HRP20051019A2 - A method for the preparation of enantiomerically pure mirtazapine - Google Patents
A method for the preparation of enantiomerically pure mirtazapineInfo
- Publication number
- HRP20051019A2 HRP20051019A2 HR20051019A HRP20051019A HRP20051019A2 HR P20051019 A2 HRP20051019 A2 HR P20051019A2 HR 20051019 A HR20051019 A HR 20051019A HR P20051019 A HRP20051019 A HR P20051019A HR P20051019 A2 HRP20051019 A2 HR P20051019A2
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- enantiomerically pure
- mirtazapine
- acid
- pure mirtazapine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03102095 | 2003-07-10 | ||
| PCT/EP2004/051357 WO2005005410A1 (en) | 2003-07-10 | 2004-07-05 | A method for the preparation of enantiomerically pure mirtazapine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20051019A2 true HRP20051019A2 (en) | 2006-02-28 |
Family
ID=34042934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20051019A HRP20051019A2 (en) | 2003-07-10 | 2005-12-22 | A method for the preparation of enantiomerically pure mirtazapine |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US8058436B2 (is) |
| EP (1) | EP1656365B1 (is) |
| JP (1) | JP4668184B2 (is) |
| KR (1) | KR20060056315A (is) |
| CN (1) | CN100558722C (is) |
| AR (1) | AR046494A1 (is) |
| AT (1) | ATE433965T1 (is) |
| AU (1) | AU2004255874B2 (is) |
| BR (1) | BRPI0412447A (is) |
| CA (1) | CA2531165C (is) |
| CO (1) | CO5640123A2 (is) |
| CY (1) | CY1109327T1 (is) |
| DE (1) | DE602004021605D1 (is) |
| DK (1) | DK1656365T3 (is) |
| EC (1) | ECSP066271A (is) |
| ES (1) | ES2327123T3 (is) |
| HK (1) | HK1086841A1 (is) |
| HR (1) | HRP20051019A2 (is) |
| IL (1) | IL172549A0 (is) |
| IS (1) | IS2674B (is) |
| LT (1) | LT5382B (is) |
| LV (1) | LV13441B (is) |
| MX (1) | MXPA06000325A (is) |
| NO (1) | NO20056175L (is) |
| NZ (1) | NZ544360A (is) |
| PE (1) | PE20050323A1 (is) |
| PL (1) | PL1656365T3 (is) |
| PT (1) | PT1656365E (is) |
| RS (1) | RS20050972A (is) |
| RU (1) | RU2352566C2 (is) |
| SG (1) | SG144914A1 (is) |
| SI (1) | SI1656365T1 (is) |
| TW (1) | TWI335915B (is) |
| UA (1) | UA83666C2 (is) |
| WO (1) | WO2005005410A1 (is) |
| ZA (1) | ZA200600019B (is) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5080050B2 (ja) * | 2005-09-26 | 2012-11-21 | 住友化学株式会社 | 光学活性なピペラジン化合物の製造方法 |
| CN102153620A (zh) * | 2005-09-26 | 2011-08-17 | 住友化学株式会社 | 光学活性的哌嗪化合物的制造方法 |
| TW200808804A (en) * | 2006-05-22 | 2008-02-16 | Organon Nv | Mirtazapine for the treatment of neuropathic pain |
| TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
| JP5438976B2 (ja) * | 2007-02-09 | 2014-03-12 | 株式会社カネカ | 光学活性２−アリールピペラジン誘導体の製造法 |
| JP5192707B2 (ja) * | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | ミルタザピンの製造方法 |
| MX2009010967A (es) * | 2007-04-11 | 2009-12-15 | Organon Nv | Un metodo para la preparacion de mirtazapina. |
| US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
| KR101485418B1 (ko) * | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | 고순도 미르타자핀의 제조방법 |
| JP6876003B2 (ja) | 2015-02-27 | 2021-05-26 | デクラ リミテッド | イヌ及びネコにおける、食欲の刺激、体重減少の管理、及び拒食症の処置 |
| KR102540021B1 (ko) * | 2020-12-02 | 2023-06-07 | (주)유케이케미팜 | 대량 생산에 적합한 미르타자핀의 제조방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3959470A (en) * | 1972-11-28 | 1976-05-25 | Mikhail Davidovich Mashkovsky | Psychotropic medicinal preparation |
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| RU2048469C1 (ru) * | 1989-10-05 | 1995-11-20 | Санкио Компани Лимитед | Способ получения азетидинового производного или его фармацевтически приемлемой соли |
| ATE289816T1 (de) | 1997-11-14 | 2005-03-15 | Akzo Nobel Nv | Verwendung von mirtazapine zur herstellung eines medikaments zur behandlung von schlafapnoen |
| JPH11222407A (ja) * | 1997-11-14 | 1999-08-17 | Sankyo Co Ltd | 新規殺菌剤 |
| CN1679586A (zh) * | 1999-04-19 | 2005-10-12 | 特瓦制药工业有限公司 | 含哌嗪环化合物的新型合成和结晶方法 |
| US20030069417A1 (en) * | 1999-04-19 | 2003-04-10 | Claude Singer | Novel synthesis and crystallization of piperazine ring-containing compounds |
| US6068695A (en) * | 1999-07-13 | 2000-05-30 | Bayer Corporation | Process for the continuous preparation of quinacridones |
| AU6476300A (en) | 1999-09-30 | 2001-05-10 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a piperazine derivative |
| AU6474200A (en) | 1999-12-13 | 2001-06-18 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
| DK1257278T3 (da) | 2000-02-11 | 2006-06-12 | Akzo Nobel Nv | Anvendelse af mirtazapin til behandling af sövnforstyrrelser |
| JP2001342188A (ja) * | 2000-03-27 | 2001-12-11 | Takeda Chem Ind Ltd | 縮合ピラゾール誘導体、その製造法および用途 |
| TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
-
2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko active IP Right Grant
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en active IP Right Grant
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh not_active Expired - Lifetime
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja not_active Expired - Lifetime
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de not_active Expired - Lifetime
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en not_active Expired - Lifetime
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en not_active Expired
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es not_active Expired - Lifetime
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
-
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-22 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
-
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
- 2006-08-17 HK HK06109133.3A patent/HK1086841A1/xx not_active IP Right Cessation
-
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
-
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20051019A2 (en) | A method for the preparation of enantiomerically pure mirtazapine | |
| ATE361345T1 (de) | Metalloxyphthalocyaninverbindungen | |
| ATE338461T1 (de) | Pyrazolpyrimidinfungizide | |
| RS53398B (en) | PROCEDURE FOR OBTAINING AMINO CROTONYL UNITS | |
| DE60230327D1 (de) | Polymorphe von clopidogrel-hydrogensulfat | |
| EA200600621A1 (ru) | Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств | |
| ATE527258T1 (de) | Pyrroloä2,3-cüpyridinverbindung, verfahren zu deren herstellung und anwendung | |
| MY144633A (en) | New tricyclic derivatives, method of preparing same and pharmaceutical compositions containing them | |
| HRP20051005A2 (en) | Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives | |
| EA200700550A1 (ru) | Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств | |
| GB0411929D0 (en) | Organic compounds | |
| ATE526312T1 (de) | Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitoren | |
| NO20061344L (no) | Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer | |
| CR9472A (es) | Derivados de aminoacidos | |
| ATE514702T1 (de) | Verfahren zur herstellung von clopidogrel und dabei verwendete zwischenprodukte | |
| ATE410485T1 (de) | Härtbare farbige zusammensetzung, farbfilter und verfahren zu deren herstellung | |
| ATE423096T1 (de) | Verfahren zur herstellung von 2- azabicycloä3.3.0üoctan-3-carbonsäurederivaten | |
| ECSP056103A (es) | Tratamiento de pigmentos de alto rendimiento | |
| DE602004014264D1 (de) | Verfahren zur herstellung von olanzapin | |
| EA200600601A1 (ru) | Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы | |
| ATE415404T1 (de) | Lösungsmittelfreies verfahren zur herstellung von diketopyrrolopyrrol-derivaten | |
| DE502007006121D1 (de) | Elektrochemische herstellung sterisch gehinderter amine | |
| ATE279191T1 (de) | Trizyklische dihydrobenzofurane, verfahren zu deren herstellung und mittel | |
| BRPI0414873A (pt) | derivados de imidazopiridina como inibidores de no-sintase induzìveis | |
| PT1317455E (pt) | Processo para a preparacao de um composto de imidazopiridina substituido |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| PPPP | Transfer of rights |
Owner name: N.V. ORGANON, NL |
|
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20110629 Year of fee payment: 8 |
|
| OBST | Application withdrawn |