HRP20090439T1 - Supstituirani derivati propenil piperazina kao novi inhibitori histonske deacetilaze - Google Patents
Supstituirani derivati propenil piperazina kao novi inhibitori histonske deacetilaze Download PDFInfo
- Publication number
- HRP20090439T1 HRP20090439T1 HR20090439T HRP20090439T HRP20090439T1 HR P20090439 T1 HRP20090439 T1 HR P20090439T1 HR 20090439 T HR20090439 T HR 20090439T HR P20090439 T HRP20090439 T HR P20090439T HR P20090439 T1 HRP20090439 T1 HR P20090439T1
- Authority
- HR
- Croatia
- Prior art keywords
- 6alkyl
- hydrogen
- independently selected
- formula
- phenyl
- Prior art date
Links
- QWLWFCBWJIJQAY-UHFFFAOYSA-N 1-prop-1-enylpiperazine Chemical class CC=CN1CCNCC1 QWLWFCBWJIJQAY-UHFFFAOYSA-N 0.000 title 1
- 102000003964 Histone deacetylase Human genes 0.000 title 1
- 108090000353 Histone deacetylase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- -1 hydroxy, cyano, amino Chemical group 0.000 claims abstract 34
- 150000001875 compounds Chemical class 0.000 claims abstract 28
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 23
- 239000001257 hydrogen Substances 0.000 claims abstract 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 16
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 15
- 125000000217 alkyl group Chemical group 0.000 claims abstract 13
- 150000002431 hydrogen Chemical class 0.000 claims abstract 13
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 12
- 125000001624 naphthyl group Chemical group 0.000 claims abstract 12
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 10
- 125000002757 morpholinyl group Chemical group 0.000 claims abstract 10
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims abstract 9
- 125000004193 piperazinyl group Chemical group 0.000 claims abstract 9
- 125000001424 substituent group Chemical group 0.000 claims abstract 9
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims abstract 9
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 7
- 125000003118 aryl group Chemical group 0.000 claims abstract 7
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims abstract 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 6
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims abstract 5
- 125000001425 triazolyl group Chemical group 0.000 claims abstract 5
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims abstract 4
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 claims abstract 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims abstract 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims abstract 3
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims abstract 3
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims abstract 3
- 125000000815 N-oxide group Chemical group 0.000 claims abstract 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 3
- 125000002541 furyl group Chemical group 0.000 claims abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract 3
- 125000002632 imidazolidinyl group Chemical group 0.000 claims abstract 3
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims abstract 3
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims abstract 3
- 125000001041 indolyl group Chemical group 0.000 claims abstract 3
- 125000001786 isothiazolyl group Chemical group 0.000 claims abstract 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims abstract 3
- 125000002971 oxazolyl group Chemical group 0.000 claims abstract 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims abstract 3
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims abstract 3
- 125000002755 pyrazolinyl group Chemical group 0.000 claims abstract 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims abstract 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims abstract 3
- 125000001422 pyrrolinyl group Chemical group 0.000 claims abstract 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 125000000335 thiazolyl group Chemical group 0.000 claims abstract 3
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims abstract 2
- 125000005883 dithianyl group Chemical group 0.000 claims abstract 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims abstract 2
- 125000001544 thienyl group Chemical group 0.000 claims abstract 2
- 125000004306 triazinyl group Chemical group 0.000 claims abstract 2
- 238000006243 chemical reaction Methods 0.000 claims 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 5
- 239000000543 intermediate Substances 0.000 claims 5
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 2
- 125000000532 dioxanyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 2
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 230000001131 transforming effect Effects 0.000 claims 2
- 125000005455 trithianyl group Chemical group 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims 1
- ATFVTAOSZBVGHC-UHFFFAOYSA-N Glycolaldehyde dimer Chemical compound OC1COC(O)CO1 ATFVTAOSZBVGHC-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 125000002636 imidazolinyl group Chemical group 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04077171 | 2004-07-28 | ||
| US59235704P | 2004-07-29 | 2004-07-29 | |
| PCT/EP2005/053611 WO2006010749A2 (en) | 2004-07-28 | 2005-07-25 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090439T1 true HRP20090439T1 (hr) | 2009-09-30 |
Family
ID=39294123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090439T HRP20090439T1 (hr) | 2004-07-28 | 2009-08-13 | Supstituirani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1776358B1 (pt) |
| JP (1) | JP5279268B2 (pt) |
| KR (1) | KR101282833B1 (pt) |
| CN (1) | CN1993356B (pt) |
| AR (1) | AR050189A1 (pt) |
| AT (1) | ATE432274T1 (pt) |
| AU (1) | AU2005266311B2 (pt) |
| BR (1) | BRPI0513891B8 (pt) |
| CA (1) | CA2572971C (pt) |
| CY (1) | CY1110358T1 (pt) |
| DE (1) | DE602005014646D1 (pt) |
| DK (1) | DK1776358T3 (pt) |
| EA (1) | EA011932B1 (pt) |
| ES (1) | ES2327253T3 (pt) |
| HK (1) | HK1106236A1 (pt) |
| HR (1) | HRP20090439T1 (pt) |
| IL (1) | IL180961A0 (pt) |
| MX (1) | MX2007001119A (pt) |
| MY (1) | MY142831A (pt) |
| NO (1) | NO20071117L (pt) |
| NZ (1) | NZ552758A (pt) |
| PL (1) | PL1776358T3 (pt) |
| PT (1) | PT1776358E (pt) |
| SI (1) | SI1776358T1 (pt) |
| TW (1) | TWI394752B (pt) |
| WO (1) | WO2006010749A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL208401B1 (pl) | 2002-03-13 | 2011-04-29 | Janssen Pharmaceutica Nv | Pochodne piperazynylowe, piperydynylowe i morfolinylowe, sposób ich wytwarzania, kompozycja je zawierająca oraz ich zastosowanie |
| CA2476296C (en) | 2002-03-13 | 2011-02-22 | Janssen Pharmaceutica N.V. | Amino-derivatives as inhibitors of histone deacetylase |
| ES2306880T3 (es) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa. |
| KR101261305B1 (ko) | 2004-07-28 | 2013-05-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로의 치환된 인돌릴알킬 아미노 유도체 |
| WO2006122926A1 (en) | 2005-05-18 | 2006-11-23 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| WO2007049262A1 (en) * | 2005-10-27 | 2007-05-03 | Berand Limited | Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders |
| US7834025B2 (en) | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| AU2007206944B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| CN101370790B (zh) * | 2006-01-19 | 2015-10-21 | 詹森药业有限公司 | 作为组蛋白去乙酰化酶抑制剂的吡啶和嘧啶衍生物 |
| ES2327972T3 (es) | 2006-01-19 | 2009-11-05 | Janssen Pharmaceutica, N.V. | Derivados de aminofenil como nuevos inhibidores de histona deacetilasa. |
| EP1839656A1 (en) * | 2006-03-31 | 2007-10-03 | TopoTarget Germany AG | Use of valproic acid for the topical treatment of mild to moderate acne vulgaris |
| CA2703718A1 (en) | 2007-11-02 | 2009-05-07 | Tammy Mallais | Inhibitors of histone deacetylase |
| CN101723896B (zh) * | 2009-11-03 | 2012-10-31 | 山东大学 | 酪氨酸衍生物类组蛋白去乙酰化酶抑制剂及其应用 |
| WO2012117421A1 (en) | 2011-03-02 | 2012-09-07 | Orchid Research Laboratories Ltd | Histone deacetylase inhibitors |
| KR101419836B1 (ko) * | 2012-05-10 | 2014-07-16 | 서울대학교산학협력단 | Δ5-2-옥소피페라진 유도체를 포함하는 중간엽 줄기세포의 연골세포로의 분화 유도용 조성물 |
| KR101586045B1 (ko) | 2013-07-30 | 2016-01-15 | 충북대학교 산학협력단 | 신규 페닐티아졸 기반 히드록삼산 및 이를 유효성분으로 포함하는 항암용 조성물 |
| KR102132078B1 (ko) | 2018-09-20 | 2020-07-08 | 원광대학교산학협력단 | 방향족 화합물, 아민 및 친핵체를 이용한 3가지 성분 반응으로 1-에틸-4-페닐피페라진 유도체를 제조하는 방법 |
| KR20230155311A (ko) | 2022-05-03 | 2023-11-10 | 충북대학교 산학협력단 | 신규한 n-히드록시프로펜아미드 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물 |
| KR20230155310A (ko) | 2022-05-03 | 2023-11-10 | 충북대학교 산학협력단 | 신규한 n-히드록시프로펜아미드 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| PL208401B1 (pl) * | 2002-03-13 | 2011-04-29 | Janssen Pharmaceutica Nv | Pochodne piperazynylowe, piperydynylowe i morfolinylowe, sposób ich wytwarzania, kompozycja je zawierająca oraz ich zastosowanie |
| CA2476296C (en) * | 2002-03-13 | 2011-02-22 | Janssen Pharmaceutica N.V. | Amino-derivatives as inhibitors of histone deacetylase |
| AU2003229883B2 (en) * | 2002-04-03 | 2009-06-11 | Topotarget Uk Limited | Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors |
-
2005
- 2005-07-25 BR BRPI0513891A patent/BRPI0513891B8/pt active IP Right Grant
- 2005-07-25 PL PL05777776T patent/PL1776358T3/pl unknown
- 2005-07-25 ES ES05777776T patent/ES2327253T3/es active Active
- 2005-07-25 DK DK05777776T patent/DK1776358T3/da active
- 2005-07-25 SI SI200530748T patent/SI1776358T1/sl unknown
- 2005-07-25 AT AT05777776T patent/ATE432274T1/de active
- 2005-07-25 KR KR1020077001641A patent/KR101282833B1/ko active IP Right Grant
- 2005-07-25 AU AU2005266311A patent/AU2005266311B2/en active Active
- 2005-07-25 MX MX2007001119A patent/MX2007001119A/es active IP Right Grant
- 2005-07-25 CA CA2572971A patent/CA2572971C/en active Active
- 2005-07-25 EA EA200700143A patent/EA011932B1/ru unknown
- 2005-07-25 DE DE602005014646T patent/DE602005014646D1/de active Active
- 2005-07-25 JP JP2007523072A patent/JP5279268B2/ja active Active
- 2005-07-25 PT PT05777776T patent/PT1776358E/pt unknown
- 2005-07-25 EP EP05777776A patent/EP1776358B1/en active Active
- 2005-07-25 WO PCT/EP2005/053611 patent/WO2006010749A2/en active Application Filing
- 2005-07-25 NZ NZ552758A patent/NZ552758A/en unknown
- 2005-07-25 CN CN2005800254878A patent/CN1993356B/zh active Active
- 2005-07-27 TW TW094125340A patent/TWI394752B/zh active
- 2005-07-28 AR ARP050103145A patent/AR050189A1/es active IP Right Grant
- 2005-07-28 MY MYPI20053492A patent/MY142831A/en unknown
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2007
- 2007-01-25 IL IL180961A patent/IL180961A0/en active IP Right Grant
- 2007-02-27 NO NO20071117A patent/NO20071117L/no not_active Application Discontinuation
- 2007-10-30 HK HK07111697.6A patent/HK1106236A1/xx unknown
-
2009
- 2009-08-06 CY CY20091100839T patent/CY1110358T1/el unknown
- 2009-08-13 HR HR20090439T patent/HRP20090439T1/hr unknown
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