HRP20090333T1 - Method for the production of substituted 3-aryl-butyl amine compounds - Google Patents
Method for the production of substituted 3-aryl-butyl amine compoundsInfo
- Publication number
- HRP20090333T1 HRP20090333T1 HR20090333T HRP20090333T HRP20090333T1 HR P20090333 T1 HRP20090333 T1 HR P20090333T1 HR 20090333 T HR20090333 T HR 20090333T HR P20090333 T HRP20090333 T HR P20090333T HR P20090333 T1 HRP20090333 T1 HR P20090333T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- polysubstituted
- mono
- unsubstituted
- saturated
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 8
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- 125000006237 oxymethylenoxy group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10326097A DE10326097A1 (de) | 2003-06-06 | 2003-06-06 | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
PCT/EP2004/006027 WO2004108658A1 (fr) | 2003-06-06 | 2004-06-04 | Procede de production des composes d'amine 3-aryle-butyle substitue |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20090333T1 true HRP20090333T1 (en) | 2009-07-31 |
Family
ID=33494923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090333T HRP20090333T1 (en) | 2003-06-06 | 2009-06-08 | Method for the production of substituted 3-aryl-butyl amine compounds |
Country Status (26)
Country | Link |
---|---|
US (1) | US7417170B2 (fr) |
EP (1) | EP1633697B1 (fr) |
JP (1) | JP4848268B2 (fr) |
KR (1) | KR101146205B1 (fr) |
CN (1) | CN1829681B (fr) |
AT (1) | ATE425136T1 (fr) |
AU (1) | AU2004245223C1 (fr) |
BR (1) | BRPI0411268C8 (fr) |
CA (1) | CA2528087C (fr) |
CY (1) | CY1109088T1 (fr) |
DE (2) | DE10326097A1 (fr) |
DK (1) | DK1633697T3 (fr) |
EC (1) | ECSP056218A (fr) |
ES (1) | ES2323870T3 (fr) |
HK (1) | HK1088597A1 (fr) |
HR (1) | HRP20090333T1 (fr) |
IL (1) | IL172357A (fr) |
MX (1) | MXPA05013193A (fr) |
NO (1) | NO335587B1 (fr) |
NZ (1) | NZ544231A (fr) |
PL (1) | PL1633697T3 (fr) |
PT (1) | PT1633697E (fr) |
RU (1) | RU2380355C2 (fr) |
SI (1) | SI1633697T1 (fr) |
WO (1) | WO2004108658A1 (fr) |
ZA (1) | ZA200600109B (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10328316A1 (de) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
DE102005052588A1 (de) | 2005-11-02 | 2007-05-10 | Grünenthal GmbH | Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse |
DK2046726T3 (da) * | 2006-07-24 | 2010-05-10 | Janssen Pharmaceutica Nv | Fremstilling af (2R,3R)-3-3-methoxyphenyl)-N,N, 2-trimethylpentanamin |
TWI448447B (zh) * | 2006-07-24 | 2014-08-11 | Gruenenthal Chemie | 製備(1r,2r)-3-(3-二甲胺基-1-乙基-2-甲基-丙基)-酚之方法 |
TWI401237B (zh) | 2006-07-24 | 2013-07-11 | 3-〔(1r,2r)-3-(二甲基氨基)-1-乙基-2-甲基丙基〕酚之製備 | |
ES2623413T3 (es) * | 2007-12-07 | 2017-07-11 | Grünenthal GmbH | Modificaciones cristalinas de (1R,2R)-3-(3-dimetilamino-1-etil-2-metilpropil)fenol |
WO2010100477A2 (fr) * | 2009-03-03 | 2010-09-10 | Shire Llc | Promédicaments de carbamate d'acide aminé et de peptide de tapentadol et leurs utilisations |
CN102002065B (zh) * | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
US8288592B2 (en) | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
IT1397189B1 (it) * | 2009-12-01 | 2013-01-04 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
MX2012007759A (es) | 2009-12-29 | 2012-08-01 | Mapi Pharma Ltd | Compuestos intermedios y procesos para la preparacion de tapentadol y compuestos relacionados. |
WO2011092719A2 (fr) * | 2010-02-01 | 2011-08-04 | Ind-Swift Laboratories Limited | Procédé de préparation de dérivés l-phényl-3-diméthylaminopropane |
AU2011222644A1 (en) | 2010-03-05 | 2012-09-06 | Actavis Group Ptc Ehf | Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
US20130096347A1 (en) | 2010-04-05 | 2013-04-18 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
ITMI20100924A1 (it) * | 2010-05-21 | 2011-11-22 | Fidia Farmaceutici | Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol |
EP2582659B1 (fr) * | 2010-06-15 | 2015-03-11 | Grünenthal GmbH | Procédé de préparation de composés 3-(1-amino-2-methylpentane-3-yl)phényle substitué |
IT1401109B1 (it) | 2010-07-02 | 2013-07-12 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
KR102146233B1 (ko) * | 2010-07-23 | 2020-08-21 | 그뤼넨탈 게엠베하 | 3-(3-디메틸아미노-1-에틸-2-메틸-프로필)-페놀의 염 또는 공결정 |
US8853456B2 (en) | 2010-08-16 | 2014-10-07 | Indoco Remedies Limited | Process for the preparation of tapentadol |
EP2619174A4 (fr) | 2010-09-20 | 2014-05-14 | Ind Swift Lab Ltd | Procédé de préparation de dérivés de l-phényl-3-diméthylaminopropane |
CN102477016B (zh) * | 2010-11-26 | 2014-12-17 | 中国医学科学院药物研究所 | 他喷他多的中间体的合成与应用 |
WO2012089181A1 (fr) * | 2010-12-30 | 2012-07-05 | Zentiva, K.S. | Acides (2r, 3r)-3-(3-hydroxyphényle)-2-méthyl-4-penténoïques o-substitués et leur procédé d'obtention |
CZ2010998A3 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
CZ302992B6 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
WO2012146978A2 (fr) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | Nouveau processus de préparation de tapentadol ou d'un sel pharmaceutiquement acceptable de ce dernier |
EP2530072A1 (fr) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | Nouveaux composés, synthèse et utilisation dans le traitement de la douleur |
WO2013016840A1 (fr) | 2011-07-29 | 2013-02-07 | 安徽省新星药物开发有限责任公司 | Nouvel intermédiaire utilisé pour préparer du tapentadol ou ses analogues |
WO2013105109A1 (fr) | 2011-11-09 | 2013-07-18 | Indoco Remedies Limited | Procédé de préparation de tapentadol |
WO2013090161A1 (fr) | 2011-12-12 | 2013-06-20 | Boehringer Ingelheim International Gmbh | Synthèse stéréosélective du tapendatol et de ses sels |
WO2013120466A1 (fr) | 2012-02-17 | 2013-08-22 | Zentiva, K.S. | Nouvelle forme solide du tapentadol et procédé pour sa préparation |
EP2674414A1 (fr) | 2012-06-15 | 2013-12-18 | Siegfried AG | Appareils dýimpression |
CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
IN2013MU03670A (fr) | 2013-11-21 | 2015-07-31 | Unimark Remedies Ltd | |
WO2015091068A1 (fr) | 2013-12-16 | 2015-06-25 | Farma Grs, D.O.O. | Formes cristallines d'intermédiaire du tapentadol |
CZ307492B6 (cs) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | Pevná forma maleátu tapentadolu a způsob její přípravy |
PL3319941T3 (pl) | 2015-07-10 | 2022-05-02 | SpecGx LLC | Dwuetapowy sposób wytwarzania 3-podstawionych fenyloalkiloamin |
EP4269384A1 (fr) | 2022-04-26 | 2023-11-01 | KRKA, d.d., Novo mesto | PROCÉDÉ DE CRISTALLISATION d'un INTERMÉDIAIRE DE TAPENTADOL, INTERMÉDIAIRE DE TAPENTADOL DE HAUTE PURETÉ, PROCÉDÉ DE FABRICATION DE TAPENTADOL ET TAPENTADOL DE HAUTE PURETÉ |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3978129A (en) * | 1972-01-28 | 1976-08-31 | A. H. Robins Company, Incorporated | Alkenyl- and alkanylamines |
DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
DE19609847A1 (de) | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
DE19857475A1 (de) * | 1998-12-14 | 2000-06-15 | Gruenenthal Gmbh | Substituierte Cycloheptene, deren Herstellung und Verwendung |
DE19933421A1 (de) | 1999-07-16 | 2001-01-25 | Gruenenthal Gmbh | 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate |
DE10000311A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Aminomethyl-Phonyl-Cyclohexanonderivate |
-
2003
- 2003-06-06 DE DE10326097A patent/DE10326097A1/de not_active Withdrawn
-
2004
- 2004-06-04 RU RU2005141518/04A patent/RU2380355C2/ru active
- 2004-06-04 EP EP04739583A patent/EP1633697B1/fr not_active Expired - Lifetime
- 2004-06-04 KR KR1020057023464A patent/KR101146205B1/ko active IP Right Grant
- 2004-06-04 AU AU2004245223A patent/AU2004245223C1/en not_active Expired
- 2004-06-04 CN CN2004800218627A patent/CN1829681B/zh not_active Expired - Lifetime
- 2004-06-04 DK DK04739583T patent/DK1633697T3/da active
- 2004-06-04 JP JP2006508271A patent/JP4848268B2/ja not_active Expired - Lifetime
- 2004-06-04 ES ES04739583T patent/ES2323870T3/es not_active Expired - Lifetime
- 2004-06-04 BR BRPI0411268A patent/BRPI0411268C8/pt active IP Right Grant
- 2004-06-04 PT PT04739583T patent/PT1633697E/pt unknown
- 2004-06-04 DE DE502004009142T patent/DE502004009142D1/de not_active Expired - Lifetime
- 2004-06-04 SI SI200431114T patent/SI1633697T1/sl unknown
- 2004-06-04 WO PCT/EP2004/006027 patent/WO2004108658A1/fr active Application Filing
- 2004-06-04 AT AT04739583T patent/ATE425136T1/de active
- 2004-06-04 CA CA2528087A patent/CA2528087C/fr not_active Expired - Lifetime
- 2004-06-04 PL PL04739583T patent/PL1633697T3/pl unknown
- 2004-06-04 MX MXPA05013193A patent/MXPA05013193A/es active IP Right Grant
- 2004-06-04 NZ NZ544231A patent/NZ544231A/en unknown
-
2005
- 2005-12-05 IL IL172357A patent/IL172357A/en not_active IP Right Cessation
- 2005-12-06 US US11/294,449 patent/US7417170B2/en active Active
- 2005-12-13 EC EC2005006218A patent/ECSP056218A/es unknown
-
2006
- 2006-01-04 NO NO20060044A patent/NO335587B1/no unknown
- 2006-01-05 ZA ZA200600109A patent/ZA200600109B/en unknown
- 2006-09-14 HK HK06110185.8A patent/HK1088597A1/xx not_active IP Right Cessation
-
2009
- 2009-05-21 CY CY20091100536T patent/CY1109088T1/el unknown
- 2009-06-08 HR HR20090333T patent/HRP20090333T1/xx unknown
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