PE20001456A1 - Compuestos calcioliticos - Google Patents

Compuestos calcioliticos

Info

Publication number
PE20001456A1
PE20001456A1 PE2000000070A PE0000702000A PE20001456A1 PE 20001456 A1 PE20001456 A1 PE 20001456A1 PE 2000000070 A PE2000000070 A PE 2000000070A PE 0000702000 A PE0000702000 A PE 0000702000A PE 20001456 A1 PE20001456 A1 PE 20001456A1
Authority
PE
Peru
Prior art keywords
carbetoxyphenyl
cyane
phenoxy
naphthyl
propyl
Prior art date
Application number
PE2000000070A
Other languages
English (en)
Inventor
Lago Amparo Maria
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20001456A1 publication Critical patent/PE20001456A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES ARILO; X ES CN, NO2, Cl, F, H; Y ES Cl, F, Br, I, H; Q ES H, R1, SO2R1, R1COOR`1, TETRAZOL, CH2OH, ENTRE OTROS; R1 Y R1' SON H, ALQUILO C1-C4, O JUNTOS FORMAN UN HETEROCICLO DE 3-7 MIEMBROS; Ar ES FENILO, NAFTILO, HETEROARILO, HETEROARILO CONDENSADO. SON COMPUESTOS PREFERIDOS HIDROCLORURO DE N-[2R-HIDROXI-3-[2-CIANO-5-[2-CARBETOXIFENIL)FENOXI]]PROPIL]-1,1-DIMETIL-2-(2-NAFTIL)ETILAMINA; HIDROCLORURO DE N-[2R-HIDROXI-3-[2-CIANO-5-[4-CARBETOXIFENIL]FENOXI]PROPIL]-1,1-DIMETIL-2-(2-NAFTIL)ETILAMINA, ENTRE OTROS. EL COMPUESTO I ES UN ANTAGONISTA DEL RECEPTOR DE CALCIO POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE UN TRASTORNO DE LA HOMEOSTASIS ANORMAL DE LOS HUESOS COMO OSTEOSARCOMA, ENFERMEDAD PERIODONTAL, CURACION DE FRACTURAS, OSTEOARTRITIS, ARTRITIS REUMATOIDE, INCREMENTAR LOS NIVELES DE HORMONA PARATIROIDEA
PE2000000070A 1999-02-02 2000-02-01 Compuestos calcioliticos PE20001456A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11824099P 1999-02-02 1999-02-02

Publications (1)

Publication Number Publication Date
PE20001456A1 true PE20001456A1 (es) 2001-01-28

Family

ID=22377367

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000070A PE20001456A1 (es) 1999-02-02 2000-02-01 Compuestos calcioliticos

Country Status (24)

Country Link
US (1) US6417215B1 (es)
EP (1) EP1148876A4 (es)
JP (1) JP2002536330A (es)
KR (1) KR20010093285A (es)
CN (1) CN1346269A (es)
AP (1) AP2001002220A0 (es)
AU (1) AU3480200A (es)
BG (1) BG105847A (es)
BR (1) BR0007922A (es)
CA (1) CA2361589A1 (es)
CO (1) CO5251439A1 (es)
CZ (1) CZ20012797A3 (es)
EA (1) EA200100854A1 (es)
HK (1) HK1042036A1 (es)
HU (1) HUP0200121A3 (es)
ID (1) ID29533A (es)
IL (1) IL144470A0 (es)
MA (1) MA25379A1 (es)
NO (1) NO20013769L (es)
OA (1) OA11757A (es)
PE (1) PE20001456A1 (es)
SK (1) SK10982001A3 (es)
WO (1) WO2000045816A1 (es)
ZA (1) ZA200106298B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100785675B1 (ko) * 2000-08-11 2007-12-14 니뽄 다바코 산교 가부시키가이샤 칼슘 수용체 길항약
US20040014723A1 (en) * 2000-10-25 2004-01-22 Pradip Bhatnagar Calcilytic compounds
US6864267B2 (en) * 2001-07-16 2005-03-08 Smithkline Beecham Corporation Calcilytic compounds
AR042132A1 (es) * 2002-11-26 2005-06-08 Smithkline Beecham Corp Compuesto de 2- hidroxi -3-(2- aril - 1, 1 - dimetiletilamino) propoxifenilo, composicion farmaceutica que lo comprende y uso del mismo para prepararla
US7105537B2 (en) 2003-01-28 2006-09-12 Bristol-Myers Squibb Company 2-substituted cyclic amines as calcium sensing receptor modulators
US7205322B2 (en) 2003-02-12 2007-04-17 Bristol-Myers Squibb Company Thiazolidine compounds as calcium sensing receptor modulators
PT1619180E (pt) 2003-04-23 2009-12-29 Japan Tobacco Inc Antagonista de casr
EP1630157A4 (en) 2003-05-28 2007-05-23 Japan Tobacco Inc ANTAGONIST OF CASR
US7265145B2 (en) 2003-05-28 2007-09-04 Bristol-Myers Squibb Company Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method
EP1964548A1 (en) * 2007-03-02 2008-09-03 Novartis AG Pharmaceutical compositions comprising a calcilytic agent
EP2292592B1 (en) * 2008-06-05 2012-09-05 Asahi Kasei Pharma Corporation Sulfonamide compound and application thereof
WO2010103429A1 (en) 2009-03-10 2010-09-16 Pfizer Inc. 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists
GB201217330D0 (en) * 2012-09-28 2012-11-14 Univ Cardiff Therapeutic for treating inflammatory lung disorders
WO2021029517A1 (en) * 2019-08-13 2021-02-18 Dongguk University Industry-Academic Cooperation Foundation Pharmaceutical composition for improving or treating post-surgical hypoparathyroidism and treatment method using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE134624T1 (de) 1990-02-19 1996-03-15 Ciba Geigy Ag Acylverbindungen
DE4102024A1 (de) 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ATE298739T1 (de) * 1996-04-09 2005-07-15 Nps Pharma Inc Calcylitische verbindungen
UY24949A1 (es) * 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos

Also Published As

Publication number Publication date
CO5251439A1 (es) 2003-02-28
US6417215B1 (en) 2002-07-09
SK10982001A3 (sk) 2001-12-03
EP1148876A1 (en) 2001-10-31
NO20013769L (no) 2001-09-26
HUP0200121A2 (hu) 2002-05-29
CZ20012797A3 (cs) 2002-01-16
AP2001002220A0 (en) 2001-09-30
MA25379A1 (fr) 2002-04-01
HUP0200121A3 (en) 2002-11-28
ZA200106298B (en) 2002-10-18
EA200100854A1 (ru) 2002-02-28
BR0007922A (pt) 2001-11-06
KR20010093285A (ko) 2001-10-27
WO2000045816A1 (en) 2000-08-10
OA11757A (en) 2005-07-19
BG105847A (en) 2002-04-30
ID29533A (id) 2001-09-06
EP1148876A4 (en) 2003-07-23
AU3480200A (en) 2000-08-25
CA2361589A1 (en) 2000-08-10
CN1346269A (zh) 2002-04-24
HK1042036A1 (zh) 2002-08-02
IL144470A0 (en) 2002-05-23
NO20013769D0 (no) 2001-08-01
JP2002536330A (ja) 2002-10-29

Similar Documents

Publication Publication Date Title
PE20001456A1 (es) Compuestos calcioliticos
CY1106697T1 (el) Ν-υποκατεστημενες υδρομορφονες και η χρηση αυτων
DE69835430D1 (de) Sulfonamidderivate, ihre herstellung und verwendung
KR930000117A (ko) 이미다졸 화합물, 이의 제조방법 및 용도
DE69532195D1 (de) Benzamidverbindung und ihre medizinische verwendung
DE60325074D1 (de) Kristall für ein orales, festes arzneimittel, und ein orales, festes arnzeimittel zur behandlung von dysurie, das diesen enthält
CY1111951T1 (el) Φαινυλο-καρβοξαμιδικες ενωσεις χρησιμες για την αντιμετωπιση πονου
CY1109490T1 (el) Τρικυκλικοι τροποποιητες πυρηνικων υποδοχεων στεροειδων ορμονων
PE20020593A1 (es) Activadores de glucocinasa del tipo isoindolin-2-ona
BRPI0418181A (pt) emprego de 2-aminotetralinas substituìdas para prevenção do tratamento de morbus parkinson
DE69928226D1 (de) Chemokin rezeptor antagonisten und verwndung
DK1461318T3 (da) Tetrahydroquinolinanaloge som muscariniske agonister
BR0316458A (pt) Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto
DE69231298T2 (de) Substituierte Dibenzoxazepinverbindungen, pharmazeutische Zusammensetzungen und Anwendungsmethoden
PE20001640A1 (es) Compuestos dihetero sustituidos como inhibidores de metaloproteasas
BR0207645A (pt) Compostos carbamato para utilização na prevenção ou tratamento de distúrbios neurodegenerativos
RU2001135802A (ru) Антагонисты рецептора брадикинина
CY1107753T1 (el) 2,5-δισυποκατεστημενο 3-μερκαπτοπεντανοϊκο οξυ
BR0207673A (pt) Compostos de carbamato para o uso no tratamento de dor
EE200000059A (et) Tetrahüdro-gamma-karboliinid
BR9916845A (pt) Compostos de (aminoiminometil ouaminometil)benzo-heteroarila substituìdos
BR0305708A (pt) Derivados de benzimidazol para o tratamento de disfunção sexual
ATE370147T1 (de) Thiazolopyrimidinderivate und deren verwendung als antagonisten des cx3cr1 rezeptors
DE69919349D1 (de) Piperidinyl- und n-amidinopiperidinyl-derivate
BR0207830A (pt) Compostos de carbamato para uso em prevenir ou tratar distúrbios de ansiedade

Legal Events

Date Code Title Description
FC Refusal