CN1820000A - 制备对映体纯的米氮平的方法 - Google Patents
制备对映体纯的米氮平的方法 Download PDFInfo
- Publication number
- CN1820000A CN1820000A CNA2004800194891A CN200480019489A CN1820000A CN 1820000 A CN1820000 A CN 1820000A CN A2004800194891 A CNA2004800194891 A CN A2004800194891A CN 200480019489 A CN200480019489 A CN 200480019489A CN 1820000 A CN1820000 A CN 1820000A
- Authority
- CN
- China
- Prior art keywords
- acid
- solvent
- mirtazapine
- compound
- enantiomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03102095 | 2003-07-10 | ||
EP03102095.1 | 2003-07-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1820000A true CN1820000A (zh) | 2006-08-16 |
CN100558722C CN100558722C (zh) | 2009-11-11 |
Family
ID=34042934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004800194891A Active CN100558722C (zh) | 2003-07-10 | 2004-07-05 | 制备对映体纯的米氮平的方法 |
Country Status (36)
Country | Link |
---|---|
US (2) | US8058436B2 (zh) |
EP (1) | EP1656365B1 (zh) |
JP (1) | JP4668184B2 (zh) |
KR (1) | KR20060056315A (zh) |
CN (1) | CN100558722C (zh) |
AR (1) | AR046494A1 (zh) |
AT (1) | ATE433965T1 (zh) |
AU (1) | AU2004255874B2 (zh) |
BR (1) | BRPI0412447A (zh) |
CA (1) | CA2531165C (zh) |
CO (1) | CO5640123A2 (zh) |
CY (1) | CY1109327T1 (zh) |
DE (1) | DE602004021605D1 (zh) |
DK (1) | DK1656365T3 (zh) |
EC (1) | ECSP066271A (zh) |
ES (1) | ES2327123T3 (zh) |
HK (1) | HK1086841A1 (zh) |
HR (1) | HRP20051019A2 (zh) |
IL (1) | IL172549A0 (zh) |
IS (1) | IS2674B (zh) |
LT (1) | LT5382B (zh) |
LV (1) | LV13441B (zh) |
MX (1) | MXPA06000325A (zh) |
NO (1) | NO20056175L (zh) |
NZ (1) | NZ544360A (zh) |
PE (1) | PE20050323A1 (zh) |
PL (1) | PL1656365T3 (zh) |
PT (1) | PT1656365E (zh) |
RS (1) | RS20050972A (zh) |
RU (1) | RU2352566C2 (zh) |
SG (1) | SG144914A1 (zh) |
SI (1) | SI1656365T1 (zh) |
TW (1) | TWI335915B (zh) |
UA (1) | UA83666C2 (zh) |
WO (1) | WO2005005410A1 (zh) |
ZA (1) | ZA200600019B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101679431B (zh) * | 2007-04-11 | 2013-08-14 | Msd欧斯股份有限公司 | 制备四环苯并氮杂卓的对映异构体的方法 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102153620A (zh) * | 2005-09-26 | 2011-08-17 | 住友化学株式会社 | 光学活性的哌嗪化合物的制造方法 |
JP5080050B2 (ja) * | 2005-09-26 | 2012-11-21 | 住友化学株式会社 | 光学活性なピペラジン化合物の製造方法 |
TW200808804A (en) * | 2006-05-22 | 2008-02-16 | Organon Nv | Mirtazapine for the treatment of neuropathic pain |
TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
EP2119709A4 (en) | 2007-02-09 | 2011-08-17 | Kaneka Corp | PROCESS FOR PREPARING OPTICALLY ACTIVE 2-ARYLPIPERAZINE DERIVATIVE |
JP5192707B2 (ja) | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | ミルタザピンの製造方法 |
US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
KR101485418B1 (ko) * | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | 고순도 미르타자핀의 제조방법 |
WO2016138357A1 (en) | 2015-02-27 | 2016-09-01 | Kindred Biosciences, Inc. | Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats |
KR102540021B1 (ko) * | 2020-12-02 | 2023-06-07 | (주)유케이케미팜 | 대량 생산에 적합한 미르타자핀의 제조방법 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3959470A (en) * | 1972-11-28 | 1976-05-25 | Mikhail Davidovich Mashkovsky | Psychotropic medicinal preparation |
NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
PT95522B (pt) * | 1989-10-05 | 1997-08-29 | Sankyo Co | Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem |
IL135825A0 (en) | 1997-11-14 | 2001-05-20 | Akzo Nobel Nv | Use of mirtazapine for treating sleep apneas |
JPH11222407A (ja) * | 1997-11-14 | 1999-08-17 | Sankyo Co Ltd | 新規殺菌剤 |
JP2004500324A (ja) * | 1999-04-19 | 2004-01-08 | テバ ファーマシューティカル インダストリーズ リミティド | ピペラジン環含有化合物の新規の合成及び結晶化 |
US20030069417A1 (en) * | 1999-04-19 | 2003-04-10 | Claude Singer | Novel synthesis and crystallization of piperazine ring-containing compounds |
US6068695A (en) * | 1999-07-13 | 2000-05-30 | Bayer Corporation | Process for the continuous preparation of quinacridones |
AU6476300A (en) | 1999-09-30 | 2001-05-10 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a piperazine derivative |
WO2001042239A1 (fr) | 1999-12-13 | 2001-06-14 | Sumika Fine Chemicals Co., Ltd. | Procede de preparation d'un compose pyridinemethanol |
RU2270680C2 (ru) | 2000-02-11 | 2006-02-27 | Акцо Нобель Н.В. | Применение миртазапина для лечения расстройств сна |
JP2001342188A (ja) * | 2000-03-27 | 2001-12-11 | Takeda Chem Ind Ltd | 縮合ピラゾール誘導体、その製造法および用途 |
TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
-
2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja active Active
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en active IP Right Grant
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es active Active
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en active Active
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko active IP Right Grant
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh active Active
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en active Active
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de active Active
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
-
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-22 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
-
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
- 2006-08-17 HK HK06109133.3A patent/HK1086841A1/xx not_active IP Right Cessation
-
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
-
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101679431B (zh) * | 2007-04-11 | 2013-08-14 | Msd欧斯股份有限公司 | 制备四环苯并氮杂卓的对映异构体的方法 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: ORGANON NV Free format text: FORMER OWNER: AKZO NOVEL N.V. CORP. Effective date: 20061229 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20061229 Address after: Holland Applicant after: N.V. ORGANON Address before: Holland Arnhem Applicant before: AKZO NOBEL N.V. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: MSD OS CO., LTD. Free format text: FORMER NAME: ORGANON NV |
|
CP01 | Change in the name or title of a patent holder |
Address after: Holland Patentee after: N.V. Organon Address before: Holland Patentee before: N.V. ORGANON |
|
ASS | Succession or assignment of patent right |
Owner name: MERCK SHARP + DOHME CORP. Free format text: FORMER OWNER: ORGANON BIOLOGICAL NETHERLANDS CO., LTD. Effective date: 20131010 Owner name: ORGANON BIOLOGICAL NETHERLANDS CO., LTD. Free format text: FORMER OWNER: MSD OUSI CO., LTD. Effective date: 20131010 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20131010 Address after: Haarlem Patentee after: MERCK SHARP & DOHME B.V. Address before: Haarlem Patentee before: Organon biological science Holland Co.,Ltd. Effective date of registration: 20131010 Address after: Haarlem Patentee after: Organon biological science Holland Co.,Ltd. Address before: Holland Patentee before: N.V. Organon |