10-05
CN107105667A (zh) 2017-08-29
EP3197277B1 (en) 2021-12-22
CN107105667B (zh) 2021-08-17
DK3197277T3 (da) 2022-01-31
CA2959533C (en) 2023-03-07
US11104691B2 (en) 2021-08-31
HUE057702T2 (hu) 2022-05-28
US20210380608A1 (en) 2021-12-09
KR20170047303A (ko) 2017-05-04
EA201790400A1 (ru) 2017-09-29
MX386798B (es) 2025-03-19
JP2017529340A (ja) 2017-10-05
AU2019283999B2 (en) 2021-07-22
JP6754353B2 (ja) 2020-09-09
US11851446B2 (en) 2023-12-26
EP3197277A1 (en) 2017-08-02
EP3197277A4 (en) 2018-04-18
HRP20220001T1 (hr) 2022-04-01
PT3197277T (pt) 2022-02-01
AU2015308769A1 (en) 2017-03-23
IL250802A0 (en) 2017-04-30

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