CN101460448B - 羰基不对称烷基化 - Google Patents

羰基不对称烷基化 Download PDF

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Publication number
CN101460448B
CN101460448B CN2007800029031A CN200780002903A CN101460448B CN 101460448 B CN101460448 B CN 101460448B CN 2007800029031 A CN2007800029031 A CN 2007800029031A CN 200780002903 A CN200780002903 A CN 200780002903A CN 101460448 B CN101460448 B CN 101460448B
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CN
China
Prior art keywords
group
compound
formula
alkyl
boronic acid
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Expired - Fee Related
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CN2007800029031A
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English (en)
Chinese (zh)
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CN101460448A (zh
Inventor
M·阿尔贝特
H·斯图尔姆
A·贝格尔
P·克雷明格
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Sandoz AG
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Sandoz AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2007800029031A 2006-01-23 2007-01-22 羰基不对称烷基化 Expired - Fee Related CN101460448B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0601286.8 2006-01-23
GBGB0601286.8A GB0601286D0 (en) 2006-01-23 2006-01-23 Asymmetric synthesis
PCT/EP2007/000516 WO2007082771A1 (en) 2006-01-23 2007-01-22 Carbonyl asymmetric alkylation

Publications (2)

Publication Number Publication Date
CN101460448A CN101460448A (zh) 2009-06-17
CN101460448B true CN101460448B (zh) 2013-05-15

Family

ID=36010766

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800029031A Expired - Fee Related CN101460448B (zh) 2006-01-23 2007-01-22 羰基不对称烷基化

Country Status (19)

Country Link
US (1) US8288569B2 (enExample)
EP (1) EP1966127B1 (enExample)
JP (1) JP5081163B2 (enExample)
KR (1) KR101379154B1 (enExample)
CN (1) CN101460448B (enExample)
AT (1) ATE504558T1 (enExample)
AU (1) AU2007207103B2 (enExample)
BR (1) BRPI0706735B1 (enExample)
CA (1) CA2636256C (enExample)
DE (1) DE602007013690D1 (enExample)
EA (1) EA016650B1 (enExample)
ES (1) ES2364502T3 (enExample)
GB (1) GB0601286D0 (enExample)
HR (1) HRP20110492T1 (enExample)
IL (1) IL192628A (enExample)
PL (1) PL1966127T3 (enExample)
SI (1) SI1966127T1 (enExample)
TW (1) TWI387577B (enExample)
WO (1) WO2007082771A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110130591A1 (en) * 2009-06-03 2011-06-02 Boehringer Ingelheim International Gmbh Steroselective synthesis of certain trifluoromethyl-substituted alcohols
MX351657B (es) * 2012-03-14 2017-10-23 Merck Sharp & Dohme Sales de alcaloide de cinchona bis-cuaternarias como catalizadores de transferencia de fase asimétrica.
HUE040244T2 (hu) * 2013-06-26 2019-02-28 Syngenta Participations Ag Eljárás pirazol-karboxamid sztereoszelektív elõállítására
US10287240B2 (en) 2014-11-14 2019-05-14 Zhejiang Hushai Pharmaceuticals Co., Ltd. Method for resolution of citalopram intermediate 5-cyano diol
KR20160109083A (ko) 2015-03-09 2016-09-21 엔팩토리주식회사 휴대용 앱세서리를 이용한 공기품질 정보제공 시스템 및 방법
US10111356B2 (en) 2016-03-31 2018-10-23 Oracle International Corporation System for electrical connection of printed circuit boards and backplanes in server enclosure
CN106892837A (zh) * 2017-03-23 2017-06-27 浙江师范大学 4‑[4‑(二甲氨基)‑1‑(4‑氟苯基)‑1‑羟丁基]‑3‑羟甲基苯腈的合成
CN108947869A (zh) * 2017-05-25 2018-12-07 万全万特制药江苏有限公司 一种艾司西酞普兰工艺杂质的制备方法
CN108640856B (zh) * 2018-06-11 2021-06-25 淮阴工学院 一种依地普仑中间体的不对称合成方法及其中间体
CN108640855A (zh) * 2018-06-11 2018-10-12 中南林业科技大学 一种依地普仑中间体的合成方法及其中间体

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1281707A1 (en) * 2001-08-02 2003-02-05 Infosint Sa Process for the preparation of 5-subtituted isobenzofurans
JP2005247710A (ja) * 2004-03-01 2005-09-15 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO2000012044A2 (en) * 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CA2402388A1 (en) 2000-03-13 2001-09-20 Hans Petersen Method for the preparation of citalopram
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
EP1522539B1 (en) 2001-07-31 2007-01-24 H. Lundbeck A/S Crystalline composition containing escitalopram
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2005066185A1 (en) 2004-01-12 2005-07-21 Jubilant Organosys Limited Process for preparing 5-substituted -1-(4-fluorophenyl) -1,3-dihydroisobenzofurans

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1281707A1 (en) * 2001-08-02 2003-02-05 Infosint Sa Process for the preparation of 5-subtituted isobenzofurans
JP2005247710A (ja) * 2004-03-01 2005-09-15 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法

Also Published As

Publication number Publication date
IL192628A (en) 2013-04-30
PL1966127T3 (pl) 2011-10-31
DE602007013690D1 (de) 2011-05-19
JP2009523749A (ja) 2009-06-25
AU2007207103B2 (en) 2011-01-06
ATE504558T1 (de) 2011-04-15
WO2007082771A1 (en) 2007-07-26
US8288569B2 (en) 2012-10-16
IL192628A0 (en) 2009-02-11
SI1966127T1 (sl) 2011-08-31
US20110009648A1 (en) 2011-01-13
GB0601286D0 (en) 2006-03-01
KR101379154B1 (ko) 2014-04-11
JP5081163B2 (ja) 2012-11-21
EA200801673A1 (ru) 2009-02-27
AU2007207103A1 (en) 2007-07-26
ES2364502T3 (es) 2011-09-05
CA2636256C (en) 2014-04-29
BRPI0706735B1 (pt) 2016-11-22
EP1966127B1 (en) 2011-04-06
KR20080090444A (ko) 2008-10-08
CN101460448A (zh) 2009-06-17
TW200800858A (en) 2008-01-01
HRP20110492T1 (hr) 2011-07-31
BRPI0706735A2 (pt) 2011-04-05
CA2636256A1 (en) 2007-07-26
EP1966127A1 (en) 2008-09-10
TWI387577B (zh) 2013-03-01
EA016650B1 (ru) 2012-06-29

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