HRP20160531T1 - Dinukleotidni prolijekovi - Google Patents

Dinukleotidni prolijekovi Download PDF

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Publication number
HRP20160531T1
HRP20160531T1 HRP20160531TT HRP20160531T HRP20160531T1 HR P20160531 T1 HRP20160531 T1 HR P20160531T1 HR P20160531T T HRP20160531T T HR P20160531TT HR P20160531 T HRP20160531 T HR P20160531T HR P20160531 T1 HRP20160531 T1 HR P20160531T1
Authority
HR
Croatia
Prior art keywords
alkyl
aryl
image
formula
compound
Prior art date
Application number
HRP20160531TT
Other languages
English (en)
Croatian (hr)
Inventor
Radhakrishnan P. Iyer
Seetharamaiyer Padmanabhan
Original Assignee
Spring Bank Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spring Bank Pharmaceuticals, Inc. filed Critical Spring Bank Pharmaceuticals, Inc.
Publication of HRP20160531T1 publication Critical patent/HRP20160531T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
HRP20160531TT 2005-12-13 2006-12-13 Dinukleotidni prolijekovi HRP20160531T1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75003605P 2005-12-13 2005-12-13
US80029406P 2006-05-15 2006-05-15
US11/637,520 US8076303B2 (en) 2005-12-13 2006-12-12 Nucleotide and oligonucleotide prodrugs
EP06848625.7A EP1968612B1 (en) 2005-12-13 2006-12-13 Dinucleotide prodrugs
PCT/US2006/047617 WO2007070598A2 (en) 2005-12-13 2006-12-13 Nucleotide and oligonucleotide prodrugs

Publications (1)

Publication Number Publication Date
HRP20160531T1 true HRP20160531T1 (hr) 2016-08-12

Family

ID=38194676

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20160531TT HRP20160531T1 (hr) 2005-12-13 2006-12-13 Dinukleotidni prolijekovi

Country Status (17)

Country Link
US (6) US8076303B2 (enExample)
EP (3) EP3553072A1 (enExample)
JP (1) JP5044854B2 (enExample)
KR (2) KR101123534B1 (enExample)
CN (2) CN102796155B (enExample)
CY (2) CY1117576T1 (enExample)
DK (2) DK3090748T3 (enExample)
ES (2) ES2573928T3 (enExample)
HR (1) HRP20160531T1 (enExample)
HU (2) HUE044034T2 (enExample)
IN (1) IN2015DN01786A (enExample)
LT (1) LT3090748T (enExample)
PL (2) PL1968612T3 (enExample)
PT (1) PT3090748T (enExample)
RS (1) RS54867B1 (enExample)
SI (2) SI3090748T1 (enExample)
WO (1) WO2007070598A2 (enExample)

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CN101659612B (zh) * 2009-09-24 2013-01-09 华润赛科药业有限责任公司 一种选择性酯化的方法
US9040234B2 (en) * 2010-08-30 2015-05-26 Spring Bank Pharmaceuticals, Inc. Oligonucleotide analogs as therapeutic agents
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CN107365339A (zh) 2011-07-19 2017-11-21 波涛生命科学有限公司 合成官能化核酸的方法
KR101327026B1 (ko) 2011-11-29 2013-11-13 현대자동차주식회사 운전자 보호장치
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CN105992587A (zh) * 2013-02-18 2016-10-05 春堤制药公司 作为疫苗佐剂和治疗试剂的短寡核苷酸的设计
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EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
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CN106794188B (zh) 2014-09-28 2022-12-02 华辉安健（北京）生物科技有限公司 聚合胆汁酸衍生物抑制乙型肝炎病毒和丁型肝炎病毒和ntcp运输
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CN110467647B (zh) * 2018-05-09 2022-08-30 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物的制备方法
CN110467646A (zh) * 2018-05-09 2019-11-19 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物
WO2019219070A1 (zh) * 2018-05-18 2019-11-21 正大天晴药业集团股份有限公司 氘代的低聚核苷酸及前体药物
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Also Published As

Publication number Publication date
KR101248873B1 (ko) 2013-04-02
RS54867B1 (sr) 2016-10-31
ES2573928T3 (es) 2016-06-13
SI3090748T1 (sl) 2019-09-30
US10047114B2 (en) 2018-08-14
EP1968612B1 (en) 2016-03-09
EP3553072A1 (en) 2019-10-16
HUE044034T2 (hu) 2019-09-30
PT3090748T (pt) 2019-06-04
WO2007070598A9 (en) 2007-11-08
US20070149462A1 (en) 2007-06-28
DK1968612T3 (en) 2017-05-22
EP3090748B1 (en) 2019-02-20
WO2007070598A3 (en) 2008-10-30
CN102796155A (zh) 2012-11-28
EP1968612A4 (en) 2013-01-09
EP1968612A2 (en) 2008-09-17
US10344046B2 (en) 2019-07-09
PL1968612T3 (pl) 2016-11-30
SI1968612T1 (sl) 2016-10-28
JP2009519345A (ja) 2009-05-14
LT3090748T (lt) 2019-08-26
CY1117576T1 (el) 2017-04-26
CN101437397B (zh) 2012-09-05
WO2007070598A8 (en) 2008-12-31
US20180273574A1 (en) 2018-09-27
CN101437397A (zh) 2009-05-20
US8076303B2 (en) 2011-12-13
KR20080072084A (ko) 2008-08-05
WO2007070598A2 (en) 2007-06-21
US20140323554A1 (en) 2014-10-30
US20160060287A1 (en) 2016-03-03
CY1121639T1 (el) 2020-07-31
KR20110125677A (ko) 2011-11-21
US20200087338A1 (en) 2020-03-19
PL3090748T3 (pl) 2020-03-31
US8691787B2 (en) 2014-04-08
US20120264709A1 (en) 2012-10-18
CN102796155B (zh) 2015-08-26
JP5044854B2 (ja) 2012-10-10
DK3090748T3 (da) 2019-05-27
EP3090748A1 (en) 2016-11-09
ES2729657T3 (es) 2019-11-05
KR101123534B1 (ko) 2012-03-13
HUE029190T2 (en) 2017-02-28
IN2015DN01786A (enExample) 2015-07-10

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