HRP20211790T1 - Kombinirana terapija za liječenje maligniteta - Google Patents

Kombinirana terapija za liječenje maligniteta Download PDF

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Publication number
HRP20211790T1
HRP20211790T1 HRP20211790TT HRP20211790T HRP20211790T1 HR P20211790 T1 HRP20211790 T1 HR P20211790T1 HR P20211790T T HRP20211790T T HR P20211790TT HR P20211790 T HRP20211790 T HR P20211790T HR P20211790 T1 HRP20211790 T1 HR P20211790T1
Authority
HR
Croatia
Prior art keywords
idh1
inhibitor
isocitrate dehydrogenase
day
demethylating agent
Prior art date
Application number
HRP20211790TT
Other languages
English (en)
Croatian (hr)
Inventor
Samuel V. Agresta
Krishnan VISWANADHAN
Jorge Dimartino
Vivek Saroj Kumar Chopra
Kyle J. Macbeth
Robert Douglas Knight
Laurie KENVIN
Qiang Xu
Original Assignee
Les Laboratoires Servier
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier, Celgene Corporation filed Critical Les Laboratoires Servier
Publication of HRP20211790T1 publication Critical patent/HRP20211790T1/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HRP20211790TT 2015-10-15 2016-10-14 Kombinirana terapija za liječenje maligniteta HRP20211790T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562242282P 2015-10-15 2015-10-15
PCT/US2016/057042 WO2017066571A1 (en) 2015-10-15 2016-10-14 Combination therapy for treating malignancies
EP16856278.3A EP3362066B1 (en) 2015-10-15 2016-10-14 Combination therapy for treating malignancies

Publications (1)

Publication Number Publication Date
HRP20211790T1 true HRP20211790T1 (hr) 2022-03-04

Family

ID=58518368

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20211790TT HRP20211790T1 (hr) 2015-10-15 2016-10-14 Kombinirana terapija za liječenje maligniteta

Country Status (28)

Country Link
US (2) US10653710B2 (OSRAM)
EP (1) EP3362066B1 (OSRAM)
JP (1) JP7033061B2 (OSRAM)
KR (1) KR102699521B1 (OSRAM)
CN (1) CN108697698B (OSRAM)
AU (1) AU2016338557B2 (OSRAM)
CA (1) CA3002068A1 (OSRAM)
CL (1) CL2018000943A1 (OSRAM)
CY (1) CY1124951T1 (OSRAM)
DK (1) DK3362066T3 (OSRAM)
EA (1) EA039829B1 (OSRAM)
ES (1) ES2897959T3 (OSRAM)
HR (1) HRP20211790T1 (OSRAM)
HU (1) HUE057263T2 (OSRAM)
IL (1) IL258685B (OSRAM)
LT (1) LT3362066T (OSRAM)
MA (1) MA43000B1 (OSRAM)
MD (1) MD3362066T2 (OSRAM)
MX (1) MX386735B (OSRAM)
PL (1) PL3362066T3 (OSRAM)
PT (1) PT3362066T (OSRAM)
RS (1) RS62829B1 (OSRAM)
SG (2) SG10202111435UA (OSRAM)
SI (1) SI3362066T1 (OSRAM)
SM (1) SMT202100658T1 (OSRAM)
UA (1) UA123400C2 (OSRAM)
WO (1) WO2017066571A1 (OSRAM)
ZA (1) ZA201803166B (OSRAM)

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US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
KR20220070066A (ko) 2014-03-14 2022-05-27 아지오스 파마슈티컬스 아이엔씨. 치료적으로 활성인 화합물의 약제학적 조성물
PT3362065T (pt) 2015-10-15 2024-06-21 Servier Lab Terapia de combinação compreendendo ivosidenib, citarabina e daunorubicina ou idarubicina para o tratamento de leucemia mielóide aguda
US10653710B2 (en) 2015-10-15 2020-05-19 Agios Pharmaceuticals, Inc. Combination therapy for treating malignancies
CA3067035A1 (en) 2017-06-12 2018-12-20 Agios Pharmaceuticals, Inc. Methods of treating brain tumors using combination therapy
WO2019025256A1 (en) * 2017-08-01 2019-02-07 Bayer Aktiengesellschaft COMBINATION OF MIDH1 INHIBITORS AND DNA HYPOMETHYLATION (AHM) AGENTS
WO2019099653A1 (en) * 2017-11-16 2019-05-23 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
US12264148B2 (en) * 2018-07-06 2025-04-01 Servier Pharmaceuticals Llc Ivosidenib forms and pharmaceutical compositions
CN109224061B (zh) * 2018-11-16 2022-01-07 上海市肺科医院 化合物ag120或其药学上可接受的盐在制备预防或治疗结核病的药物中的用途
JP2022537384A (ja) 2019-06-20 2022-08-25 セルジーン コーポレーション ベネトクラクス、ギルテリチニブ、ミドスタウリン、または白血病もしくは骨髄異形成症候群を治療するための他の化合物との組み合わせにおけるアザシチジン
GB201912411D0 (en) * 2019-08-29 2019-10-16 Johnson Matthey Plc Crystalline forms of ivosidenib
EP4041922A4 (en) 2019-10-07 2023-11-01 University Hospitals Cleveland Medical Center METHOD FOR TREATING WILD-TYPE ISOCITRATE DEHYDROGENASE-1 CANCER
GB2590601B (en) * 2019-11-13 2024-01-31 Thermo Fisher Scient Bremen Gmbh Method of mass spectrometry
IL296092A (en) 2020-03-23 2022-11-01 Lilly Co Eli Combination therapy with a mutant idh inhibitor

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