HRP20191096T1 - Sastavi koje sadrže bakterijske blautia sojeve za liječenje visceralne hipersenzitivnosti - Google Patents
Sastavi koje sadrže bakterijske blautia sojeve za liječenje visceralne hipersenzitivnosti Download PDFInfo
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- HRP20191096T1 HRP20191096T1 HRP20191096TT HRP20191096T HRP20191096T1 HR P20191096 T1 HRP20191096 T1 HR P20191096T1 HR P20191096T T HRP20191096T T HR P20191096TT HR P20191096 T HRP20191096 T HR P20191096T HR P20191096 T1 HRP20191096 T1 HR P20191096T1
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- visceral hypersensitivity
- prevention
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- 239000000203 mixture Substances 0.000 title claims 22
- 206010020751 Hypersensitivity Diseases 0.000 title claims 11
- 208000026935 allergic disease Diseases 0.000 title claims 11
- 230000009610 hypersensitivity Effects 0.000 title claims 11
- 230000009278 visceral effect Effects 0.000 title claims 11
- 230000001580 bacterial effect Effects 0.000 title claims 8
- 241001202853 Blautia Species 0.000 title 1
- 230000002265 prevention Effects 0.000 claims 8
- 241000520742 Blautia hydrogenotrophica Species 0.000 claims 5
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 5
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 5
- 108020004465 16S ribosomal RNA Proteins 0.000 claims 4
- 206010009900 Colitis ulcerative Diseases 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 4
- 201000006549 dyspepsia Diseases 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 2
- 208000002881 Colic Diseases 0.000 claims 2
- 206010021746 Infantile colic Diseases 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
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Claims (14)
1. Sastav koja obuhvaća bakterijski soj vrste Blautia hydrogenotrophica, za upotrebu u postupku liječenja ili prevenciji visceralne hipersenzitivnosti.
2. Sastav za upotrebu prema zahtjevu 1, gdje je visceralna hipersenzitivnost povezana sa IBS-om, Chronovom bolesti, ulceroznim kolitisom, funkcionalnom dispepsijom ili dojenačkim kolikama.
3. Sastav za upotrebu prema zahtjevu 2, gdje je visceralna hipersenzitivnost povezana sa IBS-om, Chronovom bolesti, ulceroznim kolitisom ili funkcionalnom dispepsijom.
4. Sastav za upotrebu prema zahtjevu 1, gdje je sastav za upotrebu u liječenju ili prevenciji visceralne hipersenzitivnosti kod subjekta kome je dijagnosticiran IBS, Chronova bolest, ulcerozni kolitis, funkcionalna dispepsija ili dojenačke kolike.
5. Sastav za upotrebu prema zahtjevu 4, gdje je sastav za upotrebu u liječenju ili prevenciji visceralne hipersenzitivnosti kod subjekta kome je dijagnosticiran IBS, Chronova bolest, ulcerozni kolitis ili funkcionalna dispepsija.
6. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, gdje je sastav za upotrebu u:
(i) smanjenju kolonizacije gastrointestinalnog trakta upotrebom bakterija koje reduciraju sulfate (SRB) u liječenju ili prevenciji visceralne hipersenzitivnosti; ili
(ii) snižavanju H2S razina ili sprječavanju povećanja H2S razina u gastrointestinalnom traktu u liječenju ili prevenciji visceralne hipersenzitivnosti; ili
(iii) liječenju ili prevenciji visceralne hipersenzitivnosti kod pacijenta koji pati od bolne distenzije gastrointestinalnog trakta, posebno u debelom crijevu ili rektumu.
7. Sastav za upotrebu prema zahtjevima 1-6, gdje bakterijski soj ima 16s rRNK sekvencu koja je najmanje 95%, 96%, 97%, 98%, 99%, 99.5% ili 99.9% identična sa 16s rRNK sekvencom bakterijskog soja Blautia hydrogenotrophica.
8. Sastav za upotrebu prema zahtjevu 7, gdje bakterijski soj ima 16s rRNK sekvencu koja je najmanje 97%, 98%, 99%, 99.5% ili 99.9% identična sa SEQ ID NO:5 ili koja ima 16s rRNK sekvencu SEQ ID NO:5.
9. Sastav za upotrebu prema zahtjevu 1, gdje sastav obuhvaća bakterijski soj vrste Blautia hydrogenotrophica, za upotrebu u:
(i) postupku liječenja ili prevenciji visceralne hipersenzitivnosti kod subjekta kojem je dijagnosticiran IBS; ili
(ii) smanjenju kolonizacije gastrointestinalnog trakta upotrebom bakterija koje reduciraju sulfate (SRB), snižavanjem H2S razina ili prevenciji povećanja H2S razina u gastrointestinalnom traktu u liječenju ili prevenciji visceralne hipersenzitivnosti.
10. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, gdje je sastav za oralnu primjenu.
11. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, gdje sastav obuhvaća jedan ili više farmaceutski prihvatljivih pomoćnih tvari ili nosača.
12. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, gdje je bakterijski soj liofiliziran ili je održiv.
13. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, pri čemu sastav obuhvaća 10 pojedinačnih sojeva vrste Blautia hydrogenotrophica.
14. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, koji obuhvaća bakterijski soj Blautia hydrogenotrophica kao dio mikrobnog konzorcija.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1603817.6A GB201603817D0 (en) | 2016-03-04 | 2016-03-04 | Compositions comprising bacterial strains |
GBGB1612191.5A GB201612191D0 (en) | 2016-07-13 | 2016-07-13 | Compositions comprising bacterial strains |
GBGB1616022.8A GB201616022D0 (en) | 2016-07-13 | 2016-09-20 | Compositions comprising bacterial strains |
EP17709911.6A EP3313423B1 (en) | 2016-03-04 | 2017-03-06 | Compositions comprising bacterial blautia strains for treating visceral hypersensitivity |
PCT/EP2017/025038 WO2017148596A1 (en) | 2016-03-04 | 2017-03-06 | Compositions comprising bacterial blautia strains for treating visceral hypersensitivity |
Publications (1)
Publication Number | Publication Date |
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HRP20191096T1 true HRP20191096T1 (hr) | 2019-09-20 |
Family
ID=59742619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20191096TT HRP20191096T1 (hr) | 2016-03-04 | 2019-06-17 | Sastavi koje sadrže bakterijske blautia sojeve za liječenje visceralne hipersenzitivnosti |
Country Status (30)
Country | Link |
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US (4) | US10086023B2 (hr) |
EP (2) | EP3313423B1 (hr) |
JP (3) | JP6441536B2 (hr) |
KR (1) | KR102010207B1 (hr) |
CN (2) | CN108883139B (hr) |
AU (2) | AU2017226831B2 (hr) |
BR (1) | BR112018067689A2 (hr) |
CA (1) | CA3016179C (hr) |
CO (1) | CO2018010459A2 (hr) |
CY (1) | CY1122142T1 (hr) |
DK (1) | DK3313423T3 (hr) |
EA (1) | EA035949B1 (hr) |
ES (1) | ES2731579T3 (hr) |
HK (1) | HK1246670B (hr) |
HR (1) | HRP20191096T1 (hr) |
HU (1) | HUE044051T2 (hr) |
IL (2) | IL261371B (hr) |
LT (1) | LT3313423T (hr) |
MA (1) | MA42560B1 (hr) |
MD (1) | MD3313423T2 (hr) |
ME (1) | ME03487B (hr) |
MX (2) | MX2018010680A (hr) |
NZ (1) | NZ745678A (hr) |
PL (1) | PL3313423T3 (hr) |
PT (1) | PT3313423T (hr) |
RS (1) | RS58869B1 (hr) |
SG (2) | SG11201807195VA (hr) |
SI (1) | SI3313423T1 (hr) |
TW (1) | TW201733601A (hr) |
WO (1) | WO2017148596A1 (hr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
NO3065748T3 (hr) | 2014-12-23 | 2018-04-21 | ||
SI3193901T1 (en) | 2014-12-23 | 2018-06-29 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
CN107847529B (zh) | 2015-06-15 | 2022-05-03 | 4D制药研究有限公司 | 包含细菌菌株的组合物 |
MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
HUE045754T2 (hu) | 2015-06-15 | 2020-01-28 | 4D Pharma Res Ltd | Blautia stercosis és wexlerae gyulladásos és autoimmun betegségek kezelésében történõ alkalmazásra |
PT3206700T (pt) | 2015-06-15 | 2019-08-21 | 4D Pharma Res Ltd | Composições compreendendo estirpes bacterianas |
MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
HUE036362T2 (hu) | 2015-11-20 | 2018-07-30 | 4D Pharma Res Ltd | Baktériumtörzseket tartalmazó készítmények |
GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
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