HRP20100633T1 - Derivati piridazinona kao agonisti receptora tiroidnih hormona - Google Patents
Derivati piridazinona kao agonisti receptora tiroidnih hormona Download PDFInfo
- Publication number
- HRP20100633T1 HRP20100633T1 HR20100633T HRP20100633T HRP20100633T1 HR P20100633 T1 HRP20100633 T1 HR P20100633T1 HR 20100633 T HR20100633 T HR 20100633T HR P20100633 T HRP20100633 T HR P20100633T HR P20100633 T1 HRP20100633 T1 HR P20100633T1
- Authority
- HR
- Croatia
- Prior art keywords
- dihydro
- oxo
- isopropyl
- phenyl
- pyridazin
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1
- 229940127535 Thyroid Hormone Receptor Agonists Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 27
- 125000000217 alkyl group Chemical group 0.000 claims abstract 12
- 150000002148 esters Chemical class 0.000 claims abstract 10
- 150000003839 salts Chemical class 0.000 claims abstract 9
- 125000004122 cyclic group Chemical group 0.000 claims abstract 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 2
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- -1 Ester compound Chemical class 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 125000004185 ester group Chemical group 0.000 claims 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- GPQLQJCVSFKHSX-UHFFFAOYSA-N 2-[3,5-dibromo-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)methyl]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(CC=2C(=CC(CC(O)=O)=CC=2Br)Br)=N1 GPQLQJCVSFKHSX-UHFFFAOYSA-N 0.000 claims 1
- AOXRZYHUTQBXCN-UHFFFAOYSA-N 2-[3,5-dibromo-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)oxy]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(OC=2C(=CC(CC(O)=O)=CC=2Br)Br)=N1 AOXRZYHUTQBXCN-UHFFFAOYSA-N 0.000 claims 1
- JFIWDBBXUIEFQL-UHFFFAOYSA-N 2-[3,5-dichloro-4-(1-methyl-6-oxo-5-propan-2-ylpyridazin-3-yl)oxyphenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile Chemical compound CN1C(=O)C(C(C)C)=CC(OC=2C(=CC(=CC=2Cl)N2C(NC(=O)C(C#N)=N2)=O)Cl)=N1 JFIWDBBXUIEFQL-UHFFFAOYSA-N 0.000 claims 1
- OORLQBMJWSBLOY-UHFFFAOYSA-N 2-[3,5-dichloro-4-(1-methyl-6-oxo-5-propan-2-ylpyridazin-3-yl)oxyphenyl]acetic acid Chemical compound CN1C(=O)C(C(C)C)=CC(OC=2C(=CC(CC(O)=O)=CC=2Cl)Cl)=N1 OORLQBMJWSBLOY-UHFFFAOYSA-N 0.000 claims 1
- LWMPMTQXFCDBBA-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(1-methyl-6-oxo-5-propan-2-ylpyridazin-3-yl)methyl]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile Chemical compound CN1C(=O)C(C(C)C)=CC(CC=2C(=CC(=CC=2Cl)N2C(NC(=O)C(C#N)=N2)=O)Cl)=N1 LWMPMTQXFCDBBA-UHFFFAOYSA-N 0.000 claims 1
- VNNFGQVGJFFVJX-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)methyl]phenyl]-1,2,4-triazine-3,5-dione Chemical compound N1C(=O)C(C(C)C)=CC(CC=2C(=CC(=CC=2Cl)N2C(NC(=O)C=N2)=O)Cl)=N1 VNNFGQVGJFFVJX-UHFFFAOYSA-N 0.000 claims 1
- ZKWUUZVSYHNCBF-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile Chemical compound N1C(=O)C(C(C)C)=CC(CC=2C(=CC(=CC=2Cl)N2C(NC(=O)C(C#N)=N2)=O)Cl)=N1 ZKWUUZVSYHNCBF-UHFFFAOYSA-N 0.000 claims 1
- HNQWGSLKZWUEDQ-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)methyl]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(CC=2C(=CC(CC(O)=O)=CC=2Cl)Cl)=N1 HNQWGSLKZWUEDQ-UHFFFAOYSA-N 0.000 claims 1
- BDVULFJNTQUGRM-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)oxy]anilino]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(OC=2C(=CC(NCC(O)=O)=CC=2Cl)Cl)=N1 BDVULFJNTQUGRM-UHFFFAOYSA-N 0.000 claims 1
- GBAQQDSIAACDRK-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)oxy]phenyl]-1,2,4-triazine-3,5-dione Chemical compound N1C(=O)C(C(C)C)=CC(OC=2C(=CC(=CC=2Cl)N2C(NC(=O)C=N2)=O)Cl)=N1 GBAQQDSIAACDRK-UHFFFAOYSA-N 0.000 claims 1
- UCWVDJLQXJXVEB-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)oxy]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(OC=2C(=CC(CC(O)=O)=CC=2Cl)Cl)=N1 UCWVDJLQXJXVEB-UHFFFAOYSA-N 0.000 claims 1
- URNDNHCCRPRCLG-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)sulfanyl]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(SC=2C(=CC(CC(O)=O)=CC=2Cl)Cl)=N1 URNDNHCCRPRCLG-UHFFFAOYSA-N 0.000 claims 1
- YNXHQQAZZSIQKZ-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)sulfinyl]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(S(=O)C=2C(=CC(CC(O)=O)=CC=2Cl)Cl)=N1 YNXHQQAZZSIQKZ-UHFFFAOYSA-N 0.000 claims 1
- FLCRQFBWKJIFKP-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)sulfonyl]phenyl]-1,2,4-triazine-3,5-dione Chemical compound N1C(=O)C(C(C)C)=CC(S(=O)(=O)C=2C(=CC(=CC=2Cl)N2C(NC(=O)C=N2)=O)Cl)=N1 FLCRQFBWKJIFKP-UHFFFAOYSA-N 0.000 claims 1
- ABJHNUXWNJQNQT-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)sulfonyl]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile Chemical compound N1C(=O)C(C(C)C)=CC(S(=O)(=O)C=2C(=CC(=CC=2Cl)N2C(NC(=O)C(C#N)=N2)=O)Cl)=N1 ABJHNUXWNJQNQT-UHFFFAOYSA-N 0.000 claims 1
- LLSSPNCWDDLGHB-UHFFFAOYSA-N 2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)sulfonyl]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(S(=O)(=O)C=2C(=CC(CC(O)=O)=CC=2Cl)Cl)=N1 LLSSPNCWDDLGHB-UHFFFAOYSA-N 0.000 claims 1
- WGHVGSIKRBXLGK-UHFFFAOYSA-N 2-[3,5-dimethyl-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)oxy]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(OC=2C(=CC(CC(O)=O)=CC=2C)C)=N1 WGHVGSIKRBXLGK-UHFFFAOYSA-N 0.000 claims 1
- CHELBMWLOMFCBW-UHFFFAOYSA-N 2-[3-chloro-5-methyl-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)oxy]phenyl]acetic acid Chemical compound N1C(=O)C(C(C)C)=CC(OC=2C(=CC(CC(O)=O)=CC=2C)Cl)=N1 CHELBMWLOMFCBW-UHFFFAOYSA-N 0.000 claims 1
- HKODZJFSSDWZGY-UHFFFAOYSA-N 3-[3,5-dibromo-4-[(6-oxo-5-propan-2-yl-1h-pyridazin-3-yl)oxy]phenyl]propanoic acid Chemical compound N1C(=O)C(C(C)C)=CC(OC=2C(=CC(CCC(O)=O)=CC=2Br)Br)=N1 HKODZJFSSDWZGY-UHFFFAOYSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000003532 hypothyroidism Diseases 0.000 claims 1
- 230000002989 hypothyroidism Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N oxalic acid Substances OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- FDBYIYFVSAHJLY-UHFFFAOYSA-N resmetirom Chemical compound N1C(=O)C(C(C)C)=CC(OC=2C(=CC(=CC=2Cl)N2C(NC(=O)C(C#N)=N2)=O)Cl)=N1 FDBYIYFVSAHJLY-UHFFFAOYSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70121505P | 2005-07-21 | 2005-07-21 | |
| PCT/EP2006/064093 WO2007009913A1 (en) | 2005-07-21 | 2006-07-11 | Pyridazinone derivatives as thyroid hormone receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100633T1 true HRP20100633T1 (hr) | 2011-01-31 |
Family
ID=37114368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100633T HRP20100633T1 (hr) | 2005-07-21 | 2010-11-23 | Derivati piridazinona kao agonisti receptora tiroidnih hormona |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US7452882B2 (ja) |
| EP (1) | EP1919878B1 (ja) |
| JP (1) | JP5000649B2 (ja) |
| KR (1) | KR100965006B1 (ja) |
| CN (1) | CN101228135B (ja) |
| AR (1) | AR054848A1 (ja) |
| AT (1) | ATE480524T1 (ja) |
| AU (1) | AU2006271721C1 (ja) |
| BR (1) | BRPI0613754B8 (ja) |
| CA (1) | CA2614529C (ja) |
| CR (1) | CR9644A (ja) |
| CY (1) | CY1110929T1 (ja) |
| DE (1) | DE602006016821D1 (ja) |
| DK (1) | DK1919878T3 (ja) |
| EC (1) | ECSP088120A (ja) |
| ES (1) | ES2349131T3 (ja) |
| HK (1) | HK1115129A1 (ja) |
| HR (1) | HRP20100633T1 (ja) |
| IL (1) | IL188476A (ja) |
| MA (1) | MA29731B1 (ja) |
| MX (1) | MX2008000818A (ja) |
| MY (1) | MY142861A (ja) |
| NO (1) | NO340679B1 (ja) |
| NZ (1) | NZ565190A (ja) |
| PL (1) | PL1919878T3 (ja) |
| PT (1) | PT1919878E (ja) |
| RS (1) | RS51639B (ja) |
| RU (1) | RU2379295C2 (ja) |
| TW (1) | TWI330636B (ja) |
| UA (1) | UA88104C2 (ja) |
| WO (1) | WO2007009913A1 (ja) |
| ZA (1) | ZA200800405B (ja) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2422450C2 (ru) | 2003-11-19 | 2011-06-27 | Метабазис Терапеутикс, Инк. | Новые фосфорсодержащие тиромиметики |
| EP1604988A1 (en) * | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals |
| EP1898926A2 (en) | 2005-05-26 | 2008-03-19 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| WO2007009913A1 (en) | 2005-07-21 | 2007-01-25 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives as thyroid hormone receptor agonists |
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