IN2013MU03670A - - Google Patents
Info
- Publication number
- IN2013MU03670A IN2013MU03670A IN3670MU2013A IN2013MU03670A IN 2013MU03670 A IN2013MU03670 A IN 2013MU03670A IN 3670MU2013 A IN3670MU2013 A IN 3670MU2013A IN 2013MU03670 A IN2013MU03670 A IN 2013MU03670A
- Authority
- IN
- India
- Prior art keywords
- solvates
- hydrates
- intermediates
- phenyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Abstract
The present invention relates to a novel process for the preparation of 1-phenyl-3-aminopropane derivative compounds corresponding to the formula (I) (I) and/or its intermediates, and/or its stereo specific isomers or pharmaceutically acceptable salts, hydrates, or solvates thereof.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2014/066225 WO2015075678A1 (en) | 2013-11-21 | 2014-11-21 | A novel process for the preparation of 1-phenyl-3-aminopropane derivatives |
IN3670MU2013 IN2013MU03670A (en) | 2013-11-21 | 2014-11-21 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3670MU2013 IN2013MU03670A (en) | 2013-11-21 | 2014-11-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013MU03670A true IN2013MU03670A (en) | 2015-07-31 |
Family
ID=52144778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN3670MU2013 IN2013MU03670A (en) | 2013-11-21 | 2014-11-21 |
Country Status (2)
Country | Link |
---|---|
IN (1) | IN2013MU03670A (en) |
WO (1) | WO2015075678A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2539442A (en) * | 2015-06-16 | 2016-12-21 | Azad Pharmaceutical Ingredients Ag | New synthesis of tapentadol-HCI intermediates |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4426245A1 (en) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-phenyl-3-dimethylamino-propane compounds with pharmacological activity |
DE19933421A1 (en) | 1999-07-16 | 2001-01-25 | Gruenenthal Gmbh | 2-benzyl-3-dimethylamino-1-phenyl propane derivative |
DE10326097A1 (en) | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Process for the preparation of dimethyl (3-aryl-butyl) -amine compounds |
DE10328316A1 (en) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Process for the preparation of dimethyl (3-aryl-butyl) -amine compounds as pharmaceutical active ingredients |
DE102005033732B4 (en) | 2005-05-27 | 2014-02-13 | Grünenthal GmbH | Separation of stereoisomeric N, N-dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkanes |
TWI448447B (en) | 2006-07-24 | 2014-08-11 | Gruenenthal Chemie | Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
TWI401237B (en) | 2006-07-24 | 2013-07-11 | Preparation of 3-[(1r, 2r)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride | |
AU2007278224C1 (en) | 2006-07-24 | 2012-06-21 | Grünenthal GmbH | Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine |
CN102002065B (en) | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | Method for preparing tapentadolhydrochloride and intermediate thereof |
IT1397189B1 (en) | 2009-12-01 | 2013-01-04 | Archimica Srl | NEW PROCESS FOR THE PREPARATION OF TAPENTADOL AND ITS INTERMEDIATES. |
WO2011080756A1 (en) | 2009-12-29 | 2011-07-07 | Ind-Swift Laboratories Limited | Process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives |
BR112012016059A2 (en) | 2009-12-29 | 2015-09-01 | Mapi Pharma Ltd | "intermediate compounds and processes for the preparation of tapentadol and related compounds". |
WO2011092719A2 (en) | 2010-02-01 | 2011-08-04 | Ind-Swift Laboratories Limited | Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives |
US20130096346A1 (en) | 2010-03-05 | 2013-04-18 | Actavis Group Ptc Ehf | Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
CA2793948A1 (en) * | 2010-04-05 | 2011-10-20 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
WO2012051246A1 (en) * | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
CN102320984B (en) | 2011-07-25 | 2014-04-02 | 江苏恩华药业股份有限公司 | Preparation method of (R)-3-(3-methoxy phenyl)-N,N,2-trimethylpent-3-ene-1-amine |
EP2674414A1 (en) | 2012-06-15 | 2013-12-18 | Siegfried AG | Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds |
CN102936205B (en) | 2012-11-12 | 2014-06-18 | 合肥市新星医药化工有限公司 | Synthesis method of tapentadol |
-
2014
- 2014-11-21 IN IN3670MU2013 patent/IN2013MU03670A/en unknown
- 2014-11-21 WO PCT/IB2014/066225 patent/WO2015075678A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2015075678A1 (en) | 2015-05-28 |
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