HRP20100042T1 - ANTAGONIST CaSR - Google Patents
ANTAGONIST CaSR Download PDFInfo
- Publication number
- HRP20100042T1 HRP20100042T1 HR20100042T HRP20100042T HRP20100042T1 HR P20100042 T1 HRP20100042 T1 HR P20100042T1 HR 20100042 T HR20100042 T HR 20100042T HR P20100042 T HRP20100042 T HR P20100042T HR P20100042 T1 HRP20100042 T1 HR P20100042T1
- Authority
- HR
- Croatia
- Prior art keywords
- amino
- methylpropan
- ethyl
- carboxylic acid
- hydroxypropoxy
- Prior art date
Links
- 102100035650 Extracellular calcium-sensing receptor Human genes 0.000 title 1
- 101710159793 Extracellular calcium-sensing receptor Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 31
- 150000001875 compounds Chemical class 0.000 claims abstract 22
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 12
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 9
- 229910052736 halogen Inorganic materials 0.000 claims abstract 9
- 125000005843 halogen group Chemical group 0.000 claims abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims abstract 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 2
- 125000004442 acylamino group Chemical group 0.000 claims abstract 2
- 125000003277 amino group Chemical group 0.000 claims abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 229940126585 therapeutic drug Drugs 0.000 claims 5
- 208000001132 Osteoporosis Diseases 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- QWDVXOKNZUMCHX-MQNHUJCZSA-N 4-[2-[1-[(2r)-3-[[1-(3-chloro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(C)C(Cl)=C1 QWDVXOKNZUMCHX-MQNHUJCZSA-N 0.000 claims 3
- XUZPXYZNDHHEST-MQNHUJCZSA-N 4-[2-[1-[(2r)-3-[[1-(3-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(C)C(F)=C1 XUZPXYZNDHHEST-MQNHUJCZSA-N 0.000 claims 3
- AQPYANXMGDKLLM-LEQGEALCSA-N 4-[2-[1-[(2r)-3-[[1-(4-chloro-2-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(Cl)C=C1F AQPYANXMGDKLLM-LEQGEALCSA-N 0.000 claims 3
- 108090000445 Parathyroid hormone Proteins 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- UNFHDRVFEQPUEL-AVKWCDSFSA-N 4-[2-[1-[(2r)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(Cl)C(F)=C1 UNFHDRVFEQPUEL-AVKWCDSFSA-N 0.000 claims 2
- 102000003982 Parathyroid hormone Human genes 0.000 claims 2
- 239000000199 parathyroid hormone Substances 0.000 claims 2
- 229960001319 parathyroid hormone Drugs 0.000 claims 2
- BVSXVRSNMHHYJM-GMLYINLCSA-N 2-butan-2-yl-4-[2-[1-[(2r)-3-[[1-(3-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]benzoic acid Chemical compound C1=C(C(O)=O)C(C(C)CC)=CC(C=2C(=CC=CC=2)C(C)OC[C@H](O)CNC(C)(C)CC=2C=C(F)C(C)=CC=2)=C1 BVSXVRSNMHHYJM-GMLYINLCSA-N 0.000 claims 1
- KMLSIUHKVREJTG-UIDYPRJRSA-N 2-ethyl-4-[2-[1-[(2r)-3-[[1-(3-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]benzoic acid Chemical compound C1=C(C(O)=O)C(CC)=CC(C=2C(=CC=CC=2)C(C)OC[C@H](O)CNC(C)(C)CC=2C=C(F)C(C)=CC=2)=C1 KMLSIUHKVREJTG-UIDYPRJRSA-N 0.000 claims 1
- UCZFIUQTYKVEIZ-NRWPOFLRSA-N 2-tert-butyl-4-[2-[1-[(2r)-3-[[1-(3-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]benzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C(C(O)=O)=CC=1)C(C)(C)C)NC(C)(C)CC1=CC=C(C)C(F)=C1 UCZFIUQTYKVEIZ-NRWPOFLRSA-N 0.000 claims 1
- YOHPPVDKKZZAMD-PIFIWZBESA-N 2-tert-butyl-4-[2-[1-[(2r)-3-[[1-(4-chloro-2-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]benzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C(C(O)=O)=CC=1)C(C)(C)C)NC(C)(C)CC1=CC=C(Cl)C=C1F YOHPPVDKKZZAMD-PIFIWZBESA-N 0.000 claims 1
- MMCQSLBONUTOPC-GWQXNCQPSA-N 2-tert-butyl-4-[2-[1-[(2r)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]benzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C(C(O)=O)=CC=1)C(C)(C)C)NC(C)(C)CC1=CC=C(Cl)C(F)=C1 MMCQSLBONUTOPC-GWQXNCQPSA-N 0.000 claims 1
- FWRORUOBZZYGEM-NRWPOFLRSA-N 3-[1-[(2r)-2-hydroxy-3-[[1-(3-methoxy-4-methylphenyl)-2-methylpropan-2-yl]amino]propoxy]ethyl]-2-methyl-4-phenylbenzoic acid Chemical compound C1=C(C)C(OC)=CC(CC(C)(C)NC[C@@H](O)COC(C)C=2C(=CC=C(C=2C)C(O)=O)C=2C=CC=CC=2)=C1 FWRORUOBZZYGEM-NRWPOFLRSA-N 0.000 claims 1
- ZCVHRWIVWANFEO-AVKWCDSFSA-N 3-[1-[(2r)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-2-methyl-4-phenylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=C(C=1C)C(O)=O)C=1C=CC=CC=1)NC(C)(C)CC1=CC=C(Cl)C(F)=C1 ZCVHRWIVWANFEO-AVKWCDSFSA-N 0.000 claims 1
- KMCHMNAFFOITSJ-NRWPOFLRSA-N 4-[2-[1-[(2r)-2-hydroxy-3-[[2-methyl-1-(4-methylphenyl)propan-2-yl]amino]propoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(C)C=C1 KMCHMNAFFOITSJ-NRWPOFLRSA-N 0.000 claims 1
- AYQOHBNPZWTGAI-MQNHUJCZSA-N 4-[2-[1-[(2r)-2-hydroxy-3-[[2-methyl-1-[4-methyl-3-(trifluoromethyl)phenyl]propan-2-yl]amino]propoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(C)C(C(F)(F)F)=C1 AYQOHBNPZWTGAI-MQNHUJCZSA-N 0.000 claims 1
- LOQSCOCDKVOMRW-MQNHUJCZSA-N 4-[2-[1-[(2r)-3-[[1-(2-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(C)C=C1F LOQSCOCDKVOMRW-MQNHUJCZSA-N 0.000 claims 1
- UEPUDNFKFGPBLV-AVKWCDSFSA-N 4-[2-[1-[(2r)-3-[[1-(3,4-dichlorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(Cl)C(Cl)=C1 UEPUDNFKFGPBLV-AVKWCDSFSA-N 0.000 claims 1
- UEIYKAQGJKLYCY-ANWICMFUSA-N 4-[2-[1-[(2r)-3-[[1-(3,4-dimethylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(C)C(C)=C1 UEIYKAQGJKLYCY-ANWICMFUSA-N 0.000 claims 1
- LVXDYQNXYOUDIO-JKSFWZLDSA-N 4-[2-[1-[(2r)-3-[[1-(3,5-dichlorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC(Cl)=CC(Cl)=C1 LVXDYQNXYOUDIO-JKSFWZLDSA-N 0.000 claims 1
- VVSQPNBBZONYQI-PIFIWZBESA-N 4-[2-[1-[(2r)-3-[[1-(3-chlorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=CC(Cl)=C1 VVSQPNBBZONYQI-PIFIWZBESA-N 0.000 claims 1
- NTVGSOANQXUMDG-IQHZPMLTSA-N 4-[2-[1-[(2r)-3-[[1-(3-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-(2-methylpropyl)benzoic acid Chemical compound C1=C(C(O)=O)C(CC(C)C)=CC(C=2C(=CC=CC=2)C(C)OC[C@H](O)CNC(C)(C)CC=2C=C(F)C(C)=CC=2)=C1 NTVGSOANQXUMDG-IQHZPMLTSA-N 0.000 claims 1
- MLPLNOFBZGWUMY-ZWAGFTRDSA-N 4-[2-[1-[(2r)-3-[[1-(3-fluoro-4-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-propylbenzoic acid Chemical compound C1=C(C(O)=O)C(CCC)=CC(C=2C(=CC=CC=2)C(C)OC[C@H](O)CNC(C)(C)CC=2C=C(F)C(C)=CC=2)=C1 MLPLNOFBZGWUMY-ZWAGFTRDSA-N 0.000 claims 1
- DESSTMCVVPPDLN-GWQXNCQPSA-N 4-[2-[1-[(2r)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-propan-2-ylbenzoic acid Chemical compound C1=C(C(O)=O)C(C(C)C)=CC(C=2C(=CC=CC=2)C(C)OC[C@H](O)CNC(C)(C)CC=2C=C(F)C(Cl)=CC=2)=C1 DESSTMCVVPPDLN-GWQXNCQPSA-N 0.000 claims 1
- MMIBOSUVABWADQ-MQNHUJCZSA-N 4-[2-[1-[(2r)-3-[[1-(4-chloro-3-methylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C([C@@H](O)COC(C)C=1C(=CC=CC=1)C=1C=C(C)C(C(O)=O)=CC=1)NC(C)(C)CC1=CC=C(Cl)C(C)=C1 MMIBOSUVABWADQ-MQNHUJCZSA-N 0.000 claims 1
- SPDZMDPQBQFFLC-UIDYPRJRSA-N 4-[2-[1-[(2r)-3-[[1-(4-ethyl-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C1=C(F)C(CC)=CC=C1CC(C)(C)NC[C@@H](O)COC(C)C1=CC=CC=C1C1=CC=C(C(O)=O)C(C)=C1 SPDZMDPQBQFFLC-UIDYPRJRSA-N 0.000 claims 1
- MYAHGDDNTAEJIN-ZWAGFTRDSA-N 4-[2-[1-[(2r)-3-[[1-(4-ethylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid Chemical compound C1=CC(CC)=CC=C1CC(C)(C)NC[C@@H](O)COC(C)C1=CC=CC=C1C1=CC=C(C(O)=O)C(C)=C1 MYAHGDDNTAEJIN-ZWAGFTRDSA-N 0.000 claims 1
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 102000055006 Calcitonin Human genes 0.000 claims 1
- 108060001064 Calcitonin Proteins 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229940123613 Calcium receptor antagonist Drugs 0.000 claims 1
- SFBODOKJTYAUCM-UHFFFAOYSA-N Ipriflavone Chemical compound C=1C(OC(C)C)=CC=C(C2=O)C=1OC=C2C1=CC=CC=C1 SFBODOKJTYAUCM-UHFFFAOYSA-N 0.000 claims 1
- 102100036893 Parathyroid hormone Human genes 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 229930003448 Vitamin K Natural products 0.000 claims 1
- 239000003263 anabolic agent Substances 0.000 claims 1
- 150000004663 bisphosphonates Chemical class 0.000 claims 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 1
- 229960004015 calcitonin Drugs 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000328 estrogen antagonist Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229960005431 ipriflavone Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims 1
- 230000000580 secretagogue effect Effects 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 235000019168 vitamin K Nutrition 0.000 claims 1
- 239000011712 vitamin K Substances 0.000 claims 1
- 150000003721 vitamin K derivatives Chemical class 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
- 229940046010 vitamin k Drugs 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
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Abstract
Spoj prikazan sljedećom formulom (1''): naznačen time štoR1' je hidroksilna skupina ili C1-6 alkoksi skupina, R2' je hidroksilna skupina, atom halogena, amino skupina, C1-7 acilamino skupina, halogen C1-6 alkilna skupina, C1-6 alkoksikarbonilna skupina, C1-6 alkoksi skupina, halogen C1-6 alkoksi skupina, C1-6 alkilna skupina, hidroksi-C1-6 alkilna skupina, di(C1-6 alkil)amino skupina ili nitro skupina, R4' je C1-6 alkilna skupina ili C3-6 cikloalkilna skupina, R6' je atom halogena, C1-6 alkilna skupina, C1-6 alkoksi skupina ili halogen C1-6 alkilna skupina, ili, kada R7' je u susjedstvu, R6' i R7' su vezani kako bi tvorili -CH=CH-CH=CH-, iR7' je atom vodika, atom halogena, C1-6 alkilna skupina, C1-6 alkoksi goup ili halogen C1-6 alkilna skupina, njegov optički aktivni oblik, njegova farmaceutski prihvatljiva sol, ili optički aktivni oblik njegove soli. Patent sadrži još 18 patentnih zahtjeva.
Claims (19)
1. Spoj prikazan sljedećom formulom (1''):
[image]
naznačen time što
R1' je hidroksilna skupina ili C1-6 alkoksi skupina,
R2' je hidroksilna skupina, atom halogena, amino skupina, C1-7 acilamino skupina, halogen C1-6 alkilna skupina, C1-6 alkoksikarbonilna skupina, C1-6 alkoksi skupina, halogen C1-6 alkoksi skupina, C1-6 alkilna skupina, hidroksi-C1-6 alkilna skupina, di(C1-6 alkil)amino skupina ili nitro skupina,
R4' je C1-6 alkilna skupina ili C3-6 cikloalkilna skupina,
R6' je atom halogena, C1-6 alkilna skupina, C1-6 alkoksi skupina ili halogen C1-6 alkilna skupina, ili, kada R7' je u susjedstvu, R6' i R7' su vezani kako bi tvorili -CH=CH-CH=CH-, i
R7' je atom vodika, atom halogena, C1-6 alkilna skupina, C1-6 alkoksi goup ili halogen C1-6 alkilna skupina,
njegov optički aktivni oblik, njegova farmaceutski prihvatljiva sol, ili optički aktivni oblik njegove soli.
2. Spoj u skladu s patentnim zahtjevom 1, prikazan sljedećom formulom (1'"):
[image]
naznačen time što
R2" je C1-6 alkilna skupina,
R4" je metilna skupina ili ciklopropilna skupina,
R6" je atom halogena ili C1-6 alkilna skupina, i
R7" je atom vodika, atom halogena, C1-6 alkilna skupina, C1-6 alkoksi skupina ili halogen C1-6 alkilna skupina,
njegov optički aktivni oblik, njegova farmaceutski prihvatljiva sol, ili optički aktivni oblik njegove soli.
3. Spoj u skladu s patentnim zahtjevom 1 ili 2, naznačen time što ga se bira iz skupine koju čine
2'-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2-[1-[(2R)-3-[[1-(4-klor-3-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3-klor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-klor-3-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-klor-2-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(2-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-etil-3-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[(ciklopropil)[(2R)-3-[[1-(4-klor-2-fluorfenil)-2-metilpropan-2-il]amino-2-hidroksipropoksi]metil]-3-metilbifenil-4-karboksilna kiselina,
2'-[(ciklopropil)[(2R)-3-[[1-(4-klor-3-fluorfenil)-2-metilpropan-2-il]amino]-2,-hidroksipropoksi]metil]-3-metilbifenil-4-karboksilna kiselina,
3-metil-2'-[1-[(2R)-3-[[1-(3,4-dimetilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksil]etil]bifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[-1-[(2R)-3-[[1-(4-klor-3-methoksil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-etilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
3-etil-2'-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]bifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3'-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-izopropilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-propilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-isobutilbifenil-4-karboksilna kiselina,
3-metil-2'-[1-[(2R)-3-[[1-(4-klor-3-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]bifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-klor-3-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-izopropilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-(1-metilpropil)bifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3-klorfenil)-2-metilpropan-2-il]amino]-2-hydrcxypropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3,4-diklorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2-[1-[(2R)-3-[[1-(3-methoksi-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3,5-dichlolorofenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-klor-3-trifluormetilfenil)-2-metilpropan-2-il]amino]-2-hidroksiproksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-t-butilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-klor-2-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-t-butilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(4-klor-3-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-t-butilbifenil-4-karboksilna kiselina, te
2'-[1-[(2R)-3-[[1-(3-trifluormetil-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
njegov optički aktivni oblik, njegova farmaceutski prihvatljiva sol ili optički aktivni oblik njegove soli.
4. Spoj u skladu s patentnim zahtjevom 3, naznačen time što ga se bira iz skupine koju čine
2'-[1-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[1-(4-klor-3-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
2'-[1-[(2R)-3-[[1-(3-klor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina, te
2'-[1-[(2R)-3-[[1-(4-klor-2-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina,
njegov optički aktivni oblik, njegova farmaceutski prihvatljiva sol ili optički aktivni oblik njegove soli.
5. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što navedeni spoj je 2'-[1-[(2R)-3-[[1-(3-fluor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina, njezin optički aktivni oblik, njezina farmaceutski prihvatljiva sol ili optički aktivni oblik njezine soli.
6. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što navedeni spoj je 2'-[1-[(2R)-3-[[1-(4-klor-3-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina, njezin optički aktivni oblik, njezina farmaceutski prihvatljiva sol ili optički aktivni oblik njezine soli.
7. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što navedeni spoj je 2'-[1-[(2R)-3-[[1-(3-klor-4-metilfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina, njezin optički aktivni oblik, njezina farmaceutski prihvatljiva sol ili optički aktivni oblik njezine soli.
8. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što navedeni spoj je 2'-[1-[(2R)-3-[[1-(4-klor-2-fluorfenil)-2-metilpropan-2-il]amino]-2-hidroksipropoksi]etil]-3-metilbifenil-4-karboksilna kiselina, njezin optički aktivni oblik, njezina farmaceutski prihvatljiva sol ili optički aktivni oblik njezine soli.
9. Spoj u skladu s patentnim zahtjevom 1 ili 2, naznačen time što ima sljedeću strukturnu formulu:
[image]
ili njegova farmaceutski prihvatljiva sol.
10. Spoj u skladu s patentnim zahtjevom 1 ili 2, naznačen time što ima sljedeću strukturnu formulu:
[image]
ili njegova farmaceutski prihvatljiva sol.
11. Spoj u skladu s patentnim zahtjevom 1 ili 2, naznačen time što ima sljedeću strukturnu formulu:
[image]
ili njegova farmaceutski prihvatljiva sol.
12. Spoj u skladu s patentnim zahtjevom 1 ili 2, naznačen time što ima sljedeću strukturnu formulu:
[image]
ili njegova farmaceutski prihvatljiva sol.
13. Spoj u skladu s patentnim zahtjevom 1 ili 2, naznačen time što ima sljedeću strukturnu formulu:
[image]
[image]
ili njegova farmaceutski prihvatljiva sol.
14. Farmaceutski pripravak, naznačen time što sadrži farmaceutski prihvatljivu podlogu, te spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 13, njegov optički aktivni oblik, njegovu farmaceutski prihvatljivu sol ili optički aktivni oblik njegove soli kao aktivni sastojak.
15. Terapijski lijek za osteoporozu, naznačen time što sadrži farmaceutski prihvatljivu podlogu, te spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 13, njegov optički aktivni oblik, njegovu farmaceutski prihvatljivu sol ili optički aktivni oblik njegove soli, kao aktivni sastojak.
16. Terapijski lijek u skladu s patentnim zahtjevom 15, naznačen time što je u kombinaciji s drugim terapijskim lijekom radi upotrebe u liječenju osteoporoze.
17. Terapijski lijek za osteoporozu u skladu s patentnim zahtjevom 16, naznačen time što drugi terapijski lijek za osteoporozu se bira iz skupine koju čine kalcijsko sredstvo, pripravak vitamina D, pripravak vitamina K, pripravak ženskog hormona, pripravak estrogenskog antagonista, pripravak anaboličkog steroida, pripravak paratireoidnog hormona (hormona nusštitnjače), kalcitoninski pripravak, bifosfonatni pripravak, te pripravak ipriflavona.
18. Antagonist kalcijskog receptora, naznačen time što sadrži farmaceutski prihvatljivu podlogu, te spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 13, njegov optički aktivni oblik, njegovu farmaceutski prihvatljiva sol ili optički aktivni oblik njegove soli kao aktivni sastojak.
19. Sekretagog PTH, naznačen time što sadrži farmaceutski prihvatljivu podlogu, te spoj u skladu s bilo kojim od patentnih zahtjeva 1 do 13, njegov optički aktivni oblik, njegovu farmaceutski prihvatljivu sol ili optički aktivni oblik njegove soli kao aktivni sastojak.
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US20070155819A1 (en) * | 2004-02-06 | 2007-07-05 | Marquis Robert W Jr | Calcilytic compounds |
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WO2010103429A1 (en) * | 2009-03-10 | 2010-09-16 | Pfizer Inc. | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
CN102365261A (zh) * | 2009-03-26 | 2012-02-29 | 日本烟草产业株式会社 | 制备羧酸化合物的方法 |
WO2010113860A1 (ja) * | 2009-03-31 | 2010-10-07 | 第一三共株式会社 | ビフェニル-環状アミン化合物 |
CA2762137A1 (en) | 2009-05-27 | 2010-12-02 | Leo Pharma A/S | Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof |
US8785494B2 (en) | 2009-05-27 | 2014-07-22 | Leo-Pharma A/S | Calcium sensing receptor modulating compounds and pharmaceutical use thereof |
US20130267516A1 (en) * | 2010-11-26 | 2013-10-10 | Leo Pharma A/S | Substituted cyclopentyl-azines as casr-active compounds |
RU2013128973A (ru) | 2010-11-26 | 2015-01-10 | Лео Фарма А/С | Соединения, активные в отношении кальций-чувствительных рецепторов |
US20130261132A1 (en) | 2010-11-26 | 2013-10-03 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
US20130244995A1 (en) | 2010-11-26 | 2013-09-19 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
GB201113538D0 (en) * | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
US9227919B2 (en) * | 2012-08-27 | 2016-01-05 | Lupin Limited | Arylalkylamine compounds as calcium sensing receptor modulators |
WO2017215591A1 (en) | 2016-06-13 | 2017-12-21 | Syneurx International (Taiwan) Corp. | Use of lithium benzoate for treating central nervous system disorders |
BR112022011127A2 (pt) * | 2019-12-09 | 2022-08-23 | Beijing Tuo Jie Biopharmaceutical Co Ltd | Composto agonista do receptor de detecção de cálcio e aplicação do mesmo |
CN116648243A (zh) | 2020-08-04 | 2023-08-25 | 柯西立提克斯疗法有限公司 | 三苯基钙敏感化合物的制剂 |
EP4213829A1 (en) | 2020-09-18 | 2023-07-26 | Calcilytix Therapeutics, Inc. | Triphenyl calcilytic compounds for the treatment of autosomal dominant hypocalcemia type 1 (adh1) |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE633760A (hr) * | 1963-06-18 | |||
DD207203A1 (de) * | 1982-06-21 | 1984-02-22 | Peter Meisel | Verfahren zur herstellung von epoxypropylethern |
DE3743265A1 (de) * | 1987-12-19 | 1989-06-29 | Boehringer Ingelheim Kg | Neue ammoniumverbindungen, ihre herstellung und verwendung |
US5276008A (en) * | 1990-08-09 | 1994-01-04 | Bayer Aktiengesellschaft | Substituted 4,5-diamino-1,2,4-triazol-3-(thi)ones |
US6818660B2 (en) | 1996-04-09 | 2004-11-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
US6022894A (en) | 1996-04-09 | 2000-02-08 | Nps Pharmaceuticals, Inc. | Method of using calcilytic compounds |
ATE215369T1 (de) * | 1996-09-05 | 2002-04-15 | Lilly Co Eli | Carbazolanaloge als selektive beta3-adrenergische agonisten |
UY24949A1 (es) | 1997-04-08 | 2001-04-30 | Smithkline Beecham Corp | Compuestos calcilíticos |
AR014975A1 (es) | 1998-04-08 | 2001-04-11 | Nps Pharma Inc | Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento |
US20020052509A1 (en) | 1998-04-08 | 2002-05-02 | Smithkline Beecham Corporation | Calcilytic compounds and method of use |
PE20000415A1 (es) | 1998-04-08 | 2000-05-21 | Smithkline Beecham Corp | Compuestos calciliticos |
US6334338B1 (en) | 1998-07-02 | 2002-01-01 | Lucent Technologies Inc. | Sol gel process of making a fiber preform with removal of oxide particles |
WO2000009132A1 (en) | 1998-08-12 | 2000-02-24 | Smithkline Beecham Corporation | Calcilytic compounds |
EP1104411A4 (en) | 1998-08-12 | 2002-10-24 | Smithkline Beecham Corp | CALCILYTIC COMPOUNDS |
HUP0104199A3 (en) * | 1998-10-23 | 2002-12-28 | Hoffmann La Roche | Substituted pyrimido pyrimidinone derivatives, pharmaceutical compositions containing the same, process for the preparation thereof and intermediates |
PE20001456A1 (es) | 1999-02-02 | 2001-01-28 | Smithkline Beecham Corp | Compuestos calcioliticos |
BR0013610A (pt) * | 1999-08-27 | 2002-07-16 | Procter & Gamble | Componentes de formulções de ação rápida,composições e métodos para lavar roupa empregando os mesmos |
IL139073A0 (en) | 1999-10-21 | 2001-11-25 | Pfizer | Treatment of neuropathy |
AR030684A1 (es) | 2000-01-24 | 2003-09-03 | Smithkline Beecham Corp | Compuestos calciliticos, uso de dichos compuestos en la manufactura de medicamentos, e intermediarios utiles en la preparacion de dichos compuestos |
US20030018203A1 (en) | 2002-07-17 | 2003-01-23 | Largo Maria Amparo | Calcilytic compounds |
US6867299B2 (en) * | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
AU2001276923B2 (en) | 2000-07-21 | 2005-02-03 | Smithkline Beecham Corporation | Calcilytic compounds |
ATE411275T1 (de) | 2000-08-11 | 2008-10-15 | Japan Tobacco Inc | Calciumrezeptor-antagonisten |
AU2002230579A1 (en) | 2000-10-25 | 2002-05-06 | Smithkline Beecham Corp | Calcilytic compounds |
JP2004519428A (ja) | 2000-10-25 | 2004-07-02 | スミスクライン・ビーチャム・コーポレイション | カルシライティック化合物 |
AR038658A1 (es) | 2001-06-15 | 2005-01-26 | Novartis Ag | Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento |
US6864267B2 (en) | 2001-07-16 | 2005-03-08 | Smithkline Beecham Corporation | Calcilytic compounds |
WO2004106280A1 (ja) * | 2003-05-28 | 2004-12-09 | Japan Tobacco Inc. | CaSRアンタゴニスト |
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