HRP20110408T1 - Inhibitori nukleozidnih fosforilaza i hidrolaza acikličkog amina - Google Patents
Inhibitori nukleozidnih fosforilaza i hidrolaza acikličkog amina Download PDFInfo
- Publication number
- HRP20110408T1 HRP20110408T1 HR20110408T HRP20110408T HRP20110408T1 HR P20110408 T1 HRP20110408 T1 HR P20110408T1 HR 20110408 T HR20110408 T HR 20110408T HR P20110408 T HRP20110408 T HR P20110408T HR P20110408 T1 HRP20110408 T1 HR P20110408T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound according
- pyrrolo
- pyrimidin
- hydroxy
- methyl
- Prior art date
Links
- -1 Acyclic amine Chemical class 0.000 title claims 6
- 108010063372 N-Glycosyl Hydrolases Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000004157 Hydrolases Human genes 0.000 title 1
- 102100036286 Purine nucleoside phosphorylase Human genes 0.000 title 1
- 108010009099 nucleoside phosphorylase Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 18
- 201000010099 disease Diseases 0.000 claims abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 6
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 claims abstract 5
- 102000010722 N-Glycosyl Hydrolases Human genes 0.000 claims abstract 4
- 208000035143 Bacterial infection Diseases 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 230000001404 mediated effect Effects 0.000 claims abstract 2
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 claims 3
- ARXKVVRQIIOZGF-UHFFFAOYSA-N 1,2,4-butanetriol Chemical compound OCCC(O)CO ARXKVVRQIIOZGF-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108010060908 purine nucleosidase Proteins 0.000 claims 2
- BGLYJTBLQSNABJ-UHFFFAOYSA-N 2-amino-7-[(2,4-dihydroxybutylamino)methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one Chemical compound O=C1NC(N)=NC2=C1NC=C2CNCC(O)CCO BGLYJTBLQSNABJ-UHFFFAOYSA-N 0.000 claims 1
- YKCZORHAJYWZPI-UHFFFAOYSA-N 2-amino-7-[[[3,4-dihydroxy-2-(hydroxymethyl)butyl]amino]methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one Chemical compound O=C1NC(N)=NC2=C1NC=C2CNCC(CO)C(O)CO YKCZORHAJYWZPI-UHFFFAOYSA-N 0.000 claims 1
- MUGWLXRKUGUISI-UHFFFAOYSA-N 2-amino-7-[[[3-hydroxy-2-(hydroxymethyl)propyl]amino]methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one Chemical compound O=C1NC(N)=NC2=C1NC=C2CNCC(CO)CO MUGWLXRKUGUISI-UHFFFAOYSA-N 0.000 claims 1
- CBYPUSIRVAYVNK-UHFFFAOYSA-N 7-[(2,4-dihydroxybutylamino)methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one Chemical compound N1=CNC(=O)C2=C1C(CNCC(O)CCO)=CN2 CBYPUSIRVAYVNK-UHFFFAOYSA-N 0.000 claims 1
- KUQJLVZYIKHFMX-OGFXRTJISA-N 7-[[[(2r)-2,3-dihydroxypropyl]amino]methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride Chemical compound Cl.N1=CN=C2C(CNC[C@@H](O)CO)=CNC2=C1O KUQJLVZYIKHFMX-OGFXRTJISA-N 0.000 claims 1
- QZLAGQIKRPVUTO-WLYNEOFISA-N 7-[[[(2r,3r)-1,3,4-trihydroxybutan-2-yl]amino]methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride Chemical compound Cl.N1=CN=C2C(CN[C@H](CO)[C@@H](O)CO)=CNC2=C1O QZLAGQIKRPVUTO-WLYNEOFISA-N 0.000 claims 1
- MXMZHPBJYLDKFX-UHFFFAOYSA-N 7-[[[3,4-dihydroxy-2-(hydroxymethyl)butyl]amino]methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one Chemical compound N1=CNC(=O)C2=C1C(CNCC(CO)C(O)CO)=CN2 MXMZHPBJYLDKFX-UHFFFAOYSA-N 0.000 claims 1
- AZMNDLXJAAHUEZ-UHFFFAOYSA-N 7-[[[3-hydroxy-2-(hydroxymethyl)propyl]amino]methyl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one Chemical compound N1=CNC(=O)C2=C1C(CNCC(CO)CO)=CN2 AZMNDLXJAAHUEZ-UHFFFAOYSA-N 0.000 claims 1
- YSGRJXDMEAXCIA-HTQZYQBOSA-N 7-[methyl-[(2r,3s)-1,3,4-trihydroxybutan-2-yl]amino]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one Chemical compound N1=CN=C2C(N([C@H](CO)[C@H](O)CO)C)=CNC2=C1O YSGRJXDMEAXCIA-HTQZYQBOSA-N 0.000 claims 1
- 101000594820 Homo sapiens Purine nucleoside phosphorylase Proteins 0.000 claims 1
- 101900329439 Plasmodium falciparum Purine nucleoside phosphorylase Proteins 0.000 claims 1
- 208000010362 Protozoan Infections Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 108700006317 Purine-nucleoside phosphorylases Proteins 0.000 abstract 2
- 206010037075 Protozoal infections Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84286706P | 2006-09-07 | 2006-09-07 | |
| PCT/NZ2007/000261 WO2008030119A1 (en) | 2006-09-07 | 2007-09-07 | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110408T1 true HRP20110408T1 (hr) | 2011-06-30 |
Family
ID=39157466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110408T HRP20110408T1 (hr) | 2006-09-07 | 2011-05-31 | Inhibitori nukleozidnih fosforilaza i hidrolaza acikličkog amina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8853224B2 (ko) |
| EP (2) | EP2057165B1 (ko) |
| JP (1) | JP5388067B2 (ko) |
| KR (1) | KR101433621B1 (ko) |
| CN (1) | CN101528749B (ko) |
| AT (1) | ATE502038T1 (ko) |
| AU (1) | AU2007293774C1 (ko) |
| CA (1) | CA2662628C (ko) |
| CY (1) | CY1111507T1 (ko) |
| DE (1) | DE602007013252D1 (ko) |
| DK (1) | DK2057165T3 (ko) |
| ES (1) | ES2362805T3 (ko) |
| HK (1) | HK1131612A1 (ko) |
| HR (1) | HRP20110408T1 (ko) |
| NZ (1) | NZ575365A (ko) |
| PL (1) | PL2057165T3 (ko) |
| PT (1) | PT2057165E (ko) |
| RS (1) | RS51864B (ko) |
| SI (1) | SI2057165T1 (ko) |
| WO (1) | WO2008030119A1 (ko) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1539783T1 (sl) | 2002-08-21 | 2011-08-31 | Einstein Coll Med | Inhibitorji nukleozidnih fosforilaz in nukleozidaz |
| NZ533360A (en) | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| US8541567B2 (en) | 2005-07-27 | 2013-09-24 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| WO2007097643A1 (en) * | 2006-02-22 | 2007-08-30 | Industrial Research Limited | Analogues of coformycin and their use for treating protozoan parasite infections |
| US8916571B2 (en) | 2006-02-24 | 2014-12-23 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase |
| CA2662626C (en) * | 2006-09-07 | 2016-07-26 | Industrial Research Limited | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
| KR20090101278A (ko) | 2006-12-22 | 2009-09-24 | 인더스트리얼 리서치 리미티드 | 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체 |
| US20090247750A1 (en) * | 2008-03-28 | 2009-10-01 | Biocryst Pharmaceuticals, Inc. | Process for preparing nucleoside analogs |
| WO2010033236A2 (en) * | 2008-09-22 | 2010-03-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| US9493465B2 (en) | 2009-07-17 | 2016-11-15 | Victoria Link Limited | 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase |
| AR077898A1 (es) | 2009-08-26 | 2011-09-28 | Nycomed Gmbh | Metilpirrolopirimidincarboxamidas |
| CN102725274A (zh) | 2009-10-16 | 2012-10-10 | Rib-X制药公司 | 抗微生物化合物和其制备和使用方法 |
| KR101972992B1 (ko) | 2009-10-16 | 2019-04-29 | 멜린타 서브시디어리 코프. | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 |
| WO2011047320A2 (en) | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
| ES2536831T3 (es) | 2010-10-15 | 2015-05-29 | Biocryst Pharmaceuticals, Inc. | Métodos y composiciones para inhibición de polimerasa |
| WO2012074912A1 (en) * | 2010-11-29 | 2012-06-07 | Albert Einstein College Of Medicine Of Yeshiva University | Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase |
| JP6107660B2 (ja) * | 2010-11-30 | 2017-04-05 | 艾達索高新材料蕪湖有限公司 | 再加工可能なエポキシ樹脂のための新規薬剤 |
| CA2833169A1 (en) * | 2011-04-15 | 2012-12-20 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
| WO2012150866A1 (en) * | 2011-05-03 | 2012-11-08 | Industrial Research Limited | Phosphoribosyltransferase inhibitors and uses thereof |
| JP5950477B2 (ja) | 2011-08-10 | 2016-07-13 | アドシア | 少なくとも１種の基礎インスリンの注射溶液 |
| CN113730555A (zh) | 2012-01-09 | 2021-12-03 | 阿道恰公司 | Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液 |
| JP6063571B2 (ja) | 2012-08-07 | 2017-01-18 | アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド | ヘリコバクター・ピロリ感染の治療 |
| US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
| FR3001895B1 (fr) | 2013-02-12 | 2015-07-03 | Adocia | Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes |
| US9616129B2 (en) | 2013-06-22 | 2017-04-11 | Nitor Therapeutics | Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency |
| NO2865735T3 (ko) | 2013-07-12 | 2018-07-21 | ||
| CA2916993C (en) | 2013-07-12 | 2019-01-15 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| JP2016529325A (ja) | 2013-09-09 | 2016-09-23 | メリンタ セラピューティクス，インコーポレイテッド | 抗微生物化合物ならびにそれの製造方法および使用方法 |
| AU2014315050A1 (en) | 2013-09-09 | 2016-03-24 | Melinta Therapeutics, Inc. | Antimicrobial compunds and methods of making and using the same |
| SG11201606595RA (en) | 2014-02-12 | 2016-09-29 | Einstein Coll Med | Treatment of h. pylori infections using mtan inhibitors |
| MX2017011616A (es) | 2015-03-11 | 2018-04-11 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos para hacerlos y usarlos. |
| MA43812A (fr) | 2016-03-06 | 2018-11-28 | Biocryst Pharm Inc | Procédés et compositions pour le traitement d'une infection par le virus zika |
| WO2017159669A1 (ja) * | 2016-03-15 | 2017-09-21 | 塩野義製薬株式会社 | フェノキシエタノール誘導体の製造方法 |
| US11098047B2 (en) | 2016-05-06 | 2021-08-24 | BioVersys AG | Antimicrobials and methods of making and using same |
| CN113045484B (zh) * | 2019-12-27 | 2024-01-26 | 南京药石科技股份有限公司 | 一种2-氨基-2-(1-甲基-4-哌啶基)丙烷-1-醇的制备方法 |
| CN111320634A (zh) * | 2020-04-14 | 2020-06-23 | 浙江工业大学 | 一种乙酰氧取代的吡咯并[2,3-d]嘧啶衍生物的制备方法 |
| GB202218782D0 (en) | 2022-12-13 | 2023-01-25 | Mehrling Thomas | Purine nucleoside phosphorylase inhibitor for metabolic syndrome |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0920777A (ja) | 1995-06-30 | 1997-01-21 | Nippon Paper Ind Co Ltd | 新規なプリンヌクレオシド誘導体、その製造方法及びその誘導体を有効成分とする酵素阻害剤 |
| AU1739097A (en) * | 1996-02-23 | 1997-09-10 | Albert Einstein College Of Medicine Of Yeshiva University | Enzyme detection/assay method and substrates |
| US5985848A (en) * | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| US6228741B1 (en) | 1998-01-13 | 2001-05-08 | Texas Instruments Incorporated | Method for trench isolation of semiconductor devices |
| ATE425165T1 (de) * | 1999-04-08 | 2009-03-15 | Ind Res Ltd | Verfahren zur zubereitung von inhibitoren des nukleosid-metabolismus |
| US6448799B1 (en) * | 1999-09-30 | 2002-09-10 | Hitachi Electronics Engineering Co., Ltd. | Timing adjustment method and apparatus for semiconductor IC tester |
| US7109331B2 (en) * | 2000-08-29 | 2006-09-19 | Industrial Research Limited | 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors |
| US6458799B1 (en) | 2000-08-31 | 2002-10-01 | Biocryst Pharmaceuticals, Inc. | Deazaguanine analog, preparation thereof and use thereof |
| JP2002296365A (ja) * | 2001-03-29 | 2002-10-09 | Seiko Epson Corp | 電子機器、電子制御式機械時計、電子機器の制御方法 |
| TW200306191A (en) * | 2002-02-22 | 2003-11-16 | Teijin Ltd | Pyrrolopyrimidine derivatives |
| US7098334B2 (en) * | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| SI1539783T1 (sl) * | 2002-08-21 | 2011-08-31 | Einstein Coll Med | Inhibitorji nukleozidnih fosforilaz in nukleozidaz |
| GB0301736D0 (en) | 2003-01-24 | 2003-02-26 | Xenova Ltd | Pharmaceutical compounds |
| NZ523970A (en) | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
| NZ533360A (en) * | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| JP2008508287A (ja) | 2004-07-27 | 2008-03-21 | バイオクリスト・フアーマシユーテイカルズ・インコーポレイテツド | ５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤 |
| NZ540160A (en) | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
| US8541567B2 (en) | 2005-07-27 | 2013-09-24 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| EP1966215A1 (en) * | 2005-12-23 | 2008-09-10 | Novartis AG | Condensed heterocyclic compounds useful as dpp-iv inhibitors |
| WO2007097648A1 (en) | 2006-02-24 | 2007-08-30 | Industrial Research Limited | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
| US8916571B2 (en) | 2006-02-24 | 2014-12-23 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase |
| CA2662626C (en) | 2006-09-07 | 2016-07-26 | Industrial Research Limited | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
| CA2663562A1 (en) | 2006-09-26 | 2008-04-03 | Vern L. Schramm | Transition state structure of human 5'-methylthioadenosine phosphorylase |
| KR20090101278A (ko) | 2006-12-22 | 2009-09-24 | 인더스트리얼 리서치 리미티드 | 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체 |
| WO2009082247A1 (en) | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
| WO2010033236A2 (en) | 2008-09-22 | 2010-03-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| US9493465B2 (en) | 2009-07-17 | 2016-11-15 | Victoria Link Limited | 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase |
-
2007
- 2007-09-07 AU AU2007293774A patent/AU2007293774C1/en active Active
- 2007-09-07 WO PCT/NZ2007/000261 patent/WO2008030119A1/en active Application Filing
- 2007-09-07 KR KR1020097006628A patent/KR101433621B1/ko active IP Right Grant
- 2007-09-07 NZ NZ575365A patent/NZ575365A/en unknown
- 2007-09-07 ES ES07834863T patent/ES2362805T3/es active Active
- 2007-09-07 EP EP07834863A patent/EP2057165B1/en active Active
- 2007-09-07 US US12/310,708 patent/US8853224B2/en active Active
- 2007-09-07 CN CN2007800402949A patent/CN101528749B/zh active Active
- 2007-09-07 DE DE602007013252T patent/DE602007013252D1/de active Active
- 2007-09-07 DK DK07834863.8T patent/DK2057165T3/da active
- 2007-09-07 EP EP11158228A patent/EP2395005A1/en not_active Withdrawn
- 2007-09-07 CA CA2662628A patent/CA2662628C/en active Active
- 2007-09-07 PT PT07834863T patent/PT2057165E/pt unknown
- 2007-09-07 RS RS20110192A patent/RS51864B/en unknown
- 2007-09-07 PL PL07834863T patent/PL2057165T3/pl unknown
- 2007-09-07 SI SI200730602T patent/SI2057165T1/sl unknown
- 2007-09-07 JP JP2009527314A patent/JP5388067B2/ja active Active
- 2007-09-07 AT AT07834863T patent/ATE502038T1/de active
-
2009
- 2009-11-10 HK HK09110497.8A patent/HK1131612A1/xx unknown
-
2011
- 2011-05-31 HR HR20110408T patent/HRP20110408T1/hr unknown
- 2011-05-31 CY CY20111100525T patent/CY1111507T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101528749B (zh) | 2013-07-31 |
| KR20090069281A (ko) | 2009-06-30 |
| KR101433621B1 (ko) | 2014-08-27 |
| AU2007293774A1 (en) | 2008-03-13 |
| EP2057165A4 (en) | 2009-09-02 |
| AU2007293774B2 (en) | 2013-07-04 |
| JP2010502696A (ja) | 2010-01-28 |
| PL2057165T3 (pl) | 2011-08-31 |
| EP2057165A1 (en) | 2009-05-13 |
| ES2362805T3 (es) | 2011-07-13 |
| AU2007293774C1 (en) | 2014-12-18 |
| DK2057165T3 (da) | 2011-06-27 |
| PT2057165E (pt) | 2011-05-12 |
| NZ575365A (en) | 2012-02-24 |
| SI2057165T1 (sl) | 2011-07-29 |
| CA2662628A1 (en) | 2008-03-13 |
| HK1131612A1 (en) | 2010-01-29 |
| US20110130412A1 (en) | 2011-06-02 |
| RS51864B (en) | 2012-02-29 |
| CA2662628C (en) | 2016-02-09 |
| WO2008030119A1 (en) | 2008-03-13 |
| CN101528749A (zh) | 2009-09-09 |
| ATE502038T1 (de) | 2011-04-15 |
| CY1111507T1 (el) | 2015-08-05 |
| US8853224B2 (en) | 2014-10-07 |
| DE602007013252D1 (de) | 2011-04-28 |
| WO2008030119A9 (en) | 2009-09-24 |
| EP2395005A1 (en) | 2011-12-14 |
| EP2057165B1 (en) | 2011-03-16 |
| JP5388067B2 (ja) | 2014-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20110408T1 (hr) | Inhibitori nukleozidnih fosforilaza i hidrolaza acikličkog amina | |
| MY150059A (en) | Pyrrolo [2,3-d] pyrimidin derivatives as protein kinase b inhibitors | |
| UY30408A1 (es) | Derivados sustituidos del acetato de 8-(4-metoxifenil)-2,3,4,8-tetrahidroimidazo-[1,5-a]-pirimidin-6-amina, composiciones farmacéuticas y aplicaciones | |
| MA33670B1 (fr) | Derives de pyrrolo[2,3-d]pyrimidine | |
| MA30226B1 (fr) | Agents cytotoxiques comprenant de nouveaux derives de tomaymycine et leur utilisation therapeutique. | |
| EA201070841A1 (ru) | НОВЫЕ ПИРАЗОЛО[3,4-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ПРОТИВОРАКОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ | |
| EA200600973A1 (ru) | ПИРИДО[2,3-d] ПИРИМИДИН-2,4-ДИАМИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ PDE 2 | |
| HK1136489A1 (en) | Imidazotriazines and imidazopyrimidines as kinase inhibitors | |
| BRPI0509369A (pt) | azaindóis úteis como inibidores de jak e outras proteìna cinases | |
| EA201001017A1 (ru) | 3h-[1,2,3]триазоло[4,5-d]пиримидиновые соединения, их применение в качестве ингибиторов киназы mtor и киназы pi3 и их синтезы | |
| MEP13408A (en) | Cdk inhibiting pyrimidines, production thereof and their use as medicaments | |
| BR122013028005B8 (pt) | compostos de ciclopentanos de pirimidila hidroxilados e metoxilados, composição farmacêutica, kit e forma de dosagem oral compreendendo os referidos compostos, uso das referidas composições, bem como processo de preparação dos referidos compostos | |
| EA200970287A1 (ru) | Способы, соединения, композиции и носители, подходящие для доставки 3-амино-1-пропансульфоновой кислоты | |
| EA200801998A1 (ru) | ПИРИДИН[3,4-b]ПИРАЗИНОНЫ | |
| MX2012007273A (es) | Pteridinonas como inhibidores de la quinasa tipo polo. | |
| NZ701440A (en) | Pyrazole derivatives as jak inhibitors | |
| EA201000614A1 (ru) | Производные пурина как лиганды аденозинового рецептора а | |
| BRPI0414864A (pt) | composição farmacêutica multiparticulada compreendendo ácido micofenólico ou micofenolato de sódio e combinação com rapamicida | |
| BRPI0516626A (pt) | pteridinas substituìdas e uso das mesmas | |
| CO5690567A2 (es) | Formulaciones de tableta de liberacion extendida de venlafaxina | |
| MA31630B1 (fr) | Dérivés de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides et de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxamides, leur préparation et leur application en thérapeutique | |
| AR086196A1 (es) | Derivados de pirazolo[3,4-c]quinolina, inhibidores de quinasa | |
| ATE541573T1 (de) | Pharmazeutische zusammensetzung enthaltend lapatinib | |
| RU2004130284A (ru) | Антипаразитарные производные артемизинина (эндопероксиды) | |
| Piplani et al. | Prodrugs of antiinfective agents: A review |