HRP20130202T1 - Spojevi imidazo[1,2-a] pirazina za lijeäśenje virusnih infekcija kao što je hepatitis - Google Patents
Spojevi imidazo[1,2-a] pirazina za lijeäśenje virusnih infekcija kao što je hepatitis Download PDFInfo
- Publication number
- HRP20130202T1 HRP20130202T1 HRP20130202AT HRP20130202T HRP20130202T1 HR P20130202 T1 HRP20130202 T1 HR P20130202T1 HR P20130202A T HRP20130202A T HR P20130202AT HR P20130202 T HRP20130202 T HR P20130202T HR P20130202 T1 HRP20130202 T1 HR P20130202T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound according
- och3
- halogen
- alkyl
- nhcor8
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0716292.8A GB0716292D0 (en) | 2007-08-21 | 2007-08-21 | Imidazopyrazine compounds |
| PCT/EP2008/060896 WO2009024585A2 (en) | 2007-08-21 | 2008-08-20 | Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130202T1 true HRP20130202T1 (hr) | 2013-04-30 |
Family
ID=38566736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130202AT HRP20130202T1 (hr) | 2007-08-21 | 2008-08-20 | Spojevi imidazo[1,2-a] pirazina za lijeäśenje virusnih infekcija kao što je hepatitis |
Country Status (20)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0716292D0 (en) * | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
| JP5216912B2 (ja) | 2008-04-29 | 2013-06-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1受容体拮抗薬としてのインダゾール化合物 |
| JP5411927B2 (ja) | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1アンタゴニストとしてのピラゾール化合物 |
| PE20110854A1 (es) | 2008-09-26 | 2011-12-23 | Boehringer Ingelheim Int | DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1 |
| TW201107329A (en) | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
| AP2012006204A0 (en) | 2009-10-21 | 2012-04-30 | Boehringer Ingelheim Int | Indazole and pyrazolopyridine compounds as CCR1 receptor antagonists. |
| JP5542214B2 (ja) | 2009-10-27 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1受容体アンタゴニストとしての複素環化合物 |
| PH12012500778A1 (en) | 2009-10-30 | 2012-11-26 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
| IN2012DN05081A (cg-RX-API-DMAC10.html) * | 2009-12-08 | 2015-10-09 | Boehringer Ingelheim Int | |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| ES2551407T3 (es) * | 2010-03-18 | 2015-11-18 | Bayer Intellectual Property Gmbh | Imidazopirazinas |
| US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
| CN103038235B (zh) | 2010-06-01 | 2015-07-29 | 拜耳知识产权有限责任公司 | 取代的咪唑并吡嗪 |
| CA2821829A1 (en) * | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| US20140135319A1 (en) | 2010-12-17 | 2014-05-15 | Bayer Intellectual Property Gmbh | 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| WO2012080228A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Pharma Aktiengesellschaft | 6-thio-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| WO2012080232A1 (en) * | 2010-12-17 | 2012-06-21 | Bayer Pharma Aktiengesellschaft | 2-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| US9284317B2 (en) * | 2010-12-17 | 2016-03-15 | Bayer Intellectual Property Gmbh | Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors |
| US20140187548A1 (en) | 2010-12-17 | 2014-07-03 | Bayer Intellectual Property Gmbh | 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| US8546442B2 (en) | 2010-12-23 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Pyrazolopiperidine compounds as CCR1 receptor antagonists |
| GB201109763D0 (en) * | 2011-06-10 | 2011-07-27 | Ucl Business Plc | Compounds |
| JP6115962B2 (ja) | 2011-06-27 | 2017-04-19 | ヤンセン ファーマシューティカ エヌ.ベー. | 1−アリール−4−メチル−[1,2,4]トリアゾロ[4,3−a]キノキサリン誘導体 |
| JPWO2013061962A1 (ja) * | 2011-10-24 | 2015-04-02 | 武田薬品工業株式会社 | 二環性化合物 |
| WO2014001314A1 (en) | 2012-06-26 | 2014-01-03 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| AU2013289284B2 (en) | 2012-07-09 | 2017-03-30 | Janssen Pharmaceutica Nv | Inhibitors of phosphodiesterase 10 enzyme |
| WO2016130501A1 (en) | 2015-02-09 | 2016-08-18 | Incyte Corporation | Aza-heteroaryl compounds as pi3k-gamma inhibitors |
| BR112017023038A2 (pt) * | 2015-04-29 | 2018-07-03 | Janssen Pharmaceutica Nv | imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa |
| BR122023023802A2 (pt) | 2015-04-29 | 2023-12-26 | Janssen Pharmaceutica Nv | Compostos azabenzimidazóis, seu uso como moduladores do receptor de ampa e composições farmacêuticas que os compreendem |
| CN107949563B (zh) * | 2015-06-24 | 2020-06-05 | 库洛维公司 | 治疗中有用的吡唑并[1,5-a]三嗪-4-胺衍生物 |
| JP6507976B2 (ja) * | 2015-09-30 | 2019-05-08 | 東レ株式会社 | イミダゾール−2−カルボン酸エステル誘導体又はその塩の製造方法 |
| RS63359B1 (sr) | 2015-11-06 | 2022-07-29 | Incyte Corp | Heterociklična jedinjenja kao inhibitori pi3k-gama |
| ES2995198T3 (en) | 2016-01-05 | 2025-02-07 | Incyte Corp | Pyridine compounds as pi3k-gamma inhibitors |
| HK1250945A1 (zh) * | 2016-03-31 | 2019-01-18 | 罗马克实验室有限公司 | 用於治疗病毒性感染的噻唑化物化合物 |
| TW201803871A (zh) | 2016-06-24 | 2018-02-01 | 英塞特公司 | 作為PI3K-γ抑制劑之雜環化合物 |
| UY37381A (es) | 2016-08-30 | 2018-03-23 | Glaxosmithkline Ip No 2 Ltd | Compuestos que inhiben proteasas 3c y 3cl y métodos de uso de los mismos |
| KR102717072B1 (ko) | 2017-10-18 | 2024-10-15 | 인사이트 코포레이션 | Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체 |
| JP7133023B2 (ja) | 2018-01-17 | 2022-09-07 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Pi4kiiiベータ阻害剤 |
| TWI811428B (zh) | 2018-08-21 | 2023-08-11 | 日商杏林製藥股份有限公司 | 雙環雜芳香環衍生物 |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165) |
| CN109369545B (zh) * | 2018-12-14 | 2020-04-10 | 东营曜康医药科技有限公司 | 2-甲基-5-甲酸吡嗪的合成工艺 |
| US20230014730A1 (en) | 2019-09-23 | 2023-01-19 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Phosphodiesterase inhibitors and use |
| WO2021061803A1 (en) | 2019-09-23 | 2021-04-01 | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. | Phosphodiesterase inhibitors and use |
| CN115667266A (zh) | 2020-06-01 | 2023-01-31 | 豪夫迈·罗氏有限公司 | 新型咪唑并吡嗪衍生物 |
| EP4161930A1 (en) * | 2020-06-08 | 2023-04-12 | F. Hoffmann-La Roche AG | Novel imidazo-pyrazine derivatives |
| CN113929633A (zh) * | 2021-10-27 | 2022-01-14 | 山东大学 | 一种法匹拉韦的合成方法及其应用 |
| CN113831255B (zh) * | 2021-11-25 | 2022-03-11 | 山东诚创蓝海医药科技有限公司 | 一种2-氨基丙二酰胺的制备方法 |
| CN115489188B (zh) * | 2022-10-09 | 2023-08-29 | 安徽国风新材料股份有限公司 | 一种家居保护用聚酯薄膜及其制备方法 |
| EP4623911A1 (en) | 2024-03-25 | 2025-10-01 | ETH Zurich | Pi4kb inhibitors for the treatment of fatty liver disease |
| EP4623912A1 (en) | 2024-03-25 | 2025-10-01 | ETH Zurich | A method for defattening a steatotic liver ex vivo |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2607813B1 (fr) * | 1986-12-05 | 1989-03-31 | Montpellier I Universite | Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique |
| DE19915178A1 (de) | 1999-04-03 | 2000-10-05 | Univ Mainz Johannes Gutenberg | Hepatitis C Virus Zellkultursystem |
| DK1296998T3 (da) | 2000-05-23 | 2011-12-12 | Univ Washington | HCV-varianter |
| AU2002225895A1 (en) | 2000-11-07 | 2002-05-21 | Anadys Pharmaceuticals, Inc. | Hepatitis c virus constructs characterized by high efficiency replication |
| ES2287074T3 (es) | 2000-12-22 | 2007-12-16 | Boehringer Ingelheim (Canada) Ltd. | Molecula de rna autorreplicante del virus de la hepatitis c. |
| EP2050822B1 (en) | 2001-01-23 | 2013-07-31 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Hepatitis C virus replicons and replicon enhanced cells |
| WO2002060492A1 (en) * | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd | Methods of inhibiting kinases |
| JP4799864B2 (ja) | 2002-09-23 | 2011-10-26 | シェーリング コーポレイション | サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン |
| AU2007200401A1 (en) * | 2002-09-23 | 2007-02-22 | Schering Corporation | Imidazopyrazines as cyclin dependent kinase inhibitors |
| US7576085B2 (en) * | 2002-09-23 | 2009-08-18 | Schering Corporation | Imidazopyrazines as cyclin dependent kinase inhibitors |
| DE602004024658D1 (de) | 2003-02-13 | 2010-01-28 | Merck & Co Inc | Verfahren zur vermittlung von zellkulturreplikationsaktivität an unterschiedliche hepatitis-c-virus-isolate |
| AR043002A1 (es) | 2003-02-18 | 2005-07-13 | Altana Pharma Ag | Imidazopirazinas 6-substituidos |
| US7186832B2 (en) | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| US7157460B2 (en) * | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| EP1945216A1 (en) | 2005-11-10 | 2008-07-23 | Schering Corporation | Methods for inhibiting protein kinases |
| EP1945644A2 (en) | 2005-11-10 | 2008-07-23 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
| WO2008030795A2 (en) | 2006-09-05 | 2008-03-13 | Boards Of Regents, The University Of Texas System | Compositions and methods for inhibition of tyrosine kinases |
| US8268809B2 (en) * | 2006-09-05 | 2012-09-18 | Emory University | Kinase inhibitors for preventing or treating pathogen infection and method of use thereof |
| PE20080931A1 (es) | 2006-11-08 | 2008-07-19 | Schering Corp | Imidazopirazinas como inhibidores de proteina quinasa |
| WO2008059373A1 (en) | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists |
| US8243049B2 (en) | 2006-12-20 | 2012-08-14 | 3M Innovative Properties Company | Untethered stylus employing low current power converter |
| GB0716292D0 (en) * | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
-
2007
- 2007-08-21 GB GBGB0716292.8A patent/GB0716292D0/en not_active Ceased
-
2008
- 2008-08-20 EP EP12188861.4A patent/EP2567960A3/en not_active Withdrawn
- 2008-08-20 KR KR1020107005549A patent/KR20100081294A/ko not_active Ceased
- 2008-08-20 EP EP08787346A patent/EP2193131B1/en not_active Not-in-force
- 2008-08-20 ES ES08787346T patent/ES2404415T3/es active Active
- 2008-08-20 PL PL08787346T patent/PL2193131T3/pl unknown
- 2008-08-20 DK DK08787346.9T patent/DK2193131T3/da active
- 2008-08-20 CA CA2707521A patent/CA2707521A1/en not_active Abandoned
- 2008-08-20 AU AU2008290531A patent/AU2008290531A1/en not_active Abandoned
- 2008-08-20 MX MX2010001733A patent/MX2010001733A/es active IP Right Grant
- 2008-08-20 WO PCT/EP2008/060896 patent/WO2009024585A2/en not_active Ceased
- 2008-08-20 HR HRP20130202AT patent/HRP20130202T1/hr unknown
- 2008-08-20 NZ NZ584108A patent/NZ584108A/en not_active IP Right Cessation
- 2008-08-20 CN CN2008801108961A patent/CN101835780B/zh not_active Expired - Fee Related
- 2008-08-20 US US12/674,525 patent/US8362018B2/en not_active Expired - Fee Related
- 2008-08-20 BR BRPI0815717-0A2A patent/BRPI0815717A2/pt not_active IP Right Cessation
- 2008-08-20 JP JP2010521417A patent/JP2010536825A/ja not_active Ceased
- 2008-08-20 PT PT87873469T patent/PT2193131E/pt unknown
- 2008-08-20 SI SI200830948T patent/SI2193131T1/sl unknown
-
2010
- 2010-03-19 ZA ZA2010/02009A patent/ZA201002009B/en unknown
-
2013
- 2013-04-03 CY CY20131100277T patent/CY1113872T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2193131T3 (da) | 2013-04-22 |
| WO2009024585A2 (en) | 2009-02-26 |
| NZ584108A (en) | 2012-06-29 |
| EP2193131B1 (en) | 2013-01-30 |
| BRPI0815717A2 (pt) | 2015-02-10 |
| MX2010001733A (es) | 2010-07-06 |
| ES2404415T3 (es) | 2013-05-27 |
| EP2567960A3 (en) | 2013-06-05 |
| ZA201002009B (en) | 2010-12-29 |
| US8362018B2 (en) | 2013-01-29 |
| GB0716292D0 (en) | 2007-09-26 |
| EP2193131A2 (en) | 2010-06-09 |
| HK1143810A1 (en) | 2011-01-14 |
| WO2009024585A3 (en) | 2009-08-06 |
| KR20100081294A (ko) | 2010-07-14 |
| PT2193131E (pt) | 2013-04-04 |
| US20110166147A1 (en) | 2011-07-07 |
| PL2193131T3 (pl) | 2013-07-31 |
| AU2008290531A1 (en) | 2009-02-26 |
| CN101835780A (zh) | 2010-09-15 |
| CA2707521A1 (en) | 2009-02-26 |
| SI2193131T1 (sl) | 2013-06-28 |
| EP2567960A2 (en) | 2013-03-13 |
| JP2010536825A (ja) | 2010-12-02 |
| CY1113872T1 (el) | 2016-07-27 |
| CN101835780B (zh) | 2013-09-18 |
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