HRP20110492T1 - Asimetrična alkilacija karbonila - Google Patents

Asimetrična alkilacija karbonila Download PDF

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Publication number
HRP20110492T1
HRP20110492T1 HR20110492T HRP20110492T HRP20110492T1 HR P20110492 T1 HRP20110492 T1 HR P20110492T1 HR 20110492 T HR20110492 T HR 20110492T HR P20110492 T HRP20110492 T HR P20110492T HR P20110492 T1 HRP20110492 T1 HR P20110492T1
Authority
HR
Croatia
Prior art keywords
compound
group
alkyl
boronic acid
aryl
Prior art date
Application number
HR20110492T
Other languages
English (en)
Croatian (hr)
Inventor
Albert Martin
Sturm Hubert
Berger Andreas
Kremminger Peter
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of HRP20110492T1 publication Critical patent/HRP20110492T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20110492T 2006-01-23 2007-01-22 Asimetrična alkilacija karbonila HRP20110492T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0601286.8A GB0601286D0 (en) 2006-01-23 2006-01-23 Asymmetric synthesis
PCT/EP2007/000516 WO2007082771A1 (en) 2006-01-23 2007-01-22 Carbonyl asymmetric alkylation

Publications (1)

Publication Number Publication Date
HRP20110492T1 true HRP20110492T1 (hr) 2011-07-31

Family

ID=36010766

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110492T HRP20110492T1 (hr) 2006-01-23 2007-01-22 Asimetrična alkilacija karbonila

Country Status (19)

Country Link
US (1) US8288569B2 (enExample)
EP (1) EP1966127B1 (enExample)
JP (1) JP5081163B2 (enExample)
KR (1) KR101379154B1 (enExample)
CN (1) CN101460448B (enExample)
AT (1) ATE504558T1 (enExample)
AU (1) AU2007207103B2 (enExample)
BR (1) BRPI0706735B1 (enExample)
CA (1) CA2636256C (enExample)
DE (1) DE602007013690D1 (enExample)
EA (1) EA016650B1 (enExample)
ES (1) ES2364502T3 (enExample)
GB (1) GB0601286D0 (enExample)
HR (1) HRP20110492T1 (enExample)
IL (1) IL192628A (enExample)
PL (1) PL1966127T3 (enExample)
SI (1) SI1966127T1 (enExample)
TW (1) TWI387577B (enExample)
WO (1) WO2007082771A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110130591A1 (en) * 2009-06-03 2011-06-02 Boehringer Ingelheim International Gmbh Steroselective synthesis of certain trifluoromethyl-substituted alcohols
EP3680240A1 (en) * 2012-03-14 2020-07-15 Merck Sharp & Dohme Corp. Asymmetric phase transfer catalysis
WO2014206855A1 (en) * 2013-06-26 2014-12-31 Syngenta Participations Ag Process for the stereoselective preparation of a pyrazole-carboxamide
CN107074750B (zh) * 2014-11-14 2022-03-25 浙江华海药业股份有限公司 一种拆分西酞普兰中间体5-氰二醇的方法
KR20160109083A (ko) 2015-03-09 2016-09-21 엔팩토리주식회사 휴대용 앱세서리를 이용한 공기품질 정보제공 시스템 및 방법
US10111356B2 (en) 2016-03-31 2018-10-23 Oracle International Corporation System for electrical connection of printed circuit boards and backplanes in server enclosure
CN106892837A (zh) * 2017-03-23 2017-06-27 浙江师范大学 4‑[4‑(二甲氨基)‑1‑(4‑氟苯基)‑1‑羟丁基]‑3‑羟甲基苯腈的合成
CN108947869A (zh) * 2017-05-25 2018-12-07 万全万特制药江苏有限公司 一种艾司西酞普兰工艺杂质的制备方法
CN108640856B (zh) * 2018-06-11 2021-06-25 淮阴工学院 一种依地普仑中间体的不对称合成方法及其中间体
CN108640855A (zh) * 2018-06-11 2018-10-12 中南林业科技大学 一种依地普仑中间体的合成方法及其中间体

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CH692421A5 (de) * 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
ES2233842T3 (es) 2001-07-31 2005-06-16 H. Lundbeck A/S Composicion cristalina que contiene escitalopram.
ES2234797T3 (es) 2001-08-02 2005-07-01 Infosint Sa Procedimiento para la preparacion de citalopram partiendo de 5-formilftalida.
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2005066185A1 (en) 2004-01-12 2005-07-21 Jubilant Organosys Limited Process for preparing 5-substituted -1-(4-fluorophenyl) -1,3-dihydroisobenzofurans
JP2005247710A (ja) * 2004-03-01 2005-09-15 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法

Also Published As

Publication number Publication date
US20110009648A1 (en) 2011-01-13
IL192628A (en) 2013-04-30
WO2007082771A1 (en) 2007-07-26
US8288569B2 (en) 2012-10-16
AU2007207103B2 (en) 2011-01-06
PL1966127T3 (pl) 2011-10-31
IL192628A0 (en) 2009-02-11
CA2636256A1 (en) 2007-07-26
ES2364502T3 (es) 2011-09-05
EA016650B1 (ru) 2012-06-29
EA200801673A1 (ru) 2009-02-27
BRPI0706735B1 (pt) 2016-11-22
JP5081163B2 (ja) 2012-11-21
TW200800858A (en) 2008-01-01
CN101460448B (zh) 2013-05-15
KR101379154B1 (ko) 2014-04-11
JP2009523749A (ja) 2009-06-25
EP1966127B1 (en) 2011-04-06
KR20080090444A (ko) 2008-10-08
SI1966127T1 (sl) 2011-08-31
AU2007207103A1 (en) 2007-07-26
TWI387577B (zh) 2013-03-01
ATE504558T1 (de) 2011-04-15
DE602007013690D1 (de) 2011-05-19
BRPI0706735A2 (pt) 2011-04-05
CA2636256C (en) 2014-04-29
CN101460448A (zh) 2009-06-17
GB0601286D0 (en) 2006-03-01
EP1966127A1 (en) 2008-09-10

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