HRP20141251T1 - Ekstracelularna hijaluronidaza iz streptomyces koganeiensis - Google Patents
Ekstracelularna hijaluronidaza iz streptomyces koganeiensis Download PDFInfo
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- HRP20141251T1 HRP20141251T1 HRP20141251TT HRP20141251T HRP20141251T1 HR P20141251 T1 HRP20141251 T1 HR P20141251T1 HR P20141251T T HRP20141251T T HR P20141251TT HR P20141251 T HRP20141251 T HR P20141251T HR P20141251 T1 HRP20141251 T1 HR P20141251T1
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- Croatia
- Prior art keywords
- hyaluronidase
- protein fraction
- activity
- hyaluronic acid
- exchange chromatography
- Prior art date
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- 241001052688 Streptomyces koganeiensis Species 0.000 title claims 3
- 108010003272 Hyaluronate lyase Proteins 0.000 claims 15
- 102000001974 Hyaluronidases Human genes 0.000 claims 15
- 229960002773 hyaluronidase Drugs 0.000 claims 15
- 230000000694 effects Effects 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 238000002305 strong-anion-exchange chromatography Methods 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 208000031462 Bovine Mastitis Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000001034 Frostbite Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 208000025157 Oral disease Diseases 0.000 claims 1
- 208000034698 Vitreous haemorrhage Diseases 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 229960004784 allergens Drugs 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 238000011026 diafiltration Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000030194 mouth disease Diseases 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 238000012437 strong cation exchange chromatography Methods 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 238000003989 weak cation exchange chromatography Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
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- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Claims (15)
1. Hijaluronidaza iz Streptomyces koganeiensis ATC 31394 koja sadrži N-terminalni slijed aminokiselina prikazan identifikacijskim brojem slijeda SEQ ID Br. 1 i ima molekulsku težinu od 21,6 kDa, izoelektričnu točku (pI) u rasponu od 4.4 do 4.8 i enzimsku aktivnost jednaku ili veću od 40,000 I.U./mg.
2. Postupak za pripremu hijaluronidaze u skladu s patentnim zahtjevom 1 obuhvaća sljedeće korake:
3. izlaganje supernatanta dobivenog fermentacijom Streptomyces koganeiensis ATC 31394 slaboj kationskoj izmjenjivačkoj kromatografiji i izoliranje frakcije proteina s aktivnošću hijaluronidaze;
4. izlaganje frakcije proteina s aktivnošću hijaluronidaze iz koraka a) dijafiltraciji i jakoj anionskoj izmjenjivačkoj kromatografiji i izoliranje frakcije proteina s aktivnošću hijaluronidaze;
5. izlaganje frakcije proteina s aktivnošću hijaluronidaze iz koraka b) jakoj kationskoj izmjenjivačkoj kromatografiji i izoliranje frakcije proteina s aktivnošću hijaluronidaze;
6. izlaganje frakcije proteina s aktivnošću hijaluronidaze iz koraka c) jakoj anionskoj izmjenjivačkoj kromatografiji i izoliranje frakcije proteina s aktivnošću hijaluronidaze.
7. Hijaluronidaza u skladu s patentnim zahtjevom 1 za uporabu kao lijek.
8. Hijaluronidaza u skladu s patentnim zahtjevom 3 za uporabu u liječenju bolesti u kojih je korisna ili poželjna razgradnja hijaluronske kiseline u zahvaćenim tkivima ili organima.
9. Hijaluronidaza za uporabu u skladu s patentnim zahtjevom 4 pri čemu su bolesti odabrane između edema, upale, ozeblina, solidnih tumora, IgE-posredovanih alergija, bolesti usne šupljine i spontanih krvarenja u staklovinu.
10. Hijaluronidaza za uporabu u skladu s patentnim zahtjevom 4 pri čemu je bolest goveđi mastitis.
11. Farmaceutski ili veterinarski sastavi koji sadrže hijaluronidazu iz patentnog zahtjeva 1 u smjesi s odgovarajućim ekscipijensima i/ili nosačima.
12. Sastavi u skladu s patentnim zahtjevom 7 u obliku injektibilnih pripravaka ili topikalnih pripravaka za epidermanu, transdermalnu ili oftalmološku primjenu.
13. Sastavi u skladu s patentnim zahtjevom 7 ili 8 nadalje sadrže jedno ili više aktivnih načela odabranih između: steroidnih i nesteroidnih protuupalnih lijekova, protutumorskih agenasa, alergena, lokalnih anestetika, antibiotika, monoklonskih protutijela, citokina, enzima i sulfatirane hijaluronske kiseline.
14. Sastavi u skladu s patentnim zahtjevom 9 u kojima je aktivno načelo sulfatirana hijaluronska kiselina i topikalni sastav za epidermalnu primjenu je u obliku kreme, gela, masti ili raspršivača.
15. Uporaba hijaluronidaze u skladu s patentnim zahtjevom 1 kao reagensa u biokemijskim određivanjima za kvalitativno/kvantitativno određivanje hijaluronske kiseline.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A000831A IT1396003B1 (it) | 2009-05-14 | 2009-05-14 | Ialuronidasi extracellulare da streptomyces koganeiensis |
| EP10718616.5A EP2432874B1 (en) | 2009-05-14 | 2010-05-12 | Extracellular yaluronidase from streptomyces koganeiensis |
| PCT/EP2010/056596 WO2010130810A1 (en) | 2009-05-14 | 2010-05-12 | Extracellular yaluronidase from streptomyces koganeiensis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20141251T1 true HRP20141251T1 (hr) | 2015-04-24 |
Family
ID=41319602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20141251TT HRP20141251T1 (hr) | 2009-05-14 | 2014-12-22 | Ekstracelularna hijaluronidaza iz streptomyces koganeiensis |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20120219554A2 (hr) |
| EP (1) | EP2432874B1 (hr) |
| CN (1) | CN102439144B (hr) |
| CA (1) | CA2759373C (hr) |
| DK (1) | DK2432874T3 (hr) |
| ES (1) | ES2527618T3 (hr) |
| HK (1) | HK1165487A1 (hr) |
| HR (1) | HRP20141251T1 (hr) |
| HU (1) | HUE024101T2 (hr) |
| IT (1) | IT1396003B1 (hr) |
| PL (1) | PL2432874T3 (hr) |
| RU (1) | RU2553205C2 (hr) |
| SI (1) | SI2432874T1 (hr) |
| SM (1) | SMT201500006B (hr) |
| WO (1) | WO2010130810A1 (hr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1396003B1 (it) * | 2009-05-14 | 2012-11-09 | Fidia Farmaceutici | Ialuronidasi extracellulare da streptomyces koganeiensis |
| CZ302503B6 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace |
| CZ2009836A3 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace |
| CN103255076B (zh) | 2012-02-21 | 2015-09-30 | 华熙福瑞达生物医药有限公司 | 一种芽孢杆菌、一种透明质酸酶及其制备方法和用途 |
| CZ2012136A3 (cs) | 2012-02-28 | 2013-06-05 | Contipro Biotech S.R.O. | Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CZ304512B6 (cs) | 2012-08-08 | 2014-06-11 | Contipro Biotech S.R.O. | Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití |
| CZ304140B6 (cs) | 2012-09-27 | 2013-11-13 | Contipro Biotech S.R.O. | Enzym hyaluronan-lyáza, zpusob jeho výroby, pouzití a zpusob prípravy nízkomolekulárního hyaluronanu |
| KR101454646B1 (ko) * | 2012-11-05 | 2014-10-27 | (주)한국비엠아이 | 히알루로니다아제의 안정화 제제 및 이를 포함하는 액상제제 |
| CZ2012842A3 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| ITMI20130992A1 (it) | 2013-06-17 | 2014-12-18 | Fidia Farmaceutici | Ialuronidasi batterica e metodo per la sua produzione |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| CZ305153B6 (cs) | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| CZ306479B6 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| JP2018531065A (ja) * | 2015-10-02 | 2018-10-25 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 多チャンバシリンジユニットおよび多チャンバシリンジを作製する方法 |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| RU2658605C2 (ru) * | 2016-07-01 | 2018-06-21 | Наталья Владимировна Глазова | Способ получения гиалуронидазы из семенников крупного рогатого скота |
| KR102439221B1 (ko) | 2017-12-14 | 2022-09-01 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| RU2692061C1 (ru) * | 2018-06-21 | 2019-06-20 | Федеральное государственное бюджетное образовательное учреждение высшего образования Санкт-Петербургская государственная академия ветеринарной медицины ФГБОУ ВО СПбГАВМ | Способ лечения хронического мастита у коров с помощью медицинских пиявок |
| CN109880758B (zh) * | 2019-03-05 | 2020-11-10 | 山东安华生物医药股份有限公司 | 一种植物乳杆菌诱变菌株及其诱变方法和应用 |
| CN115671267A (zh) * | 2021-07-23 | 2023-02-03 | 上海宝济药业有限公司 | 一种皮下抗生素药物组合物 |
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|---|---|---|---|---|
| JPS6033474B2 (ja) * | 1978-05-11 | 1985-08-02 | 藤沢薬品工業株式会社 | 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法 |
| SU1723121A1 (ru) * | 1990-01-19 | 1992-03-30 | Всесоюзный Научно-Исследовательский Институт Биотехнологии | Способ получени гиалуронидазы |
| US5270051A (en) * | 1991-10-15 | 1993-12-14 | Harris Donald H | Enzyme-orthokeratology |
| RU2005488C1 (ru) * | 1992-06-16 | 1994-01-15 | Российская фармацевтическая компания "Фарма" | Средство для лечения болезней соединительной ткани |
| ITPD980037A1 (it) * | 1998-02-25 | 1999-08-25 | Fidia Advanced Biopolymers Srl | Acido ialuronico solfatato e i suoi derivati legati covalentemente a polimeri sintetici pe la preparazione di biomateriali e per il rivesti |
| ITPD20060219A1 (it) * | 2006-05-31 | 2007-12-01 | Fidia Farmaceutici | Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi |
| RU2471867C2 (ru) * | 2007-06-19 | 2013-01-10 | Тамара П. Уваркина | Гиалуронидаза и способ ее применения |
| IT1396003B1 (it) * | 2009-05-14 | 2012-11-09 | Fidia Farmaceutici | Ialuronidasi extracellulare da streptomyces koganeiensis |
-
2009
- 2009-05-14 IT ITMI2009A000831A patent/IT1396003B1/it active
- 2009-05-14 US US13/318,476 patent/US20120219554A2/en not_active Abandoned
-
2010
- 2010-05-12 WO PCT/EP2010/056596 patent/WO2010130810A1/en active Application Filing
- 2010-05-12 SI SI201030842T patent/SI2432874T1/sl unknown
- 2010-05-12 CN CN201080021089.XA patent/CN102439144B/zh active Active
- 2010-05-12 DK DK10718616.5T patent/DK2432874T3/en active
- 2010-05-12 ES ES10718616.5T patent/ES2527618T3/es active Active
- 2010-05-12 RU RU2011150814/10A patent/RU2553205C2/ru active
- 2010-05-12 PL PL10718616T patent/PL2432874T3/pl unknown
- 2010-05-12 CA CA2759373A patent/CA2759373C/en active Active
- 2010-05-12 EP EP10718616.5A patent/EP2432874B1/en active Active
- 2010-05-12 HU HUE10718616A patent/HUE024101T2/hu unknown
-
2012
- 2012-06-20 HK HK12106088.6A patent/HK1165487A1/xx unknown
-
2014
- 2014-12-22 HR HRP20141251TT patent/HRP20141251T1/hr unknown
-
2015
- 2015-01-08 SM SM201500006T patent/SMT201500006B/xx unknown
-
2016
- 2016-08-02 US US15/226,593 patent/US10208300B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20120070441A1 (en) | 2012-03-22 |
| PL2432874T3 (pl) | 2015-03-31 |
| US20120219554A2 (en) | 2012-08-30 |
| CA2759373A1 (en) | 2010-11-18 |
| SMT201500006B (it) | 2015-03-05 |
| ES2527618T3 (es) | 2015-01-27 |
| CA2759373C (en) | 2018-06-12 |
| RU2011150814A (ru) | 2013-06-20 |
| US10208300B2 (en) | 2019-02-19 |
| WO2010130810A1 (en) | 2010-11-18 |
| CN102439144B (zh) | 2014-05-21 |
| HUE024101T2 (hu) | 2016-02-29 |
| ITMI20090831A1 (it) | 2010-11-15 |
| RU2553205C2 (ru) | 2015-06-10 |
| CN102439144A (zh) | 2012-05-02 |
| IT1396003B1 (it) | 2012-11-09 |
| EP2432874A1 (en) | 2012-03-28 |
| DK2432874T3 (en) | 2015-01-19 |
| EP2432874B1 (en) | 2014-10-29 |
| HK1165487A1 (en) | 2012-10-05 |
| SI2432874T1 (sl) | 2015-03-31 |
| US20170101634A1 (en) | 2017-04-13 |
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