CN107105667B - 用于成像亨廷顿蛋白的探针 - Google Patents

用于成像亨廷顿蛋白的探针 Download PDF

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Publication number
CN107105667B
CN107105667B CN201580058314.XA CN201580058314A CN107105667B CN 107105667 B CN107105667 B CN 107105667B CN 201580058314 A CN201580058314 A CN 201580058314A CN 107105667 B CN107105667 B CN 107105667B
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Prior art keywords
imidazo
benzofuran
methoxy
pyridine
carbonitrile
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Chinese (zh)
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CN107105667A (zh
Inventor
C·多敏古兹
J·维恰克
J·巴德
A·基谢廖夫
C·J·布朗
M·E·普莱姆
P·D·约翰逊
D·克拉克-弗鲁
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CHDI Foundation Inc
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CHDI Foundation Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201580058314.XA 2014-08-29 2015-08-28 用于成像亨廷顿蛋白的探针 Active CN107105667B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462043590P 2014-08-29 2014-08-29
US62/043,590 2014-08-29
PCT/US2015/047401 WO2016033440A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
CN107105667A CN107105667A (zh) 2017-08-29
CN107105667B true CN107105667B (zh) 2021-08-17

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US (2) US11104691B2 (enExample)
EP (1) EP3197277B1 (enExample)
JP (1) JP6754353B2 (enExample)
KR (1) KR102410733B1 (enExample)
CN (1) CN107105667B (enExample)
AU (2) AU2015308769A1 (enExample)
BR (1) BR112017004140B1 (enExample)
CA (1) CA2959533C (enExample)
DK (1) DK3197277T3 (enExample)
EA (1) EA039923B1 (enExample)
ES (1) ES2905095T3 (enExample)
HR (1) HRP20220001T1 (enExample)
HU (1) HUE057702T2 (enExample)
IL (1) IL250802B (enExample)
MX (1) MX386798B (enExample)
PL (1) PL3197277T3 (enExample)
PT (1) PT3197277T (enExample)
SG (1) SG11201701592SA (enExample)
SI (1) SI3197277T1 (enExample)
WO (1) WO2016033440A1 (enExample)

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PL3186233T3 (pl) 2014-08-29 2022-02-28 Chdi Foundation, Inc. Sondy do obrazowania białka huntingtyny
ES2818107T3 (es) 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina
WO2016033440A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
ES2841746T3 (es) 2014-08-29 2021-07-09 Chdi Foundation Inc Sondas para la imagen de la proteína de Huntington
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
US20190381030A1 (en) * 2017-10-12 2019-12-19 University Of Kansas Methods of treating radiation induced gastrointestinal syndrome (rigs) and related disease states using yel002/bcn057
JP7619952B2 (ja) 2019-02-25 2025-01-22 シーエイチディーアイ ファウンデーション，インコーポレーテッド 変異型ハンチンチンタンパク質を標的とするための化合物及びその使用
TWI804079B (zh) 2019-05-09 2023-06-01 瑞士商赫孚孟拉羅股份公司 經標記之咪唑并[1,2-a]嘧啶之合成
CN114773312B (zh) * 2021-10-29 2024-03-26 北京鑫诺康桥药物研究有限公司 一种盐酸阿罗洛尔中间体的制备工艺

Citations (2)

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US20040023972A1 (en) * 2000-10-13 2004-02-05 Gruenenthal Gmbh Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS
CN101909658A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法

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KR20090025282A (ko) * 2006-06-21 2009-03-10 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
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US20090252680A1 (en) * 2006-11-17 2009-10-08 Nihon- Medi-Physics Co., Ltd Novel compound with affinity for amyloid
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KR20090101469A (ko) * 2007-01-22 2009-09-28 아스트라제네카 아베 신규 헤테로아릴 치환된 이미다조〔１，２­ａ〕피리딘 유도체
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PL3186233T3 (pl) 2014-08-29 2022-02-28 Chdi Foundation, Inc. Sondy do obrazowania białka huntingtyny
ES2818107T3 (es) 2014-08-29 2021-04-09 Chdi Foundation Inc Sondas para obtener imágenes de la proteína huntingtina
WO2016033440A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
ES2841746T3 (es) 2014-08-29 2021-07-09 Chdi Foundation Inc Sondas para la imagen de la proteína de Huntington
HRP20211156T1 (hr) 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina

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US20040023972A1 (en) * 2000-10-13 2004-02-05 Gruenenthal Gmbh Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS
CN101909658A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法

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AU2019283999B2 (en) 2021-07-22
EA039923B1 (ru) 2022-03-28
ES2905095T3 (es) 2022-04-07
JP2017529340A (ja) 2017-10-05
CA2959533C (en) 2023-03-07
BR112017004140A2 (pt) 2017-12-12
CA2959533A1 (en) 2016-03-03
EP3197277A1 (en) 2017-08-02
HRP20220001T1 (hr) 2022-04-01
SI3197277T1 (sl) 2022-04-29
AU2015308769A1 (en) 2017-03-23
HUE057702T2 (hu) 2022-05-28
US11851446B2 (en) 2023-12-26
JP6754353B2 (ja) 2020-09-09
KR20170047303A (ko) 2017-05-04
WO2016033440A1 (en) 2016-03-03
IL250802A0 (en) 2017-04-30
BR112017004140B1 (pt) 2023-01-10
DK3197277T3 (da) 2022-01-31
US20170283439A1 (en) 2017-10-05
KR102410733B1 (ko) 2022-06-20
EA201790400A1 (ru) 2017-09-29
CN107105667A (zh) 2017-08-29
PT3197277T (pt) 2022-02-01
IL250802B (en) 2020-08-31
AU2019283999A1 (en) 2020-01-23
MX386798B (es) 2025-03-19
US20210380608A1 (en) 2021-12-09
US11104691B2 (en) 2021-08-31
SG11201701592SA (en) 2017-03-30
PL3197277T3 (pl) 2022-04-04
MX2017002702A (es) 2017-10-23
EP3197277B1 (en) 2021-12-22
EP3197277A4 (en) 2018-04-18

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