DE602004024668D1 - CaSR-ANTAGONIST - Google Patents

CaSR-ANTAGONIST

Info

Publication number
DE602004024668D1
DE602004024668D1 DE602004024668T DE602004024668T DE602004024668D1 DE 602004024668 D1 DE602004024668 D1 DE 602004024668D1 DE 602004024668 T DE602004024668 T DE 602004024668T DE 602004024668 T DE602004024668 T DE 602004024668T DE 602004024668 D1 DE602004024668 D1 DE 602004024668D1
Authority
DE
Germany
Prior art keywords
casr antagonist
casr
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004024668T
Other languages
English (en)
Inventor
Yuko Shinagawa
Teruhiko Inoue
Toshihiro Kiguchi
Taku Ikenogami
Naoki Ogawa
Kenji Fukuda
Takashi Nakagawa
Masanori Shindo
Yuki Soejima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of DE602004024668D1 publication Critical patent/DE602004024668D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
DE602004024668T 2003-04-23 2004-04-23 CaSR-ANTAGONIST Expired - Lifetime DE602004024668D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003119131 2003-04-23
PCT/JP2004/005886 WO2004094362A1 (ja) 2003-04-23 2004-04-23 CaSRアンタゴニスト

Publications (1)

Publication Number Publication Date
DE602004024668D1 true DE602004024668D1 (de) 2010-01-28

Family

ID=33308093

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004024668T Expired - Lifetime DE602004024668D1 (de) 2003-04-23 2004-04-23 CaSR-ANTAGONIST

Country Status (31)

Country Link
US (4) US7304174B2 (de)
EP (3) EP2189439A3 (de)
JP (1) JP3751312B2 (de)
KR (1) KR100696927B1 (de)
CN (2) CN100577633C (de)
AR (1) AR044075A1 (de)
AT (1) ATE452121T1 (de)
AU (1) AU2004232604C1 (de)
BR (1) BRPI0407097A (de)
CA (1) CA2513738C (de)
CL (1) CL2004000868A1 (de)
CO (1) CO5640091A2 (de)
CY (1) CY1109880T1 (de)
DE (1) DE602004024668D1 (de)
DK (1) DK1619180T3 (de)
ES (1) ES2337576T3 (de)
HK (1) HK1083096A1 (de)
HR (1) HRP20100042T1 (de)
IL (1) IL169575A (de)
MX (1) MXPA05007609A (de)
MY (1) MY138734A (de)
NO (1) NO20054868L (de)
NZ (1) NZ541188A (de)
PE (1) PE20050460A1 (de)
PL (1) PL1619180T3 (de)
PT (1) PT1619180E (de)
RU (1) RU2315036C2 (de)
SI (1) SI1619180T1 (de)
TW (1) TWI329628B (de)
WO (1) WO2004094362A1 (de)
ZA (1) ZA200505587B (de)

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GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
JPWO2004106280A1 (ja) * 2003-05-28 2006-07-20 日本たばこ産業株式会社 ＣａＳＲアンタゴニスト
EP1713758A4 (de) * 2004-02-06 2008-02-13 Smithkline Beecham Corp Kalzilytische verbindungen
CN101437490A (zh) 2006-04-20 2009-05-20 安美基公司 稳定乳液配方
EP2139462B1 (de) 2007-03-30 2014-01-22 Amgen Inc. Calcimimetische verbindungen zur verwendung bei der behandlung von darmerkrankungen
DK2292592T3 (da) 2008-06-05 2012-10-08 Asahi Kasei Pharma Corp Sulfonamidforbindelse og anvendelse deraf
CN102307852B (zh) 2008-12-24 2013-12-18 第一三共株式会社 环状胺化合物
CA2748250A1 (en) 2008-12-24 2010-07-01 Daiichi Sankyo Company, Limited Indanyl compounds
WO2010103429A1 (en) * 2009-03-10 2010-09-16 Pfizer Inc. 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists
WO2010104882A1 (en) 2009-03-10 2010-09-16 Amgen Inc. Methods of modulating sperm motility
EP2412697A1 (de) 2009-03-26 2012-02-01 Japan Tobacco, Inc. Verfahren zur herstellung einer carboxylsäureverbindung
WO2010113860A1 (ja) * 2009-03-31 2010-10-07 第一三共株式会社 ビフェニル－環状アミン化合物
CA2762130A1 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
EP2435404A1 (de) 2009-05-27 2012-04-04 Leo Pharma A/S Neue, calciumempfindliche rezeptoren modulierende verbindungen und deren pharmazeutische verwendung
EP2643298A1 (de) 2010-11-26 2013-10-02 Leo Pharma A/S Substituierte cyclopentylazine als casr-aktive verbindungen
EP2643292A1 (de) 2010-11-26 2013-10-02 Leo Pharma A/S Casr-aktive verbindungen
US20130244995A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
CN103270018A (zh) 2010-11-26 2013-08-28 利奥制药有限公司 钙敏感受体激活化合物
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
AU2013308081A1 (en) * 2012-08-27 2015-02-26 Lupin Atlantis Holdings Sa Arylalkylamine compounds as calcium sensing receptor modulators
CN109562089A (zh) 2016-06-13 2019-04-02 心悦生医股份有限公司 苯甲酸锂用于治疗中枢神经系统疾病的用途
AU2020399030A1 (en) * 2019-12-09 2022-06-23 Beijing Tuo Jie Biopharmaceutical Co. Ltd. Calcium-sensing receptor agonist compound and application thereof
MX2023001438A (es) 2020-08-04 2023-06-15 Calcilytix Therapeutics Inc Formulaciones de compuestos calciliticos de trifenilo.
JP2023542932A (ja) * 2020-09-18 2023-10-12 カルシリティクス セラピューティクス，インコーポレイティド 常染色体優性低カルシウム血症１型（ａｄｈ１）の治療のためのトリフェニルカルシリティック化合物

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EP1404654A4 (de) 2000-10-25 2008-12-03 Smithkline Beecham Corp Kalzilytische verbindungen
ATE343390T1 (de) 2000-10-25 2006-11-15 Smithkline Beecham Corp Kalzilytische verbindungen
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JPWO2004106280A1 (ja) * 2003-05-28 2006-07-20 日本たばこ産業株式会社 ＣａＳＲアンタゴニスト

Also Published As

Publication number Publication date
ATE452121T1 (de) 2010-01-15
US20080255042A1 (en) 2008-10-16
JPWO2004094362A1 (ja) 2006-07-13
WO2004094362A1 (ja) 2004-11-04
AU2004232604A1 (en) 2004-11-04
HRP20100042T1 (hr) 2010-02-28
PE20050460A1 (es) 2005-07-08
AU2004232604C1 (en) 2008-06-05
KR100696927B1 (ko) 2007-03-20
US20050032796A1 (en) 2005-02-10
RU2005123985A (ru) 2006-01-27
CO5640091A2 (es) 2006-05-31
US20090326058A1 (en) 2009-12-31
CA2513738A1 (en) 2004-11-04
HK1083096A1 (en) 2006-06-23
EP2189439A3 (de) 2011-05-04
US20120301552A1 (en) 2012-11-29
PT1619180E (pt) 2009-12-29
US7304174B2 (en) 2007-12-04
CN101723921A (zh) 2010-06-09
TWI329628B (en) 2010-09-01
NZ541188A (en) 2008-01-31
ES2337576T3 (es) 2010-04-27
ZA200505587B (en) 2006-09-27
KR20050094047A (ko) 2005-09-26
AU2004232604A8 (en) 2004-11-04
IL169575A (en) 2011-07-31
EP2308828A2 (de) 2011-04-13
EP1619180A4 (de) 2006-05-24
CN100577633C (zh) 2010-01-06
BRPI0407097A (pt) 2006-01-24
NO20054868D0 (no) 2005-10-21
IL169575A0 (en) 2007-07-04
CN1741984A (zh) 2006-03-01
EP1619180A1 (de) 2006-01-25
MXPA05007609A (es) 2005-09-30
JP3751312B2 (ja) 2006-03-01
RU2315036C2 (ru) 2008-01-20
AU2004232604B2 (en) 2007-09-13
SI1619180T1 (sl) 2010-04-30
DK1619180T3 (da) 2010-03-29
CL2004000868A1 (es) 2005-01-21
PL1619180T3 (pl) 2010-05-31
EP2189439A2 (de) 2010-05-26
TW200505823A (en) 2005-02-16
EP2308828A3 (de) 2013-05-22
NO20054868L (no) 2005-12-20
CY1109880T1 (el) 2014-09-10
AU2004232604B8 (en) 2004-11-04
MY138734A (en) 2009-07-31
EP1619180B1 (de) 2009-12-16
CA2513738C (en) 2010-04-06
AR044075A1 (es) 2005-08-24

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