AR044075A1 - Antagonista de un receptor sensible al calcio - Google Patents
Antagonista de un receptor sensible al calcioInfo
- Publication number
- AR044075A1 AR044075A1 ARP040101388A ARP040101388A AR044075A1 AR 044075 A1 AR044075 A1 AR 044075A1 AR P040101388 A ARP040101388 A AR P040101388A AR P040101388 A ARP040101388 A AR P040101388A AR 044075 A1 AR044075 A1 AR 044075A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
Abstract
Un compuesto que posee una acción antagónica sensible al receptor de calcio, una composición farmacéutica que comprende el compuesto, particularmente se provee un antagonista a receptor de calcio y una droga terapéutica para osteoporosis. Reivindicación 1: Un compuesto representado por la fórmula (1), caracteriza porque: n es 0 ó 1; p es un entero de valor 1 a 3; R1 es un grupo hidroxilo, un grupo alcoxilo C1-6 ó RA, en donde RA es Rc-OC(=O)-alquileno(C1-4)-O- ó OH-NH- , en donde Rc es un grupo alquilo C1-6 o un grupo cicloalquilo C3-6; R2 y R3 son iguales o diferentes y cada uno es un átomo de hidrógeno, un grupo hidroxilo, un átomo halógeno, un grupo amino, grupo acilamino C1-7, un grupo haloalquilo C1-6, un grupo carboxilo, un grupo alcoxicarbonilo C1-6, un grupo alcoxilo C1-6, un grupo haloalcoxilo C1-6, un grupo alquilo C1-6, un grupo hidroxialquilo C1-6, un grupo acilamino(C1-7)-alquilo(C1-6), un grupo alquenilo C2-6, un grupo aralquilo, un grupo fenilo, grupo alquilamino C1-6, un grupo di(alquil C1-6)amino, un grupo alcoxi(C1-6)-alquilo(C1-6), un grupo mercapto, un grupo ciano, un grupo nitro, un grupo morfolino, un grupo piperidino o un grupo pirrolidino, o R2 y R3 forman un grupo etilenoxilo; X1 es -C=C-, -C=N-, un átomo de oxígeno o átomo de azufre; Z es -S-, -SO-, -SO2-, -(CH2)m1-O-, -O-(CH2)m1-, -(CH2)m2-NH-, -NH-(CH2)m2-, -(CH2)m3-N(CH3)-, -N(CH3)-(CH2)m3-, un grupo alquileno C1-4, -SO2-N(CH3)-, N(CH3)-SO2-, -NHCO-, - CONH- o un grupo alquenileno C2-4, en donde m1, m2 y m3 son cada uno un entero de valor 0 a 2; X2 es -C=C-, un átomo de oxígeno o un átomo de azufre; R4 es un grupo alquilo C1-6 o un grupo cicloalquilo C3-6; R5 es un átomo de hidrógeno o RB; en donde RB es un grupo acilo C1-7 opcionalmente sustituido por un grupo carboxilo; Y es un átomo de carbono o un átomo de nitrógeno; y R6, R7 y R8 son iguales o diferentes y cada uno es un átomo de hidrógeno, un átomo halógeno, un grupo alquilo C1-6, un grupo alcoxilo C1-6, un grupo haloalquilo C1-6, un grupo haloalcoxilo C1-6, un grupo carboxilo, un grupo hidroxilo, un grupo ciano, un grupo nitro, un grupo fenilo, un grupo cicloalquilo C3-6, un grupo di(alquilo C1-6)aminocarbonilo o un grupo hidroxialquilo C1-6, o R6 y R7 adyacentes se unen para formar -CH=CH-CH=CH-, -C(OH)=CH-CH=CH-, -CH=C(OH)-CH=CH-, -O-(CH2)k1-O-, -O-(CH2)k2- ó -(CH2)k3-, en donde k1 es un entero de valor 1 a 4, k2 es un entero de valor 2 a 5, k3 es un entero de valor 3 a 6, con la condición que cuando R2 y R34 son átomos de hidrógeno y n es 1, entonces Z debe ser un grupo distinto de -SO2-N(CH3)- en donde el átomo de azufre se une al anillo V y un átomo de nitrógeno se une al anillo w, una sal farmacéuticamente aceptable del mismo o una forma ópticamente activa del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003119131 | 2003-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR044075A1 true AR044075A1 (es) | 2005-08-24 |
Family
ID=33308093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101388A AR044075A1 (es) | 2003-04-23 | 2004-04-23 | Antagonista de un receptor sensible al calcio |
Country Status (31)
Country | Link |
---|---|
US (4) | US7304174B2 (es) |
EP (3) | EP2189439A3 (es) |
JP (1) | JP3751312B2 (es) |
KR (1) | KR100696927B1 (es) |
CN (2) | CN101723921A (es) |
AR (1) | AR044075A1 (es) |
AT (1) | ATE452121T1 (es) |
AU (1) | AU2004232604C1 (es) |
BR (1) | BRPI0407097A (es) |
CA (1) | CA2513738C (es) |
CL (1) | CL2004000868A1 (es) |
CO (1) | CO5640091A2 (es) |
CY (1) | CY1109880T1 (es) |
DE (1) | DE602004024668D1 (es) |
DK (1) | DK1619180T3 (es) |
ES (1) | ES2337576T3 (es) |
HK (1) | HK1083096A1 (es) |
HR (1) | HRP20100042T1 (es) |
IL (1) | IL169575A (es) |
MX (1) | MXPA05007609A (es) |
MY (1) | MY138734A (es) |
NO (1) | NO20054868L (es) |
NZ (1) | NZ541188A (es) |
PE (1) | PE20050460A1 (es) |
PL (1) | PL1619180T3 (es) |
PT (1) | PT1619180E (es) |
RU (1) | RU2315036C2 (es) |
SI (1) | SI1619180T1 (es) |
TW (1) | TWI329628B (es) |
WO (1) | WO2004094362A1 (es) |
ZA (1) | ZA200505587B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
WO2004106280A1 (ja) * | 2003-05-28 | 2004-12-09 | Japan Tobacco Inc. | CaSRアンタゴニスト |
US20070155819A1 (en) * | 2004-02-06 | 2007-07-05 | Marquis Robert W Jr | Calcilytic compounds |
WO2007124465A2 (en) * | 2006-04-20 | 2007-11-01 | Amgen Inc. | Stable emulsion formulations |
WO2008121386A2 (en) | 2007-03-30 | 2008-10-09 | Amgen Inc. | Calcimimetic compounds for use in the treatment of bowel disorders |
EP2292592B1 (en) * | 2008-06-05 | 2012-09-05 | Asahi Kasei Pharma Corporation | Sulfonamide compound and application thereof |
CN102307847A (zh) | 2008-12-24 | 2012-01-04 | 第一三共株式会社 | 茚满基化合物 |
RU2478616C2 (ru) * | 2008-12-24 | 2013-04-10 | Дайити Санкио Компани, Лимитед | Циклические аминосоединения |
WO2010104882A1 (en) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Methods of modulating sperm motility |
WO2010103429A1 (en) * | 2009-03-10 | 2010-09-16 | Pfizer Inc. | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
CN102365261A (zh) * | 2009-03-26 | 2012-02-29 | 日本烟草产业株式会社 | 制备羧酸化合物的方法 |
WO2010113860A1 (ja) * | 2009-03-31 | 2010-10-07 | 第一三共株式会社 | ビフェニル-環状アミン化合物 |
CA2762137A1 (en) | 2009-05-27 | 2010-12-02 | Leo Pharma A/S | Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof |
US8785494B2 (en) | 2009-05-27 | 2014-07-22 | Leo-Pharma A/S | Calcium sensing receptor modulating compounds and pharmaceutical use thereof |
US20130267516A1 (en) * | 2010-11-26 | 2013-10-10 | Leo Pharma A/S | Substituted cyclopentyl-azines as casr-active compounds |
RU2013128973A (ru) | 2010-11-26 | 2015-01-10 | Лео Фарма А/С | Соединения, активные в отношении кальций-чувствительных рецепторов |
US20130261132A1 (en) | 2010-11-26 | 2013-10-03 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
US20130244995A1 (en) | 2010-11-26 | 2013-09-19 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
GB201113538D0 (en) * | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
US9227919B2 (en) * | 2012-08-27 | 2016-01-05 | Lupin Limited | Arylalkylamine compounds as calcium sensing receptor modulators |
WO2017215591A1 (en) | 2016-06-13 | 2017-12-21 | Syneurx International (Taiwan) Corp. | Use of lithium benzoate for treating central nervous system disorders |
BR112022011127A2 (pt) * | 2019-12-09 | 2022-08-23 | Beijing Tuo Jie Biopharmaceutical Co Ltd | Composto agonista do receptor de detecção de cálcio e aplicação do mesmo |
CN116648243A (zh) | 2020-08-04 | 2023-08-25 | 柯西立提克斯疗法有限公司 | 三苯基钙敏感化合物的制剂 |
EP4213829A1 (en) | 2020-09-18 | 2023-07-26 | Calcilytix Therapeutics, Inc. | Triphenyl calcilytic compounds for the treatment of autosomal dominant hypocalcemia type 1 (adh1) |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
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BE633760A (es) * | 1963-06-18 | |||
DD207203A1 (de) * | 1982-06-21 | 1984-02-22 | Peter Meisel | Verfahren zur herstellung von epoxypropylethern |
DE3743265A1 (de) * | 1987-12-19 | 1989-06-29 | Boehringer Ingelheim Kg | Neue ammoniumverbindungen, ihre herstellung und verwendung |
US5276008A (en) * | 1990-08-09 | 1994-01-04 | Bayer Aktiengesellschaft | Substituted 4,5-diamino-1,2,4-triazol-3-(thi)ones |
US6818660B2 (en) | 1996-04-09 | 2004-11-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
US6022894A (en) | 1996-04-09 | 2000-02-08 | Nps Pharmaceuticals, Inc. | Method of using calcilytic compounds |
ATE215369T1 (de) * | 1996-09-05 | 2002-04-15 | Lilly Co Eli | Carbazolanaloge als selektive beta3-adrenergische agonisten |
UY24949A1 (es) | 1997-04-08 | 2001-04-30 | Smithkline Beecham Corp | Compuestos calcilíticos |
AR014975A1 (es) | 1998-04-08 | 2001-04-11 | Nps Pharma Inc | Compuestos calciliticos, una composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de un medicamento |
US20020052509A1 (en) | 1998-04-08 | 2002-05-02 | Smithkline Beecham Corporation | Calcilytic compounds and method of use |
PE20000415A1 (es) | 1998-04-08 | 2000-05-21 | Smithkline Beecham Corp | Compuestos calciliticos |
US6334338B1 (en) | 1998-07-02 | 2002-01-01 | Lucent Technologies Inc. | Sol gel process of making a fiber preform with removal of oxide particles |
WO2000009132A1 (en) | 1998-08-12 | 2000-02-24 | Smithkline Beecham Corporation | Calcilytic compounds |
EP1104411A4 (en) | 1998-08-12 | 2002-10-24 | Smithkline Beecham Corp | CALCILYTIC COMPOUNDS |
HUP0104199A3 (en) * | 1998-10-23 | 2002-12-28 | Hoffmann La Roche | Substituted pyrimido pyrimidinone derivatives, pharmaceutical compositions containing the same, process for the preparation thereof and intermediates |
PE20001456A1 (es) | 1999-02-02 | 2001-01-28 | Smithkline Beecham Corp | Compuestos calcioliticos |
BR0013610A (pt) * | 1999-08-27 | 2002-07-16 | Procter & Gamble | Componentes de formulções de ação rápida,composições e métodos para lavar roupa empregando os mesmos |
IL139073A0 (en) | 1999-10-21 | 2001-11-25 | Pfizer | Treatment of neuropathy |
AR030684A1 (es) | 2000-01-24 | 2003-09-03 | Smithkline Beecham Corp | Compuestos calciliticos, uso de dichos compuestos en la manufactura de medicamentos, e intermediarios utiles en la preparacion de dichos compuestos |
US20030018203A1 (en) | 2002-07-17 | 2003-01-23 | Largo Maria Amparo | Calcilytic compounds |
US6867299B2 (en) * | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
AU2001276923B2 (en) | 2000-07-21 | 2005-02-03 | Smithkline Beecham Corporation | Calcilytic compounds |
ATE411275T1 (de) | 2000-08-11 | 2008-10-15 | Japan Tobacco Inc | Calciumrezeptor-antagonisten |
AU2002230579A1 (en) | 2000-10-25 | 2002-05-06 | Smithkline Beecham Corp | Calcilytic compounds |
JP2004519428A (ja) | 2000-10-25 | 2004-07-02 | スミスクライン・ビーチャム・コーポレイション | カルシライティック化合物 |
AR038658A1 (es) | 2001-06-15 | 2005-01-26 | Novartis Ag | Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento |
US6864267B2 (en) | 2001-07-16 | 2005-03-08 | Smithkline Beecham Corporation | Calcilytic compounds |
WO2004106280A1 (ja) * | 2003-05-28 | 2004-12-09 | Japan Tobacco Inc. | CaSRアンタゴニスト |
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2004
- 2004-04-23 CL CL200400868A patent/CL2004000868A1/es unknown
- 2004-04-23 ZA ZA200505587A patent/ZA200505587B/en unknown
- 2004-04-23 EP EP09177717A patent/EP2189439A3/en not_active Withdrawn
- 2004-04-23 NZ NZ541188A patent/NZ541188A/en not_active IP Right Cessation
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- 2004-04-23 CN CN200910253477A patent/CN101723921A/zh active Pending
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- 2004-04-23 WO PCT/JP2004/005886 patent/WO2004094362A1/ja active Application Filing
- 2004-04-23 CN CN200480002843A patent/CN100577633C/zh not_active Expired - Fee Related
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- 2004-04-23 EP EP10179435.2A patent/EP2308828A3/en not_active Withdrawn
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2006
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2010
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