IN2013MU03670A - - Google Patents

Info

Publication number
IN2013MU03670A
IN2013MU03670A IN3670MU2013A IN2013MU03670A IN 2013MU03670 A IN2013MU03670 A IN 2013MU03670A IN 3670MU2013 A IN3670MU2013 A IN 3670MU2013A IN 2013MU03670 A IN2013MU03670 A IN 2013MU03670A
Authority
IN
India
Prior art keywords
solvates
hydrates
intermediates
phenyl
formula
Prior art date
Application number
Other languages
English (en)
Inventor
Ashok J Kalaria
Mukesh Kumar
Ankur A Sidhdhpura
Yogendra Chauhan
Original Assignee
Unimark Remedies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unimark Remedies Ltd filed Critical Unimark Remedies Ltd
Priority to IN3670MU2013 priority Critical patent/IN2013MU03670A/en
Priority to PCT/IB2014/066225 priority patent/WO2015075678A1/fr
Publication of IN2013MU03670A publication Critical patent/IN2013MU03670A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IN3670MU2013 2013-11-21 2014-11-21 IN2013MU03670A (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN3670MU2013 IN2013MU03670A (fr) 2013-11-21 2014-11-21
PCT/IB2014/066225 WO2015075678A1 (fr) 2013-11-21 2014-11-21 Nouveau procédé pour la préparation de dérivés de 1-phényl-3-aminopropane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3670MU2013 IN2013MU03670A (fr) 2013-11-21 2014-11-21

Publications (1)

Publication Number Publication Date
IN2013MU03670A true IN2013MU03670A (fr) 2015-07-31

Family

ID=52144778

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3670MU2013 IN2013MU03670A (fr) 2013-11-21 2014-11-21

Country Status (2)

Country Link
IN (1) IN2013MU03670A (fr)
WO (1) WO2015075678A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2539442A (en) * 2015-06-16 2016-12-21 Azad Pharmaceutical Ingredients Ag New synthesis of tapentadol-HCI intermediates

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19933421A1 (de) 1999-07-16 2001-01-25 Gruenenthal Gmbh 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate
DE10326097A1 (de) 2003-06-06 2005-01-05 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102005033732B4 (de) 2005-05-27 2014-02-13 Grünenthal GmbH Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
TWI448447B (zh) 2006-07-24 2014-08-11 Gruenenthal Chemie 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
SI2046726T1 (sl) 2006-07-24 2010-05-31 Janssen Pharmaceutica Nv Priprava R R metoksifenil N N trimetilpentanamina
CN102002065B (zh) 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
IT1397189B1 (it) 2009-12-01 2013-01-04 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
WO2011080756A1 (fr) 2009-12-29 2011-07-07 Ind-Swift Laboratories Limited Procédé de préparation de dérivés de 1-phényl-3-diméthylaminopropane
CA2785035A1 (fr) 2009-12-29 2011-07-07 Mapi Pharma Limited Composes intermediaires et procedes pour la preparation de tapentadol et de composes apparentes
WO2011092719A2 (fr) 2010-02-01 2011-08-04 Ind-Swift Laboratories Limited Procédé de préparation de dérivés l-phényl-3-diméthylaminopropane
WO2011107876A2 (fr) 2010-03-05 2011-09-09 Actavis Group Ptc Ehf Procédés de résolution perfectionnés pour l'isolement d'énantiomères souhaités d'intermédiaires du tapentadol et leur utilisation pour la préparation de tapentadol
WO2011128784A2 (fr) * 2010-04-05 2011-10-20 Actavis Group Ptc Ehf Nouveau procédé de synthèse de tapentadol de pureté élevée ou de l'un de ses sels de qualité pharmaceutique
WO2012051246A1 (fr) * 2010-10-12 2012-04-19 Ratiopharm Gmbh Bromhydrate de tapentadol et formes cristallines de celui-ci
CN102320984B (zh) 2011-07-25 2014-04-02 江苏恩华药业股份有限公司 (r)-3-(3-甲氧基苯基)-n,n,2-三甲基戊-3-烯-1-胺的制备方法
EP2674414A1 (fr) 2012-06-15 2013-12-18 Siegfried AG Appareils dýimpression
CN102936205B (zh) 2012-11-12 2014-06-18 合肥市新星医药化工有限公司 一种他喷他多的合成方法

Also Published As

Publication number Publication date
WO2015075678A1 (fr) 2015-05-28

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